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The map label for this gene is aroB

Identifier: 23099239

GI number: 23099239

Start: 1821253

End: 1822332

Strand: Reverse

Name: aroB

Synonym: OB1784

Alternate gene names: 23099239

Gene position: 1822332-1821253 (Counterclockwise)

Preceding gene: 23099240

Following gene: 23099238

Centisome position: 50.19

GC content: 34.17

Gene sequence:

>1080_bases
ATGGAAGAAATGACAGTGCAATCGAACCAAAGCTCGTACCCAATTTATATTGGTCAAGGCTTACGATATCAACTAAGTTC
CTATATTGAAAAAAAATATACAAAACTATTTATTATTACAGATGATCAAGTAGGAAGTCGTTATCTTAAAGATGTATTAC
ATGGTTATCCATCTGAGGAAAATATCTGTCATTTCACCATTCCTTCTGGAGAAAGTTCAAAGAGTATCGATAACTTTTAT
CGTTTGCAAACAGAGGCACTCCAGAATGGTTTAGACCGACATTCATTAATTATTGCATTAGGCGGAGGGGTAGTAGGTGA
TTTGGCTGGTTTAGTTGCTGCTACTTTTATGCGCGGAATTGATTATATCCAAGTTCCAACTACAATTCTTGCACATGATA
GTAGTGTAGGTGGAAAAGTCGCAATTAATCATCATTTGGGAAAAAATTTAATCGGAAGTTTTTTCCCACCCGTTGCCGTA
ATTTACGATATAGAAACATTGTCAACATTACCTCCTCATGAGATTAGAAGTGGTTATGCTGAAATCGTCAAAGAGGGTTT
AATTGCAAATCAAAAAATGTTTTTATCATTATTGGATCATTCATTAGCTTCAATAAAACCTCATCAACTTGAAATATATT
TAAAAGCAGGAATTCAAGTAAAATCAAGAATTGTAGAACAAGATGAGAAAGAGGCTAACATAAGAAAGTTTCTCAATCTA
GGACATACATTAGGTCATGCATTAGAAACGATTCACGGCTATGGGAATATCACTCATGGGGAAGCAGTTGCAAATGGTTT
GTTATTTGCGCTTCATGTCAGTGAATATGAATTTGAAATACAACTGCCTTTTTATCAATTATATCAGTGGTTAAAAGATA
ACGAATATCCTATTCTCTCTTTTTCCGAAGAAGAAATCACACAGTTAATAGAGCTTATGAAAACTGATAAAAAATCAGTT
GGCGGCACAATACAGATGGTTCTTTTAAAAGAAGTGGAAGACCCTGTAACTGTCTCATTAGATAATTCAATGATGAAACA
ACATCTATCGACCTATTTAGAAAGGATGGAGAAACTGTGA

Upstream 100 bases:

>100_bases
AATTAGCAAAAGCCCTTACCGAACAATTTTCTAGCGATCAATTGCCACAATTAAAAAAAGCAATTGATGATTACAGAGAA
GAAATTAGGTGCTTCTAAAA

Downstream 100 bases:

>100_bases
CCAGAGGTGTACGAGGAGCTACAACAATTCAAGAAAATAATGCAGAAGAGATCGTCTTGCGGACCGAAGAACTTGTTAAA
GCTATGGTAGAACAGAACAA

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MEEMTVQSNQSSYPIYIGQGLRYQLSSYIEKKYTKLFIITDDQVGSRYLKDVLHGYPSEENICHFTIPSGESSKSIDNFY
RLQTEALQNGLDRHSLIIALGGGVVGDLAGLVAATFMRGIDYIQVPTTILAHDSSVGGKVAINHHLGKNLIGSFFPPVAV
IYDIETLSTLPPHEIRSGYAEIVKEGLIANQKMFLSLLDHSLASIKPHQLEIYLKAGIQVKSRIVEQDEKEANIRKFLNL
GHTLGHALETIHGYGNITHGEAVANGLLFALHVSEYEFEIQLPFYQLYQWLKDNEYPILSFSEEEITQLIELMKTDKKSV
GGTIQMVLLKEVEDPVTVSLDNSMMKQHLSTYLERMEKL

Sequences:

>Translated_359_residues
MEEMTVQSNQSSYPIYIGQGLRYQLSSYIEKKYTKLFIITDDQVGSRYLKDVLHGYPSEENICHFTIPSGESSKSIDNFY
RLQTEALQNGLDRHSLIIALGGGVVGDLAGLVAATFMRGIDYIQVPTTILAHDSSVGGKVAINHHLGKNLIGSFFPPVAV
IYDIETLSTLPPHEIRSGYAEIVKEGLIANQKMFLSLLDHSLASIKPHQLEIYLKAGIQVKSRIVEQDEKEANIRKFLNL
GHTLGHALETIHGYGNITHGEAVANGLLFALHVSEYEFEIQLPFYQLYQWLKDNEYPILSFSEEEITQLIELMKTDKKSV
GGTIQMVLLKEVEDPVTVSLDNSMMKQHLSTYLERMEKL
>Mature_359_residues
MEEMTVQSNQSSYPIYIGQGLRYQLSSYIEKKYTKLFIITDDQVGSRYLKDVLHGYPSEENICHFTIPSGESSKSIDNFY
RLQTEALQNGLDRHSLIIALGGGVVGDLAGLVAATFMRGIDYIQVPTTILAHDSSVGGKVAINHHLGKNLIGSFFPPVAV
IYDIETLSTLPPHEIRSGYAEIVKEGLIANQKMFLSLLDHSLASIKPHQLEIYLKAGIQVKSRIVEQDEKEANIRKFLNL
GHTLGHALETIHGYGNITHGEAVANGLLFALHVSEYEFEIQLPFYQLYQWLKDNEYPILSFSEEEITQLIELMKTDKKSV
GGTIQMVLLKEVEDPVTVSLDNSMMKQHLSTYLERMEKL

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; second step. [C]

COG id: COG0337

COG function: function code E; 3-dehydroquinate synthetase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dehydroquinate synthase family

Homologues:

Organism=Escherichia coli, GI1789791, Length=335, Percent_Identity=37.6119402985075, Blast_Score=205, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6320332, Length=323, Percent_Identity=31.5789473684211, Blast_Score=155, Evalue=9e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROB_OCEIH (Q8EQB7)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_692705.1
- ProteinModelPortal:   Q8EQB7
- SMR:   Q8EQB7
- GeneID:   1018278
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB1784
- NMPDR:   fig|221109.1.peg.1785
- HOGENOM:   HBG632303
- OMA:   YINEFAL
- BioCyc:   OIHE221109:OB1784-MONOMER
- BRENDA:   4.2.3.4
- GO:   GO:0005737
- HAMAP:   MF_00110
- InterPro:   IPR016303
- InterPro:   IPR002658
- InterPro:   IPR016037
- PANTHER:   PTHR21090:SF1
- PIRSF:   PIRSF001455
- TIGRFAMs:   TIGR01357

Pfam domain/function: PF01761 DHQ_synthase

EC number: =4.2.3.4

Molecular weight: Translated: 40348; Mature: 40348

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEMTVQSNQSSYPIYIGQGLRYQLSSYIEKKYTKLFIITDDQVGSRYLKDVLHGYPSEE
CCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHCEEEEEEECCHHHHHHHHHHHCCCCCCC
NICHFTIPSGESSKSIDNFYRLQTEALQNGLDRHSLIIALGGGVVGDLAGLVAATFMRGI
CEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCC
DYIQVPTTILAHDSSVGGKVAINHHLGKNLIGSFFPPVAVIYDIETLSTLPPHEIRSGYA
CEEECCCEEEECCCCCCCEEEEEHHHCHHHHHHHCCCCEEEEEHHHHCCCCCHHHHHHHH
EIVKEGLIANQKMFLSLLDHSLASIKPHQLEIYLKAGIQVKSRIVEQDEKEANIRKFLNL
HHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHCCHHHHHHHHHHHH
GHTLGHALETIHGYGNITHGEAVANGLLFALHVSEYEFEIQLPFYQLYQWLKDNEYPILS
HHHHHHHHHHHHCCCCCCCHHHHHCCEEEEEEEECEEEEEECCHHHHHHHHCCCCCCEEE
FSEEEITQLIELMKTDKKSVGGTIQMVLLKEVEDPVTVSLDNSMMKQHLSTYLERMEKL
ECHHHHHHHHHHHHHHHHHCCCEEEEEEEHHCCCCEEEEECHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEEMTVQSNQSSYPIYIGQGLRYQLSSYIEKKYTKLFIITDDQVGSRYLKDVLHGYPSEE
CCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHCEEEEEEECCHHHHHHHHHHHCCCCCCC
NICHFTIPSGESSKSIDNFYRLQTEALQNGLDRHSLIIALGGGVVGDLAGLVAATFMRGI
CEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCC
DYIQVPTTILAHDSSVGGKVAINHHLGKNLIGSFFPPVAVIYDIETLSTLPPHEIRSGYA
CEEECCCEEEECCCCCCCEEEEEHHHCHHHHHHHCCCCEEEEEHHHHCCCCCHHHHHHHH
EIVKEGLIANQKMFLSLLDHSLASIKPHQLEIYLKAGIQVKSRIVEQDEKEANIRKFLNL
HHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHCCHHHHHHHHHHHH
GHTLGHALETIHGYGNITHGEAVANGLLFALHVSEYEFEIQLPFYQLYQWLKDNEYPILS
HHHHHHHHHHHHCCCCCCCHHHHHCCEEEEEEEECEEEEEECCHHHHHHHHCCCCCCEEE
FSEEEITQLIELMKTDKKSVGGTIQMVLLKEVEDPVTVSLDNSMMKQHLSTYLERMEKL
ECHHHHHHHHHHHHHHHHHCCCEEEEEEEHHCCCCEEEEECHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376