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The map label for this gene is ytkP [H]

Identifier: 23099158

GI number: 23099158

Start: 1747466

End: 1748389

Strand: Direct

Name: ytkP [H]

Synonym: OB1703

Alternate gene names: 23099158

Gene position: 1747466-1748389 (Clockwise)

Preceding gene: 23099157

Following gene: 23099159

Centisome position: 48.13

GC content: 40.15

Gene sequence:

>924_bases
ATGCGTGTAGTCAATGATGTAACTGAATTAATTGGTCAAACACCAATGGTTAAGTTAAATCGTCTCCAACCAGAAAATGC
AGCTGACATATATGTAAAGTTAGAGATGTTTAATCCGAGCGGTAGTGTAAAAGACCGAGCTGCATCCCATATGATACGTG
TAGCAGAAGAACAAGGGTTAATAAAACAAGGAGCCACTATTATAGAACCTACAAGTGGAAATACAGGCATCGGTTTGGCA
ATGGCGGCATCTGCTAAAGGATATAAAGCAATTATGATTATGCCGGATAATAGTACGATGGAACGTCGAAATATATTAAA
GGCGTATGGAGCAGAAGTCGTACTTACGCCAAGTGAGGAAAAAATGCCTGGATCCATACGTAAAGCGCTAGAACTTCAAA
AATCCATTCCTAACAGTTTTATACCTCAACAATTTGAAAATGTAGCTAACCCAGATGTTCATCGTATTAGCACTGCTTTA
GAAATCTTGGAACAGATGGATAATCAATTAGATGCGTTTGTCTGTACTGCAGGAACTGGTGGTACGGTAACAGGTACAGG
AGAAACATTAAAGGAAAAGTTACCACATGTGCATGTGGCGGTTGTGGAACCAGAAGGATCACCCGTCTTATCAGGAGGAA
AGCCGGGACCGCATAAACTCGTTGGCACAAGTCCGGGATTCGTACCTGATATTTTAAATACGGATGTATACGATGAAATC
ATTCAAATTAAAGATGAACAAGCTGTCACTTTATTAAAAGACCTTGCTCAAAAAGAAGGGATTTTTCTTGGTCCATCTGG
AGCAGCTGCTGTATATGCGGCAATGGAAGTAGCGAAGAAGCTTGGCCCAAACAAAAAGCTTGTATGTATAGCACCAGATA
CAGGAGAACGTTATCTATCCATGGATATGTTTGATGAAAAGTAA

Upstream 100 bases:

>100_bases
AGAGAAAGAATCATTCTTACAGCAGTTAATGGATATCAATCCTGACATATCTATTGATAAGCGATTATTAGAAAGTATTG
AAAGAAAGTAGGGATATCAC

Downstream 100 bases:

>100_bases
AATAAAACTTTTACCGTAATAGTGAGAAAGGTCATGAACAAATGATCTTTCTCACTATTTTTCTATTTGAATGGAGAACG
AAGGTTTAGTCGCGAGTGAT

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MRVVNDVTELIGQTPMVKLNRLQPENAADIYVKLEMFNPSGSVKDRAASHMIRVAEEQGLIKQGATIIEPTSGNTGIGLA
MAASAKGYKAIMIMPDNSTMERRNILKAYGAEVVLTPSEEKMPGSIRKALELQKSIPNSFIPQQFENVANPDVHRISTAL
EILEQMDNQLDAFVCTAGTGGTVTGTGETLKEKLPHVHVAVVEPEGSPVLSGGKPGPHKLVGTSPGFVPDILNTDVYDEI
IQIKDEQAVTLLKDLAQKEGIFLGPSGAAAVYAAMEVAKKLGPNKKLVCIAPDTGERYLSMDMFDEK

Sequences:

>Translated_307_residues
MRVVNDVTELIGQTPMVKLNRLQPENAADIYVKLEMFNPSGSVKDRAASHMIRVAEEQGLIKQGATIIEPTSGNTGIGLA
MAASAKGYKAIMIMPDNSTMERRNILKAYGAEVVLTPSEEKMPGSIRKALELQKSIPNSFIPQQFENVANPDVHRISTAL
EILEQMDNQLDAFVCTAGTGGTVTGTGETLKEKLPHVHVAVVEPEGSPVLSGGKPGPHKLVGTSPGFVPDILNTDVYDEI
IQIKDEQAVTLLKDLAQKEGIFLGPSGAAAVYAAMEVAKKLGPNKKLVCIAPDTGERYLSMDMFDEK
>Mature_307_residues
MRVVNDVTELIGQTPMVKLNRLQPENAADIYVKLEMFNPSGSVKDRAASHMIRVAEEQGLIKQGATIIEPTSGNTGIGLA
MAASAKGYKAIMIMPDNSTMERRNILKAYGAEVVLTPSEEKMPGSIRKALELQKSIPNSFIPQQFENVANPDVHRISTAL
EILEQMDNQLDAFVCTAGTGGTVTGTGETLKEKLPHVHVAVVEPEGSPVLSGGKPGPHKLVGTSPGFVPDILNTDVYDEI
IQIKDEQAVTLLKDLAQKEGIFLGPSGAAAVYAAMEVAKKLGPNKKLVCIAPDTGERYLSMDMFDEK

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=314, Percent_Identity=39.171974522293, Blast_Score=225, Evalue=4e-59,
Organism=Homo sapiens, GI295821200, Length=314, Percent_Identity=39.171974522293, Blast_Score=225, Evalue=4e-59,
Organism=Homo sapiens, GI4557415, Length=314, Percent_Identity=39.171974522293, Blast_Score=225, Evalue=4e-59,
Organism=Homo sapiens, GI11345492, Length=302, Percent_Identity=24.5033112582781, Blast_Score=72, Evalue=9e-13,
Organism=Escherichia coli, GI2367138, Length=299, Percent_Identity=40.8026755852843, Blast_Score=222, Evalue=3e-59,
Organism=Escherichia coli, GI1788754, Length=321, Percent_Identity=42.9906542056075, Blast_Score=219, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17535051, Length=300, Percent_Identity=44.6666666666667, Blast_Score=244, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI115535073, Length=304, Percent_Identity=44.4078947368421, Blast_Score=228, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17562970, Length=306, Percent_Identity=40.1960784313725, Blast_Score=215, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI32566674, Length=299, Percent_Identity=41.4715719063545, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17561720, Length=304, Percent_Identity=38.4868421052632, Blast_Score=183, Evalue=8e-47,
Organism=Caenorhabditis elegans, GI17534315, Length=320, Percent_Identity=36.25, Blast_Score=167, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI25147552, Length=318, Percent_Identity=35.5345911949685, Blast_Score=154, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI32566672, Length=214, Percent_Identity=37.8504672897196, Blast_Score=147, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6321594, Length=325, Percent_Identity=34.1538461538462, Blast_Score=179, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6321449, Length=327, Percent_Identity=35.7798165137615, Blast_Score=157, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24643623, Length=314, Percent_Identity=39.171974522293, Blast_Score=214, Evalue=5e-56,
Organism=Drosophila melanogaster, GI20129101, Length=314, Percent_Identity=39.171974522293, Blast_Score=214, Evalue=5e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 33009; Mature: 33009

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVVNDVTELIGQTPMVKLNRLQPENAADIYVKLEMFNPSGSVKDRAASHMIRVAEEQGL
CCHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCH
IKQGATIIEPTSGNTGIGLAMAASAKGYKAIMIMPDNSTMERRNILKAYGAEVVLTPSEE
HHCCCEEEECCCCCCCEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHCCCEEEECCCCC
KMPGSIRKALELQKSIPNSFIPQQFENVANPDVHRISTALEILEQMDNQLDAFVCTAGTG
CCCHHHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCC
GTVTGTGETLKEKLPHVHVAVVEPEGSPVLSGGKPGPHKLVGTSPGFVPDILNTDVYDEI
CEEECCCHHHHHHCCEEEEEEECCCCCEECCCCCCCCCCEECCCCCCCHHHHCCHHHHHH
IQIKDEQAVTLLKDLAQKEGIFLGPSGAAAVYAAMEVAKKLGPNKKLVCIAPDTGERYLS
HHCCCHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEE
MDMFDEK
CCCCCCC
>Mature Secondary Structure
MRVVNDVTELIGQTPMVKLNRLQPENAADIYVKLEMFNPSGSVKDRAASHMIRVAEEQGL
CCHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCH
IKQGATIIEPTSGNTGIGLAMAASAKGYKAIMIMPDNSTMERRNILKAYGAEVVLTPSEE
HHCCCEEEECCCCCCCEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHCCCEEEECCCCC
KMPGSIRKALELQKSIPNSFIPQQFENVANPDVHRISTALEILEQMDNQLDAFVCTAGTG
CCCHHHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCC
GTVTGTGETLKEKLPHVHVAVVEPEGSPVLSGGKPGPHKLVGTSPGFVPDILNTDVYDEI
CEEECCCHHHHHHCCEEEEEEECCCCCEECCCCCCCCCCEECCCCCCCHHHHCCHHHHHH
IQIKDEQAVTLLKDLAQKEGIFLGPSGAAAVYAAMEVAKKLGPNKKLVCIAPDTGERYLS
HHCCCHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEE
MDMFDEK
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]