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The map label for this gene is yngE [H]

Identifier: 23099154

GI number: 23099154

Start: 1740370

End: 1741899

Strand: Direct

Name: yngE [H]

Synonym: OB1699

Alternate gene names: 23099154

Gene position: 1740370-1741899 (Clockwise)

Preceding gene: 23099153

Following gene: 23099155

Centisome position: 47.94

GC content: 37.58

Gene sequence:

>1530_bases
ATGGATTATATTCAGGAATTACAACAACGAATAGAAAAAATAGAAAAAGGCGGAAAGCAAAAGTATCATGACAGTAACAC
GGATAAAGGTAAACTATTTGCTCGAAAACGAATCGAACTTTTATTCGATCAAGATATTAATGTAGAAGATGCGTTATTTG
CCAATCATTCAGCAGAGGATTTACCTGCTGATGGAGTGATTACTGCTATAGGAAAAATTAATGGTCAGACTGTATGTGTG
ATGGCAAATGACTCGACTGTAAAAGCAGGGTCTTGGGGTAAACGCACAGTGGAAAAAATATTGCGTATTCAGGAAACGGC
AGAGAAAATGGAAGTTCCGATCCTTTATCTAGTAGATTCAGCTGGTGCTAGAATTACCGATCAGGTAGAAATGTTCCCAG
GCCGAAGAGGAGCAGGGCGTATCTTCTATAATCAAATAAAACTTTCCGGTAGAGTACCACAAATTTGTTTATTGTTTGGT
CCTTCTGCTGCAGGAGGGGCATACATTCCTGCTTTTTGTGATATTGTCGTGATGGTAGATGGCAATGCTTCTATGTATTT
AGGGTCACCGCGGATGGCGGAAAAAGTAATAGGCGAAAAAGTTACATTGGAAGAAATGGGCGGAGCTAATATGCATTGTT
CTGTTTCTGGTGTTGGCGATGTACTAGTCGAATCTGAGGAAGAGGCTATTGCTTTTGCAAGAACGTATTTAGATTATTTT
CCTGCAAATTTCCGTCAAAAACCATTGCCGAAAGAAGCAAGATTACCTAAACAGCAAGATAAAACTATTGAAGAAATAAT
ACCAACGAACCAGAATGCTGCATTTGATATGTATGAACTCATTAATCGAACGATTGATGAAGATAGCTTTTGTGAAATCA
AGAAAAAGTTTGCACCAGAATTAATAACTGGTCTTGCAAGATTAAATGGAAAGAGTGTAGGTATTATCGCTAATCAACCA
AGGGTAAAAGGCGGAGTTCTTTTTACTGATTCAGCGGATAAAGCAGCAAAATTCATTCAACTTTGTGATGCATTTGAAAT
ACCTTTACTATTTTTGACAGATGTTCCAGGATTTATGATTGGTACAGGTGTAGAAAAGCAAGGAATTATTCGGCATGGTG
CAAAAATGTTATTTGCAATGAGTGAAGTTACCGTTCCAAAAATATCGGTAATCGTTCGGAAAGCATATGGTGCGGGTCTT
TATGCAATGTCGGGACCAGCATTTGAACCAGACTGTTGCCTCGCATTTCCTAACGCACAAATCGCAGTTATGGGGCCTGA
AGCTGCAGTTAATGCTGTAGAAGCAAATAAAATTGCTAAATTACCGGAAGAAGAAAGAGCTGCATTTATTAAACAAAAAC
AAGATGAATATAAGGAAAATATTGATGTGTATCGACTGGCTTCTGAGATGGTAATTGATGATATTATCAATCCAAATGAA
CTGCGCCAGGAATTAATACAACGCTTCAGTATTTACGAAAATAAAAAAATGACATTCACAGAAAGAAAACATGGTGTTTA
TCCTGTTTAA

Upstream 100 bases:

>100_bases
GTAATACCTACTCATGATAGGCGAGAAGGTCTTCAAGCTTTTGCAGAAAAGAGAAAACCAGATTACCAAGGTAGATAACA
GTAAAGGGAGGAGCGAGTCT

Downstream 100 bases:

>100_bases
TCAATATGGTATATACGTATCCCGAATGAAGTAGTTTACATTCGGGATATTTTTTTATAAGGAGATAGAATGTTTGTTGT
ATTAATTTGCATTACAAACG

Product: propionyl-CoA carboxylase beta subunit

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MDYIQELQQRIEKIEKGGKQKYHDSNTDKGKLFARKRIELLFDQDINVEDALFANHSAEDLPADGVITAIGKINGQTVCV
MANDSTVKAGSWGKRTVEKILRIQETAEKMEVPILYLVDSAGARITDQVEMFPGRRGAGRIFYNQIKLSGRVPQICLLFG
PSAAGGAYIPAFCDIVVMVDGNASMYLGSPRMAEKVIGEKVTLEEMGGANMHCSVSGVGDVLVESEEEAIAFARTYLDYF
PANFRQKPLPKEARLPKQQDKTIEEIIPTNQNAAFDMYELINRTIDEDSFCEIKKKFAPELITGLARLNGKSVGIIANQP
RVKGGVLFTDSADKAAKFIQLCDAFEIPLLFLTDVPGFMIGTGVEKQGIIRHGAKMLFAMSEVTVPKISVIVRKAYGAGL
YAMSGPAFEPDCCLAFPNAQIAVMGPEAAVNAVEANKIAKLPEEERAAFIKQKQDEYKENIDVYRLASEMVIDDIINPNE
LRQELIQRFSIYENKKMTFTERKHGVYPV

Sequences:

>Translated_509_residues
MDYIQELQQRIEKIEKGGKQKYHDSNTDKGKLFARKRIELLFDQDINVEDALFANHSAEDLPADGVITAIGKINGQTVCV
MANDSTVKAGSWGKRTVEKILRIQETAEKMEVPILYLVDSAGARITDQVEMFPGRRGAGRIFYNQIKLSGRVPQICLLFG
PSAAGGAYIPAFCDIVVMVDGNASMYLGSPRMAEKVIGEKVTLEEMGGANMHCSVSGVGDVLVESEEEAIAFARTYLDYF
PANFRQKPLPKEARLPKQQDKTIEEIIPTNQNAAFDMYELINRTIDEDSFCEIKKKFAPELITGLARLNGKSVGIIANQP
RVKGGVLFTDSADKAAKFIQLCDAFEIPLLFLTDVPGFMIGTGVEKQGIIRHGAKMLFAMSEVTVPKISVIVRKAYGAGL
YAMSGPAFEPDCCLAFPNAQIAVMGPEAAVNAVEANKIAKLPEEERAAFIKQKQDEYKENIDVYRLASEMVIDDIINPNE
LRQELIQRFSIYENKKMTFTERKHGVYPV
>Mature_509_residues
MDYIQELQQRIEKIEKGGKQKYHDSNTDKGKLFARKRIELLFDQDINVEDALFANHSAEDLPADGVITAIGKINGQTVCV
MANDSTVKAGSWGKRTVEKILRIQETAEKMEVPILYLVDSAGARITDQVEMFPGRRGAGRIFYNQIKLSGRVPQICLLFG
PSAAGGAYIPAFCDIVVMVDGNASMYLGSPRMAEKVIGEKVTLEEMGGANMHCSVSGVGDVLVESEEEAIAFARTYLDYF
PANFRQKPLPKEARLPKQQDKTIEEIIPTNQNAAFDMYELINRTIDEDSFCEIKKKFAPELITGLARLNGKSVGIIANQP
RVKGGVLFTDSADKAAKFIQLCDAFEIPLLFLTDVPGFMIGTGVEKQGIIRHGAKMLFAMSEVTVPKISVIVRKAYGAGL
YAMSGPAFEPDCCLAFPNAQIAVMGPEAAVNAVEANKIAKLPEEERAAFIKQKQDEYKENIDVYRLASEMVIDDIINPNE
LRQELIQRFSIYENKKMTFTERKHGVYPV

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=522, Percent_Identity=37.9310344827586, Blast_Score=332, Evalue=6e-91,
Organism=Homo sapiens, GI295821216, Length=542, Percent_Identity=36.7158671586716, Blast_Score=320, Evalue=1e-87,
Organism=Homo sapiens, GI11545863, Length=520, Percent_Identity=35.9615384615385, Blast_Score=291, Evalue=1e-78,
Organism=Homo sapiens, GI310133460, Length=121, Percent_Identity=37.1900826446281, Blast_Score=66, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI25147359, Length=514, Percent_Identity=36.3813229571984, Blast_Score=332, Evalue=2e-91,
Organism=Caenorhabditis elegans, GI25147362, Length=514, Percent_Identity=36.3813229571984, Blast_Score=332, Evalue=2e-91,
Organism=Caenorhabditis elegans, GI17552936, Length=517, Percent_Identity=34.6228239845261, Blast_Score=320, Evalue=8e-88,
Organism=Caenorhabditis elegans, GI133931226, Length=309, Percent_Identity=23.9482200647249, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24586065, Length=515, Percent_Identity=36.1165048543689, Blast_Score=321, Evalue=7e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 56417; Mature: 56417

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYIQELQQRIEKIEKGGKQKYHDSNTDKGKLFARKRIELLFDQDINVEDALFANHSAED
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHEECCCCCCCHHHHCCCCCCC
LPADGVITAIGKINGQTVCVMANDSTVKAGSWGKRTVEKILRIQETAEKMEVPILYLVDS
CCCCCEEEEEECCCCCEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEC
AGARITDQVEMFPGRRGAGRIFYNQIKLSGRVPQICLLFGPSAAGGAYIPAFCDIVVMVD
CCCCCCHHHHHCCCCCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCCCCCEEEEEEEEC
GNASMYLGSPRMAEKVIGEKVTLEEMGGANMHCSVSGVGDVLVESEEEAIAFARTYLDYF
CCCEEEECCCHHHHHHHCCEEEHHHCCCCCEEEEECCCCCCEECCCHHHHHHHHHHHHHC
PANFRQKPLPKEARLPKQQDKTIEEIIPTNQNAAFDMYELINRTIDEDSFCEIKKKFAPE
CCCCCCCCCCHHHCCCCHHCCHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHH
LITGLARLNGKSVGIIANQPRVKGGVLFTDSADKAAKFIQLCDAFEIPLLFLTDVPGFMI
HHHHHHHCCCCEEEEEECCCCCCCCEEEECCHHHHHHHHHHHHHHCCCEEEEECCCCCEE
GTGVEKQGIIRHGAKMLFAMSEVTVPKISVIVRKAYGAGLYAMSGPAFEPDCCLAFPNAQ
ECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEECCCCCCCCCEEECCCCE
IAVMGPEAAVNAVEANKIAKLPEEERAAFIKQKQDEYKENIDVYRLASEMVIDDIINPNE
EEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHH
LRQELIQRFSIYENKKMTFTERKHGVYPV
HHHHHHHHHHHHCCCCCEEECCCCCCCCC
>Mature Secondary Structure
MDYIQELQQRIEKIEKGGKQKYHDSNTDKGKLFARKRIELLFDQDINVEDALFANHSAED
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHEECCCCCCCHHHHCCCCCCC
LPADGVITAIGKINGQTVCVMANDSTVKAGSWGKRTVEKILRIQETAEKMEVPILYLVDS
CCCCCEEEEEECCCCCEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEC
AGARITDQVEMFPGRRGAGRIFYNQIKLSGRVPQICLLFGPSAAGGAYIPAFCDIVVMVD
CCCCCCHHHHHCCCCCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCCCCCEEEEEEEEC
GNASMYLGSPRMAEKVIGEKVTLEEMGGANMHCSVSGVGDVLVESEEEAIAFARTYLDYF
CCCEEEECCCHHHHHHHCCEEEHHHCCCCCEEEEECCCCCCEECCCHHHHHHHHHHHHHC
PANFRQKPLPKEARLPKQQDKTIEEIIPTNQNAAFDMYELINRTIDEDSFCEIKKKFAPE
CCCCCCCCCCHHHCCCCHHCCHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHH
LITGLARLNGKSVGIIANQPRVKGGVLFTDSADKAAKFIQLCDAFEIPLLFLTDVPGFMI
HHHHHHHCCCCEEEEEECCCCCCCCEEEECCHHHHHHHHHHHHHHCCCEEEEECCCCCEE
GTGVEKQGIIRHGAKMLFAMSEVTVPKISVIVRKAYGAGLYAMSGPAFEPDCCLAFPNAQ
ECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEECCCCCCCCCEEECCCCE
IAVMGPEAAVNAVEANKIAKLPEEERAAFIKQKQDEYKENIDVYRLASEMVIDDIINPNE
EEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHH
LRQELIQRFSIYENKKMTFTERKHGVYPV
HHHHHHHHHHHHCCCCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]