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The map label for this gene is fabD [H]

Identifier: 23098978

GI number: 23098978

Start: 1567493

End: 1568431

Strand: Direct

Name: fabD [H]

Synonym: OB1523

Alternate gene names: 23098978

Gene position: 1567493-1568431 (Clockwise)

Preceding gene: 23098977

Following gene: 23098979

Centisome position: 43.18

GC content: 38.02

Gene sequence:

>939_bases
TTGAAAAAAGTAGCATTCATGTTTCCTGGACAAGGTTCACAAACAGTCGGGATGGGTAAGGAATTATATGATGCACATCC
AATGATTCAAGAGCTTTATTCAGAAGCAAACCAGATATTAGATAAAGATATTCAAGAATTAATGTTTGAAGGGCCTGAGA
AAGAGTTAACCCAGACAGAAAACACACAACCAGCTCTTTTATTATCAAGTGTAGCTGTTCAAAAATTATTAGAAGAACGA
GGAGTAACTCCAGCAATGACAGTCGGTCATAGTCTAGGGGAATATAGTGCTCTAGTTGCTTCAGGAGCATTTACTTGGCA
AGACGCTTTAACATTAGTGCAAATACGTGGACGATTAATGGAAGCAGCATTTCCGAAAGGGCAGGGAACGATGGCTGCAG
TACTAGGTCTTGATGCAACTACGATTGAATCGACTTTATCAGAAATTAAAGATCAAGTAGTTGATATTGCTAACCTGAAT
TGTCCAGGCCAAGTTGTTATTTCTGGATCTGTAAAAGGTGTAGAACAGGCAACTATTCTTTTGAAAGATAAAGGAGCAAA
ACGAGTACTTCCGTTAAATGTAAGTGGACCATTCCATTCAAAGCTAATGAAGGCAGCAAATGATGAGTTCGCTACTTATT
TAGATGATGTAGAAATTAGTGATGCAAAACCACCAGTATATGCAAATGTATCAGCAAGTGCTACATCAGATAGCGGAGAA
TTAAAGGAATTACTACTTAAACAACTATATTCTCCAGTCAGATTTGAAGAGTCGATAAATCATATGATTGAAAGTGGTGT
CGATGCCTTTGTCGAAATTGGGACAGGGAAAGTTTTATCGGGGTTAGTAAAGAAAATCAACCGCCGAATGCCTACTTTTG
CAATTCAAGACCAGGCATCTCTAGATAAATTTATGGAATGGTACGAGGAGGAAGTATAA

Upstream 100 bases:

>100_bases
ATAATGCTATTAAGCAAGCAAAACATATGGTGGAATTTGAAGTTACACCGACGATAACAGCTACAGTGGAATCTATAGGG
AAAGTAGAGGAGGAGTAAAC

Downstream 100 bases:

>100_bases
ATGCTACAAGGGAAAAATGCGATCGTAACAGGAGCTTCTCGAGGTATAGGTAGATCTATTGCACTTGAACTTGCAAAACA
AGGTGCAAATGTTGTAGTGA

Product: malonyl CoA-acyl carrier protein transacylase

Products: NA

Alternate protein names: MCT [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MKKVAFMFPGQGSQTVGMGKELYDAHPMIQELYSEANQILDKDIQELMFEGPEKELTQTENTQPALLLSSVAVQKLLEER
GVTPAMTVGHSLGEYSALVASGAFTWQDALTLVQIRGRLMEAAFPKGQGTMAAVLGLDATTIESTLSEIKDQVVDIANLN
CPGQVVISGSVKGVEQATILLKDKGAKRVLPLNVSGPFHSKLMKAANDEFATYLDDVEISDAKPPVYANVSASATSDSGE
LKELLLKQLYSPVRFEESINHMIESGVDAFVEIGTGKVLSGLVKKINRRMPTFAIQDQASLDKFMEWYEEEV

Sequences:

>Translated_312_residues
MKKVAFMFPGQGSQTVGMGKELYDAHPMIQELYSEANQILDKDIQELMFEGPEKELTQTENTQPALLLSSVAVQKLLEER
GVTPAMTVGHSLGEYSALVASGAFTWQDALTLVQIRGRLMEAAFPKGQGTMAAVLGLDATTIESTLSEIKDQVVDIANLN
CPGQVVISGSVKGVEQATILLKDKGAKRVLPLNVSGPFHSKLMKAANDEFATYLDDVEISDAKPPVYANVSASATSDSGE
LKELLLKQLYSPVRFEESINHMIESGVDAFVEIGTGKVLSGLVKKINRRMPTFAIQDQASLDKFMEWYEEEV
>Mature_312_residues
MKKVAFMFPGQGSQTVGMGKELYDAHPMIQELYSEANQILDKDIQELMFEGPEKELTQTENTQPALLLSSVAVQKLLEER
GVTPAMTVGHSLGEYSALVASGAFTWQDALTLVQIRGRLMEAAFPKGQGTMAAVLGLDATTIESTLSEIKDQVVDIANLN
CPGQVVISGSVKGVEQATILLKDKGAKRVLPLNVSGPFHSKLMKAANDEFATYLDDVEISDAKPPVYANVSASATSDSGE
LKELLLKQLYSPVRFEESINHMIESGVDAFVEIGTGKVLSGLVKKINRRMPTFAIQDQASLDKFMEWYEEEV

Specific function: Fatty acid biosynthesis. [C]

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=308, Percent_Identity=32.7922077922078, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI27477045, Length=113, Percent_Identity=37.1681415929204, Blast_Score=79, Evalue=4e-15,
Organism=Escherichia coli, GI1787334, Length=308, Percent_Identity=42.2077922077922, Blast_Score=238, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI71984332, Length=298, Percent_Identity=28.8590604026846, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17550940, Length=292, Percent_Identity=27.3972602739726, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI212642053, Length=301, Percent_Identity=27.5747508305648, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24665753, Length=299, Percent_Identity=33.7792642140468, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI221330659, Length=297, Percent_Identity=25.2525252525253, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI19920632, Length=297, Percent_Identity=25.2525252525253, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR004410
- InterPro:   IPR016036 [H]

Pfam domain/function: PF00698 Acyl_transf_1 [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 33991; Mature: 33991

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVAFMFPGQGSQTVGMGKELYDAHPMIQELYSEANQILDKDIQELMFEGPEKELTQTE
CCCEEEEECCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCC
NTQPALLLSSVAVQKLLEERGVTPAMTVGHSLGEYSALVASGAFTWQDALTLVQIRGRLM
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
EAAFPKGQGTMAAVLGLDATTIESTLSEIKDQVVDIANLNCPGQVVISGSVKGVEQATIL
HHHCCCCCCCEEHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHEEEE
LKDKGAKRVLPLNVSGPFHSKLMKAANDEFATYLDDVEISDAKPPVYANVSASATSDSGE
EECCCCCEEEEEECCCHHHHHHHHHHCHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCHH
LKELLLKQLYSPVRFEESINHMIESGVDAFVEIGTGKVLSGLVKKINRRMPTFAIQDQAS
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEECCHHH
LDKFMEWYEEEV
HHHHHHHHHHCC
>Mature Secondary Structure
MKKVAFMFPGQGSQTVGMGKELYDAHPMIQELYSEANQILDKDIQELMFEGPEKELTQTE
CCCEEEEECCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCC
NTQPALLLSSVAVQKLLEERGVTPAMTVGHSLGEYSALVASGAFTWQDALTLVQIRGRLM
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
EAAFPKGQGTMAAVLGLDATTIESTLSEIKDQVVDIANLNCPGQVVISGSVKGVEQATIL
HHHCCCCCCCEEHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHEEEE
LKDKGAKRVLPLNVSGPFHSKLMKAANDEFATYLDDVEISDAKPPVYANVSASATSDSGE
EECCCCCEEEEEECCCHHHHHHHHHHCHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCHH
LKELLLKQLYSPVRFEESINHMIESGVDAFVEIGTGKVLSGLVKKINRRMPTFAIQDQAS
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEECCHHH
LDKFMEWYEEEV
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759840; 9534248; 9384377 [H]