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The map label for this gene is ykuM [H]

Identifier: 23098952

GI number: 23098952

Start: 1538335

End: 1539192

Strand: Direct

Name: ykuM [H]

Synonym: OB1497

Alternate gene names: 23098952

Gene position: 1538335-1539192 (Clockwise)

Preceding gene: 23098950

Following gene: 23098953

Centisome position: 42.37

GC content: 36.83

Gene sequence:

>858_bases
ATGAGGATGGATGATTATGAATTATTAATCCGTTTAAATGAAATTGGTACCATTCGTGGAACGGCTAAAGCTGTATTGAT
TTCTCAACCAGCTGTTACTCAACGCTTAAAATATATGGAGGAATATTTCGGTGAGGCGATATTTATCCGTACTTCTAAAC
GTCTATTACCAACTCCTGCCGGGGAGATCGTTATTCAGCATGCAAAGCAAGTCATACATCAAGAAAAAGTCTTAAAGAAC
CGATTGGCGGAGACTGGAGAAGAAATCCAAGGAACTCTCGCAATTGCGTGTTCTACCTTAATTAGCCAGCGATTTTTACC
GAGTATTTTAGGTGAATTTACAGCTAAGTATCCGAAAGTCGCAATTGACTTAGTTACAGGTATTAGTGAAGATATTAGAC
GAAATCACAAAAAGTACCATATTTGTATCATACGTGGAGAGAAGCTAAAGGAATCGACTTCGGTTCATTTATTTGATGAT
CCACTGTATATGTTTGACACAGAACCATTTCCATCTAATCATGCAAAAGAAAGGCCGTTAATTTCTTTTAAAAGTGATGA
CAGTATGCACGAACTTGTAGATAATTGGTTATATCATCACCAAGAATTTATTAAGCCCGAAAAAACATTGACCGTAGATC
AAATCGAAACATGCAAACAGTTTATGAAGCAAGGAATTGGCATGGCGGTTTTACCTGAAAGTGTTTCGGATCATTTAAAA
GAAGAATATCCACATATTGCGCTTAAAATTAATGGGAAGGCGGTAACACGGGATACGTGGGTATGTTATCAAGAAGGTAT
ACGCAAATTACCACAGGTAGATCATTTTCTAGAATTACTGCAGAACACTACTTTTTAA

Upstream 100 bases:

>100_bases
TTACAATTTCATTTACTAATAGTTTATGTGGTATTATATAATAAGTAAAATACAATAAATTGATTAATATTGATAATATA
TACTTATATGAGGTGTTTGA

Downstream 100 bases:

>100_bases
ATTTTTATGTTTACAAATCGAATGTAACGGAAATATAAGAACTATACGTTAAAATAATAAGGAGTAGTGATCGTATGAGT
GATATTCTATTTACTTCAAC

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MRMDDYELLIRLNEIGTIRGTAKAVLISQPAVTQRLKYMEEYFGEAIFIRTSKRLLPTPAGEIVIQHAKQVIHQEKVLKN
RLAETGEEIQGTLAIACSTLISQRFLPSILGEFTAKYPKVAIDLVTGISEDIRRNHKKYHICIIRGEKLKESTSVHLFDD
PLYMFDTEPFPSNHAKERPLISFKSDDSMHELVDNWLYHHQEFIKPEKTLTVDQIETCKQFMKQGIGMAVLPESVSDHLK
EEYPHIALKINGKAVTRDTWVCYQEGIRKLPQVDHFLELLQNTTF

Sequences:

>Translated_285_residues
MRMDDYELLIRLNEIGTIRGTAKAVLISQPAVTQRLKYMEEYFGEAIFIRTSKRLLPTPAGEIVIQHAKQVIHQEKVLKN
RLAETGEEIQGTLAIACSTLISQRFLPSILGEFTAKYPKVAIDLVTGISEDIRRNHKKYHICIIRGEKLKESTSVHLFDD
PLYMFDTEPFPSNHAKERPLISFKSDDSMHELVDNWLYHHQEFIKPEKTLTVDQIETCKQFMKQGIGMAVLPESVSDHLK
EEYPHIALKINGKAVTRDTWVCYQEGIRKLPQVDHFLELLQNTTF
>Mature_285_residues
MRMDDYELLIRLNEIGTIRGTAKAVLISQPAVTQRLKYMEEYFGEAIFIRTSKRLLPTPAGEIVIQHAKQVIHQEKVLKN
RLAETGEEIQGTLAIACSTLISQRFLPSILGEFTAKYPKVAIDLVTGISEDIRRNHKKYHICIIRGEKLKESTSVHLFDD
PLYMFDTEPFPSNHAKERPLISFKSDDSMHELVDNWLYHHQEFIKPEKTLTVDQIETCKQFMKQGIGMAVLPESVSDHLK
EEYPHIALKINGKAVTRDTWVCYQEGIRKLPQVDHFLELLQNTTF

Specific function: Hydrogen Peroxide Sensor. Activates The Expression Of A Regulon Of Hydrogen Peroxide-Inducible Genes Such As Katg, Gor, Ahpc, Ahpf, Oxys (A Regulatory RNA), Dps, Fur And Grxa. Oxyr Expression Is Negatively Autoregulated By Binding To A 43 Bp Region Upstre

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790399, Length=242, Percent_Identity=25.6198347107438, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787530, Length=242, Percent_Identity=21.0743801652893, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787601, Length=112, Percent_Identity=26.7857142857143, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788297, Length=249, Percent_Identity=23.2931726907631, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI157672245, Length=116, Percent_Identity=26.7241379310345, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790208, Length=296, Percent_Identity=22.972972972973, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32848; Mature: 32848

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMDDYELLIRLNEIGTIRGTAKAVLISQPAVTQRLKYMEEYFGEAIFIRTSKRLLPTPA
CCCCHHHHHEEECCCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCH
GEIVIQHAKQVIHQEKVLKNRLAETGEEIQGTLAIACSTLISQRFLPSILGEFTAKYPKV
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
AIDLVTGISEDIRRNHKKYHICIIRGEKLKESTSVHLFDDPLYMFDTEPFPSNHAKERPL
HHHHHHCCHHHHHCCCCEEEEEEEECCCCCCCCCEEEECCCEEEEECCCCCCCCCCCCCE
ISFKSDDSMHELVDNWLYHHQEFIKPEKTLTVDQIETCKQFMKQGIGMAVLPESVSDHLK
EEECCCCHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHCCCCEEECCHHHHHHHH
EEYPHIALKINGKAVTRDTWVCYQEGIRKLPQVDHFLELLQNTTF
HHCCEEEEEECCEEEECHHHHHHHHHHHHCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MRMDDYELLIRLNEIGTIRGTAKAVLISQPAVTQRLKYMEEYFGEAIFIRTSKRLLPTPA
CCCCHHHHHEEECCCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCH
GEIVIQHAKQVIHQEKVLKNRLAETGEEIQGTLAIACSTLISQRFLPSILGEFTAKYPKV
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
AIDLVTGISEDIRRNHKKYHICIIRGEKLKESTSVHLFDDPLYMFDTEPFPSNHAKERPL
HHHHHHCCHHHHHCCCCEEEEEEEECCCCCCCCCEEEECCCEEEEECCCCCCCCCCCCCE
ISFKSDDSMHELVDNWLYHHQEFIKPEKTLTVDQIETCKQFMKQGIGMAVLPESVSDHLK
EEECCCCHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHCCCCEEECCHHHHHHHH
EEYPHIALKINGKAVTRDTWVCYQEGIRKLPQVDHFLELLQNTTF
HHCCEEEEEECCEEEECHHHHHHHHHHHHCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]