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The map label for this gene is czcD [H]

Identifier: 23098854

GI number: 23098854

Start: 1441294

End: 1442196

Strand: Reverse

Name: czcD [H]

Synonym: OB1399

Alternate gene names: 23098854

Gene position: 1442196-1441294 (Counterclockwise)

Preceding gene: 23098855

Following gene: 23098853

Centisome position: 39.72

GC content: 34.0

Gene sequence:

>903_bases
TTGGAACACAATCATGATCATTCCCATCATCACCATACAACAAATAAGAAAGTACTATTTTGGAGCTTTCTTATTATATT
CTCATTTATGATTATGGAAGCTGTTGGGGGTATACTCACAAATAGTTTAGCATTACTATCGGATGCAGGGCATATGTTAA
GTGATGCAGCTGCTTTAGGGTTAACACTCCTTGCATTTAATATCGGAGAAAAAAGCATTACCGCTAATAAAACGTTTGGT
TATAAGCGGTTTGAAATTATAGCTGCGTTTATTAATGGTGTAACGCTTATTTTAATTTCGATCTTTATTTTTATCGAAGC
CCTTCGACGATTTGTTGAACCACCTGAAGTTAGTGGAGCTATGATGATTATAGCTTTTATCGGTTTCTGTGTTAATATAC
TCGTTGCTTGGCTATTAATGAAAGGGAACGCAGAAGAAAATTTAAATTTAAAAAGTGCCCTACTCCATGTAATGGGTGAT
CTATTAGGATCTATCGGAGCTTTGGTTGCAGGAGCTTTGATTTTACTATTTAATTGGAATATTGCGGACCCAATAGCGAG
TATTATCGTAGCAATATTAATTATTATTTCTGGCATTCGTATTACTAAAGATTCGTTGCATATTTTAATGGAAGGTAAGC
CAACGAATGTTAATATTGATGAAATGAAAAGAAGTTTACTGTCATTATCAGGAGTACAAGACGTACACGATCTTCATGTA
TGGTCTATTACTTCCGAATTTCCATCCATGAGTTGTCATATACAAGTAACAGAACAAACAAATAGAGATCAATTATTAGA
AGAAGCAACAAAAATACTTCAAGATTCATTCTCTATATCTCATTGCACAATTCAAATGGAAGGAAGGAACATCTCTTCTT
GTGAATCATGTGATCACTCCTAA

Upstream 100 bases:

>100_bases
AAAAAAACATGTACTTTTATTCTCCTGATGATGAGCATGTAATTAAATTGTTAGAACAAGCTATTGAACATATGGAGCAT
ACAACGAAGGAGGTATAATA

Downstream 100 bases:

>100_bases
CGCATTATTTAAAGAAGCTACATGGTGGTAGTACAACACTTATGAACTATGTAGTTCTTCTTTTTAGCTTTTTTCTTTTA
TTAAATGTAATTCTTACTAA

Product: cation efflux system permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MEHNHDHSHHHHTTNKKVLFWSFLIIFSFMIMEAVGGILTNSLALLSDAGHMLSDAAALGLTLLAFNIGEKSITANKTFG
YKRFEIIAAFINGVTLILISIFIFIEALRRFVEPPEVSGAMMIIAFIGFCVNILVAWLLMKGNAEENLNLKSALLHVMGD
LLGSIGALVAGALILLFNWNIADPIASIIVAILIIISGIRITKDSLHILMEGKPTNVNIDEMKRSLLSLSGVQDVHDLHV
WSITSEFPSMSCHIQVTEQTNRDQLLEEATKILQDSFSISHCTIQMEGRNISSCESCDHS

Sequences:

>Translated_300_residues
MEHNHDHSHHHHTTNKKVLFWSFLIIFSFMIMEAVGGILTNSLALLSDAGHMLSDAAALGLTLLAFNIGEKSITANKTFG
YKRFEIIAAFINGVTLILISIFIFIEALRRFVEPPEVSGAMMIIAFIGFCVNILVAWLLMKGNAEENLNLKSALLHVMGD
LLGSIGALVAGALILLFNWNIADPIASIIVAILIIISGIRITKDSLHILMEGKPTNVNIDEMKRSLLSLSGVQDVHDLHV
WSITSEFPSMSCHIQVTEQTNRDQLLEEATKILQDSFSISHCTIQMEGRNISSCESCDHS
>Mature_300_residues
MEHNHDHSHHHHTTNKKVLFWSFLIIFSFMIMEAVGGILTNSLALLSDAGHMLSDAAALGLTLLAFNIGEKSITANKTFG
YKRFEIIAAFINGVTLILISIFIFIEALRRFVEPPEVSGAMMIIAFIGFCVNILVAWLLMKGNAEENLNLKSALLHVMGD
LLGSIGALVAGALILLFNWNIADPIASIIVAILIIISGIRITKDSLHILMEGKPTNVNIDEMKRSLLSLSGVQDVHDLHV
WSITSEFPSMSCHIQVTEQTNRDQLLEEATKILQDSFSISHCTIQMEGRNISSCESCDHS

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI21359890, Length=304, Percent_Identity=32.2368421052632, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI52352805, Length=299, Percent_Identity=30.7692307692308, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI21361112, Length=315, Percent_Identity=30.7936507936508, Blast_Score=158, Evalue=5e-39,
Organism=Homo sapiens, GI20070323, Length=319, Percent_Identity=29.153605015674, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI289803013, Length=275, Percent_Identity=33.0909090909091, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI289803009, Length=275, Percent_Identity=33.0909090909091, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI289803007, Length=275, Percent_Identity=33.0909090909091, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI289803003, Length=275, Percent_Identity=33.0909090909091, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI64762489, Length=275, Percent_Identity=33.0909090909091, Blast_Score=134, Evalue=8e-32,
Organism=Homo sapiens, GI14210520, Length=230, Percent_Identity=29.5652173913043, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI222080086, Length=121, Percent_Identity=33.8842975206612, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI40255009, Length=121, Percent_Identity=33.8842975206612, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI52351208, Length=162, Percent_Identity=27.7777777777778, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI52352803, Length=123, Percent_Identity=35.7723577235772, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI21687224, Length=279, Percent_Identity=23.2974910394265, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI301898545, Length=279, Percent_Identity=23.2974910394265, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1786966, Length=286, Percent_Identity=44.0559440559441, Blast_Score=209, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI193210990, Length=325, Percent_Identity=30.7692307692308, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17555794, Length=319, Percent_Identity=28.8401253918495, Blast_Score=164, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17555796, Length=305, Percent_Identity=29.1803278688525, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI32564488, Length=303, Percent_Identity=28.7128712871287, Blast_Score=125, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6320411, Length=173, Percent_Identity=33.5260115606936, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6323899, Length=153, Percent_Identity=32.0261437908497, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324892, Length=136, Percent_Identity=33.8235294117647, Blast_Score=73, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24583858, Length=325, Percent_Identity=26.1538461538462, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24656728, Length=330, Percent_Identity=26.969696969697, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24656724, Length=330, Percent_Identity=26.969696969697, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24656720, Length=330, Percent_Identity=26.969696969697, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24656715, Length=330, Percent_Identity=26.969696969697, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI21357035, Length=330, Percent_Identity=26.969696969697, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24584409, Length=160, Percent_Identity=30.625, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI28574430, Length=160, Percent_Identity=30.625, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24585900, Length=145, Percent_Identity=33.7931034482759, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24585898, Length=145, Percent_Identity=33.7931034482759, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24585896, Length=145, Percent_Identity=33.7931034482759, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI19921672, Length=145, Percent_Identity=33.7931034482759, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24645863, Length=140, Percent_Identity=27.1428571428571, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 33077; Mature: 33077

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHNHDHSHHHHTTNKKVLFWSFLIIFSFMIMEAVGGILTNSLALLSDAGHMLSDAAALG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTLLAFNIGEKSITANKTFGYKRFEIIAAFINGVTLILISIFIFIEALRRFVEPPEVSGA
HHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
MMIIAFIGFCVNILVAWLLMKGNAEENLNLKSALLHVMGDLLGSIGALVAGALILLFNWN
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
IADPIASIIVAILIIISGIRITKDSLHILMEGKPTNVNIDEMKRSLLSLSGVQDVHDLHV
HHHHHHHHHHHHHHHHCCCEEECCCEEEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHE
WSITSEFPSMSCHIQVTEQTNRDQLLEEATKILQDSFSISHCTIQMEGRNISSCESCDHS
EEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MEHNHDHSHHHHTTNKKVLFWSFLIIFSFMIMEAVGGILTNSLALLSDAGHMLSDAAALG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTLLAFNIGEKSITANKTFGYKRFEIIAAFINGVTLILISIFIFIEALRRFVEPPEVSGA
HHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
MMIIAFIGFCVNILVAWLLMKGNAEENLNLKSALLHVMGDLLGSIGALVAGALILLFNWN
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
IADPIASIIVAILIIISGIRITKDSLHILMEGKPTNVNIDEMKRSLLSLSGVQDVHDLHV
HHHHHHHHHHHHHHHHCCCEEECCCEEEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHE
WSITSEFPSMSCHIQVTEQTNRDQLLEEATKILQDSFSISHCTIQMEGRNISSCESCDHS
EEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA