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The map label for this gene is prpE

Identifier: 23098678

GI number: 23098678

Start: 1272406

End: 1273158

Strand: Reverse

Name: prpE

Synonym: OB1223

Alternate gene names: 23098678

Gene position: 1273158-1272406 (Counterclockwise)

Preceding gene: 23098681

Following gene: 23098674

Centisome position: 35.07

GC content: 34.79

Gene sequence:

>753_bases
ATGAAAATCGATATTATTGGAGATGTGCATGGTTGTTTAGAGGAATTAGAGGAACTATTGTTCAAATTAGGATATCAAAT
AAAGAATGGTACTTATCAACACTCTAATAACCGTCAAATAGTCTTTGTAGGAGATATAACAGATCGGGGTCCAGATTCCA
TTAAAGTAATAAAATTGGTTTATCAGCTTGTAAAAGAGAAGCTTGCCTATTATATACCTGGAAATCATTGCAACAAGCTC
TATCGTTTCTTTCAAGGTAATAAAGTAATGGAAAAGCATGGTTTGGAGACAACAACAGCAGAATATCGTAGTTTATCAAA
AGAGAAACAAAACAACATAAAGCATAAATTCATAGAGCTGTATGAGCGTTCTCCCCTTTATCTTCACTTAAAAAATATTA
ATGTAATCATCGCCCACGCCGGTATACCAGAGCACTTAATTGGAAAAAAAGATAAACGGACAAAAACTTTCGTCTTATAC
GGGGATATTACAGGAGAATTCGATACAACAGGAAAACCTATCCGCCGCGATTGGGCTAAGCATTATCACGGTGATAGTTG
GATTGTATATGGACATACTCCTGTACTTGAACCAAGAGTGGTAAATCATACAATAAATATTGATACTGGTTGTGTATTCG
GAAATAAATTGACGGCATATCGATTTCCAGAAAAGGAATTTGTCTCCGTAGCTTCAAGACAACCATTTATTGCTGAGAAA
TTTACCGATTTTAATGTGTCAAATGAGCATTAA

Upstream 100 bases:

>100_bases
ATTGATTTAGCATGTGAAAGGTTTAAATATAATACTAACTTGTATAGATTAAAACACCACAACGTTTACCGTCAAATTTT
TTATTAAGGAGATTAATGAT

Downstream 100 bases:

>100_bases
ACGCTTCAATAATATTCCCATGTCTTCTGGAAGACTTGCTTCAAGTTGAATTGGTTGATTTTTGATTGGATGCATCATTG
TAATTTGCTTACAATGCAAG

Product: diadenosine tetraphosphatase

Products: NA

Alternate protein names: Ap4A hydrolase; Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase; Diadenosine tetraphosphatase

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MKIDIIGDVHGCLEELEELLFKLGYQIKNGTYQHSNNRQIVFVGDITDRGPDSIKVIKLVYQLVKEKLAYYIPGNHCNKL
YRFFQGNKVMEKHGLETTTAEYRSLSKEKQNNIKHKFIELYERSPLYLHLKNINVIIAHAGIPEHLIGKKDKRTKTFVLY
GDITGEFDTTGKPIRRDWAKHYHGDSWIVYGHTPVLEPRVVNHTINIDTGCVFGNKLTAYRFPEKEFVSVASRQPFIAEK
FTDFNVSNEH

Sequences:

>Translated_250_residues
MKIDIIGDVHGCLEELEELLFKLGYQIKNGTYQHSNNRQIVFVGDITDRGPDSIKVIKLVYQLVKEKLAYYIPGNHCNKL
YRFFQGNKVMEKHGLETTTAEYRSLSKEKQNNIKHKFIELYERSPLYLHLKNINVIIAHAGIPEHLIGKKDKRTKTFVLY
GDITGEFDTTGKPIRRDWAKHYHGDSWIVYGHTPVLEPRVVNHTINIDTGCVFGNKLTAYRFPEKEFVSVASRQPFIAEK
FTDFNVSNEH
>Mature_250_residues
MKIDIIGDVHGCLEELEELLFKLGYQIKNGTYQHSNNRQIVFVGDITDRGPDSIKVIKLVYQLVKEKLAYYIPGNHCNKL
YRFFQGNKVMEKHGLETTTAEYRSLSKEKQNNIKHKFIELYERSPLYLHLKNINVIIAHAGIPEHLIGKKDKRTKTFVLY
GDITGEFDTTGKPIRRDWAKHYHGDSWIVYGHTPVLEPRVVNHTINIDTGCVFGNKLTAYRFPEKEFVSVASRQPFIAEK
FTDFNVSNEH

Specific function: Asymmetrically hydrolyzes Ap4p to yield AMP and ATP

COG id: COG0639

COG function: function code T; Diadenosine tetraphosphatase and related serine/threonine protein phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prpE family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PRPE_OCEIH (Q8ERS7)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_692144.1
- ProteinModelPortal:   Q8ERS7
- GeneID:   1017395
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB1223
- NMPDR:   fig|221109.1.peg.1222
- HOGENOM:   HBG724457
- OMA:   HCNKLYR
- BioCyc:   OIHE221109:OB1223-MONOMER
- BRENDA:   3.6.1.17
- HAMAP:   MF_01443
- InterPro:   IPR004843
- InterPro:   IPR006186
- PANTHER:   PTHR11668
- PRINTS:   PR00114

Pfam domain/function: PF00149 Metallophos

EC number: =3.6.1.17

Molecular weight: Translated: 28983; Mature: 28983

Theoretical pI: Translated: 9.14; Mature: 9.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIDIIGDVHGCLEELEELLFKLGYQIKNGTYQHSNNRQIVFVGDITDRGPDSIKVIKLV
CEEEEECCHHHHHHHHHHHHHHCCCEECCCEEEECCCCEEEEEECCCCCCCCHHHHHHHH
YQLVKEKLAYYIPGNHCNKLYRFFQGNKVMEKHGLETTTAEYRSLSKEKQNNIKHKFIEL
HHHHHHHHEEECCCHHHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
YERSPLYLHLKNINVIIAHAGIPEHLIGKKDKRTKTFVLYGDITGEFDTTGKPIRRDWAK
HCCCCEEEEEECCEEEEEECCCCHHHCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHH
HYHGDSWIVYGHTPVLEPRVVNHTINIDTGCVFGNKLTAYRFPEKEFVSVASRQPFIAEK
HHCCCEEEEECCCCCCCCEEEEEEEECCCCEEECCCEEEEECCHHHHHHHHCCCCCHHHH
FTDFNVSNEH
CCCCCCCCCC
>Mature Secondary Structure
MKIDIIGDVHGCLEELEELLFKLGYQIKNGTYQHSNNRQIVFVGDITDRGPDSIKVIKLV
CEEEEECCHHHHHHHHHHHHHHCCCEECCCEEEECCCCEEEEEECCCCCCCCHHHHHHHH
YQLVKEKLAYYIPGNHCNKLYRFFQGNKVMEKHGLETTTAEYRSLSKEKQNNIKHKFIEL
HHHHHHHHEEECCCHHHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
YERSPLYLHLKNINVIIAHAGIPEHLIGKKDKRTKTFVLYGDITGEFDTTGKPIRRDWAK
HCCCCEEEEEECCEEEEEECCCCHHHCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHH
HYHGDSWIVYGHTPVLEPRVVNHTINIDTGCVFGNKLTAYRFPEKEFVSVASRQPFIAEK
HHCCCEEEEECCCCCCCCEEEEEEEECCCCEEECCCEEEEECCHHHHHHHHCCCCCHHHH
FTDFNVSNEH
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376