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The map label for this gene is hemY [H]

Identifier: 23098624

GI number: 23098624

Start: 1218766

End: 1220172

Strand: Direct

Name: hemY [H]

Synonym: OB1169

Alternate gene names: 23098624

Gene position: 1218766-1220172 (Clockwise)

Preceding gene: 23098623

Following gene: 23098625

Centisome position: 33.57

GC content: 36.6

Gene sequence:

>1407_bases
ATGACCACTAACAAGAAGGTTGTTGTTGTTGGCGGCGGAATTACAGGTCTATCCGCCGCCTACTATCTTCAAAAAGAAAA
AGAAGCGCAAGAATTGCCAATTGATATCACTTTAGTAGAAGCGTCGGACCGAGTTGGTGGAAGAATTCATACAGTAAAAC
GTGATGGGTTCACGATTGAAAGAGGACCAGACTCATTACTATCTCGAAAGCCTGCTGCTATGGAATTAGTAAACTCACTG
AACATTCAAAGTAAAGTTGTAAGAAATTCTACTGGACAGTCTTATATATTAGTAAAAAATAAATTACATAAAATGCCAAA
AGGAGCCTATATGGGGGTTCCAAAAGAAATAAAACCTTTACTAAACTCAAAGGCGATATCTACACGTGGAAAATTACGAG
CATTAATGGATGTAGTCTTGCCAAAATCAAAGGGTGCTAAAGATCAGTCTTTAGGTAGTTTTATGCGACATAGATTTGGT
GATGAACTAGTTGATAATCAAATCGATCCCTTATTATCAGGCATACATTCCGGAGATATTGATCAAATGAGTTTACAAGC
AATTTATCCAATTTTTGAACGCATGGAACAAGAGTATGGTAGTGTAATGAAAGGATTACAGAAAACCATGCCAGCTTCGA
AAACGAAAAAAACTTCTAAAAAGCCCTCTGTTGGCATGTTTTTCTCATTTGAAGGTGGTTTACAAACACTTGTGGATGCG
TTGAGCAGTCACTTAAATGGTATTATTCAATGTAATCGAGCTGTAGATCATATTGAAAAAAAGGAAGATGGGTACCATTT
ATTACTAAATAACGGAGAGGTCCTTTTTGCTGATGTCGTTATTATGACTGCCCCTCATACGAAGGTTCCGGAGATGTTAA
GTAAGCATGAGCCAATGAAACAACTAAACAAAATACCTGCTACATCTACGGCTAACGTTATATTAGCATTTGATGATAAA
CAGATAAAACGTGATTTAGATGGAACAGGATTTTTAATAACAAGAAACAGTGATTATCGTATAACTGCCTGCACATGGAC
ACATCGGAAGTGGGCGAATACGACACCAGACGGTAAAGCTCTTCTACGTTGCTATGTAGGTAAGCCAGATGATCAAGGTG
TTGTAGATCTGACGGATGAGGAGATTACTGAAATAGTATTGAAAGATTTAAATAAAGTTATGAAAATAAAAGGGAAACCT
CTGTTTTATGAGGTTACAAGATTCAAAAATGCTCGCCCGCAATATCATGTAGGACATCTTGATATTGTTCATGAAGTACG
TCACTATATTGATCATTATTTACCTGGATTTGTTTTAACAGGAAGTTCTTATGATGGTACAGGTATTCCAGATTGTATTG
AACATGGAAAATCAAGTGCGCATCAAGCAATGAATCTGATCAAATAA

Upstream 100 bases:

>100_bases
TTGGTGCAAGCTATTATCGCCCAGATATGCCAAATGTTCATCCTGAGTTCATTGAGACATTAGCAAATGTTGTAATGAAA
AAAGCAAAGAGTGAAGTTAG

Downstream 100 bases:

>100_bases
TTGGAACACTGGAATATAAAATCGTTTAATCGGACTAACTTTTTAATCTTTAGTTAGTATGAACATTTGATTAAATGGTT
TTTGACCAGTGTTTTTTTGT

Product: protoporphyrinogen oxidase

Products: NA

Alternate protein names: PPO [H]

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MTTNKKVVVVGGGITGLSAAYYLQKEKEAQELPIDITLVEASDRVGGRIHTVKRDGFTIERGPDSLLSRKPAAMELVNSL
NIQSKVVRNSTGQSYILVKNKLHKMPKGAYMGVPKEIKPLLNSKAISTRGKLRALMDVVLPKSKGAKDQSLGSFMRHRFG
DELVDNQIDPLLSGIHSGDIDQMSLQAIYPIFERMEQEYGSVMKGLQKTMPASKTKKTSKKPSVGMFFSFEGGLQTLVDA
LSSHLNGIIQCNRAVDHIEKKEDGYHLLLNNGEVLFADVVIMTAPHTKVPEMLSKHEPMKQLNKIPATSTANVILAFDDK
QIKRDLDGTGFLITRNSDYRITACTWTHRKWANTTPDGKALLRCYVGKPDDQGVVDLTDEEITEIVLKDLNKVMKIKGKP
LFYEVTRFKNARPQYHVGHLDIVHEVRHYIDHYLPGFVLTGSSYDGTGIPDCIEHGKSSAHQAMNLIK

Sequences:

>Translated_468_residues
MTTNKKVVVVGGGITGLSAAYYLQKEKEAQELPIDITLVEASDRVGGRIHTVKRDGFTIERGPDSLLSRKPAAMELVNSL
NIQSKVVRNSTGQSYILVKNKLHKMPKGAYMGVPKEIKPLLNSKAISTRGKLRALMDVVLPKSKGAKDQSLGSFMRHRFG
DELVDNQIDPLLSGIHSGDIDQMSLQAIYPIFERMEQEYGSVMKGLQKTMPASKTKKTSKKPSVGMFFSFEGGLQTLVDA
LSSHLNGIIQCNRAVDHIEKKEDGYHLLLNNGEVLFADVVIMTAPHTKVPEMLSKHEPMKQLNKIPATSTANVILAFDDK
QIKRDLDGTGFLITRNSDYRITACTWTHRKWANTTPDGKALLRCYVGKPDDQGVVDLTDEEITEIVLKDLNKVMKIKGKP
LFYEVTRFKNARPQYHVGHLDIVHEVRHYIDHYLPGFVLTGSSYDGTGIPDCIEHGKSSAHQAMNLIK
>Mature_467_residues
TTNKKVVVVGGGITGLSAAYYLQKEKEAQELPIDITLVEASDRVGGRIHTVKRDGFTIERGPDSLLSRKPAAMELVNSLN
IQSKVVRNSTGQSYILVKNKLHKMPKGAYMGVPKEIKPLLNSKAISTRGKLRALMDVVLPKSKGAKDQSLGSFMRHRFGD
ELVDNQIDPLLSGIHSGDIDQMSLQAIYPIFERMEQEYGSVMKGLQKTMPASKTKKTSKKPSVGMFFSFEGGLQTLVDAL
SSHLNGIIQCNRAVDHIEKKEDGYHLLLNNGEVLFADVVIMTAPHTKVPEMLSKHEPMKQLNKIPATSTANVILAFDDKQ
IKRDLDGTGFLITRNSDYRITACTWTHRKWANTTPDGKALLRCYVGKPDDQGVVDLTDEEITEIVLKDLNKVMKIKGKPL
FYEVTRFKNARPQYHVGHLDIVHEVRHYIDHYLPGFVLTGSSYDGTGIPDCIEHGKSSAHQAMNLIK

Specific function: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. Also oxidizes the pathway intermediate coproporphyrinogen-III [H]

COG id: COG1232

COG function: function code H; Protoporphyrinogen oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protoporphyrinogen oxidase family [H]

Homologues:

Organism=Homo sapiens, GI170650615, Length=486, Percent_Identity=26.9547325102881, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI4506001, Length=486, Percent_Identity=26.9547325102881, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24649745, Length=453, Percent_Identity=26.4900662251656, Blast_Score=122, Evalue=7e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002937
- InterPro:   IPR016040
- InterPro:   IPR004572 [H]

Pfam domain/function: PF01593 Amino_oxidase [H]

EC number: =1.3.3.4 [H]

Molecular weight: Translated: 52078; Mature: 51947

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTNKKVVVVGGGITGLSAAYYLQKEKEAQELPIDITLVEASDRVGGRIHTVKRDGFTIE
CCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCEEEEEECCCEEEE
RGPDSLLSRKPAAMELVNSLNIQSKVVRNSTGQSYILVKNKLHKMPKGAYMGVPKEIKPL
CCCHHHHHCCCHHHHHHHHCCHHHHHHHCCCCCEEEEEEHHHHCCCCCCCCCCCHHHHHH
LNSKAISTRGKLRALMDVVLPKSKGAKDQSLGSFMRHRFGDELVDNQIDPLLSGIHSGDI
HCCHHHCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCC
DQMSLQAIYPIFERMEQEYGSVMKGLQKTMPASKTKKTSKKPSVGMFFSFEGGLQTLVDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCEEEEEECCCHHHHHHH
LSSHLNGIIQCNRAVDHIEKKEDGYHLLLNNGEVLFADVVIMTAPHTKVPEMLSKHEPMK
HHHHHHHHEEHHHHHHHHHHCCCCCEEEEECCCEEEEEEEEEECCCCHHHHHHHCCCHHH
QLNKIPATSTANVILAFDDKQIKRDLDGTGFLITRNSDYRITACTWTHRKWANTTPDGKA
HHHCCCCCCCCCEEEEECCHHHHHCCCCCEEEEEECCCEEEEEEEECCCCCCCCCCCHHH
LLRCYVGKPDDQGVVDLTDEEITEIVLKDLNKVMKIKGKPLFYEVTRFKNARPQYHVGHL
HHEEECCCCCCCCCEECCHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHCCCCCCEECCHH
DIVHEVRHYIDHYLPGFVLTGSSYDGTGIPDCIEHGKSSAHQAMNLIK
HHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHCCHHHHHHHHHCC
>Mature Secondary Structure 
TTNKKVVVVGGGITGLSAAYYLQKEKEAQELPIDITLVEASDRVGGRIHTVKRDGFTIE
CCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCEEEEEECCCEEEE
RGPDSLLSRKPAAMELVNSLNIQSKVVRNSTGQSYILVKNKLHKMPKGAYMGVPKEIKPL
CCCHHHHHCCCHHHHHHHHCCHHHHHHHCCCCCEEEEEEHHHHCCCCCCCCCCCHHHHHH
LNSKAISTRGKLRALMDVVLPKSKGAKDQSLGSFMRHRFGDELVDNQIDPLLSGIHSGDI
HCCHHHCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCC
DQMSLQAIYPIFERMEQEYGSVMKGLQKTMPASKTKKTSKKPSVGMFFSFEGGLQTLVDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCEEEEEECCCHHHHHHH
LSSHLNGIIQCNRAVDHIEKKEDGYHLLLNNGEVLFADVVIMTAPHTKVPEMLSKHEPMK
HHHHHHHHEEHHHHHHHHHHCCCCCEEEEECCCEEEEEEEEEECCCCHHHHHHHCCCHHH
QLNKIPATSTANVILAFDDKQIKRDLDGTGFLITRNSDYRITACTWTHRKWANTTPDGKA
HHHCCCCCCCCCEEEEECCHHHHHCCCCCEEEEEECCCEEEEEEEECCCCCCCCCCCHHH
LLRCYVGKPDDQGVVDLTDEEITEIVLKDLNKVMKIKGKPLFYEVTRFKNARPQYHVGHL
HHEEECCCCCCCCCEECCHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHCCCCCCEECCHH
DIVHEVRHYIDHYLPGFVLTGSSYDGTGIPDCIEHGKSSAHQAMNLIK
HHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1459957; 9579061; 9384377; 8288631 [H]