Click here to switch to the map view.

The map label for this gene is map [H]

Identifier: 23098571

GI number: 23098571

Start: 1169309

End: 1170061

Strand: Direct

Name: map [H]

Synonym: OB1116

Alternate gene names: 23098571

Gene position: 1169309-1170061 (Clockwise)

Preceding gene: 23098568

Following gene: 23098574

Centisome position: 32.21

GC content: 38.65

Gene sequence:

>753_bases
ATGATTTCAAGAAAAAGTAAGCGAGAAGTAGAGCAAATGCAAGCTGCTGCAGATGTTCTAGTTGCCTGTCATAAAGAAAT
TGCAAAAATGATTAAACCGGGTATTTCAACGATTGAAATAGATAACTTTGTTGAAGGCTTTTTAGAAAAACATGGTGCTA
CTCCTGAACAAAAAGGCTATAATGGTTATCCTTATGCAATTTGTGCATCGTTAAATGATGAGATCTGCCATGGGTTTCCT
ACTGAAAAACCATTAAAGGATGGAGATATAGTAACCATTGATATGGTTGTTAATTTAAATGGTGGTCTAGCTGATTCAGC
TTGGACATACGCTGTCGGTAACGTAGATGAAAAAGGAAAACGGTTAATCGATGTGACCAAAGAAGCGCTTTATAAGGGGT
TAGAACAGGCACAGCCAGGTAATCGAATAGGTGATATCGGTCATGCTATCCAAACTTTTGCTGAAGCAGAAGGGTTTTCG
GTAGTACGTGACTTTACAGGTCATGGAATAGGTCCGACTATTCATGAAGACCCACATATTCCTCACTATGGTTTGCCAAA
CAAAGGGCTTCGTCTAAAAGAAGGAATGGTAATTACAATCGAACCTATGATTAATGAGGGAGCTTGGCAAAGCAAGATGG
ATGATAATGGATGGACTGCTAGGACAATCGATAAAGGACGTTCTGCTCAGTTTGAACACCAGATTTTCATTACAGAGAAT
GGACCACTTATTTTCACAGAACAAGATAAATAA

Upstream 100 bases:

>100_bases
AAGTTCATATGTTAGAATTTACATTGGAATAACTAACGAATGAGCTATGCATAGTATTAGTATAACGTACTTATAGATAG
AATTGGAGAGGAAGAAGTTA

Downstream 100 bases:

>100_bases
CAAGCAAAAGAGGCTGAGACAAAAGTATTTAATCAAAAGACAAATCCAAATGATTGGACTATAAAATCCCGCTTCAGAAA
TATACTGCGCTTTCCATGGG

Product: methionyl aminopeptidase

Products: NA

Alternate protein names: MAP 1; Peptidase M [H]

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MISRKSKREVEQMQAAADVLVACHKEIAKMIKPGISTIEIDNFVEGFLEKHGATPEQKGYNGYPYAICASLNDEICHGFP
TEKPLKDGDIVTIDMVVNLNGGLADSAWTYAVGNVDEKGKRLIDVTKEALYKGLEQAQPGNRIGDIGHAIQTFAEAEGFS
VVRDFTGHGIGPTIHEDPHIPHYGLPNKGLRLKEGMVITIEPMINEGAWQSKMDDNGWTARTIDKGRSAQFEHQIFITEN
GPLIFTEQDK

Sequences:

>Translated_250_residues
MISRKSKREVEQMQAAADVLVACHKEIAKMIKPGISTIEIDNFVEGFLEKHGATPEQKGYNGYPYAICASLNDEICHGFP
TEKPLKDGDIVTIDMVVNLNGGLADSAWTYAVGNVDEKGKRLIDVTKEALYKGLEQAQPGNRIGDIGHAIQTFAEAEGFS
VVRDFTGHGIGPTIHEDPHIPHYGLPNKGLRLKEGMVITIEPMINEGAWQSKMDDNGWTARTIDKGRSAQFEHQIFITEN
GPLIFTEQDK
>Mature_250_residues
MISRKSKREVEQMQAAADVLVACHKEIAKMIKPGISTIEIDNFVEGFLEKHGATPEQKGYNGYPYAICASLNDEICHGFP
TEKPLKDGDIVTIDMVVNLNGGLADSAWTYAVGNVDEKGKRLIDVTKEALYKGLEQAQPGNRIGDIGHAIQTFAEAEGFS
VVRDFTGHGIGPTIHEDPHIPHYGLPNKGLRLKEGMVITIEPMINEGAWQSKMDDNGWTARTIDKGRSAQFEHQIFITEN
GPLIFTEQDK

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=243, Percent_Identity=39.917695473251, Blast_Score=192, Evalue=2e-49,
Organism=Homo sapiens, GI40385867, Length=246, Percent_Identity=36.9918699186992, Blast_Score=176, Evalue=1e-44,
Organism=Escherichia coli, GI1786364, Length=248, Percent_Identity=42.741935483871, Blast_Score=204, Evalue=6e-54,
Organism=Caenorhabditis elegans, GI71996291, Length=242, Percent_Identity=38.4297520661157, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6323273, Length=224, Percent_Identity=39.2857142857143, Blast_Score=170, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6319380, Length=206, Percent_Identity=29.126213592233, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21355531, Length=240, Percent_Identity=39.5833333333333, Blast_Score=179, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24583427, Length=245, Percent_Identity=37.1428571428571, Blast_Score=171, Evalue=5e-43,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 27576; Mature: 27576

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISRKSKREVEQMQAAADVLVACHKEIAKMIKPGISTIEIDNFVEGFLEKHGATPEQKGY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCCC
NGYPYAICASLNDEICHGFPTEKPLKDGDIVTIDMVVNLNGGLADSAWTYAVGNVDEKGK
CCCCEEEEECCCHHHHCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCEEEEECCCCHHHH
RLIDVTKEALYKGLEQAQPGNRIGDIGHAIQTFAEAEGFSVVRDFTGHGIGPTIHEDPHI
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCC
PHYGLPNKGLRLKEGMVITIEPMINEGAWQSKMDDNGWTARTIDKGRSAQFEHQIFITEN
CCCCCCCCCCEECCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEEEEECC
GPLIFTEQDK
CCEEEEECCC
>Mature Secondary Structure
MISRKSKREVEQMQAAADVLVACHKEIAKMIKPGISTIEIDNFVEGFLEKHGATPEQKGY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCCC
NGYPYAICASLNDEICHGFPTEKPLKDGDIVTIDMVVNLNGGLADSAWTYAVGNVDEKGK
CCCCEEEEECCCHHHHCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCEEEEECCCCHHHH
RLIDVTKEALYKGLEQAQPGNRIGDIGHAIQTFAEAEGFSVVRDFTGHGIGPTIHEDPHI
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCC
PHYGLPNKGLRLKEGMVITIEPMINEGAWQSKMDDNGWTARTIDKGRSAQFEHQIFITEN
CCCCCCCCCCEECCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEEEEECC
GPLIFTEQDK
CCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2113521; 8635744; 9384377 [H]