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The map label for this gene is pdxA

Identifier: 23098468

GI number: 23098468

Start: 1056962

End: 1057960

Strand: Direct

Name: pdxA

Synonym: OB1013

Alternate gene names: 23098468

Gene position: 1056962-1057960 (Clockwise)

Preceding gene: 23098467

Following gene: 23098471

Centisome position: 29.11

GC content: 38.04

Gene sequence:

>999_bases
ATGAGTAAGAAACCAATTATCGGAATAACTATGGGAGATGCAGCTGGGGTAGGACCAGAAATTATCATCAAAAGCTTACG
TAATCGCGAGTTATATGAACAAGCTCATCCGATTGTAATTGGTGATACAAAAATGCTAGAAAGAGCTGCAAAAATATTAG
ATGTCGATGTATCTTTTGACAAGAAAACAAAAGATGAAGAATTGATGGATACGGAGTTTGGGAAAATTACTTGTATTGAT
TTGGATATACTTCCCGAAGACTTAGCATACGGAGAGGTCTCCCCTGTATCTGGAAATGCCGCTTTTGAGTATTTACGAAT
GGCAATAGAACTTGCTAATGAAGGAAAAATTCAAGCGATATGTACAGCACCTTTAAATAAAGAAGCGCTACAAAAAGGCG
GTCATATGTATCCAGGGCATACAGAGATTCTTGCTGAATTAACAAATACCGAAGAATTTTCTATGATGCTGTCCTCGCCT
AAGTTAAAGGTTATTCATGTTACGACACATGTTGGTCTTATTCAAGCGATACAGATGATTAAACCAGAACGAGTGCATAA
AGTAATTCAATTAGCGCATGAAACACTATCAAATTCAGGTATTAAAAATCCTAAAATTGGCGTTTGTGGTATTAATCCTC
ATGCTGGAGAGAATGGTTTATTTGGTAATGGTGAAGAAGAAGAAAAAATTATTCCAGCCATTCAACAAGCGGTAAAAGAA
GGAATCAATGTAGAGGGACCTTTACCTGCTGACACTTTATTTTTCCGAGCGCAACGTGGAGATTTCGATATTGTTGTAGC
GATGTATCATGATCAAGGTCATGGTCCAATTAAGGTATTGGGACTGGAAGCCGGCGTAAATATAACCGTAGGCTTACCAA
TTATTCGTACAAGTGTTGACCACGGAACAGCATTTGATATTGCTGGTAAAGGGATTGTGGATGAAAGAAGCATGTTAGAA
GCACTTCACCAAGCAATTGAGTTAGCCCCGACAAAATAA

Upstream 100 bases:

>100_bases
ATAGGAAGTCATGAAAGTTTAGTTGTCACCAAAGCGGGAGCATTTGGTAAAGAAAATTCTATTTATAAAGCAATGCTCCA
ACTGAAAGGAGAAATTATCG

Downstream 100 bases:

>100_bases
TAAAAAACCTTAAGGAAAACAGAATTATCCGTTCTCCTTAAGGTTTTTTATTTGTTGATATTATTTACTATGGAAAAAAT
AGAGGAGATGGATTCCTCAT

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MSKKPIIGITMGDAAGVGPEIIIKSLRNRELYEQAHPIVIGDTKMLERAAKILDVDVSFDKKTKDEELMDTEFGKITCID
LDILPEDLAYGEVSPVSGNAAFEYLRMAIELANEGKIQAICTAPLNKEALQKGGHMYPGHTEILAELTNTEEFSMMLSSP
KLKVIHVTTHVGLIQAIQMIKPERVHKVIQLAHETLSNSGIKNPKIGVCGINPHAGENGLFGNGEEEEKIIPAIQQAVKE
GINVEGPLPADTLFFRAQRGDFDIVVAMYHDQGHGPIKVLGLEAGVNITVGLPIIRTSVDHGTAFDIAGKGIVDERSMLE
ALHQAIELAPTK

Sequences:

>Translated_332_residues
MSKKPIIGITMGDAAGVGPEIIIKSLRNRELYEQAHPIVIGDTKMLERAAKILDVDVSFDKKTKDEELMDTEFGKITCID
LDILPEDLAYGEVSPVSGNAAFEYLRMAIELANEGKIQAICTAPLNKEALQKGGHMYPGHTEILAELTNTEEFSMMLSSP
KLKVIHVTTHVGLIQAIQMIKPERVHKVIQLAHETLSNSGIKNPKIGVCGINPHAGENGLFGNGEEEEKIIPAIQQAVKE
GINVEGPLPADTLFFRAQRGDFDIVVAMYHDQGHGPIKVLGLEAGVNITVGLPIIRTSVDHGTAFDIAGKGIVDERSMLE
ALHQAIELAPTK
>Mature_331_residues
SKKPIIGITMGDAAGVGPEIIIKSLRNRELYEQAHPIVIGDTKMLERAAKILDVDVSFDKKTKDEELMDTEFGKITCIDL
DILPEDLAYGEVSPVSGNAAFEYLRMAIELANEGKIQAICTAPLNKEALQKGGHMYPGHTEILAELTNTEEFSMMLSSPK
LKVIHVTTHVGLIQAIQMIKPERVHKVIQLAHETLSNSGIKNPKIGVCGINPHAGENGLFGNGEEEEKIIPAIQQAVKEG
INVEGPLPADTLFFRAQRGDFDIVVAMYHDQGHGPIKVLGLEAGVNITVGLPIIRTSVDHGTAFDIAGKGIVDERSMLEA
LHQAIELAPTK

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family

Homologues:

Organism=Escherichia coli, GI1786237, Length=329, Percent_Identity=36.4741641337386, Blast_Score=196, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXA_OCEIH (Q8CUU4)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_691934.1
- ProteinModelPortal:   Q8CUU4
- GeneID:   1016871
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB1013
- NMPDR:   fig|221109.1.peg.1016
- HOGENOM:   HBG451136
- OMA:   FKEPRIA
- ProtClustDB:   PRK00232
- BioCyc:   OIHE221109:OB1013-MONOMER
- BRENDA:   1.1.1.262
- GO:   GO:0005737
- HAMAP:   MF_00536
- InterPro:   IPR005255
- TIGRFAMs:   TIGR00557

Pfam domain/function: PF04166 PdxA

EC number: =1.1.1.262

Molecular weight: Translated: 36017; Mature: 35886

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: BINDING 140-140 BINDING 141-141 BINDING 278-278 BINDING 287-287 BINDING 296-296

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKPIIGITMGDAAGVGPEIIIKSLRNRELYEQAHPIVIGDTKMLERAAKILDVDVSFD
CCCCCEEEEEECCCCCCCHHHHHHHHHCHHHHHHCCCEEECCHHHHHHHHHHEEEECCCC
KKTKDEELMDTEFGKITCIDLDILPEDLAYGEVSPVSGNAAFEYLRMAIELANEGKIQAI
CCCCCHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEE
CTAPLNKEALQKGGHMYPGHTEILAELTNTEEFSMMLSSPKLKVIHVTTHVGLIQAIQMI
EECCCCHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHCCCCEEEEEEEHHHHHHHHHHHH
KPERVHKVIQLAHETLSNSGIKNPKIGVCGINPHAGENGLFGNGEEEEKIIPAIQQAVKE
CHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
GINVEGPLPADTLFFRAQRGDFDIVVAMYHDQGHGPIKVLGLEAGVNITVGLPIIRTSVD
CCCCCCCCCHHHEEEEECCCCEEEEEEEEECCCCCCEEEEEEECCCEEEECCEEEEECCC
HGTAFDIAGKGIVDERSMLEALHQAIELAPTK
CCCEEEECCCCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SKKPIIGITMGDAAGVGPEIIIKSLRNRELYEQAHPIVIGDTKMLERAAKILDVDVSFD
CCCCEEEEEECCCCCCCHHHHHHHHHCHHHHHHCCCEEECCHHHHHHHHHHEEEECCCC
KKTKDEELMDTEFGKITCIDLDILPEDLAYGEVSPVSGNAAFEYLRMAIELANEGKIQAI
CCCCCHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEE
CTAPLNKEALQKGGHMYPGHTEILAELTNTEEFSMMLSSPKLKVIHVTTHVGLIQAIQMI
EECCCCHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHCCCCEEEEEEEHHHHHHHHHHHH
KPERVHKVIQLAHETLSNSGIKNPKIGVCGINPHAGENGLFGNGEEEEKIIPAIQQAVKE
CHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
GINVEGPLPADTLFFRAQRGDFDIVVAMYHDQGHGPIKVLGLEAGVNITVGLPIIRTSVD
CCCCCCCCCHHHEEEEECCCCEEEEEEEEECCCCCCEEEEEEECCCEEEECCEEEEECCC
HGTAFDIAGKGIVDERSMLEALHQAIELAPTK
CCCEEEECCCCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376