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The map label for this gene is ermA1 [H]

Identifier: 23098376

GI number: 23098376

Start: 972847

End: 973581

Strand: Reverse

Name: ermA1 [H]

Synonym: OB0921

Alternate gene names: 23098376

Gene position: 973581-972847 (Counterclockwise)

Preceding gene: 23098391

Following gene: 23098375

Centisome position: 26.82

GC content: 33.2

Gene sequence:

>735_bases
ATGAACCATAAAAACCCAAAGGACACTCAAAATTTTATTACTTCTAAAAAGCATGTAAAAGAAATATTGGATCATACGAG
TATCAATAAACAAGATAACGTAATAGAAATCGGATCAGGAAAAGGGCATTTTACCAAAGAGCTTGTCAAAATGAGTCGGT
GGGTGCATTCTATAGAAATTGATGAGGACTTGTGTCAAGTCACCCAAAAAGCGGTGAAGCCTTTTCAGAATATAAAAGTT
ATCCATACGGATATTCTGAAATTTAACTTCCACAAAAACAAAGACTATAAAATATTTGGTAATATTCCCTTTAACATCAG
TACTGATATTGTCAAAAAAATCGCTTCTGAAAGCCAGTCGAAATTTAGTTACCTTATCGTGGAGAAAGGTTTTGCAAAAA
GATTACAAAATACTAAACGAGCTTTAGGTTTGCTGTTGATGGTTGAAATGGATATCAAAATCCTCACAAAAGTGCCTCGA
ACTTATTTCCACCCGAGGCCAAGCGTGGATTCTGTATTAATCGTCCTTGAACGCCACGAGCCATTGATTTTAAAGAAAGA
CTACAAAAAATATCAATCGTTTGTCTATAGATGGGTAAACAAAGAATATCACGCTCTTTTTACTAAAAATCAGTTCAGAC
AAGCCTTGAGGCATGCAAAAATAGCTGACTTAAATAACGTTAACTTTAAACAATTTTTATCTCTTTTCAATAGTTACAAA
TTGTTTAATAAGTAG

Upstream 100 bases:

>100_bases
TGTGTCGTTAATAGAGTTCATTATCAACCAGATCAAAAATAAATTGGTTATAATGAACTTTTAATGTCAGTTCATTATAA
CCAGCAAGGAGAAGGTTATA

Downstream 100 bases:

>100_bases
TGTTAAGGGGATTGCTTTATTGAGAGCAACCCCTTAAACTTATTTCCCTTAGATACTTTGTTAGACTCACTCTATTCACG
CATTATACTCTACAATCGTT

Product: erythromycin resistance protein

Products: NA

Alternate protein names: Erythromycin resistance protein; Macrolide-lincosamide-streptogramin B resistance protein [H]

Number of amino acids: Translated: 244; Mature: 244

Protein sequence:

>244_residues
MNHKNPKDTQNFITSKKHVKEILDHTSINKQDNVIEIGSGKGHFTKELVKMSRWVHSIEIDEDLCQVTQKAVKPFQNIKV
IHTDILKFNFHKNKDYKIFGNIPFNISTDIVKKIASESQSKFSYLIVEKGFAKRLQNTKRALGLLLMVEMDIKILTKVPR
TYFHPRPSVDSVLIVLERHEPLILKKDYKKYQSFVYRWVNKEYHALFTKNQFRQALRHAKIADLNNVNFKQFLSLFNSYK
LFNK

Sequences:

>Translated_244_residues
MNHKNPKDTQNFITSKKHVKEILDHTSINKQDNVIEIGSGKGHFTKELVKMSRWVHSIEIDEDLCQVTQKAVKPFQNIKV
IHTDILKFNFHKNKDYKIFGNIPFNISTDIVKKIASESQSKFSYLIVEKGFAKRLQNTKRALGLLLMVEMDIKILTKVPR
TYFHPRPSVDSVLIVLERHEPLILKKDYKKYQSFVYRWVNKEYHALFTKNQFRQALRHAKIADLNNVNFKQFLSLFNSYK
LFNK
>Mature_244_residues
MNHKNPKDTQNFITSKKHVKEILDHTSINKQDNVIEIGSGKGHFTKELVKMSRWVHSIEIDEDLCQVTQKAVKPFQNIKV
IHTDILKFNFHKNKDYKIFGNIPFNISTDIVKKIASESQSKFSYLIVEKGFAKRLQNTKRALGLLLMVEMDIKILTKVPR
TYFHPRPSVDSVLIVLERHEPLILKKDYKKYQSFVYRWVNKEYHALFTKNQFRQALRHAKIADLNNVNFKQFLSLFNSYK
LFNK

Specific function: This protein produces a dimethylation of the adenine residue at position 2085 in 23S rRNA, resulting in reduced affinity between ribosomes and macrolide-lincosamide-streptogramin B antibiotics [H]

COG id: COG0030

COG function: function code J; Dimethyladenosine transferase (rRNA methylation)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI25146882, Length=187, Percent_Identity=25.668449197861, Blast_Score=67, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023165
- InterPro:   IPR020596
- InterPro:   IPR001737
- InterPro:   IPR020598 [H]

Pfam domain/function: PF00398 RrnaAD [H]

EC number: =2.1.1.184 [H]

Molecular weight: Translated: 28810; Mature: 28810

Theoretical pI: Translated: 10.54; Mature: 10.54

Prosite motif: PS01131 RRNA_A_DIMETH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHKNPKDTQNFITSKKHVKEILDHTSINKQDNVIEIGSGKGHFTKELVKMSRWVHSIEI
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCC
DEDLCQVTQKAVKPFQNIKVIHTDILKFNFHKNKDYKIFGNIPFNISTDIVKKIASESQS
CHHHHHHHHHHHHHHHCCHHHHHHHHEEECCCCCCEEEEECCCCCCCHHHHHHHHHCCHH
KFSYLIVEKGFAKRLQNTKRALGLLLMVEMDIKILTKVPRTYFHPRPSVDSVLIVLERHE
HHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCEEEEEECCC
PLILKKDYKKYQSFVYRWVNKEYHALFTKNQFRQALRHAKIADLNNVNFKQFLSLFNSYK
CEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LFNK
HCCC
>Mature Secondary Structure
MNHKNPKDTQNFITSKKHVKEILDHTSINKQDNVIEIGSGKGHFTKELVKMSRWVHSIEI
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCC
DEDLCQVTQKAVKPFQNIKVIHTDILKFNFHKNKDYKIFGNIPFNISTDIVKKIASESQS
CHHHHHHHHHHHHHHHCCHHHHHHHHEEECCCCCCEEEEECCCCCCCHHHHHHHHHCCHH
KFSYLIVEKGFAKRLQNTKRALGLLLMVEMDIKILTKVPRTYFHPRPSVDSVLIVLERHE
HHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCEEEEEECCC
PLILKKDYKKYQSFVYRWVNKEYHALFTKNQFRQALRHAKIADLNNVNFKQFLSLFNSYK
CEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LFNK
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]