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The map label for this gene is hemL1

Identifier: 23098356

GI number: 23098356

Start: 952244

End: 953542

Strand: Reverse

Name: hemL1

Synonym: OB0901

Alternate gene names: 23098356

Gene position: 953542-952244 (Counterclockwise)

Preceding gene: 23098361

Following gene: 23098352

Centisome position: 26.26

GC content: 40.34

Gene sequence:

>1299_bases
ATGAAATTTACAAATTCAGAAAAGCTACATCAAGAGGCTCTTCAACATATTGTAGGAGGAGTTAACTCTCCTTCTCGTGC
ATATAAAGCTGTAGGTGGAGGTTCACCTGTATATATGGAACGAGGACAAGGGGCTTACTTTTGGGATGTGGATGATAATA
AATATATTGATTATTTAGCGGCTTATGGACCAATCATTACCGGCCATGCACATCCGCATATAGCAAAAGCAATAGCTCAT
GCTGCAACAACCGGTGTTCTATATGGTACTCCAACGTGTTTAGAAAATGAATTTGCCCAAATGTTAAAAGAAGCAATTCC
TTCATTAGAGAAGGTTCGATTTAATAACTCTGGTACAGAAGCTGTAATGACAACGATTCGTGTAGCAAGAGCTTATACCG
GGCGTACAAAAATAATTAAATTTGCTGGTTGCTACCACGGGCATTTTGATGCTGTTTTAGTGGAAGCCGGATCGGGACCT
TCTACATTAGGTACTCCAGATTCAGCTGGGGTTCCAGCTTCAACCGCATCGGATGTAATTACTGTACCGTTCAATGATAT
TGAAGCATATAAAGCAGCATTAAATAAATGGGGAGATCAAGTAGCTGCTGTACTTGTTGAACCAATCGTTGGGAATTTTG
GAATCGTAGAACCTTTTAAAGGGTTTCTACAAGAGGTAAATGAATTAACCCACCGAGCAGGAGCATTAGTAATATACGAT
GAAGTAATTACTGCATTCCGATTCACTTATGGAAGTGCTCAACAGATTTATGGTGTAGAACCAGATATGACTGCTATGGG
TAAAATAATTGGTGGTGGTTTGCCTATCGGTGCTTACGGAGGTAGAAAAGATATAATGGAACAAGTGGCACCACTAGGTC
CTGCATATCAAGCTGGAACGATGTCAGGTAATCCGGCATCAATGGCTGCAGGTATCGCGTGTTTAGAAGTGTTAAAAGAA
GAAGGCGTCTATGAAGAATTAGATCGTCTCGGGAAAAGACTCGAAGAAGGCATTCTCGAACAAGCTCGCGAGCATGGTAT
TCATATCACTGTTAATCGACTTTGTGGTGCTTTAACGGTGTACTTCGGTGTCGATCAAATAACGAATTACGCAGAAGCAG
ATGCTTCAGACGGAGAAGCCTTTGCAAAATTCTTCCAACTAATGTTGCGAGAAGGAATTAATCTAGCACCTTCTAAATAT
GAAGCTTGGTTCTTAACAACAGAACATAAAGATTCAGACATTGAAAATACTATTGATGCTGTTGGTCGAAGCTTTGCTGA
AATGGCTAAAACATTATAG

Upstream 100 bases:

>100_bases
CAAAGAGCTTGTTCAAAAAATAAAAATGTACGTTTTATAAGAATTTCTAAGTGATTTTTGATATATTAGTAACTGGTTAG
ATAGAGGAGGAAAATAACTG

Downstream 100 bases:

>100_bases
TTAATAAAATAAAGGCCTACAAGCTGGAATATCAGTTTGTAGGCCCTTTTTTCACAATAAAAAACATATGCTTTTTTAAT
ATGCACATAATCAGAATACG

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA 1; Glutamate-1-semialdehyde aminotransferase 1; GSA-AT 1

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MKFTNSEKLHQEALQHIVGGVNSPSRAYKAVGGGSPVYMERGQGAYFWDVDDNKYIDYLAAYGPIITGHAHPHIAKAIAH
AATTGVLYGTPTCLENEFAQMLKEAIPSLEKVRFNNSGTEAVMTTIRVARAYTGRTKIIKFAGCYHGHFDAVLVEAGSGP
STLGTPDSAGVPASTASDVITVPFNDIEAYKAALNKWGDQVAAVLVEPIVGNFGIVEPFKGFLQEVNELTHRAGALVIYD
EVITAFRFTYGSAQQIYGVEPDMTAMGKIIGGGLPIGAYGGRKDIMEQVAPLGPAYQAGTMSGNPASMAAGIACLEVLKE
EGVYEELDRLGKRLEEGILEQAREHGIHITVNRLCGALTVYFGVDQITNYAEADASDGEAFAKFFQLMLREGINLAPSKY
EAWFLTTEHKDSDIENTIDAVGRSFAEMAKTL

Sequences:

>Translated_432_residues
MKFTNSEKLHQEALQHIVGGVNSPSRAYKAVGGGSPVYMERGQGAYFWDVDDNKYIDYLAAYGPIITGHAHPHIAKAIAH
AATTGVLYGTPTCLENEFAQMLKEAIPSLEKVRFNNSGTEAVMTTIRVARAYTGRTKIIKFAGCYHGHFDAVLVEAGSGP
STLGTPDSAGVPASTASDVITVPFNDIEAYKAALNKWGDQVAAVLVEPIVGNFGIVEPFKGFLQEVNELTHRAGALVIYD
EVITAFRFTYGSAQQIYGVEPDMTAMGKIIGGGLPIGAYGGRKDIMEQVAPLGPAYQAGTMSGNPASMAAGIACLEVLKE
EGVYEELDRLGKRLEEGILEQAREHGIHITVNRLCGALTVYFGVDQITNYAEADASDGEAFAKFFQLMLREGINLAPSKY
EAWFLTTEHKDSDIENTIDAVGRSFAEMAKTL
>Mature_432_residues
MKFTNSEKLHQEALQHIVGGVNSPSRAYKAVGGGSPVYMERGQGAYFWDVDDNKYIDYLAAYGPIITGHAHPHIAKAIAH
AATTGVLYGTPTCLENEFAQMLKEAIPSLEKVRFNNSGTEAVMTTIRVARAYTGRTKIIKFAGCYHGHFDAVLVEAGSGP
STLGTPDSAGVPASTASDVITVPFNDIEAYKAALNKWGDQVAAVLVEPIVGNFGIVEPFKGFLQEVNELTHRAGALVIYD
EVITAFRFTYGSAQQIYGVEPDMTAMGKIIGGGLPIGAYGGRKDIMEQVAPLGPAYQAGTMSGNPASMAAGIACLEVLKE
EGVYEELDRLGKRLEEGILEQAREHGIHITVNRLCGALTVYFGVDQITNYAEADASDGEAFAKFFQLMLREGINLAPSKY
EAWFLTTEHKDSDIENTIDAVGRSFAEMAKTL

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=318, Percent_Identity=33.9622641509434, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI13994255, Length=333, Percent_Identity=29.1291291291291, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI37574042, Length=374, Percent_Identity=26.7379679144385, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI24119277, Length=368, Percent_Identity=26.0869565217391, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI226442705, Length=373, Percent_Identity=26.0053619302949, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI226442709, Length=334, Percent_Identity=27.2455089820359, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI284507298, Length=235, Percent_Identity=33.6170212765957, Blast_Score=93, Evalue=5e-19,
Organism=Escherichia coli, GI1786349, Length=427, Percent_Identity=49.1803278688525, Blast_Score=439, Evalue=1e-124,
Organism=Escherichia coli, GI1789016, Length=338, Percent_Identity=28.1065088757396, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI145693181, Length=367, Percent_Identity=30.5177111716621, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI1789759, Length=304, Percent_Identity=31.5789473684211, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788044, Length=334, Percent_Identity=30.5389221556886, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1787560, Length=353, Percent_Identity=29.4617563739377, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1786991, Length=325, Percent_Identity=23.3846153846154, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI25144271, Length=356, Percent_Identity=29.7752808988764, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI71992977, Length=397, Percent_Identity=26.7002518891688, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI25144274, Length=184, Percent_Identity=32.0652173913043, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71981843, Length=108, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323470, Length=347, Percent_Identity=29.971181556196, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324432, Length=327, Percent_Identity=24.7706422018349, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21357415, Length=313, Percent_Identity=29.7124600638978, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI161085790, Length=346, Percent_Identity=28.3236994219653, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI28574759, Length=347, Percent_Identity=28.2420749279539, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI21356575, Length=327, Percent_Identity=29.0519877675841, Blast_Score=102, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSA1_OCEIH (Q8CV56)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_691822.1
- ProteinModelPortal:   Q8CV56
- SMR:   Q8CV56
- GeneID:   1016548
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB0901
- NMPDR:   fig|221109.1.peg.907
- HOGENOM:   HBG725944
- OMA:   HSEADIL
- ProtClustDB:   PRK12389
- BioCyc:   OIHE221109:OB0901-MONOMER
- BRENDA:   5.4.3.8
- GO:   GO:0005737
- HAMAP:   MF_00375
- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR00713

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =5.4.3.8

Molecular weight: Translated: 46533; Mature: 46533

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFTNSEKLHQEALQHIVGGVNSPSRAYKAVGGGSPVYMERGQGAYFWDVDDNKYIDYLA
CCCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEEECCCCCEEEECCCCHHHHHHH
AYGPIITGHAHPHIAKAIAHAATTGVLYGTPTCLENEFAQMLKEAIPSLEKVRFNNSGTE
HHCCEEECCCCHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHCCHHHHEECCCCCHH
AVMTTIRVARAYTGRTKIIKFAGCYHGHFDAVLVEAGSGPSTLGTPDSAGVPASTASDVI
HHHHHHHHHHHHCCCHHEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEE
TVPFNDIEAYKAALNKWGDQVAAVLVEPIVGNFGIVEPFKGFLQEVNELTHRAGALVIYD
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEHH
EVITAFRFTYGSAQQIYGVEPDMTAMGKIIGGGLPIGAYGGRKDIMEQVAPLGPAYQAGT
HHHHHHHHCCCCCCCEECCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCC
MSGNPASMAAGIACLEVLKEEGVYEELDRLGKRLEEGILEQAREHGIHITVNRLCGALTV
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHH
YFGVDQITNYAEADASDGEAFAKFFQLMLREGINLAPSKYEAWFLTTEHKDSDIENTIDA
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHH
VGRSFAEMAKTL
HHHHHHHHHHCC
>Mature Secondary Structure
MKFTNSEKLHQEALQHIVGGVNSPSRAYKAVGGGSPVYMERGQGAYFWDVDDNKYIDYLA
CCCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEEECCCCCEEEECCCCHHHHHHH
AYGPIITGHAHPHIAKAIAHAATTGVLYGTPTCLENEFAQMLKEAIPSLEKVRFNNSGTE
HHCCEEECCCCHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHCCHHHHEECCCCCHH
AVMTTIRVARAYTGRTKIIKFAGCYHGHFDAVLVEAGSGPSTLGTPDSAGVPASTASDVI
HHHHHHHHHHHHCCCHHEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEE
TVPFNDIEAYKAALNKWGDQVAAVLVEPIVGNFGIVEPFKGFLQEVNELTHRAGALVIYD
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEHH
EVITAFRFTYGSAQQIYGVEPDMTAMGKIIGGGLPIGAYGGRKDIMEQVAPLGPAYQAGT
HHHHHHHHCCCCCCCEECCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCC
MSGNPASMAAGIACLEVLKEEGVYEELDRLGKRLEEGILEQAREHGIHITVNRLCGALTV
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHH
YFGVDQITNYAEADASDGEAFAKFFQLMLREGINLAPSKYEAWFLTTEHKDSDIENTIDA
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHH
VGRSFAEMAKTL
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376