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The map label for this gene is qor [C]

Identifier: 23098273

GI number: 23098273

Start: 873584

End: 874519

Strand: Direct

Name: qor [C]

Synonym: OB0818

Alternate gene names: 23098273

Gene position: 873584-874519 (Clockwise)

Preceding gene: 23098271

Following gene: 23098275

Centisome position: 24.06

GC content: 36.0

Gene sequence:

>936_bases
ATGAAAGCAATTGTTATTGAAAATTATGGACATGCAGATGAACTTCATGAACAAGATGTTCCTAAACCTACAATAAATGA
TAATCAGATTTTAATAGAACAATATGCAACGTCAATTAACCCAATTGATTGGAAATTGCGTGAAGGGTATTTGAAGGATG
GATTTAATTTTGAATTTCCAATTATTCTAGGCTGGGACTCTGCAGGTGTTGTAGCTGAGGTTGGAAAAAATGTAAGTCAA
TTTAAGGTTGGGGACCGTGTATTTTCACGACCAGCGACTACTGCTCAAGGAACTTATGCAGAATTTGTAGCAGTTGAGGA
ATCAAGAGTGGCTAAAATTCCAGAAAATGTGTCGTTTGAAGAAGCAGCAAGTGTTCCACTCGCAGGTCTTACTGCTTGGC
AATGTCTAGTAGATTTTTCAGCAATAAAAAAAGGTGACAAAGTTCTTATTCATGCTGGTTCCGGTGGTGTTGGTAGCTTT
GCCATTCAATTCGCTAAGCATTTTGGTGCTTATGTAGCGACTACAGCAAGTGGTAAAAATGAGTCATTAGTAAAAGAATT
AGGAGCCGATCGATTCATTAATTATAAAGAAGAGAATTTTAACGAAGTGCTAGAGGATTATGATATTGTTGTCGACACAT
TAGGTGGAGATATATTAGAGCAAAGTTTTGAAGTCTTAAAAGAAGGTGGAAAACTAGTATCTATTGCAGGAAATCCAGAT
GAAGAAAAAGCAAAAGAAAAAGGGATAAAAGCTGGGTTCCTTTGGTTAGAAGAAAATGGAAAGCAACTTAGTGAAGTAGC
AGATCTCTTAGAAAACGGTAAAGTAAAATCAGTTATTGGTCACACCTTCCCATTAACAGAACAAGGATTACGAGAAGCAC
ATCAATTAAGTGAAACACATCATGCTAGAGGGAAAATCGTAATAAAGATTAAATAA

Upstream 100 bases:

>100_bases
TCATTTATTCTCCAATAAATTAATATCATTGTATGAGAATGATTAATTTATACTATAATGGGGAACAAAATACATAGAAT
GTAATAGAAAGAGGGATAAG

Downstream 100 bases:

>100_bases
ATTTGGGGAATAGTTGGTAAGGCCCCGTTTGCTGAAGCAATCTAGGGGTCTTACCGAGATCTCCTTCTAATCATTATCCC
AATATCTTTTGAATGATTAA

Product: zinc-binding oxidoreductase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MKAIVIENYGHADELHEQDVPKPTINDNQILIEQYATSINPIDWKLREGYLKDGFNFEFPIILGWDSAGVVAEVGKNVSQ
FKVGDRVFSRPATTAQGTYAEFVAVEESRVAKIPENVSFEEAASVPLAGLTAWQCLVDFSAIKKGDKVLIHAGSGGVGSF
AIQFAKHFGAYVATTASGKNESLVKELGADRFINYKEENFNEVLEDYDIVVDTLGGDILEQSFEVLKEGGKLVSIAGNPD
EEKAKEKGIKAGFLWLEENGKQLSEVADLLENGKVKSVIGHTFPLTEQGLREAHQLSETHHARGKIVIKIK

Sequences:

>Translated_311_residues
MKAIVIENYGHADELHEQDVPKPTINDNQILIEQYATSINPIDWKLREGYLKDGFNFEFPIILGWDSAGVVAEVGKNVSQ
FKVGDRVFSRPATTAQGTYAEFVAVEESRVAKIPENVSFEEAASVPLAGLTAWQCLVDFSAIKKGDKVLIHAGSGGVGSF
AIQFAKHFGAYVATTASGKNESLVKELGADRFINYKEENFNEVLEDYDIVVDTLGGDILEQSFEVLKEGGKLVSIAGNPD
EEKAKEKGIKAGFLWLEENGKQLSEVADLLENGKVKSVIGHTFPLTEQGLREAHQLSETHHARGKIVIKIK
>Mature_311_residues
MKAIVIENYGHADELHEQDVPKPTINDNQILIEQYATSINPIDWKLREGYLKDGFNFEFPIILGWDSAGVVAEVGKNVSQ
FKVGDRVFSRPATTAQGTYAEFVAVEESRVAKIPENVSFEEAASVPLAGLTAWQCLVDFSAIKKGDKVLIHAGSGGVGSF
AIQFAKHFGAYVATTASGKNESLVKELGADRFINYKEENFNEVLEDYDIVVDTLGGDILEQSFEVLKEGGKLVSIAGNPD
EEKAKEKGIKAGFLWLEENGKQLSEVADLLENGKVKSVIGHTFPLTEQGLREAHQLSETHHARGKIVIKIK

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=355, Percent_Identity=33.2394366197183, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI194239674, Length=328, Percent_Identity=30.1829268292683, Blast_Score=147, Evalue=9e-36,
Organism=Homo sapiens, GI13236495, Length=328, Percent_Identity=30.1829268292683, Blast_Score=147, Evalue=9e-36,
Organism=Homo sapiens, GI194239676, Length=316, Percent_Identity=30.0632911392405, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI22538446, Length=341, Percent_Identity=28.4457478005865, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI22538444, Length=341, Percent_Identity=28.4457478005865, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI18379349, Length=242, Percent_Identity=31.404958677686, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI24308257, Length=237, Percent_Identity=28.6919831223629, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI28557745, Length=226, Percent_Identity=29.2035398230088, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI67078404, Length=314, Percent_Identity=23.5668789808917, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI67078406, Length=278, Percent_Identity=25.1798561151079, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI156627571, Length=317, Percent_Identity=24.2902208201893, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI90669511, Length=158, Percent_Identity=33.5443037974684, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI197927207, Length=191, Percent_Identity=27.7486910994764, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI41872631, Length=135, Percent_Identity=31.1111111111111, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1790485, Length=305, Percent_Identity=29.8360655737705, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1790045, Length=308, Percent_Identity=24.3506493506494, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17507255, Length=331, Percent_Identity=30.8157099697885, Blast_Score=120, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI71987554, Length=367, Percent_Identity=28.6103542234332, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17562876, Length=339, Percent_Identity=25.0737463126844, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17536829, Length=216, Percent_Identity=30.0925925925926, Blast_Score=78, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI71988145, Length=198, Percent_Identity=27.7777777777778, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17556000, Length=222, Percent_Identity=27.027027027027, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17562878, Length=223, Percent_Identity=26.9058295964126, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6319520, Length=334, Percent_Identity=30.8383233532934, Blast_Score=105, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6324195, Length=239, Percent_Identity=30.5439330543933, Blast_Score=83, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6319945, Length=290, Percent_Identity=24.4827586206897, Blast_Score=69, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6323493, Length=290, Percent_Identity=25.1724137931034, Blast_Score=69, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6320948, Length=368, Percent_Identity=23.3695652173913, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319401, Length=271, Percent_Identity=28.0442804428044, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323980, Length=333, Percent_Identity=27.9279279279279, Blast_Score=66, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6323801, Length=339, Percent_Identity=25.6637168141593, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24581339, Length=360, Percent_Identity=27.7777777777778, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24581341, Length=360, Percent_Identity=27.7777777777778, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI45550423, Length=300, Percent_Identity=24, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221330659, Length=257, Percent_Identity=28.0155642023346, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI19920632, Length=257, Percent_Identity=28.0155642023346, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 34092; Mature: 34092

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS01162 QOR_ZETA_CRYSTAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIVIENYGHADELHEQDVPKPTINDNQILIEQYATSINPIDWKLREGYLKDGFNFEFP
CCEEEEECCCCHHHHHHHCCCCCCCCCCEEEHHHHHCCCCCCCHHHHCCHHCCCCCEECE
IILGWDSAGVVAEVGKNVSQFKVGDRVFSRPATTAQGTYAEFVAVEESRVAKIPENVSFE
EEEECCCCCHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHEEEECCHHHHCCCCCCCHH
EAASVPLAGLTAWQCLVDFSAIKKGDKVLIHAGSGGVGSFAIQFAKHFGAYVATTASGKN
HHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCC
ESLVKELGADRFINYKEENFNEVLEDYDIVVDTLGGDILEQSFEVLKEGGKLVSIAGNPD
HHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEECCCCC
EEKAKEKGIKAGFLWLEENGKQLSEVADLLENGKVKSVIGHTFPLTEQGLREAHQLSETH
HHHHHHCCCEEEEEEEECCCHHHHHHHHHHHCCCEEHHHCCCCCCCHHHHHHHHHHHHHH
HARGKIVIKIK
CCCCEEEEEEC
>Mature Secondary Structure
MKAIVIENYGHADELHEQDVPKPTINDNQILIEQYATSINPIDWKLREGYLKDGFNFEFP
CCEEEEECCCCHHHHHHHCCCCCCCCCCEEEHHHHHCCCCCCCHHHHCCHHCCCCCEECE
IILGWDSAGVVAEVGKNVSQFKVGDRVFSRPATTAQGTYAEFVAVEESRVAKIPENVSFE
EEEECCCCCHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHEEEECCHHHHCCCCCCCHH
EAASVPLAGLTAWQCLVDFSAIKKGDKVLIHAGSGGVGSFAIQFAKHFGAYVATTASGKN
HHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCC
ESLVKELGADRFINYKEENFNEVLEDYDIVVDTLGGDILEQSFEVLKEGGKLVSIAGNPD
HHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEECCCCC
EEKAKEKGIKAGFLWLEENGKQLSEVADLLENGKVKSVIGHTFPLTEQGLREAHQLSETH
HHHHHHCCCEEEEEEEECCCHHHHHHHHHHHCCCEEHHHCCCCCCCHHHHHHHHHHHHHH
HARGKIVIKIK
CCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.26 {1,4-naphthoquinone}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]