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The map label for this gene is adhA [H]

Identifier: 23098241

GI number: 23098241

Start: 841721

End: 842761

Strand: Direct

Name: adhA [H]

Synonym: OB0786

Alternate gene names: 23098241

Gene position: 841721-842761 (Clockwise)

Preceding gene: 23098239

Following gene: 23098242

Centisome position: 23.18

GC content: 39.77

Gene sequence:

>1041_bases
ATGTATACTGCTAAAGCAAGGGCTGTCGATGGGCCACATCAACCATTTCACGCAACGGAAATTAAACGGCGTAATCTTGA
TTCACATGATGTTTTAATCGAGATTAAGTATTCAGGTATATGCCATTCTGACATTCATACTGCTCATGGTGAGTGGGGAG
AAGTAAATTATCCCCTAGTACCAGGACATGAAATTGCTGGGGTAGTATCAGATGTTGGACCTGAAGTTACCAAATATAAG
GTTGGTGACCGAGTAGGAGTAGGATGTATGGTTGACTCTTGTGGCGAATGTGAAAATTGCCGCAGAGGAGAAGAACAATA
CTGTCATCAAGGAAATGTCCAAACTTATGGCGGTGTTGATAAATATGGTGAACCAACTCAAGGCGGATACTCTACTCATA
TTGTCGTAACAGAAGATTTTGTACTCAGAATTCCTGATAATATCGAATTGGATGTTGCAGCACCGTTACTCTGTGCTGGT
ATTACAACGTATTCTCCATTAAATCATTGGAATGCTGGTCCAGGAAAGAAAGTAGCTGTTGTTGGTATGGGCGGCCTCGG
TCATATGGCTGTTAAGATTGCACATGCTATGGGAGCAGAGGTTACGGTTTTATCCAGAACATTAAATAAAAAAGAAGATG
GACTGGAATTCGGAGCAGAAAATTATTATGCTACTAGTGAGAAAGAAACTTTCGAGACACTTGCGGGATCATTTGATTTA
ATTATTAATACAGTAAGTGCCAAGCTTGATATGGATGCTTACTTTAGTCTTCTAAATCTTGATGGTTCCTTGGTAAATGT
CGGAGCACCGGCAGAACCATTGTCCGTTAATGTATTCTCTCTGATTGGACATCGCCGTTCATTTGCTGGTTCTTTAATCG
GAGGAATTCGCGAAACTCAGGAAATGCTAGATTTCTGTGCAGAGCATAATATTGTTCCAAAAATTGAAGTGATTTCTGCA
GATCAAATTGATGAAGCATATACACGAGTATTAGATTCAGATGTGAAATATCGCTTTGTTATTGATGTCAGCACAATTTA
A

Upstream 100 bases:

>100_bases
GGAAGTTTAAAAAATAAAGGATAAACCTCTTGACTTAGAGTTAACTATAACGTTTACCATTAATTTGTAAGTAAACATAA
ATTTCTAGGAGGTTCTTTAT

Downstream 100 bases:

>100_bases
CTTTAATAGTTTAAATATAAGGTGTTCTATAAGCTATGCTTATGGAACATCTTTTTTTTAAGCAAATGTTTCCGGTGGAT
AAGGCTTCAGTCTTTACAAA

Product: NADP-dependent alcohol dehydrogenase

Products: aldehyde; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MYTAKARAVDGPHQPFHATEIKRRNLDSHDVLIEIKYSGICHSDIHTAHGEWGEVNYPLVPGHEIAGVVSDVGPEVTKYK
VGDRVGVGCMVDSCGECENCRRGEEQYCHQGNVQTYGGVDKYGEPTQGGYSTHIVVTEDFVLRIPDNIELDVAAPLLCAG
ITTYSPLNHWNAGPGKKVAVVGMGGLGHMAVKIAHAMGAEVTVLSRTLNKKEDGLEFGAENYYATSEKETFETLAGSFDL
IINTVSAKLDMDAYFSLLNLDGSLVNVGAPAEPLSVNVFSLIGHRRSFAGSLIGGIRETQEMLDFCAEHNIVPKIEVISA
DQIDEAYTRVLDSDVKYRFVIDVSTI

Sequences:

>Translated_346_residues
MYTAKARAVDGPHQPFHATEIKRRNLDSHDVLIEIKYSGICHSDIHTAHGEWGEVNYPLVPGHEIAGVVSDVGPEVTKYK
VGDRVGVGCMVDSCGECENCRRGEEQYCHQGNVQTYGGVDKYGEPTQGGYSTHIVVTEDFVLRIPDNIELDVAAPLLCAG
ITTYSPLNHWNAGPGKKVAVVGMGGLGHMAVKIAHAMGAEVTVLSRTLNKKEDGLEFGAENYYATSEKETFETLAGSFDL
IINTVSAKLDMDAYFSLLNLDGSLVNVGAPAEPLSVNVFSLIGHRRSFAGSLIGGIRETQEMLDFCAEHNIVPKIEVISA
DQIDEAYTRVLDSDVKYRFVIDVSTI
>Mature_346_residues
MYTAKARAVDGPHQPFHATEIKRRNLDSHDVLIEIKYSGICHSDIHTAHGEWGEVNYPLVPGHEIAGVVSDVGPEVTKYK
VGDRVGVGCMVDSCGECENCRRGEEQYCHQGNVQTYGGVDKYGEPTQGGYSTHIVVTEDFVLRIPDNIELDVAAPLLCAG
ITTYSPLNHWNAGPGKKVAVVGMGGLGHMAVKIAHAMGAEVTVLSRTLNKKEDGLEFGAENYYATSEKETFETLAGSFDL
IINTVSAKLDMDAYFSLLNLDGSLVNVGAPAEPLSVNVFSLIGHRRSFAGSLIGGIRETQEMLDFCAEHNIVPKIEVISA
DQIDEAYTRVLDSDVKYRFVIDVSTI

Specific function: Functions in the protection against aldehyde-stress [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501929, Length=314, Percent_Identity=27.7070063694268, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI4501933, Length=322, Percent_Identity=27.0186335403727, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI34577061, Length=322, Percent_Identity=27.0186335403727, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI71565154, Length=367, Percent_Identity=26.158038147139, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4501939, Length=352, Percent_Identity=24.7159090909091, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI156523966, Length=352, Percent_Identity=24.7159090909091, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI71743840, Length=332, Percent_Identity=25.6024096385542, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI262073058, Length=332, Percent_Identity=25.6024096385542, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI71565152, Length=205, Percent_Identity=27.8048780487805, Blast_Score=75, Evalue=6e-14,
Organism=Escherichia coli, GI1786518, Length=336, Percent_Identity=54.4642857142857, Blast_Score=318, Evalue=4e-88,
Organism=Escherichia coli, GI87082401, Length=318, Percent_Identity=38.3647798742138, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI87081918, Length=323, Percent_Identity=29.1021671826625, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1790045, Length=296, Percent_Identity=28.7162162162162, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1788075, Length=285, Percent_Identity=26.3157894736842, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788073, Length=193, Percent_Identity=30.0518134715026, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI87082125, Length=323, Percent_Identity=26.3157894736842, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786552, Length=357, Percent_Identity=27.4509803921569, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787863, Length=270, Percent_Identity=28.1481481481481, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI226510992, Length=248, Percent_Identity=29.0322580645161, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1788407, Length=210, Percent_Identity=28.5714285714286, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1786825, Length=211, Percent_Identity=26.5402843601896, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=334, Percent_Identity=30.2395209580838, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17562584, Length=338, Percent_Identity=28.1065088757396, Blast_Score=141, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17562582, Length=349, Percent_Identity=28.3667621776504, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17562878, Length=180, Percent_Identity=32.2222222222222, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17562876, Length=180, Percent_Identity=31.1111111111111, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI25146526, Length=327, Percent_Identity=25.3822629969419, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71997431, Length=329, Percent_Identity=25.2279635258359, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17565904, Length=200, Percent_Identity=31, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319949, Length=321, Percent_Identity=41.1214953271028, Blast_Score=212, Evalue=9e-56,
Organism=Saccharomyces cerevisiae, GI6323980, Length=331, Percent_Identity=40.1812688821752, Blast_Score=209, Evalue=6e-55,
Organism=Saccharomyces cerevisiae, GI6324486, Length=340, Percent_Identity=31.7647058823529, Blast_Score=155, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6323961, Length=324, Percent_Identity=33.641975308642, Blast_Score=155, Evalue=9e-39,
Organism=Saccharomyces cerevisiae, GI6319621, Length=324, Percent_Identity=30.8641975308642, Blast_Score=154, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6323729, Length=337, Percent_Identity=29.673590504451, Blast_Score=143, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6320033, Length=318, Percent_Identity=29.874213836478, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6319258, Length=300, Percent_Identity=26.3333333333333, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6322619, Length=288, Percent_Identity=29.1666666666667, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319955, Length=288, Percent_Identity=29.1666666666667, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319257, Length=296, Percent_Identity=25, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17137530, Length=210, Percent_Identity=30, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17737897, Length=207, Percent_Identity=29.4685990338164, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17737895, Length=327, Percent_Identity=24.4648318042813, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.2

Molecular weight: Translated: 37592; Mature: 37592

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTAKARAVDGPHQPFHATEIKRRNLDSHDVLIEIKYSGICHSDIHTAHGEWGEVNYPLV
CCCCCCCCCCCCCCCCCHHHHHHCCCCCCCEEEEEEECCEECCCCCCCCCCCCCCCCCCC
PGHEIAGVVSDVGPEVTKYKVGDRVGVGCMVDSCGECENCRRGEEQYCHQGNVQTYGGVD
CCHHHHHHHHHCCCCCEEEECCCCCCCEEEECCCCCCHHHCCCCHHHHHCCCCCCCCCCC
KYGEPTQGGYSTHIVVTEDFVLRIPDNIELDVAAPLLCAGITTYSPLNHWNAGPGKKVAV
CCCCCCCCCEEEEEEEECCEEEECCCCCEEEHHHHHHHHCCCCCCCCCCCCCCCCCEEEE
VGMGGLGHMAVKIAHAMGAEVTVLSRTLNKKEDGLEFGAENYYATSEKETFETLAGSFDL
EECCCCHHHHHHHHHHCCCEEEEEHHHHCCCCCCHHCCCCCCEECCCHHHHHHHHCCCEE
IINTVSAKLDMDAYFSLLNLDGSLVNVGAPAEPLSVNVFSLIGHRRSFAGSLIGGIRETQ
EEEEHHHHCCHHHHHHHHCCCCCEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
EMLDFCAEHNIVPKIEVISADQIDEAYTRVLDSDVKYRFVIDVSTI
HHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCCCCEEEEEEEEECC
>Mature Secondary Structure
MYTAKARAVDGPHQPFHATEIKRRNLDSHDVLIEIKYSGICHSDIHTAHGEWGEVNYPLV
CCCCCCCCCCCCCCCCCHHHHHHCCCCCCCEEEEEEECCEECCCCCCCCCCCCCCCCCCC
PGHEIAGVVSDVGPEVTKYKVGDRVGVGCMVDSCGECENCRRGEEQYCHQGNVQTYGGVD
CCHHHHHHHHHCCCCCEEEECCCCCCCEEEECCCCCCHHHCCCCHHHHHCCCCCCCCCCC
KYGEPTQGGYSTHIVVTEDFVLRIPDNIELDVAAPLLCAGITTYSPLNHWNAGPGKKVAV
CCCCCCCCCEEEEEEEECCEEEECCCCCEEEHHHHHHHHCCCCCCCCCCCCCCCCCEEEE
VGMGGLGHMAVKIAHAMGAEVTVLSRTLNKKEDGLEFGAENYYATSEKETFETLAGSFDL
EECCCCHHHHHHHHHHCCCEEEEEHHHHCCCCCCHHCCCCCCEECCCHHHHHHHHCCCEE
IINTVSAKLDMDAYFSLLNLDGSLVNVGAPAEPLSVNVFSLIGHRRSFAGSLIGGIRETQ
EEEEHHHHCCHHHHHHHHCCCCCEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
EMLDFCAEHNIVPKIEVISADQIDEAYTRVLDSDVKYRFVIDVSTI
HHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NADP+

Specific reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9141695; 9384377 [H]