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The map label for this gene is groEL

Identifier: 23098111

GI number: 23098111

Start: 690217

End: 691854

Strand: Direct

Name: groEL

Synonym: OB0656

Alternate gene names: 23098111

Gene position: 690217-691854 (Clockwise)

Preceding gene: 23098110

Following gene: 23098112

Centisome position: 19.01

GC content: 40.66

Gene sequence:

>1638_bases
ATGGCTAAAGACTTAAAATTTAGTGAAGACGCTCGTCGCGCAATGCTACGTGGTGTAGATACATTGGCAGATGCAGTAAA
AGTTACGCTTGGACCAAAAGGACGTAATGTTGTATTAGATAAAAAATTCGGTTCACCTCTAATTACAAATGATGGTGTTA
CGATTGCAAAAGAAATTGAATTAGAAGATGCATTTGAAAACATGGGTGCTCAATTAGTATCTGAAGTTGCATCAAAAACA
AATGATGTTGCTGGTGATGGTACTACAACAGCGACTGTACTTGCTCAAGCAATGATTCGTGAAGGATTGAAAAACGTAAC
TTCTGGTGCAAACCCAGTAGGAATCCGTCGCGGTATTGAAAAAGCTGTTGAATTAGCAGTTCAAGAATTAAAAGGAATTT
CACAACCAATTGAAAGTAAAGAAGCTATTTCACAAATTGCTGCCGTATCTTCTGGAGATGAAGAAGTAGGTCAATTGATT
GCTGAAGCAATGGAACGTGTAGGTAACGATGGTGTTATCACTATTGAAGAATCTAAAGGTTTCAACACAGAGCTTGAAGT
AGTAGAAGGTATGCAATTTGATCGTGGATATGCTTCTCCATACATGGTTACTGACCAAGATAAAATGGAGGCTGTTTTAG
AAGATCCTTATATCTTAATAACAGATAAGAAAATAGGCAATATCCAAGAAGTATTACCAGTGTTAGAGCAAGTAGTTCAA
CAAGGTAAACCTCTTCTAATGATCGCTGAAGATGTAGAAGGAGAAGCACTTGCTACATTAGTAGTAAATAAACTTCGCGG
TACATTCAATGCTGTAGCTGTAAAAGCTCCTGGATTTGGTGACCGTCGTAAAGCAATGCTAGAAGATATTGCAGTACTAA
CTGGTGCAGAAGTAATTACAGAAGATCTTGGTTTAGATCTTAAATCTGCTAGCATCGACCAATTAGGCCGCGCTTCTAAA
GTTGTGGTAACTAAAGAAAACACAACAGTAGTAGAAGGTTCTGGAGATCCAGAAGCAATTTCTAGCCGTGTTGCACAAAT
CCGTGCACAAGCAGAAGAATCTACTTCTGACTTCGATAAAGAAAAATTACAAGAACGTTTAGCTAAACTAGCTGGTGGCG
TAGCAGTAATTAAAGTTGGTGCAGCTACAGAAACAGAATTGAAAGAACGTAAGCTTCGTATTGAAGATGCTTTAAACTCT
ACTCGTGCTGGTGTTGAGGAAGGAATGGTTCCTGGAGGCGGTACAGCCCTTGTGAATATTCATCGTCAAGTAAGTGAACT
AACACTAGAAGGAGATGAAGCAACTGGTGCAAGCATCGTTCTCCGTGCTTTAGAAGAGCCAGTACGTCAAATCGTACACA
ATGCTGGCTTAGAAGGTTCTATCATTGTAGAACGTCTAAAAGGTGAAAAAGTGGGTATTGGTTACAATGCGGCAACTGAC
GAATGGGTAAACATGGTAGAAGCTGGTATCGTTGATCCTACTAAAGTTACTCGTTCTGCATTACAAAACGCAGCATCTGT
AGCAGCTATGTTCCTAACGACCGAAGCAGTAGTCGCTGATAAGCCTGAAGAAAATGGCGGTGCCGGTGGCGGCATGCCTG
ACATGGGCGGCATGGGTGGAATGGGCGGCATGATGTAA

Upstream 100 bases:

>100_bases
TCTTCGTGAAAATGATATTTTAGCTATTATTGGCTAAACTCTTATGAAAAATTTAGATTAAAACGATAAATACGTAACTA
CATTCAAGGAGGAATAAAGA

Downstream 100 bases:

>100_bases
TAAACATCATGAAGCCTTGATATATCAATTGATTGGATGGTTATTTTTAACCACCGAAAAAACAACCGATATACTCAATA
GAGATTTTCAGAGAGGTCTT

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MAKDLKFSEDARRAMLRGVDTLADAVKVTLGPKGRNVVLDKKFGSPLITNDGVTIAKEIELEDAFENMGAQLVSEVASKT
NDVAGDGTTTATVLAQAMIREGLKNVTSGANPVGIRRGIEKAVELAVQELKGISQPIESKEAISQIAAVSSGDEEVGQLI
AEAMERVGNDGVITIEESKGFNTELEVVEGMQFDRGYASPYMVTDQDKMEAVLEDPYILITDKKIGNIQEVLPVLEQVVQ
QGKPLLMIAEDVEGEALATLVVNKLRGTFNAVAVKAPGFGDRRKAMLEDIAVLTGAEVITEDLGLDLKSASIDQLGRASK
VVVTKENTTVVEGSGDPEAISSRVAQIRAQAEESTSDFDKEKLQERLAKLAGGVAVIKVGAATETELKERKLRIEDALNS
TRAGVEEGMVPGGGTALVNIHRQVSELTLEGDEATGASIVLRALEEPVRQIVHNAGLEGSIIVERLKGEKVGIGYNAATD
EWVNMVEAGIVDPTKVTRSALQNAASVAAMFLTTEAVVADKPEENGGAGGGMPDMGGMGGMGGMM

Sequences:

>Translated_545_residues
MAKDLKFSEDARRAMLRGVDTLADAVKVTLGPKGRNVVLDKKFGSPLITNDGVTIAKEIELEDAFENMGAQLVSEVASKT
NDVAGDGTTTATVLAQAMIREGLKNVTSGANPVGIRRGIEKAVELAVQELKGISQPIESKEAISQIAAVSSGDEEVGQLI
AEAMERVGNDGVITIEESKGFNTELEVVEGMQFDRGYASPYMVTDQDKMEAVLEDPYILITDKKIGNIQEVLPVLEQVVQ
QGKPLLMIAEDVEGEALATLVVNKLRGTFNAVAVKAPGFGDRRKAMLEDIAVLTGAEVITEDLGLDLKSASIDQLGRASK
VVVTKENTTVVEGSGDPEAISSRVAQIRAQAEESTSDFDKEKLQERLAKLAGGVAVIKVGAATETELKERKLRIEDALNS
TRAGVEEGMVPGGGTALVNIHRQVSELTLEGDEATGASIVLRALEEPVRQIVHNAGLEGSIIVERLKGEKVGIGYNAATD
EWVNMVEAGIVDPTKVTRSALQNAASVAAMFLTTEAVVADKPEENGGAGGGMPDMGGMGGMGGMM
>Mature_544_residues
AKDLKFSEDARRAMLRGVDTLADAVKVTLGPKGRNVVLDKKFGSPLITNDGVTIAKEIELEDAFENMGAQLVSEVASKTN
DVAGDGTTTATVLAQAMIREGLKNVTSGANPVGIRRGIEKAVELAVQELKGISQPIESKEAISQIAAVSSGDEEVGQLIA
EAMERVGNDGVITIEESKGFNTELEVVEGMQFDRGYASPYMVTDQDKMEAVLEDPYILITDKKIGNIQEVLPVLEQVVQQ
GKPLLMIAEDVEGEALATLVVNKLRGTFNAVAVKAPGFGDRRKAMLEDIAVLTGAEVITEDLGLDLKSASIDQLGRASKV
VVTKENTTVVEGSGDPEAISSRVAQIRAQAEESTSDFDKEKLQERLAKLAGGVAVIKVGAATETELKERKLRIEDALNST
RAGVEEGMVPGGGTALVNIHRQVSELTLEGDEATGASIVLRALEEPVRQIVHNAGLEGSIIVERLKGEKVGIGYNAATDE
WVNMVEAGIVDPTKVTRSALQNAASVAAMFLTTEAVVADKPEENGGAGGGMPDMGGMGGMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=527, Percent_Identity=49.5256166982922, Blast_Score=511, Evalue=1e-145,
Organism=Homo sapiens, GI31542947, Length=527, Percent_Identity=49.5256166982922, Blast_Score=511, Evalue=1e-145,
Organism=Homo sapiens, GI24307939, Length=229, Percent_Identity=24.4541484716157, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI38455427, Length=150, Percent_Identity=30.6666666666667, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1790586, Length=526, Percent_Identity=61.9771863117871, Blast_Score=648, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=531, Percent_Identity=48.5875706214689, Blast_Score=497, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI193210679, Length=212, Percent_Identity=47.6415094339623, Blast_Score=185, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI25144674, Length=173, Percent_Identity=31.2138728323699, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=51.3358778625954, Blast_Score=525, Evalue=1e-149,
Organism=Saccharomyces cerevisiae, GI6322524, Length=121, Percent_Identity=33.0578512396694, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=48.8636363636364, Blast_Score=514, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=48.8636363636364, Blast_Score=514, Evalue=1e-146,
Organism=Drosophila melanogaster, GI45550936, Length=526, Percent_Identity=47.7186311787072, Blast_Score=486, Evalue=1e-137,
Organism=Drosophila melanogaster, GI45550132, Length=526, Percent_Identity=47.7186311787072, Blast_Score=486, Evalue=1e-137,
Organism=Drosophila melanogaster, GI45550935, Length=526, Percent_Identity=47.7186311787072, Blast_Score=486, Evalue=1e-137,
Organism=Drosophila melanogaster, GI17864606, Length=551, Percent_Identity=42.2867513611615, Blast_Score=441, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24584129, Length=527, Percent_Identity=35.673624288425, Blast_Score=294, Evalue=1e-79,
Organism=Drosophila melanogaster, GI19921262, Length=527, Percent_Identity=35.673624288425, Blast_Score=294, Evalue=1e-79,
Organism=Drosophila melanogaster, GI17647245, Length=186, Percent_Identity=30.6451612903226, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24652903, Length=174, Percent_Identity=31.6091954022989, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24583944, Length=159, Percent_Identity=31.4465408805031, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24645179, Length=540, Percent_Identity=22.5925925925926, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH60_OCEIH (Q8CXL3)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_691577.1
- ProteinModelPortal:   Q8CXL3
- SMR:   Q8CXL3
- GeneID:   1016061
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB0656
- NMPDR:   fig|221109.1.peg.662
- HOGENOM:   HBG625289
- OMA:   MEDATIL
- BioCyc:   OIHE221109:OB0656-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 57509; Mature: 57378

Theoretical pI: Translated: 4.34; Mature: 4.34

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKDLKFSEDARRAMLRGVDTLADAVKVTLGPKGRNVVLDKKFGSPLITNDGVTIAKEIE
CCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCEEECCCCEEEECCC
LEDAFENMGAQLVSEVASKTNDVAGDGTTTATVLAQAMIREGLKNVTSGANPVGIRRGIE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
KAVELAVQELKGISQPIESKEAISQIAAVSSGDEEVGQLIAEAMERVGNDGVITIEESKG
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCC
FNTELEVVEGMQFDRGYASPYMVTDQDKMEAVLEDPYILITDKKIGNIQEVLPVLEQVVQ
CCCHHHHHHCCCCCCCCCCCCEECCHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHH
QGKPLLMIAEDVEGEALATLVVNKLRGTFNAVAVKAPGFGDRRKAMLEDIAVLTGAEVIT
CCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
EDLGLDLKSASIDQLGRASKVVVTKENTTVVEGSGDPEAISSRVAQIRAQAEESTSDFDK
HHHCCCCCCCCHHHHCCCCEEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCH
EKLQERLAKLAGGVAVIKVGAATETELKERKLRIEDALNSTRAGVEEGMVPGGGTALVNI
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCEEEHH
HRQVSELTLEGDEATGASIVLRALEEPVRQIVHNAGLEGSIIVERLKGEKVGIGYNAATD
HHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCEECCCCCCCHH
EWVNMVEAGIVDPTKVTRSALQNAASVAAMFLTTEAVVADKPEENGGAGGGMPDMGGMGG
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
MGGMM
CCCCC
>Mature Secondary Structure 
AKDLKFSEDARRAMLRGVDTLADAVKVTLGPKGRNVVLDKKFGSPLITNDGVTIAKEIE
CCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCEEECCCCEEEECCC
LEDAFENMGAQLVSEVASKTNDVAGDGTTTATVLAQAMIREGLKNVTSGANPVGIRRGIE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
KAVELAVQELKGISQPIESKEAISQIAAVSSGDEEVGQLIAEAMERVGNDGVITIEESKG
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCC
FNTELEVVEGMQFDRGYASPYMVTDQDKMEAVLEDPYILITDKKIGNIQEVLPVLEQVVQ
CCCHHHHHHCCCCCCCCCCCCEECCHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHH
QGKPLLMIAEDVEGEALATLVVNKLRGTFNAVAVKAPGFGDRRKAMLEDIAVLTGAEVIT
CCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
EDLGLDLKSASIDQLGRASKVVVTKENTTVVEGSGDPEAISSRVAQIRAQAEESTSDFDK
HHHCCCCCCCCHHHHCCCCEEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCH
EKLQERLAKLAGGVAVIKVGAATETELKERKLRIEDALNSTRAGVEEGMVPGGGTALVNI
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCEEEHH
HRQVSELTLEGDEATGASIVLRALEEPVRQIVHNAGLEGSIIVERLKGEKVGIGYNAATD
HHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCEECCCCCCCHH
EWVNMVEAGIVDPTKVTRSALQNAASVAAMFLTTEAVVADKPEENGGAGGGMPDMGGMGG
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
MGGMM
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376