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The map label for this gene is hisB

Identifier: 23098005

GI number: 23098005

Start: 582106

End: 582690

Strand: Reverse

Name: hisB

Synonym: OB0550

Alternate gene names: 23098005

Gene position: 582690-582106 (Counterclockwise)

Preceding gene: 23098006

Following gene: 23098004

Centisome position: 16.05

GC content: 36.92

Gene sequence:

>585_bases
ATGCGTAAAGCATCTTTAAGCAGAAAAACCAATGAGACATCTGTTCATTTAACTCTAGAATTAGATGGAGAAGGAACATC
TACTATCGAAACAGGAATAGGTTTCTTTGATCATATGCTAACCCTTTTAGCGAAACACGGTGGTATAAATTTAGACTTAT
CATGCGACGGAGATTTAGAAGTAGATCAGCATCACACTGTAGAAGATATTGGTATTGTACTCGGTCAAACACTTCGTGAA
GCTTTAGGGAATAAAGAAGGAATTACCCGCTATGCCAATGTCATGAGCCCGATGGATGAAGCATTATCTTCGATTGCATT
CGATATAAGTGGACGTTCTTACCTCGTTTACAACGTAGAAGGATTAAAAGAAAAAGTAGGTACCTTTGATACAGAGTTAG
TTCAGGAATTTTTTCAAGCTTTTGCAAGCAACGCTCAAGTAACACTCCATATTAATCTTTTATACGGAGTTAATTCTCAT
CATATTATTGAATCGATATTTAAAGGATTCGGGCGTGTGATCCGTCAAGGTTGTTCCATCGACCTAAACCAAAAAGGAAT
ACCTTCAACAAAAGGAAGTTTATAG

Upstream 100 bases:

>100_bases
AACAAATTAGCAGAAGCTGCAGATACAATAATTACACTTGCAGAAGCGGAAGGCCTAACAGCACATGCAAATGCAATCCG
TATTCGAAAGGAGAATGACA

Downstream 100 bases:

>100_bases
GGGGCAATAGCATTGATTGCAATTATTGATTATGGCGCTGGAAATATAAAAAGTCTTCAATTTGCATTAGATAAATTGAA
TAAACATTCCATTGTTACAA

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MRKASLSRKTNETSVHLTLELDGEGTSTIETGIGFFDHMLTLLAKHGGINLDLSCDGDLEVDQHHTVEDIGIVLGQTLRE
ALGNKEGITRYANVMSPMDEALSSIAFDISGRSYLVYNVEGLKEKVGTFDTELVQEFFQAFASNAQVTLHINLLYGVNSH
HIIESIFKGFGRVIRQGCSIDLNQKGIPSTKGSL

Sequences:

>Translated_194_residues
MRKASLSRKTNETSVHLTLELDGEGTSTIETGIGFFDHMLTLLAKHGGINLDLSCDGDLEVDQHHTVEDIGIVLGQTLRE
ALGNKEGITRYANVMSPMDEALSSIAFDISGRSYLVYNVEGLKEKVGTFDTELVQEFFQAFASNAQVTLHINLLYGVNSH
HIIESIFKGFGRVIRQGCSIDLNQKGIPSTKGSL
>Mature_194_residues
MRKASLSRKTNETSVHLTLELDGEGTSTIETGIGFFDHMLTLLAKHGGINLDLSCDGDLEVDQHHTVEDIGIVLGQTLRE
ALGNKEGITRYANVMSPMDEALSSIAFDISGRSYLVYNVEGLKEKVGTFDTELVQEFFQAFASNAQVTLHINLLYGVNSH
HIIESIFKGFGRVIRQGCSIDLNQKGIPSTKGSL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=193, Percent_Identity=46.6321243523316, Blast_Score=178, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6324776, Length=218, Percent_Identity=39.9082568807339, Blast_Score=159, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_OCEIH (Q8ESR9)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_691471.1
- ProteinModelPortal:   Q8ESR9
- SMR:   Q8ESR9
- GeneID:   1015848
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB0550
- NMPDR:   fig|221109.1.peg.553
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- BioCyc:   OIHE221109:OB0550-MONOMER
- BRENDA:   4.2.1.19
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21228; Mature: 21228

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKASLSRKTNETSVHLTLELDGEGTSTIETGIGFFDHMLTLLAKHGGINLDLSCDGDLE
CCCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
VDQHHTVEDIGIVLGQTLREALGNKEGITRYANVMSPMDEALSSIAFDISGRSYLVYNVE
CCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCEEEEEEHH
GLKEKVGTFDTELVQEFFQAFASNAQVTLHINLLYGVNSHHIIESIFKGFGRVIRQGCSI
HHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCC
DLNQKGIPSTKGSL
CCCCCCCCCCCCCC
>Mature Secondary Structure
MRKASLSRKTNETSVHLTLELDGEGTSTIETGIGFFDHMLTLLAKHGGINLDLSCDGDLE
CCCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
VDQHHTVEDIGIVLGQTLREALGNKEGITRYANVMSPMDEALSSIAFDISGRSYLVYNVE
CCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCEEEEEEHH
GLKEKVGTFDTELVQEFFQAFASNAQVTLHINLLYGVNSHHIIESIFKGFGRVIRQGCSI
HHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCC
DLNQKGIPSTKGSL
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376