Click here to switch to the map view.

The map label for this gene is mdmC [H]

Identifier: 23097750

GI number: 23097750

Start: 329360

End: 330025

Strand: Direct

Name: mdmC [H]

Synonym: OB0295

Alternate gene names: 23097750

Gene position: 329360-330025 (Clockwise)

Preceding gene: 23097749

Following gene: 23097752

Centisome position: 9.07

GC content: 37.69

Gene sequence:

>666_bases
ATGAAAAATCACTCATTATGGAAGAATGTAGACGAGTACTTTGAGGCAAAACTTTTACCCGATGATAAGATATTGAATCA
AACTTTAGACAATAATCAAGCAGCAGGATTACCACAAATCGATGTGGCACCTTTGCAAGGGAAGTTATTATACCTATTAA
CAAAAATGAAGTCTGCGAGACAAGTGTTAGAGATTGGAACATTGGGCGGTTACAGTTCGATATGGTTTGCCAAAGCAGTA
ACACAGAATGGAAAGGTAATATCATTGGAAGCAAATCAAAGCCATGCCGAAGTAGCAAGGCAGAATATAGAGAATGCTGG
GTTTAAACAAACAGTGCAAGTACTCGTTGGAAATGCGCTTGATACGCTTCCGACTTTAGAAAATGCAGGAGAATCATTTG
ACGTTATTTTTATCGATGCGGATAAACAAAATAATCCCAAGTATTTAGAATGGGCATTACGATTAGCCAATGAAGGAGCA
CTTCTCATTGCAGATAATGTTGTGCGAAACGGAGAAGTGATTGATCAAAAAAGCGAGGATGAACGTATTCAAGGCTTGAG
AGAGTTTGTGAATATGCTTGAAAATGAAGAGCGTATTGAATCTACTGCTATTCAAACAGTTGGCTCTAAAGATTATGATG
GTTTTGTTATTGGGATAGTGAAGTGA

Upstream 100 bases:

>100_bases
TTCTTCTTTAAAAGGTTTTAAGGAAAGAATCTATATGGAGAGATATTCATAGGTTAATTGTGTATTAGTATATAATAGTA
AACAGAGAGGGGAGAAATTT

Downstream 100 bases:

>100_bases
GTTGGATTTGTCGCAGATGTTTACCGAACCTATTTATTACTATCTTGTTCTGATCAAGCGTAAGCTAATCTTTATATAGA
TTTATATTGTTCGACTTCAG

Product: O-methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MKNHSLWKNVDEYFEAKLLPDDKILNQTLDNNQAAGLPQIDVAPLQGKLLYLLTKMKSARQVLEIGTLGGYSSIWFAKAV
TQNGKVISLEANQSHAEVARQNIENAGFKQTVQVLVGNALDTLPTLENAGESFDVIFIDADKQNNPKYLEWALRLANEGA
LLIADNVVRNGEVIDQKSEDERIQGLREFVNMLENEERIESTAIQTVGSKDYDGFVIGIVK

Sequences:

>Translated_221_residues
MKNHSLWKNVDEYFEAKLLPDDKILNQTLDNNQAAGLPQIDVAPLQGKLLYLLTKMKSARQVLEIGTLGGYSSIWFAKAV
TQNGKVISLEANQSHAEVARQNIENAGFKQTVQVLVGNALDTLPTLENAGESFDVIFIDADKQNNPKYLEWALRLANEGA
LLIADNVVRNGEVIDQKSEDERIQGLREFVNMLENEERIESTAIQTVGSKDYDGFVIGIVK
>Mature_221_residues
MKNHSLWKNVDEYFEAKLLPDDKILNQTLDNNQAAGLPQIDVAPLQGKLLYLLTKMKSARQVLEIGTLGGYSSIWFAKAV
TQNGKVISLEANQSHAEVARQNIENAGFKQTVQVLVGNALDTLPTLENAGESFDVIFIDADKQNNPKYLEWALRLANEGA
LLIADNVVRNGEVIDQKSEDERIQGLREFVNMLENEERIESTAIQTVGSKDYDGFVIGIVK

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI31542747, Length=156, Percent_Identity=30.1282051282051, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI25148771, Length=182, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI72001127, Length=169, Percent_Identity=30.1775147928994, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 24574; Mature: 24574

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNHSLWKNVDEYFEAKLLPDDKILNQTLDNNQAAGLPQIDVAPLQGKLLYLLTKMKSAR
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
QVLEIGTLGGYSSIWFAKAVTQNGKVISLEANQSHAEVARQNIENAGFKQTVQVLVGNAL
HHHHHHCCCCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHH
DTLPTLENAGESFDVIFIDADKQNNPKYLEWALRLANEGALLIADNVVRNGEVIDQKSED
HHHCCHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHH
ERIQGLREFVNMLENEERIESTAIQTVGSKDYDGFVIGIVK
HHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEEEEC
>Mature Secondary Structure
MKNHSLWKNVDEYFEAKLLPDDKILNQTLDNNQAAGLPQIDVAPLQGKLLYLLTKMKSAR
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
QVLEIGTLGGYSSIWFAKAVTQNGKVISLEANQSHAEVARQNIENAGFKQTVQVLVGNAL
HHHHHHCCCCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHH
DTLPTLENAGESFDVIFIDADKQNNPKYLEWALRLANEGALLIADNVVRNGEVIDQKSED
HHHCCHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHH
ERIQGLREFVNMLENEERIESTAIQTVGSKDYDGFVIGIVK
HHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]