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The map label for this gene is yqjI [H]

Identifier: 23097640

GI number: 23097640

Start: 200368

End: 201774

Strand: Direct

Name: yqjI [H]

Synonym: OB0185

Alternate gene names: 23097640

Gene position: 200368-201774 (Clockwise)

Preceding gene: 23097638

Following gene: 23097641

Centisome position: 5.52

GC content: 39.16

Gene sequence:

>1407_bases
ATGAAACAACAAATTGGTGTTATCGGCTTAGCCGTTATGGGAAAAAATATCGCACTTAACATGGAAAGCAAAGGCTTTTC
TGTAGCTGTTTTTAATCGTTCTTACGAGAAGACAGAGAACTTCTTAGCGAATGAAGCAAGCGGGAAAAAATTTATTGGTG
CAAAAACAATTGAAGAATTTGTGGATTCATTGGAAAAACCACGTAAGATCATGTTGATGGTAAAAGCTGGTCCAGCAACG
GATGCTACGATTGAATCATTGAAACCACATCTTGATAAAGGCGATATTCTTATCGACGGTGGAAATACATTATATGAAGA
TACGATTCGTCGTAATAAAGAATTAGATGAGTCTGGAATTCATTTCATTGGGACAGGTGTTTCTGGTGGCGAAGAGGGAG
CTTTAAATGGTCCTTCTATTATGCCAGGTGGACAAGCAGAAGCGTATAAATTAGTTGCTCCTATTTTTGAAGCGATATCT
GCAAAAGTAGATAAAGATCCATGTGTAACCTATATTGGGCCAAATGGCGCGGGGCACTTTGTGAAAATGGTTCATAATGG
AATTGAATATGGAGATATGCAATTAATCGCAGAAGCATATGATTTAATGAAAAATGTTCTAGGACTTGATGCAAAAGAGC
TTCACAACGTATTCAAGGAATGGAATGATGGAGAATTAGACAGTTATCTGATTGAAATAACTGCAGATATCTTCACTAAA
GTGGATGAAGAGACTGGGAAGCCTCTAGTGGAGGTAATTCTAGATAAAGCAGGTCAAAAAGGGACTGGAAAATGGACGAG
TAAAAATGCACTTGATTTAGGAGTACCGCTTCCATTAATTACAGAGTCTGTGTTTGCACGCTTTATTTCATCCTTAAAAG
ATGAGCGTGTTCGTGCAAGCAAAGAATTGAGTGGACCAACGAATGCAATGCTAGGTGAAAGTAAAGAGGAGCTTATCGAA
GCAATCCGTCAAGCACTTTATATGAGTAAGATCGTATCTTATGCGCAAGGGTTTGCTCAAATGCGAGCAGCTTCTGATGA
GTACGATTGGAATTTAAGTTATGGTGACATCGCAATGATTTGGCGTGGCGGATGTATCATTCGTGCGAAGTTCCTACAAA
AGATCAAAGATGCCTATGACAGAGATTCTCAATTACCGAACTTAATGCTCGACCCTTACTTCAAGGAAATTGTAGAAGGC
TACCAGTCTTCATTACGAAAAGTTGTATCTCTAGCGGTTGCACATGGTATTGCAGTTCCAACGTTCTCAAGTGCAATTGC
ATACTATGATAGCTATCGTTCAGAAGATTTACCAGCAAATCTTATTCAAGCACAACGTGACTACTTTGGTGCACACACGT
ATGAGCGAAAAGATAAAGACGGCATATTCCACTCTCAGTGGTTTTAA

Upstream 100 bases:

>100_bases
TTTTTTAGATATCAGAGTGGATATTGGTTTCCTCTTACTAAATTCGCTATAATAGGTATGATTCATTTCAAAATAATTTA
AGAGAGGAAATGATGGATTG

Downstream 100 bases:

>100_bases
GGGTTAAAGTTAAAAGGATCTGATTAACAACATATTAATCAGATCCTTTTTCTGCCTTTTCGAGAGTTTTCCTATAGAGC
GGTGGTCTGTAAAAATTTAT

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: GNTZII [H]

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MKQQIGVIGLAVMGKNIALNMESKGFSVAVFNRSYEKTENFLANEASGKKFIGAKTIEEFVDSLEKPRKIMLMVKAGPAT
DATIESLKPHLDKGDILIDGGNTLYEDTIRRNKELDESGIHFIGTGVSGGEEGALNGPSIMPGGQAEAYKLVAPIFEAIS
AKVDKDPCVTYIGPNGAGHFVKMVHNGIEYGDMQLIAEAYDLMKNVLGLDAKELHNVFKEWNDGELDSYLIEITADIFTK
VDEETGKPLVEVILDKAGQKGTGKWTSKNALDLGVPLPLITESVFARFISSLKDERVRASKELSGPTNAMLGESKEELIE
AIRQALYMSKIVSYAQGFAQMRAASDEYDWNLSYGDIAMIWRGGCIIRAKFLQKIKDAYDRDSQLPNLMLDPYFKEIVEG
YQSSLRKVVSLAVAHGIAVPTFSSAIAYYDSYRSEDLPANLIQAQRDYFGAHTYERKDKDGIFHSQWF

Sequences:

>Translated_468_residues
MKQQIGVIGLAVMGKNIALNMESKGFSVAVFNRSYEKTENFLANEASGKKFIGAKTIEEFVDSLEKPRKIMLMVKAGPAT
DATIESLKPHLDKGDILIDGGNTLYEDTIRRNKELDESGIHFIGTGVSGGEEGALNGPSIMPGGQAEAYKLVAPIFEAIS
AKVDKDPCVTYIGPNGAGHFVKMVHNGIEYGDMQLIAEAYDLMKNVLGLDAKELHNVFKEWNDGELDSYLIEITADIFTK
VDEETGKPLVEVILDKAGQKGTGKWTSKNALDLGVPLPLITESVFARFISSLKDERVRASKELSGPTNAMLGESKEELIE
AIRQALYMSKIVSYAQGFAQMRAASDEYDWNLSYGDIAMIWRGGCIIRAKFLQKIKDAYDRDSQLPNLMLDPYFKEIVEG
YQSSLRKVVSLAVAHGIAVPTFSSAIAYYDSYRSEDLPANLIQAQRDYFGAHTYERKDKDGIFHSQWF
>Mature_468_residues
MKQQIGVIGLAVMGKNIALNMESKGFSVAVFNRSYEKTENFLANEASGKKFIGAKTIEEFVDSLEKPRKIMLMVKAGPAT
DATIESLKPHLDKGDILIDGGNTLYEDTIRRNKELDESGIHFIGTGVSGGEEGALNGPSIMPGGQAEAYKLVAPIFEAIS
AKVDKDPCVTYIGPNGAGHFVKMVHNGIEYGDMQLIAEAYDLMKNVLGLDAKELHNVFKEWNDGELDSYLIEITADIFTK
VDEETGKPLVEVILDKAGQKGTGKWTSKNALDLGVPLPLITESVFARFISSLKDERVRASKELSGPTNAMLGESKEELIE
AIRQALYMSKIVSYAQGFAQMRAASDEYDWNLSYGDIAMIWRGGCIIRAKFLQKIKDAYDRDSQLPNLMLDPYFKEIVEG
YQSSLRKVVSLAVAHGIAVPTFSSAIAYYDSYRSEDLPANLIQAQRDYFGAHTYERKDKDGIFHSQWF

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=465, Percent_Identity=58.0645161290323, Blast_Score=529, Evalue=1e-150,
Organism=Escherichia coli, GI1788341, Length=468, Percent_Identity=68.1623931623932, Blast_Score=660, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17542558, Length=466, Percent_Identity=54.2918454935622, Blast_Score=523, Evalue=1e-149,
Organism=Saccharomyces cerevisiae, GI6321695, Length=454, Percent_Identity=56.8281938325991, Blast_Score=534, Evalue=1e-152,
Organism=Saccharomyces cerevisiae, GI6321977, Length=458, Percent_Identity=56.1135371179039, Blast_Score=509, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24639279, Length=465, Percent_Identity=55.9139784946236, Blast_Score=499, Evalue=1e-141,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 51766; Mature: 51766

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQQIGVIGLAVMGKNIALNMESKGFSVAVFNRSYEKTENFLANEASGKKFIGAKTIEEF
CCCCCCEEEHEEECCCEEEEECCCCCEEEEECCCHHHHHHHHHCCCCCCCCHHHHHHHHH
VDSLEKPRKIMLMVKAGPATDATIESLKPHLDKGDILIDGGNTLYEDTIRRNKELDESGI
HHHHCCCCEEEEEEECCCCCCHHHHHHCCCCCCCCEEEECCCHHHHHHHHHCCCCCCCCC
HFIGTGVSGGEEGALNGPSIMPGGQAEAYKLVAPIFEAISAKVDKDPCVTYIGPNGAGHF
EEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHH
VKMVHNGIEYGDMQLIAEAYDLMKNVLGLDAKELHNVFKEWNDGELDSYLIEITADIFTK
HHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
VDEETGKPLVEVILDKAGQKGTGKWTSKNALDLGVPLPLITESVFARFISSLKDERVRAS
HHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KELSGPTNAMLGESKEELIEAIRQALYMSKIVSYAQGFAQMRAASDEYDWNLSYGDIAMI
HHCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEE
WRGGCIIRAKFLQKIKDAYDRDSQLPNLMLDPYFKEIVEGYQSSLRKVVSLAVAHGIAVP
ECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TFSSAIAYYDSYRSEDLPANLIQAQRDYFGAHTYERKDKDGIFHSQWF
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKQQIGVIGLAVMGKNIALNMESKGFSVAVFNRSYEKTENFLANEASGKKFIGAKTIEEF
CCCCCCEEEHEEECCCEEEEECCCCCEEEEECCCHHHHHHHHHCCCCCCCCHHHHHHHHH
VDSLEKPRKIMLMVKAGPATDATIESLKPHLDKGDILIDGGNTLYEDTIRRNKELDESGI
HHHHCCCCEEEEEEECCCCCCHHHHHHCCCCCCCCEEEECCCHHHHHHHHHCCCCCCCCC
HFIGTGVSGGEEGALNGPSIMPGGQAEAYKLVAPIFEAISAKVDKDPCVTYIGPNGAGHF
EEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHH
VKMVHNGIEYGDMQLIAEAYDLMKNVLGLDAKELHNVFKEWNDGELDSYLIEITADIFTK
HHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
VDEETGKPLVEVILDKAGQKGTGKWTSKNALDLGVPLPLITESVFARFISSLKDERVRAS
HHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KELSGPTNAMLGESKEELIEAIRQALYMSKIVSYAQGFAQMRAASDEYDWNLSYGDIAMI
HHCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEE
WRGGCIIRAKFLQKIKDAYDRDSQLPNLMLDPYFKEIVEGYQSSLRKVVSLAVAHGIAVP
ECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TFSSAIAYYDSYRSEDLPANLIQAQRDYFGAHTYERKDKDGIFHSQWF
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10568751; 9298659 [H]