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The map label for this gene is adk

Identifier: 23097595

GI number: 23097595

Start: 151864

End: 152511

Strand: Direct

Name: adk

Synonym: OB0140

Alternate gene names: 23097595

Gene position: 151864-152511 (Clockwise)

Preceding gene: 23097594

Following gene: 23097596

Centisome position: 4.18

GC content: 38.58

Gene sequence:

>648_bases
TTGAATTTGATTTTGATGGGCTTACCTGGTGCTGGTAAAGGCACACAGGCTGCGAAAATTAATGAAAAGTATAACATCCC
TCATATTTCAACAGGAGATATGTTCCGATTAGCTATTAAAGAGGGTACTGAACTCGGTAAAAAAGCAAAGGAATTTATGG
ATCAAGGTGACCTTGTTCCAGACGAAGTTACTGTTGGGATTGTTAAGGAACGCCTAGCGATGGACGATTGTGCAAATGGT
TTCCTTTTAGACGGATTCCCTCGCACAACTCGACAAGCAGAAGAATTACAAAATCTACTGTCTGACCTAGGTAAGTCAAT
AGATTATGTCATCCATGTGGATGTACCAGAAGAAAAATTGGTAGAGCGTTTAACTGGACGGAGAATTTGTCCGACATGCG
GAACAGCTTATCATGTGGTGTATAATCCTCCAAAAGAGGAAGGCATCTGTGATAAAGATGGCTCCCAGTTAATTCAGCGA
GATGATGACCAACCAGAAACAGTTAAAAACCGTTTAGCTGTTAATATAGAGCAAACACAACCATTACTTGATTTTTATCA
AGATAAAGGTTATCTTGTGAAAGTGAACGGAGATAGAGATATCAATGTTGTTTTCCAAGATATTGAATCCATTTTAGAGA
AAAAATAG

Upstream 100 bases:

>100_bases
GCATTACAGACAATGAAGCAATTAGAAGGACAGCTCGTGAAGCGTCACTACAAAGGATTCATTAAGTAATTAAGAAGCCA
ACAAAAGCGAGGGGAAGCAA

Downstream 100 bases:

>100_bases
TTCACTTATTTAGTAATATTCAGTTTAGATGCATTTCTAGTACTGAAAAGTTATAATGAAATAAGTAATGTGTATTGCTT
TGGAAATAGTAACAGAAATG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MNLILMGLPGAGKGTQAAKINEKYNIPHISTGDMFRLAIKEGTELGKKAKEFMDQGDLVPDEVTVGIVKERLAMDDCANG
FLLDGFPRTTRQAEELQNLLSDLGKSIDYVIHVDVPEEKLVERLTGRRICPTCGTAYHVVYNPPKEEGICDKDGSQLIQR
DDDQPETVKNRLAVNIEQTQPLLDFYQDKGYLVKVNGDRDINVVFQDIESILEKK

Sequences:

>Translated_215_residues
MNLILMGLPGAGKGTQAAKINEKYNIPHISTGDMFRLAIKEGTELGKKAKEFMDQGDLVPDEVTVGIVKERLAMDDCANG
FLLDGFPRTTRQAEELQNLLSDLGKSIDYVIHVDVPEEKLVERLTGRRICPTCGTAYHVVYNPPKEEGICDKDGSQLIQR
DDDQPETVKNRLAVNIEQTQPLLDFYQDKGYLVKVNGDRDINVVFQDIESILEKK
>Mature_215_residues
MNLILMGLPGAGKGTQAAKINEKYNIPHISTGDMFRLAIKEGTELGKKAKEFMDQGDLVPDEVTVGIVKERLAMDDCANG
FLLDGFPRTTRQAEELQNLLSDLGKSIDYVIHVDVPEEKLVERLTGRRICPTCGTAYHVVYNPPKEEGICDKDGSQLIQR
DDDQPETVKNRLAVNIEQTQPLLDFYQDKGYLVKVNGDRDINVVFQDIESILEKK

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=211, Percent_Identity=43.6018957345972, Blast_Score=186, Evalue=1e-47,
Organism=Homo sapiens, GI4502013, Length=211, Percent_Identity=43.6018957345972, Blast_Score=186, Evalue=1e-47,
Organism=Homo sapiens, GI19923437, Length=219, Percent_Identity=42.4657534246575, Blast_Score=173, Evalue=1e-43,
Organism=Homo sapiens, GI310110345, Length=219, Percent_Identity=34.703196347032, Blast_Score=139, Evalue=1e-33,
Organism=Homo sapiens, GI53832003, Length=219, Percent_Identity=34.703196347032, Blast_Score=139, Evalue=1e-33,
Organism=Homo sapiens, GI8051579, Length=219, Percent_Identity=34.703196347032, Blast_Score=139, Evalue=1e-33,
Organism=Homo sapiens, GI53832001, Length=219, Percent_Identity=34.703196347032, Blast_Score=139, Evalue=1e-33,
Organism=Homo sapiens, GI4502011, Length=207, Percent_Identity=31.8840579710145, Blast_Score=114, Evalue=7e-26,
Organism=Homo sapiens, GI22749187, Length=209, Percent_Identity=33.0143540669856, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI7706497, Length=218, Percent_Identity=27.5229357798165, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI28144899, Length=205, Percent_Identity=28.780487804878, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI28144897, Length=215, Percent_Identity=27.4418604651163, Blast_Score=87, Evalue=8e-18,
Organism=Escherichia coli, GI1786680, Length=217, Percent_Identity=50.2304147465438, Blast_Score=213, Evalue=7e-57,
Organism=Caenorhabditis elegans, GI17552384, Length=214, Percent_Identity=38.3177570093458, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17567503, Length=214, Percent_Identity=32.2429906542056, Blast_Score=120, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17537943, Length=216, Percent_Identity=29.6296296296296, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17533833, Length=216, Percent_Identity=29.6296296296296, Blast_Score=95, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17550688, Length=213, Percent_Identity=24.4131455399061, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI25147457, Length=216, Percent_Identity=23.6111111111111, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320432, Length=215, Percent_Identity=44.1860465116279, Blast_Score=193, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6321018, Length=205, Percent_Identity=36.0975609756098, Blast_Score=136, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6322828, Length=210, Percent_Identity=29.0476190476191, Blast_Score=97, Evalue=2e-21,
Organism=Drosophila melanogaster, GI22026816, Length=215, Percent_Identity=43.7209302325581, Blast_Score=181, Evalue=3e-46,
Organism=Drosophila melanogaster, GI17737899, Length=195, Percent_Identity=37.4358974358974, Blast_Score=131, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24645822, Length=195, Percent_Identity=37.4358974358974, Blast_Score=131, Evalue=4e-31,
Organism=Drosophila melanogaster, GI17647141, Length=218, Percent_Identity=27.0642201834862, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24663208, Length=218, Percent_Identity=27.0642201834862, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI221459597, Length=213, Percent_Identity=25.8215962441315, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI21356893, Length=213, Percent_Identity=25.8215962441315, Blast_Score=87, Evalue=9e-18,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_OCEIH (Q8ETW3)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_691061.1
- ProteinModelPortal:   Q8ETW3
- SMR:   Q8ETW3
- GeneID:   1015236
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB0140
- NMPDR:   fig|221109.1.peg.141
- HOGENOM:   HBG630208
- OMA:   EINQPLE
- BioCyc:   OIHE221109:OB0140-MONOMER
- BRENDA:   2.7.4.3
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 24065; Mature: 24065

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLILMGLPGAGKGTQAAKINEKYNIPHISTGDMFRLAIKEGTELGKKAKEFMDQGDLVP
CCEEEEECCCCCCCCCCEECCCCCCCCCCCCCCEEEEHHHHCHHHHHHHHHHHHCCCCCC
DEVTVGIVKERLAMDDCANGFLLDGFPRTTRQAEELQNLLSDLGKSIDYVIHVDVPEEKL
CHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCHHHH
VERLTGRRICPTCGTAYHVVYNPPKEEGICDKDGSQLIQRDDDQPETVKNRLAVNIEQTQ
HHHHHCCEECCCCCCEEEEEECCCCCCCCCCCCHHHHHHCCCCCHHHHHHHEEEEEHHHH
PLLDFYQDKGYLVKVNGDRDINVVFQDIESILEKK
HHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNLILMGLPGAGKGTQAAKINEKYNIPHISTGDMFRLAIKEGTELGKKAKEFMDQGDLVP
CCEEEEECCCCCCCCCCEECCCCCCCCCCCCCCEEEEHHHHCHHHHHHHHHHHHCCCCCC
DEVTVGIVKERLAMDDCANGFLLDGFPRTTRQAEELQNLLSDLGKSIDYVIHVDVPEEKL
CHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCHHHH
VERLTGRRICPTCGTAYHVVYNPPKEEGICDKDGSQLIQRDDDQPETVKNRLAVNIEQTQ
HHHHHCCEECCCCCCEEEEEECCCCCCCCCCCCHHHHHHCCCCCHHHHHHHEEEEEHHHH
PLLDFYQDKGYLVKVNGDRDINVVFQDIESILEKK
HHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376