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The map label for this gene is clpB

Identifier: 23097548

GI number: 23097548

Start: 111692

End: 114121

Strand: Direct

Name: clpB

Synonym: OB0093

Alternate gene names: 23097548

Gene position: 111692-114121 (Clockwise)

Preceding gene: 23097547

Following gene: 23097549

Centisome position: 3.08

GC content: 38.89

Gene sequence:

>2430_bases
ATGATGTTTGGACGCTTTACAGAAAGAGCACAAAAAGTACTCGCACTATCACAGGAAGAAGCAGTACGTTTAGGACATAA
TAACATTGGTACAGAACACATTTTGCTAGGACTTGTACGAGAAGGAGAAGGAATTGCAGCAAAAGCTCTACAATCTCTAG
GTCTAGAAGTATCCAAAATACAAGAAGAAGTAGAGAAATTAATCGGAGTAGGAAAACAACCTACACAATCGATTCACTAT
ACACCTCGTGCCAAAAAAGTAGTTGAACTTTCTCAAGATGAAGCACGAAAACTAGGTCACTCTTATGTAGGTACAGAGCA
TATTCTACTTGGATTGATTAGAGAAGGAGAAGGAGTAGCTGCTAGAGTACTTAATAATCTAGGTGTAAGTCTTAATAAAG
CAAGACAACAAGTTCTCCAACTACTAGGTAGCAATGAATCACAAGCTGGTCGTCAAGGGCGTTCAGGACAACAGTCAAAT
GCAAGCACACCAACATTGGATTCATTAGCTCGAGATTTAACAGTTAGTGCCAAAGAGGGCAAAATTGACCCAGTAATTGG
TCGCTCTAAAGAAATTGAACGAGTGATTCAAGTGCTTAGCCGTCGTACAAAGAACAATCCTGTTTTGATAGGGGAACCTG
GTGTAGGTAAAACGGCTGTCGCCGAAGGACTTGCACAACAAATTATAGACAATGAAGTTCCAGAAACCTTACGTGATAAA
CGAGTAATGACATTAGACATGGGGACAGTTGTTGCCGGTACAAAATATCGTGGTGAATTCGAAGACCGCTTGAAGAAAGT
AATGGAAGAAATTCGCCAGGCAGGTAATATTATTCTATTCATTGATGAGTTACACACGCTTATCGGAGCTGGAGGAGCAG
AAGGGGCTATTGATGCTTCAAACATCCTCAAACCATCTCTTGCACGTGGAGAATTACAATGTATTGGTGCAACTACACTT
GATGAATATCGGAAATATATTGAAAAAGACGCTGCATTAGAACGACGTTTCCAACCAATTCAAGTAGATGAACCAACATT
GGAAGAAACCATTCAAATTCTAAATGGATTACGTGATCGTTATGAAGCGCATCACCGTGTAACCATTACTGACGAAGCGA
TCGAAGCAGCAGCTTCACTATCTGATCGTTATATTACCGATCGATTCTTGCCAGATAAAGCGATTGACTTAATCGACGAA
GCAGGATCAAAAGTAAGGTTACGCTCTTATACTGTTCCACCAAACTTAAAAGAGTTGGAACAGAAACTAGATGAAGTTCG
TAAAGAAAAAGACGCGGCGGTACAAAGCCAAGAATTTGAAAAAGCTGCATCTTTACGAGATTCGGAGCAACGTTTCCGCG
AAGAATTAGAAACAACGAAAAATCAATGGAAAGAAAAACAAGGGCAAACAGATTCAGAAGTTACCATGGAAGATATTGCT
GCAGTTGTGTCTACATGGACGGGAGTACCTGTTTCTAAATTAACAAAAGATGAAACTGATCGACTTCTAAATATGGAAAA
AATCCTTCATGACCGCGTTATCGGGCAGTCGGAAGCGGTTAATGCAGTTGCTAAAGCAATACGACGTGCTCGTGCAGGTT
TAAAAGATCCAAAACGTCCAATTGGTTCGTTTATTTTCTTAGGACCAACGGGTGTAGGTAAAACGGAACTTGCTCGTGCG
TTAGCAGAAGTAATGTTTGCAGATGAAGATGCGATGATCCGTATTGATATGTCTGAGTATATGGAGAGACATGCAACTTC
ACGCTTGGTTGGTTCACCACCAGGATATGTTGGATACGACGAAGGTGGACAATTAACTGAAAAAGTTCGTCGTAAGCCTT
ACTCTGTTGTTCTATTAGATGAGGTGGAAAAAGCACATCCAGAAGTATTTAATATTCTTTTACAAGTGCTAGAAGATGGT
CGCTTAACTGATTCAAAAGGAAGAGTGGTTGATTTCCGTAATACAGTTATCATCATGACGTCCAATGTTGGGGCAAGCGA
ATTAAAACGTAATAAATATGTTGGTTTCGCTTTAGATAATGAGGAAAAAGACTATAAAGATATGAAATCAAAAGTGATCG
AAGAATTGAAGAAAGCTTTCCGTCCAGAGTTTTTAAATCGTATTGATGAAACAATTGTCTTCCATTCTTTAGAAAAAGAG
CATATGAAAGATATTGTGACATTGATGGTACAACAATTACAAAAACGACTAAAAGAACAAGACCTTCACCTATCATTAAC
AGATAAGGCGATTGAAAAAATAGCTAATGAAGGCTTCGATCCAGAATACGGTGCTCGACCTTTACGTCGATCCATTCAAA
AAAATATCGAAGACTTATTGTCAGAAGAGCTATTAAGAGGAGCCATTGAAAAAGAGCAACAGGTTAAAATTGGTTTAAAT
AATAAAGGTGAATTTATTGTTTTACCATAG

Upstream 100 bases:

>100_bases
AGAAGGCTTTTGTTTCTACGTATAATCACATTTAAATATATAGCCGATATTCGACCTACCGATATCGATTAAATCTCAGA
ATAATAGGAGGAAAATCCTT

Downstream 100 bases:

>100_bases
AAAAAGGTAATATGATGGAATAGTGATAAAGCTAGAGGATTTGATTCTTCTAGCTTTTATTTCCATTTAAGGGATTTCGA
TGTCAAAACGCTTGGTTGTG

Product: ATP-dependent Clp protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 809; Mature: 809

Protein sequence:

>809_residues
MMFGRFTERAQKVLALSQEEAVRLGHNNIGTEHILLGLVREGEGIAAKALQSLGLEVSKIQEEVEKLIGVGKQPTQSIHY
TPRAKKVVELSQDEARKLGHSYVGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNESQAGRQGRSGQQSN
ASTPTLDSLARDLTVSAKEGKIDPVIGRSKEIERVIQVLSRRTKNNPVLIGEPGVGKTAVAEGLAQQIIDNEVPETLRDK
RVMTLDMGTVVAGTKYRGEFEDRLKKVMEEIRQAGNIILFIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTL
DEYRKYIEKDAALERRFQPIQVDEPTLEETIQILNGLRDRYEAHHRVTITDEAIEAAASLSDRYITDRFLPDKAIDLIDE
AGSKVRLRSYTVPPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDSEQRFREELETTKNQWKEKQGQTDSEVTMEDIA
AVVSTWTGVPVSKLTKDETDRLLNMEKILHDRVIGQSEAVNAVAKAIRRARAGLKDPKRPIGSFIFLGPTGVGKTELARA
LAEVMFADEDAMIRIDMSEYMERHATSRLVGSPPGYVGYDEGGQLTEKVRRKPYSVVLLDEVEKAHPEVFNILLQVLEDG
RLTDSKGRVVDFRNTVIIMTSNVGASELKRNKYVGFALDNEEKDYKDMKSKVIEELKKAFRPEFLNRIDETIVFHSLEKE
HMKDIVTLMVQQLQKRLKEQDLHLSLTDKAIEKIANEGFDPEYGARPLRRSIQKNIEDLLSEELLRGAIEKEQQVKIGLN
NKGEFIVLP

Sequences:

>Translated_809_residues
MMFGRFTERAQKVLALSQEEAVRLGHNNIGTEHILLGLVREGEGIAAKALQSLGLEVSKIQEEVEKLIGVGKQPTQSIHY
TPRAKKVVELSQDEARKLGHSYVGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNESQAGRQGRSGQQSN
ASTPTLDSLARDLTVSAKEGKIDPVIGRSKEIERVIQVLSRRTKNNPVLIGEPGVGKTAVAEGLAQQIIDNEVPETLRDK
RVMTLDMGTVVAGTKYRGEFEDRLKKVMEEIRQAGNIILFIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTL
DEYRKYIEKDAALERRFQPIQVDEPTLEETIQILNGLRDRYEAHHRVTITDEAIEAAASLSDRYITDRFLPDKAIDLIDE
AGSKVRLRSYTVPPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDSEQRFREELETTKNQWKEKQGQTDSEVTMEDIA
AVVSTWTGVPVSKLTKDETDRLLNMEKILHDRVIGQSEAVNAVAKAIRRARAGLKDPKRPIGSFIFLGPTGVGKTELARA
LAEVMFADEDAMIRIDMSEYMERHATSRLVGSPPGYVGYDEGGQLTEKVRRKPYSVVLLDEVEKAHPEVFNILLQVLEDG
RLTDSKGRVVDFRNTVIIMTSNVGASELKRNKYVGFALDNEEKDYKDMKSKVIEELKKAFRPEFLNRIDETIVFHSLEKE
HMKDIVTLMVQQLQKRLKEQDLHLSLTDKAIEKIANEGFDPEYGARPLRRSIQKNIEDLLSEELLRGAIEKEQQVKIGLN
NKGEFIVLP
>Mature_809_residues
MMFGRFTERAQKVLALSQEEAVRLGHNNIGTEHILLGLVREGEGIAAKALQSLGLEVSKIQEEVEKLIGVGKQPTQSIHY
TPRAKKVVELSQDEARKLGHSYVGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNESQAGRQGRSGQQSN
ASTPTLDSLARDLTVSAKEGKIDPVIGRSKEIERVIQVLSRRTKNNPVLIGEPGVGKTAVAEGLAQQIIDNEVPETLRDK
RVMTLDMGTVVAGTKYRGEFEDRLKKVMEEIRQAGNIILFIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTL
DEYRKYIEKDAALERRFQPIQVDEPTLEETIQILNGLRDRYEAHHRVTITDEAIEAAASLSDRYITDRFLPDKAIDLIDE
AGSKVRLRSYTVPPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDSEQRFREELETTKNQWKEKQGQTDSEVTMEDIA
AVVSTWTGVPVSKLTKDETDRLLNMEKILHDRVIGQSEAVNAVAKAIRRARAGLKDPKRPIGSFIFLGPTGVGKTELARA
LAEVMFADEDAMIRIDMSEYMERHATSRLVGSPPGYVGYDEGGQLTEKVRRKPYSVVLLDEVEKAHPEVFNILLQVLEDG
RLTDSKGRVVDFRNTVIIMTSNVGASELKRNKYVGFALDNEEKDYKDMKSKVIEELKKAFRPEFLNRIDETIVFHSLEKE
HMKDIVTLMVQQLQKRLKEQDLHLSLTDKAIEKIANEGFDPEYGARPLRRSIQKNIEDLLSEELLRGAIEKEQQVKIGLN
NKGEFIVLP

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Homo sapiens, GI13540606, Length=310, Percent_Identity=37.4193548387097, Blast_Score=207, Evalue=4e-53,
Organism=Escherichia coli, GI1788943, Length=873, Percent_Identity=47.651775486827, Blast_Score=757, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=402, Percent_Identity=41.2935323383085, Blast_Score=299, Evalue=4e-82,
Organism=Saccharomyces cerevisiae, GI6320464, Length=724, Percent_Identity=47.2375690607735, Blast_Score=636, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=876, Percent_Identity=36.5296803652968, Blast_Score=538, Evalue=1e-153,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): CLPB_OCEIH (Q8EU05)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_691014.1
- ProteinModelPortal:   Q8EU05
- SMR:   Q8EU05
- GeneID:   1015172
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB0093
- NMPDR:   fig|221109.1.peg.94
- HOGENOM:   HBG413133
- OMA:   TIDESIQ
- BioCyc:   OIHE221109:OB0093-MONOMER
- GO:   GO:0005737
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- InterPro:   IPR001943
- Gene3D:   G3DSA:1.10.1780.10
- PRINTS:   PR00300
- SMART:   SM00382

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small; PF02151 UVR

EC number: NA

Molecular weight: Translated: 90505; Mature: 90505

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00870 CLPAB_1; PS00871 CLPAB_2; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMFGRFTERAQKVLALSQEEAVRLGHNNIGTEHILLGLVREGEGIAAKALQSLGLEVSKI
CCCCHHHHHHHHHHHHCHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCHHHHH
QEEVEKLIGVGKQPTQSIHYTPRAKKVVELSQDEARKLGHSYVGTEHILLGLIREGEGVA
HHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHCCCCHH
ARVLNNLGVSLNKARQQVLQLLGSNESQAGRQGRSGQQSNASTPTLDSLARDLTVSAKEG
HHHHHHCCCCHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCC
KIDPVIGRSKEIERVIQVLSRRTKNNPVLIGEPGVGKTAVAEGLAQQIIDNEVPETLRDK
CCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHCC
RVMTLDMGTVVAGTKYRGEFEDRLKKVMEEIRQAGNIILFIDELHTLIGAGGAEGAIDAS
EEEEEECCHHEECCCCCCCHHHHHHHHHHHHHHHCCEEEEHHHHHHHHCCCCCCCCCCHH
NILKPSLARGELQCIGATTLDEYRKYIEKDAALERRFQPIQVDEPTLEETIQILNGLRDR
HHCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
YEAHHRVTITDEAIEAAASLSDRYITDRFLPDKAIDLIDEAGSKVRLRSYTVPPNLKELE
HHCCCEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEEECCCCCHHHHH
QKLDEVRKEKDAAVQSQEFEKAASLRDSEQRFREELETTKNQWKEKQGQTDSEVTMEDIA
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
AVVSTWTGVPVSKLTKDETDRLLNMEKILHDRVIGQSEAVNAVAKAIRRARAGLKDPKRP
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCC
IGSFIFLGPTGVGKTELARALAEVMFADEDAMIRIDMSEYMERHATSRLVGSPPGYVGYD
CCCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHCCCCCCCCCCC
EGGQLTEKVRRKPYSVVLLDEVEKAHPEVFNILLQVLEDGRLTDSKGRVVDFRNTVIIMT
CCCHHHHHHHCCCCEEEEEHHHHHHCHHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEE
SNVGASELKRNKYVGFALDNEEKDYKDMKSKVIEELKKAFRPEFLNRIDETIVFHSLEKE
CCCCHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
HMKDIVTLMVQQLQKRLKEQDLHLSLTDKAIEKIANEGFDPEYGARPLRRSIQKNIEDLL
HHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
SEELLRGAIEKEQQVKIGLNNKGEFIVLP
HHHHHHHHHCCCCEEEEECCCCCCEEEEC
>Mature Secondary Structure
MMFGRFTERAQKVLALSQEEAVRLGHNNIGTEHILLGLVREGEGIAAKALQSLGLEVSKI
CCCCHHHHHHHHHHHHCHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCHHHHH
QEEVEKLIGVGKQPTQSIHYTPRAKKVVELSQDEARKLGHSYVGTEHILLGLIREGEGVA
HHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHCCCCHH
ARVLNNLGVSLNKARQQVLQLLGSNESQAGRQGRSGQQSNASTPTLDSLARDLTVSAKEG
HHHHHHCCCCHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCC
KIDPVIGRSKEIERVIQVLSRRTKNNPVLIGEPGVGKTAVAEGLAQQIIDNEVPETLRDK
CCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHCC
RVMTLDMGTVVAGTKYRGEFEDRLKKVMEEIRQAGNIILFIDELHTLIGAGGAEGAIDAS
EEEEEECCHHEECCCCCCCHHHHHHHHHHHHHHHCCEEEEHHHHHHHHCCCCCCCCCCHH
NILKPSLARGELQCIGATTLDEYRKYIEKDAALERRFQPIQVDEPTLEETIQILNGLRDR
HHCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
YEAHHRVTITDEAIEAAASLSDRYITDRFLPDKAIDLIDEAGSKVRLRSYTVPPNLKELE
HHCCCEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEEECCCCCHHHHH
QKLDEVRKEKDAAVQSQEFEKAASLRDSEQRFREELETTKNQWKEKQGQTDSEVTMEDIA
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
AVVSTWTGVPVSKLTKDETDRLLNMEKILHDRVIGQSEAVNAVAKAIRRARAGLKDPKRP
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCC
IGSFIFLGPTGVGKTELARALAEVMFADEDAMIRIDMSEYMERHATSRLVGSPPGYVGYD
CCCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHCCCCCCCCCCC
EGGQLTEKVRRKPYSVVLLDEVEKAHPEVFNILLQVLEDGRLTDSKGRVVDFRNTVIIMT
CCCHHHHHHHCCCCEEEEEHHHHHHCHHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEE
SNVGASELKRNKYVGFALDNEEKDYKDMKSKVIEELKKAFRPEFLNRIDETIVFHSLEKE
CCCCHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
HMKDIVTLMVQQLQKRLKEQDLHLSLTDKAIEKIANEGFDPEYGARPLRRSIQKNIEDLL
HHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
SEELLRGAIEKEQQVKIGLNNKGEFIVLP
HHHHHHHHHCCCCEEEEECCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376