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The map label for this gene is guaB [H]

Identifier: 23097465

GI number: 23097465

Start: 12072

End: 13541

Strand: Direct

Name: guaB [H]

Synonym: OB0010

Alternate gene names: 23097465

Gene position: 12072-13541 (Clockwise)

Preceding gene: 23097463

Following gene: 23097466

Centisome position: 0.33

GC content: 37.96

Gene sequence:

>1470_bases
ATGAGAGAAGACAAGTTTGCAAAAGAAGGATTAACCTTTGATGATGTATTGTTATTGCCTGCAAAATCAGAAGTATTGCC
AAATCAAGTAGATTTAAGTGTTGAATTAACCTCTACGTTAAAATTAAAATCTCCATTTATAAGTGCTGGCATGGATACAG
TTACAGAAGCAGAAATGGCGATTGCAATGGCACGTCAAGGTGGATTTGGTGTTATTCATAAAAATATGTCGATTGAAGAT
CAAGCAGAACAAGTAGACAAAGTAAAACGTTCTGAAAGTGGTGTTATTACGAATCCATTCTTTTTAACTCCAGAACATCA
AGTCTACGATGCAGAGCATTTAATGGGTAAATTTCGAATTTCTGGTGTTCCAATTGTAAACAATATTGAAGAACAAAAGC
TTGTCGGCATTTTAACGAATCGTGACCTTCGTTTTATACAAGATTATTCGATCTCTATTTCAGAAGTAATGACAAGTGAA
AATCTTGTAACGGCTCCTGTTGGAACAACGTTACAGGAAGCAGAAAAATTACTTCAACAATATAAAATTGAAAAACTTCC
ACTTGTAGATGATCGAAATATATTAAAAGGACTTATAACAATTAAAGATATTGAGAAAGTCATTGAATTCCCAAATTCAG
CAAAAGACGCTCAAGGTAGATTAATTGTTGGAGCGGCTGTTGGAGTAACTGGAGATGCAATGAAACGTATTGAAAAACTT
GTAAGTGTTGGTGTTGATGCAATCGTTATCGATACAGCTCATGGACATTCACAAGGTGTATTAGAACAATTGAAAAAAGT
ACGTCAAGCCTATCCAGACCTTCAAATCATTGCTGGTAATGTAGCTACCCCAGAAGGAACTAAAGCATTAATCGAAGCAG
GTGTATCGGTAGTTAAAGTAGGAATTGGACCTGGATCTATTTGTACAACTCGTGTTGTAGCTGGAGTAGGGGTACCACAA
ATCACTGCAGTTCATGATTGTGCTTTAGCTGCGGCAGAGTATGGTGTTCCGGTTATTGCAGATGGAGGAATTAAGTACTC
CGGCGATATTGTAAAAGCTCTAGCAGCTGGTGCACATGCAGTTATGATCGGAAGCATGTTCGCAGGTGTATCGGAAAGCC
CAGGAGAAACAGAAATTTTCCAAGGACGTCAATATAAAGTATATCGTGGAATGGGCTCAGTTGGCGCCATGGCAGCTGGT
TCCAAAGATCGTTATTTCCAAAGTGAATCACAAAACAAAAAACTTGTACCAGAAGGTATTGAAGGTCGTGTAGCTTATAA
AGGACCATTAAGTGACACGTTCCATCAGCTTGTTGGTGGCCTTCGTTCTGGTATGGGATACTGTGGTACAAAATCAATTG
AGGCCCTTCGTAATGATGGTAAATTTATTCGTATCACAAATGCAGGTTTACGTGAAAGTCATCCGCATGATGTTCAAATT
ACGAAAGAAGCACCAAACTATACTTTATAA

Upstream 100 bases:

>100_bases
CTGGCATTATTCATGCCTAGAAAATGATATTACCGCATGTAGTTAGAACTGCAAAAGCGGTTGAAATATGGGAATTCAAA
TTTAAAAGGAGGAAGTAAAA

Downstream 100 bases:

>100_bases
GCTAAACTTCTTTGAAAACAAATTGTACGGTAAAATGAATATCATCATTTTTTAATAAAAATGTAAATAAACTTCACTTT
GCCATATAATTGCCATATTC

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH; Superoxide-inducible protein 12; SOI12 [H]

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MREDKFAKEGLTFDDVLLLPAKSEVLPNQVDLSVELTSTLKLKSPFISAGMDTVTEAEMAIAMARQGGFGVIHKNMSIED
QAEQVDKVKRSESGVITNPFFLTPEHQVYDAEHLMGKFRISGVPIVNNIEEQKLVGILTNRDLRFIQDYSISISEVMTSE
NLVTAPVGTTLQEAEKLLQQYKIEKLPLVDDRNILKGLITIKDIEKVIEFPNSAKDAQGRLIVGAAVGVTGDAMKRIEKL
VSVGVDAIVIDTAHGHSQGVLEQLKKVRQAYPDLQIIAGNVATPEGTKALIEAGVSVVKVGIGPGSICTTRVVAGVGVPQ
ITAVHDCALAAAEYGVPVIADGGIKYSGDIVKALAAGAHAVMIGSMFAGVSESPGETEIFQGRQYKVYRGMGSVGAMAAG
SKDRYFQSESQNKKLVPEGIEGRVAYKGPLSDTFHQLVGGLRSGMGYCGTKSIEALRNDGKFIRITNAGLRESHPHDVQI
TKEAPNYTL

Sequences:

>Translated_489_residues
MREDKFAKEGLTFDDVLLLPAKSEVLPNQVDLSVELTSTLKLKSPFISAGMDTVTEAEMAIAMARQGGFGVIHKNMSIED
QAEQVDKVKRSESGVITNPFFLTPEHQVYDAEHLMGKFRISGVPIVNNIEEQKLVGILTNRDLRFIQDYSISISEVMTSE
NLVTAPVGTTLQEAEKLLQQYKIEKLPLVDDRNILKGLITIKDIEKVIEFPNSAKDAQGRLIVGAAVGVTGDAMKRIEKL
VSVGVDAIVIDTAHGHSQGVLEQLKKVRQAYPDLQIIAGNVATPEGTKALIEAGVSVVKVGIGPGSICTTRVVAGVGVPQ
ITAVHDCALAAAEYGVPVIADGGIKYSGDIVKALAAGAHAVMIGSMFAGVSESPGETEIFQGRQYKVYRGMGSVGAMAAG
SKDRYFQSESQNKKLVPEGIEGRVAYKGPLSDTFHQLVGGLRSGMGYCGTKSIEALRNDGKFIRITNAGLRESHPHDVQI
TKEAPNYTL
>Mature_489_residues
MREDKFAKEGLTFDDVLLLPAKSEVLPNQVDLSVELTSTLKLKSPFISAGMDTVTEAEMAIAMARQGGFGVIHKNMSIED
QAEQVDKVKRSESGVITNPFFLTPEHQVYDAEHLMGKFRISGVPIVNNIEEQKLVGILTNRDLRFIQDYSISISEVMTSE
NLVTAPVGTTLQEAEKLLQQYKIEKLPLVDDRNILKGLITIKDIEKVIEFPNSAKDAQGRLIVGAAVGVTGDAMKRIEKL
VSVGVDAIVIDTAHGHSQGVLEQLKKVRQAYPDLQIIAGNVATPEGTKALIEAGVSVVKVGIGPGSICTTRVVAGVGVPQ
ITAVHDCALAAAEYGVPVIADGGIKYSGDIVKALAAGAHAVMIGSMFAGVSESPGETEIFQGRQYKVYRGMGSVGAMAAG
SKDRYFQSESQNKKLVPEGIEGRVAYKGPLSDTFHQLVGGLRSGMGYCGTKSIEALRNDGKFIRITNAGLRESHPHDVQI
TKEAPNYTL

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=458, Percent_Identity=43.8864628820961, Blast_Score=353, Evalue=3e-97,
Organism=Homo sapiens, GI156616279, Length=458, Percent_Identity=43.8864628820961, Blast_Score=352, Evalue=4e-97,
Organism=Homo sapiens, GI34328928, Length=458, Percent_Identity=43.8864628820961, Blast_Score=352, Evalue=4e-97,
Organism=Homo sapiens, GI34328930, Length=458, Percent_Identity=43.4497816593886, Blast_Score=352, Evalue=4e-97,
Organism=Homo sapiens, GI217035152, Length=450, Percent_Identity=44, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI66933016, Length=455, Percent_Identity=41.978021978022, Blast_Score=342, Evalue=5e-94,
Organism=Homo sapiens, GI217035148, Length=458, Percent_Identity=43.0131004366812, Blast_Score=340, Evalue=1e-93,
Organism=Homo sapiens, GI217035150, Length=458, Percent_Identity=40.6113537117904, Blast_Score=317, Evalue=2e-86,
Organism=Homo sapiens, GI156104880, Length=244, Percent_Identity=39.344262295082, Blast_Score=162, Evalue=8e-40,
Organism=Homo sapiens, GI50541954, Length=263, Percent_Identity=38.4030418250951, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI50541952, Length=263, Percent_Identity=38.4030418250951, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI50541948, Length=263, Percent_Identity=38.4030418250951, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI50541956, Length=263, Percent_Identity=38.4030418250951, Blast_Score=160, Evalue=3e-39,
Organism=Escherichia coli, GI1788855, Length=486, Percent_Identity=57.201646090535, Blast_Score=509, Evalue=1e-145,
Organism=Escherichia coli, GI1786293, Length=258, Percent_Identity=36.046511627907, Blast_Score=155, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI71994385, Length=475, Percent_Identity=35.7894736842105, Blast_Score=285, Evalue=4e-77,
Organism=Caenorhabditis elegans, GI71994389, Length=427, Percent_Identity=36.768149882904, Blast_Score=269, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI17560440, Length=221, Percent_Identity=42.5339366515837, Blast_Score=166, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6323585, Length=464, Percent_Identity=40.5172413793103, Blast_Score=325, Evalue=1e-89,
Organism=Saccharomyces cerevisiae, GI6322012, Length=464, Percent_Identity=39.0086206896552, Blast_Score=321, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6323464, Length=464, Percent_Identity=40.301724137931, Blast_Score=320, Evalue=4e-88,
Organism=Saccharomyces cerevisiae, GI6319352, Length=344, Percent_Identity=37.7906976744186, Blast_Score=244, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6319353, Length=116, Percent_Identity=40.5172413793103, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24641071, Length=480, Percent_Identity=41.0416666666667, Blast_Score=339, Evalue=3e-93,
Organism=Drosophila melanogaster, GI24641073, Length=480, Percent_Identity=41.0416666666667, Blast_Score=339, Evalue=3e-93,
Organism=Drosophila melanogaster, GI28571163, Length=438, Percent_Identity=40.8675799086758, Blast_Score=301, Evalue=1e-81,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52488; Mature: 52488

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREDKFAKEGLTFDDVLLLPAKSEVLPNQVDLSVELTSTLKLKSPFISAGMDTVTEAEMA
CCCCHHHHCCCCCCCEEEECCCCCCCCCCEEEEEEEEEEEEECCCHHHCCCHHHHHHHHH
IAMARQGGFGVIHKNMSIEDQAEQVDKVKRSESGVITNPFFLTPEHQVYDAEHLMGKFRI
HHHHCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCEECCEEECCCCHHCCHHHHHHHHEE
SGVPIVNNIEEQKLVGILTNRDLRFIQDYSISISEVMTSENLVTAPVGTTLQEAEKLLQQ
CCCCEECCCCHHHEEEEEECCCEEEECCCCCCHHHHHCCCCEEECCCCCCHHHHHHHHHH
YKIEKLPLVDDRNILKGLITIKDIEKVIEFPNSAKDAQGRLIVGAAVGVTGDAMKRIEKL
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHH
VSVGVDAIVIDTAHGHSQGVLEQLKKVRQAYPDLQIIAGNVATPEGTKALIEAGVSVVKV
HHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHCCCEEEEE
GIGPGSICTTRVVAGVGVPQITAVHDCALAAAEYGVPVIADGGIKYSGDIVKALAAGAHA
ECCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEECCCEEECHHHHHHHHCCCHH
VMIGSMFAGVSESPGETEIFQGRQYKVYRGMGSVGAMAAGSKDRYFQSESQNKKLVPEGI
HHHHHHHCCCCCCCCCCHHHCCCEEEEEECCCCCCHHCCCCCCCCCCCCCCCCCCCCCCC
EGRVAYKGPLSDTFHQLVGGLRSGMGYCGTKSIEALRNDGKFIRITNAGLRESHPHDVQI
CCEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCEEE
TKEAPNYTL
EECCCCCCC
>Mature Secondary Structure
MREDKFAKEGLTFDDVLLLPAKSEVLPNQVDLSVELTSTLKLKSPFISAGMDTVTEAEMA
CCCCHHHHCCCCCCCEEEECCCCCCCCCCEEEEEEEEEEEEECCCHHHCCCHHHHHHHHH
IAMARQGGFGVIHKNMSIEDQAEQVDKVKRSESGVITNPFFLTPEHQVYDAEHLMGKFRI
HHHHCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCEECCEEECCCCHHCCHHHHHHHHEE
SGVPIVNNIEEQKLVGILTNRDLRFIQDYSISISEVMTSENLVTAPVGTTLQEAEKLLQQ
CCCCEECCCCHHHEEEEEECCCEEEECCCCCCHHHHHCCCCEEECCCCCCHHHHHHHHHH
YKIEKLPLVDDRNILKGLITIKDIEKVIEFPNSAKDAQGRLIVGAAVGVTGDAMKRIEKL
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHH
VSVGVDAIVIDTAHGHSQGVLEQLKKVRQAYPDLQIIAGNVATPEGTKALIEAGVSVVKV
HHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHCCCEEEEE
GIGPGSICTTRVVAGVGVPQITAVHDCALAAAEYGVPVIADGGIKYSGDIVKALAAGAHA
ECCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEECCCEEECHHHHHHHHCCCHH
VMIGSMFAGVSESPGETEIFQGRQYKVYRGMGSVGAMAAGSKDRYFQSESQNKKLVPEGI
HHHHHHHCCCCCCCCCCHHHCCCEEEEEECCCCCCHHCCCCCCCCCCCCCCCCCCCCCCC
EGRVAYKGPLSDTFHQLVGGLRSGMGYCGTKSIEALRNDGKFIRITNAGLRESHPHDVQI
CCEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCEEE
TKEAPNYTL
EECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1979163; 7584024; 9384377; 9298659 [H]