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The map label for this gene is glmU [H]

Identifier: 22128001

GI number: 22128001

Start: 4588003

End: 4589379

Strand: Reverse

Name: glmU [H]

Synonym: y4133

Alternate gene names: 22128001

Gene position: 4589379-4588003 (Counterclockwise)

Preceding gene: 22128002

Following gene: 22128000

Centisome position: 99.75

GC content: 47.42

Gene sequence:

>1377_bases
TTGCTTATGTCTAACAGCTCAATGAGTGTCGTCATCCTTGCCGCGGGTAAGGGGACACGTATGTATTCCGACCTTCCTAA
GGTATTGCACCCATTGGCAGGTAAGCCAATGGTTCAGCATGTTATTGATGCTGCCATGAAGCTAGGTGCACAACATGTTC
ATCTGGTTTATGGGCACGGGGGTGAGTTACTGAAGAAGACCTTGGCCGATCCATCCTTGAATTGGGTATTACAGGCTGAG
CAACTGGGTACTGGCCATGCGATGCAGCAAGCTGCCCCACATTTTGCTGATGATGAAGATATTTTGATGTTGTATGGCGA
TGTGCCGCTGATCTCTGTTGATACGCTACAACGTCTGCTGGCCGCTAAGCCCGAGGGCGGGATTGGCTTGTTGACAGTAA
AACTGGATAACCCAAGCGGTTATGGCCGTATCGTTCGTGAGAATGGCGATGTCGTCGGGATCGTTGAACATAAAGATGCC
AGCGATGCACAACGGGAAATCAACGAGATCAATACGGGGATTCTGGTCGCAAATGGGCGCGATTTAAAACGCTGGCTATC
ATTGTTGGATAATAATAATGCTCAAGGTGAGTTTTATATCACTGACATTATTGCGTTAGCGCATGCCGATGGTAAGAAAA
TTGCCACTGTCCATCCTACCCGCTTGAGTGAAGTGGAAGGGGTGAATAATCGCCTGCAATTGTCTGCTCTTGAGCGCGTA
TTTCAGACAGAACAAGCGGAAAAATTATTGTTAGCGGGCGTGATGCTATTGGATCCCTCCCGTTTTGATTTGCGCGGAGA
ATTAACTCATGGTCGCGATATTACTATCGATACCAATGTCATTATTGAAGGTCATGTGATTTTAGGTGACCGGGTGCGAA
TTGGTACGGGGTGTGTACTCAAAAACTGTGTGATTGGTGATGACTCAGAAATAAGCCCATATACCGTTTTAGAAGATGCC
CGCCTGGATGCCAACTGTACTGTTGGGCCATTTGCTCGTCTGCGTCCTGGCGCTGAATTGGCTGAAGGTGCACATGTTGG
TAATTTTGTTGAAATCAAAAAAGCCCGTTTGGGTAAAGGCTCTAAAGCCGGTCATCTCTCTTATCTAGGTGACGCTGAGA
TTGGGGCTGGCGTCAATATTGGCGCGGGAACTATAACGTGTAACTATGACGGGGCTAATAAATTTAAAACTATTATTGGC
GATGATGTTTTTGTCGGATCGGATACTCAATTAGTTGCCCCGGTCACCGTTGCAAACGGTGCAACCATTGGCGCGGGTAC
GACTGTCACCCGTGATGTTGCCGAAAATGAATTAGTCATCAGCCGGGTTAAGCAGGTTCATATTCAGGGATGGAAGCGCC
CGGTAAAGAAAAAGTAA

Upstream 100 bases:

>100_bases
CCTTTAGCCACGCGGGTTGTGTACGTTTTTCGTTGAGAAATATGTAGTAATTATTTCGGTAAACAGGTTTACTTCCGTCT
ATTAAATTGGAGTTATCAGG

Downstream 100 bases:

>100_bases
CGTTATTAAAAGCACCCTTCAAGGTGAATTATGCTTCTTTGAAGGGATGTTTTGCCCTGTATTTTTGGTTTACTGAAAAT
ACAGTACAAAACATAATAAT

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MLMSNSSMSVVILAAGKGTRMYSDLPKVLHPLAGKPMVQHVIDAAMKLGAQHVHLVYGHGGELLKKTLADPSLNWVLQAE
QLGTGHAMQQAAPHFADDEDILMLYGDVPLISVDTLQRLLAAKPEGGIGLLTVKLDNPSGYGRIVRENGDVVGIVEHKDA
SDAQREINEINTGILVANGRDLKRWLSLLDNNNAQGEFYITDIIALAHADGKKIATVHPTRLSEVEGVNNRLQLSALERV
FQTEQAEKLLLAGVMLLDPSRFDLRGELTHGRDITIDTNVIIEGHVILGDRVRIGTGCVLKNCVIGDDSEISPYTVLEDA
RLDANCTVGPFARLRPGAELAEGAHVGNFVEIKKARLGKGSKAGHLSYLGDAEIGAGVNIGAGTITCNYDGANKFKTIIG
DDVFVGSDTQLVAPVTVANGATIGAGTTVTRDVAENELVISRVKQVHIQGWKRPVKKK

Sequences:

>Translated_458_residues
MLMSNSSMSVVILAAGKGTRMYSDLPKVLHPLAGKPMVQHVIDAAMKLGAQHVHLVYGHGGELLKKTLADPSLNWVLQAE
QLGTGHAMQQAAPHFADDEDILMLYGDVPLISVDTLQRLLAAKPEGGIGLLTVKLDNPSGYGRIVRENGDVVGIVEHKDA
SDAQREINEINTGILVANGRDLKRWLSLLDNNNAQGEFYITDIIALAHADGKKIATVHPTRLSEVEGVNNRLQLSALERV
FQTEQAEKLLLAGVMLLDPSRFDLRGELTHGRDITIDTNVIIEGHVILGDRVRIGTGCVLKNCVIGDDSEISPYTVLEDA
RLDANCTVGPFARLRPGAELAEGAHVGNFVEIKKARLGKGSKAGHLSYLGDAEIGAGVNIGAGTITCNYDGANKFKTIIG
DDVFVGSDTQLVAPVTVANGATIGAGTTVTRDVAENELVISRVKQVHIQGWKRPVKKK
>Mature_458_residues
MLMSNSSMSVVILAAGKGTRMYSDLPKVLHPLAGKPMVQHVIDAAMKLGAQHVHLVYGHGGELLKKTLADPSLNWVLQAE
QLGTGHAMQQAAPHFADDEDILMLYGDVPLISVDTLQRLLAAKPEGGIGLLTVKLDNPSGYGRIVRENGDVVGIVEHKDA
SDAQREINEINTGILVANGRDLKRWLSLLDNNNAQGEFYITDIIALAHADGKKIATVHPTRLSEVEGVNNRLQLSALERV
FQTEQAEKLLLAGVMLLDPSRFDLRGELTHGRDITIDTNVIIEGHVILGDRVRIGTGCVLKNCVIGDDSEISPYTVLEDA
RLDANCTVGPFARLRPGAELAEGAHVGNFVEIKKARLGKGSKAGHLSYLGDAEIGAGVNIGAGTITCNYDGANKFKTIIG
DDVFVGSDTQLVAPVTVANGATIGAGTTVTRDVAENELVISRVKQVHIQGWKRPVKKK

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1790168, Length=456, Percent_Identity=82.2368421052632, Blast_Score=770, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 49085; Mature: 49085

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMSNSSMSVVILAAGKGTRMYSDLPKVLHPLAGKPMVQHVIDAAMKLGAQHVHLVYGHG
CEECCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEECCC
GELLKKTLADPSLNWVLQAEQLGTGHAMQQAAPHFADDEDILMLYGDVPLISVDTLQRLL
HHHHHHHHCCCCCEEEEEECCCCCCHHHHHCCCCCCCCCCEEEEECCCCEEEHHHHHHHH
AAKPEGGIGLLTVKLDNPSGYGRIVRENGDVVGIVEHKDASDAQREINEINTGILVANGR
HCCCCCCEEEEEEEECCCCCCCEEEECCCCEEEEEECCCCCHHHHHHHHCCCCEEEECCC
DLKRWLSLLDNNNAQGEFYITDIIALAHADGKKIATVHPTRLSEVEGVNNRLQLSALERV
CHHHHHHHHCCCCCCCEEEEEEEEEEECCCCCEEEEECCCHHHHHCCCCCEEHHHHHHHH
FQTEQAEKLLLAGVMLLDPSRFDLRGELTHGRDITIDTNVIIEGHVILGDRVRIGTGCVL
HHHHHHHHHHHHCEEEECCCCCCEEEEECCCCEEEEECEEEEEEEEEECCEEEECCCEEE
KNCVIGDDSEISPYTVLEDARLDANCTVGPFARLRPGAELAEGAHVGNFVEIKKARLGKG
EEEEECCCCCCCCEEEEECCCCCCCCCCCCHHHCCCCCHHHCCCCCCCEEEEHHHHCCCC
SKAGHLSYLGDAEIGAGVNIGAGTITCNYDGANKFKTIIGDDVFVGSDTQLVAPVTVANG
CCCCCEEEECCCCCCCCEEECCCEEEEECCCCCHHHHEECCCEEECCCCEEEEEEEEECC
ATIGAGTTVTRDVAENELVISRVKQVHIQGWKRPVKKK
CEECCCCEEEHHHHCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLMSNSSMSVVILAAGKGTRMYSDLPKVLHPLAGKPMVQHVIDAAMKLGAQHVHLVYGHG
CEECCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEECCC
GELLKKTLADPSLNWVLQAEQLGTGHAMQQAAPHFADDEDILMLYGDVPLISVDTLQRLL
HHHHHHHHCCCCCEEEEEECCCCCCHHHHHCCCCCCCCCCEEEEECCCCEEEHHHHHHHH
AAKPEGGIGLLTVKLDNPSGYGRIVRENGDVVGIVEHKDASDAQREINEINTGILVANGR
HCCCCCCEEEEEEEECCCCCCCEEEECCCCEEEEEECCCCCHHHHHHHHCCCCEEEECCC
DLKRWLSLLDNNNAQGEFYITDIIALAHADGKKIATVHPTRLSEVEGVNNRLQLSALERV
CHHHHHHHHCCCCCCCEEEEEEEEEEECCCCCEEEEECCCHHHHHCCCCCEEHHHHHHHH
FQTEQAEKLLLAGVMLLDPSRFDLRGELTHGRDITIDTNVIIEGHVILGDRVRIGTGCVL
HHHHHHHHHHHHCEEEECCCCCCEEEEECCCCEEEEECEEEEEEEEEECCEEEECCCEEE
KNCVIGDDSEISPYTVLEDARLDANCTVGPFARLRPGAELAEGAHVGNFVEIKKARLGKG
EEEEECCCCCCCCEEEEECCCCCCCCCCCCHHHCCCCCHHHCCCCCCCEEEEHHHHCCCC
SKAGHLSYLGDAEIGAGVNIGAGTITCNYDGANKFKTIIGDDVFVGSDTQLVAPVTVANG
CCCCCEEEECCCCCCCCEEECCCEEEEECCCCCHHHHEECCCEEECCCCEEEEEEEEECC
ATIGAGTTVTRDVAENELVISRVKQVHIQGWKRPVKKK
CEECCCCEEEHHHHCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA