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The map label for this gene is oxaA

Identifier: 22127984

GI number: 22127984

Start: 4567959

End: 4569599

Strand: Direct

Name: oxaA

Synonym: y4117

Alternate gene names: 22127984

Gene position: 4567959-4569599 (Clockwise)

Preceding gene: 22127983

Following gene: 22127986

Centisome position: 99.29

GC content: 48.14

Gene sequence:

>1641_bases
ATGGATTCGCAACGCAATCTTCTACTCATCGCTCTGCTGTTCGTGTCTTTCATGATCTGGCAAGCTTGGCAAGTGGATAA
CAATCCACAACCAACCGCTCAGACCACGCAACAGACTACGAATACCGCTACCGGTGATAAAGCAAGCCAGGCTGTGCCAG
GCAGCGGTCAGGGTCAACTGATCACTGTAAAAACTGATGTGCTGTCTCTGACTATTAATACCCGTGGCGGTGACATTGAG
CAGGCTAACCTGCTGGCTTACCCAGATACTTTGGGTTCAAGTAATACGTTCGAATTACTGGAAACCACTCCAAGTTTCGT
TTATCAGGCACAAAGTGGTCTGACAGGCAAAAATGGCCCGGATAACCCAGCGAATGGCGACCGTCCTTTGTTTGAAGTGC
CACAAACCAGCTTTGTTCTGGCAGATGGTCAGGATGAACTGCGCATTCCATTGACCTTCACAAGTAAAGATGGCTCTGTT
TTCATTAAGACTTTCGTGCTGAAACGTAACGATTACGCCATTGGCGTGGATTATCACGTTAACAACGCCTCCGCTGCCCC
ACTGGAGCTGACGCTGTTTGGTCAATTGAAACAAAGCATCAACTTGCCTAAAAAGCGTGATACCGGTAGCAATAACTTTG
CGCTACAGACTTATCGTGGTGCGGCTTACTCTTCTGATGAAACTAAATATAAGAAATATAGCTTTAGTGACATCGAAGAC
AAAAATCTGGACATCACCACCAAAGGTGGTTGGGTCGCTATGTTGCAGCAGTATTTCGCCACAGCATGGATCCCAGCGGC
TAACGAAACCAACACCTTCTACTCTGCTGAGTTAGGTAACGGCCTGGCCGCAATTGGTTTCAAAGGTGCACCTGTTGTTA
TCCAACCCGGTGAACAGAAACAACTGAGTGCCACACTGTGGGTGGGCCCAGAGATTCAGAATAAAATGGCGGAAATTGCG
CCACATCTGGACCTGACTGTTGATTATGGTTGGTTGTGGTTCATTTCTCAGCCACTGTTCAAACTGCTGAAGTTTATCCA
CAGCTTTGTGGGGAACTGGGGCTTCTCCATCATCGTTATTACCTTTATCGTGCGCGGTATCATGTACCCGCTAACAAAAG
CGCAATACACCTCGATGGCGAAAATGCGTTTGCTGCAGCCTAAACTGGCCGCCATGCGTGAGCGTATCGGTGACGATAAG
CAGCGTATGAGTCAGGAGATGATGGCGCTGTACAAAGCGGAGAAGGTTAACCCGCTGGGTGGCTGCTTACCGCTGATCAT
TCAGATGCCAATCTTCTTGGCGTTGTACTACATGTTGATGAGTTCTGTTGAGTTGCGCCATGCGCCATTCATTCTGTGGA
TTCATGACCTGTCAGCACAAGACCCGTACTACATTCTGCCAATTCTGATGGGTATCACCATGTACTTCATTCAGAAGATG
TCACCAACCACCGTGACTGATCCAATGCAGCAGAAGATCATGACCTTTATGCCGGTTATCTTCACGGTATTCTTCCTCTG
GTTCCCGGCAGGTCTGGTGCTGTACTATATCGTCAGCAACCTGGTGACCATCCTGCAACAACAGCTGATTTATCGTGGTC
TGGAAAAACGTGGCTTACACAGCCGCGAGAAGAAAAAATAA

Upstream 100 bases:

>100_bases
GTTGGTTAACACTGAAACGCGTATTAAAATGCCACCCTTTGAACTCAGGTGGTGATGACCCCGTGCCGCCGAAACTCGAC
GATAACAGAGAACACTAACG

Downstream 100 bases:

>100_bases
CCCACAGCGATAATCATGAGTATTTAGGGCGGTCAATATGACCGCCTTATTCTTTTTACAGAAGCCTGATTTTTCACCTT
CAGATTTGTGTAAAAATAAT

Product: putative inner membrane protein translocase component YidC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 546; Mature: 546

Protein sequence:

>546_residues
MDSQRNLLLIALLFVSFMIWQAWQVDNNPQPTAQTTQQTTNTATGDKASQAVPGSGQGQLITVKTDVLSLTINTRGGDIE
QANLLAYPDTLGSSNTFELLETTPSFVYQAQSGLTGKNGPDNPANGDRPLFEVPQTSFVLADGQDELRIPLTFTSKDGSV
FIKTFVLKRNDYAIGVDYHVNNASAAPLELTLFGQLKQSINLPKKRDTGSNNFALQTYRGAAYSSDETKYKKYSFSDIED
KNLDITTKGGWVAMLQQYFATAWIPAANETNTFYSAELGNGLAAIGFKGAPVVIQPGEQKQLSATLWVGPEIQNKMAEIA
PHLDLTVDYGWLWFISQPLFKLLKFIHSFVGNWGFSIIVITFIVRGIMYPLTKAQYTSMAKMRLLQPKLAAMRERIGDDK
QRMSQEMMALYKAEKVNPLGGCLPLIIQMPIFLALYYMLMSSVELRHAPFILWIHDLSAQDPYYILPILMGITMYFIQKM
SPTTVTDPMQQKIMTFMPVIFTVFFLWFPAGLVLYYIVSNLVTILQQQLIYRGLEKRGLHSREKKK

Sequences:

>Translated_546_residues
MDSQRNLLLIALLFVSFMIWQAWQVDNNPQPTAQTTQQTTNTATGDKASQAVPGSGQGQLITVKTDVLSLTINTRGGDIE
QANLLAYPDTLGSSNTFELLETTPSFVYQAQSGLTGKNGPDNPANGDRPLFEVPQTSFVLADGQDELRIPLTFTSKDGSV
FIKTFVLKRNDYAIGVDYHVNNASAAPLELTLFGQLKQSINLPKKRDTGSNNFALQTYRGAAYSSDETKYKKYSFSDIED
KNLDITTKGGWVAMLQQYFATAWIPAANETNTFYSAELGNGLAAIGFKGAPVVIQPGEQKQLSATLWVGPEIQNKMAEIA
PHLDLTVDYGWLWFISQPLFKLLKFIHSFVGNWGFSIIVITFIVRGIMYPLTKAQYTSMAKMRLLQPKLAAMRERIGDDK
QRMSQEMMALYKAEKVNPLGGCLPLIIQMPIFLALYYMLMSSVELRHAPFILWIHDLSAQDPYYILPILMGITMYFIQKM
SPTTVTDPMQQKIMTFMPVIFTVFFLWFPAGLVLYYIVSNLVTILQQQLIYRGLEKRGLHSREKKK
>Mature_546_residues
MDSQRNLLLIALLFVSFMIWQAWQVDNNPQPTAQTTQQTTNTATGDKASQAVPGSGQGQLITVKTDVLSLTINTRGGDIE
QANLLAYPDTLGSSNTFELLETTPSFVYQAQSGLTGKNGPDNPANGDRPLFEVPQTSFVLADGQDELRIPLTFTSKDGSV
FIKTFVLKRNDYAIGVDYHVNNASAAPLELTLFGQLKQSINLPKKRDTGSNNFALQTYRGAAYSSDETKYKKYSFSDIED
KNLDITTKGGWVAMLQQYFATAWIPAANETNTFYSAELGNGLAAIGFKGAPVVIQPGEQKQLSATLWVGPEIQNKMAEIA
PHLDLTVDYGWLWFISQPLFKLLKFIHSFVGNWGFSIIVITFIVRGIMYPLTKAQYTSMAKMRLLQPKLAAMRERIGDDK
QRMSQEMMALYKAEKVNPLGGCLPLIIQMPIFLALYYMLMSSVELRHAPFILWIHDLSAQDPYYILPILMGITMYFIQKM
SPTTVTDPMQQKIMTFMPVIFTVFFLWFPAGLVLYYIVSNLVTILQQQLIYRGLEKRGLHSREKKK

Specific function: Required for the insertion of integral membrane proteins into the membrane. Probably plays an essential role in the integration of proteins of the respiratory chain complexes. Involved in integration of membrane proteins that insert dependently and indepe

COG id: COG0706

COG function: function code U; Preprotein translocase subunit YidC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the OXA1/oxaA family. Type 1 subfamily

Homologues:

Organism=Escherichia coli, GI1790140, Length=547, Percent_Identity=77.3308957952468, Blast_Score=870, Evalue=0.0,
Organism=Drosophila melanogaster, GI24662345, Length=206, Percent_Identity=25.2427184466019, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21356443, Length=206, Percent_Identity=25.2427184466019, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OXAA_YERPE (Q8Z9U3)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AB0498
- RefSeq:   NP_671407.1
- RefSeq:   NP_995271.1
- RefSeq:   YP_002348953.1
- ProteinModelPortal:   Q8Z9U3
- SMR:   Q8Z9U3
- IntAct:   Q8Z9U3
- GeneID:   1149063
- GeneID:   1176930
- GeneID:   2764769
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO4102
- KEGG:   ypk:y4117
- KEGG:   ypm:YP_4009
- HOGENOM:   HBG507812
- OMA:   TYRGAAF
- ProtClustDB:   PRK01318
- BioCyc:   YPES187410:Y4117-MONOMER
- BioCyc:   YPES214092:YPO4102-MONOMER
- HAMAP:   MF_01810
- InterPro:   IPR019998
- InterPro:   IPR001708
- PANTHER:   PTHR12428
- PRINTS:   PR00701
- PRINTS:   PR01900
- TIGRFAMs:   TIGR03593
- TIGRFAMs:   TIGR03592

Pfam domain/function: PF02096 60KD_IMP

EC number: NA

Molecular weight: Translated: 61292; Mature: 61292

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: PS00496 PII_GLNB_UMP

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xd3896c8)-; HASH(0x138f24b4)-; HASH(0x12fa61e4)-; HASH(0x1324018c)-; HASH(0x136a21b4)-;

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSQRNLLLIALLFVSFMIWQAWQVDNNPQPTAQTTQQTTNTATGDKASQAVPGSGQGQL
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCEE
ITVKTDVLSLTINTRGGDIEQANLLAYPDTLGSSNTFELLETTPSFVYQAQSGLTGKNGP
EEEEEEEEEEEEECCCCCCCCCCEEECCCCCCCCCCHHHHHCCHHHHHHHHCCCCCCCCC
DNPANGDRPLFEVPQTSFVLADGQDELRIPLTFTSKDGSVFIKTFVLKRNDYAIGVDYHV
CCCCCCCCCEEECCCCEEEEECCCCCEEEEEEEECCCCCEEEEEEEEECCCEEEEEEEEE
NNASAAPLELTLFGQLKQSINLPKKRDTGSNNFALQTYRGAAYSSDETKYKKYSFSDIED
CCCCCCCEEEEEHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHEECCCCCCCC
KNLDITTKGGWVAMLQQYFATAWIPAANETNTFYSAELGNGLAAIGFKGAPVVIQPGEQK
CCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCEEEECCCCCCEEECCCCCC
QLSATLWVGPEIQNKMAEIAPHLDLTVDYGWLWFISQPLFKLLKFIHSFVGNWGFSIIVI
CEEEEEEECHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
TFIVRGIMYPLTKAQYTSMAKMRLLQPKLAAMRERIGDDKQRMSQEMMALYKAEKVNPLG
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCC
GCLPLIIQMPIFLALYYMLMSSVELRHAPFILWIHDLSAQDPYYILPILMGITMYFIQKM
HHHHHHHHHHHHHHHHHHHHCCCHHCCCCEEEEEECCCCCCCEEHHHHHHHHHHHHHHHC
SPTTVTDPMQQKIMTFMPVIFTVFFLWFPAGLVLYYIVSNLVTILQQQLIYRGLEKRGLH
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SREKKK
CHHCCH
>Mature Secondary Structure
MDSQRNLLLIALLFVSFMIWQAWQVDNNPQPTAQTTQQTTNTATGDKASQAVPGSGQGQL
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCEE
ITVKTDVLSLTINTRGGDIEQANLLAYPDTLGSSNTFELLETTPSFVYQAQSGLTGKNGP
EEEEEEEEEEEEECCCCCCCCCCEEECCCCCCCCCCHHHHHCCHHHHHHHHCCCCCCCCC
DNPANGDRPLFEVPQTSFVLADGQDELRIPLTFTSKDGSVFIKTFVLKRNDYAIGVDYHV
CCCCCCCCCEEECCCCEEEEECCCCCEEEEEEEECCCCCEEEEEEEEECCCEEEEEEEEE
NNASAAPLELTLFGQLKQSINLPKKRDTGSNNFALQTYRGAAYSSDETKYKKYSFSDIED
CCCCCCCEEEEEHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHEECCCCCCCC
KNLDITTKGGWVAMLQQYFATAWIPAANETNTFYSAELGNGLAAIGFKGAPVVIQPGEQK
CCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCEEEECCCCCCEEECCCCCC
QLSATLWVGPEIQNKMAEIAPHLDLTVDYGWLWFISQPLFKLLKFIHSFVGNWGFSIIVI
CEEEEEEECHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
TFIVRGIMYPLTKAQYTSMAKMRLLQPKLAAMRERIGDDKQRMSQEMMALYKAEKVNPLG
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCC
GCLPLIIQMPIFLALYYMLMSSVELRHAPFILWIHDLSAQDPYYILPILMGITMYFIQKM
HHHHHHHHHHHHHHHHHHHHCCCHHCCCCEEEEEECCCCCCCEEHHHHHHHHHHHHHHHC
SPTTVTDPMQQKIMTFMPVIFTVFFLWFPAGLVLYYIVSNLVTILQQQLIYRGLEKRGLH
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SREKKK
CHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430