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The map label for this gene is tdcB [H]

Identifier: 22127973

GI number: 22127973

Start: 4555369

End: 4556406

Strand: Direct

Name: tdcB [H]

Synonym: y4105

Alternate gene names: 22127973

Gene position: 4555369-4556406 (Clockwise)

Preceding gene: 22127972

Following gene: 22127974

Centisome position: 99.01

GC content: 52.12

Gene sequence:

>1038_bases
TTGCAGGAAGCAGCTAGCGCGCAGACAACTTGCTGTACCACGGATATATTGAAAATAAAATTTAAAGGAATCGAGATGAA
TACGTTGTTTGATGCCATCAGAGAGGCCCACCAGATATTACGCCCACAAGTGAGAGTCACGCCGTTGGAGCATAGCCCAC
TGCTATCTCAACACAGCGGTTGTGAGATCTATCTTAAATGTGAGCACCTGCAGCACACCGGTTCTTTTAAATTTCGTGGG
GCCAGTAACAAGTTACGTTTACTCAATGAGGCACAACGCCAGCAAGGTGTGATCACCGCCTCCACCGGTAACCATGGGCA
AGGTGTGGCGCTGGCCGCAAAACTGGCGGGGATTAAATCCACTATTTACGCCCCAGAACAGGCGGCAGCCATCAAGCTGG
ATGTGATCCGTGCACTGGGGGGGCAAATTGAATTAGTCTCCGGAGATGCCTTAAATGCTGAACTGGCCGCCGGTATCGCC
GCTGAGCAACAAGGTAAAGTGTATATCTCACCGTATAACGACCCGCAGGTCATTGCCGGGCAAGGCACCTGTGGCATGGA
GATGGTCGAACAGCAGCCCGATCTTGATGCGGTGTTTGTTGCCGTTGGTGGTGGTGGCCTGATTTCAGGTATTGCGACCG
TATTGAAAACATTATCGGATAAAACGCAGGTGATTGGTTGCTGGCCAGCCAATGCCACCAGCCTGTATACCTGTCTGGAG
AAAGGACAGATTCAGGAGGTGGCAGAGCAAGAAACGCTGTCTGACGGAACCGCCGGTGGTATCGAACCGGGAGCGATCAC
CTTTGCACTGTGCCAACAGTTAATCGATCAGAAGGTGCTGGTGAGTGAGCAAGAAATCAAAGAGGCCATGGGTTTGATTG
CCCGTACTGACCGCTGGATGATTGAAGGTGCCGCCGGTGTGGCACTGGCTGCGGCACTGAAATTGGCTCCGCAATGGCAA
GGTAAGAAAGTGGCGGTGGTGTTGTGCGGTAAAAATATCGTGCTGGAGAAATATCTGGGAGCTGTCAGCGGATGCTAA

Upstream 100 bases:

>100_bases
ATGATAAGTTGCAAATGACATTTTTTGCTGAATATGTATGCCATTATGACACACAGAACGCCCCGTCATGTTTTGACGTA
TATCCCCCAAATAATTCGAG

Downstream 100 bases:

>100_bases
TTCTGAATAAACAAAAAATTCTCGACAAGTTCGATGCGGATCGCATCACATTATTGCTCAAAGAGGGCTTTATTGCTTTT
AGTCAGCAACGGGTCCAGAT

Product: hypothetical protein

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MQEAASAQTTCCTTDILKIKFKGIEMNTLFDAIREAHQILRPQVRVTPLEHSPLLSQHSGCEIYLKCEHLQHTGSFKFRG
ASNKLRLLNEAQRQQGVITASTGNHGQGVALAAKLAGIKSTIYAPEQAAAIKLDVIRALGGQIELVSGDALNAELAAGIA
AEQQGKVYISPYNDPQVIAGQGTCGMEMVEQQPDLDAVFVAVGGGGLISGIATVLKTLSDKTQVIGCWPANATSLYTCLE
KGQIQEVAEQETLSDGTAGGIEPGAITFALCQQLIDQKVLVSEQEIKEAMGLIARTDRWMIEGAAGVALAAALKLAPQWQ
GKKVAVVLCGKNIVLEKYLGAVSGC

Sequences:

>Translated_345_residues
MQEAASAQTTCCTTDILKIKFKGIEMNTLFDAIREAHQILRPQVRVTPLEHSPLLSQHSGCEIYLKCEHLQHTGSFKFRG
ASNKLRLLNEAQRQQGVITASTGNHGQGVALAAKLAGIKSTIYAPEQAAAIKLDVIRALGGQIELVSGDALNAELAAGIA
AEQQGKVYISPYNDPQVIAGQGTCGMEMVEQQPDLDAVFVAVGGGGLISGIATVLKTLSDKTQVIGCWPANATSLYTCLE
KGQIQEVAEQETLSDGTAGGIEPGAITFALCQQLIDQKVLVSEQEIKEAMGLIARTDRWMIEGAAGVALAAALKLAPQWQ
GKKVAVVLCGKNIVLEKYLGAVSGC
>Mature_345_residues
MQEAASAQTTCCTTDILKIKFKGIEMNTLFDAIREAHQILRPQVRVTPLEHSPLLSQHSGCEIYLKCEHLQHTGSFKFRG
ASNKLRLLNEAQRQQGVITASTGNHGQGVALAAKLAGIKSTIYAPEQAAAIKLDVIRALGGQIELVSGDALNAELAAGIA
AEQQGKVYISPYNDPQVIAGQGTCGMEMVEQQPDLDAVFVAVGGGGLISGIATVLKTLSDKTQVIGCWPANATSLYTCLE
KGQIQEVAEQETLSDGTAGGIEPGAITFALCQQLIDQKVLVSEQEIKEAMGLIARTDRWMIEGAAGVALAAALKLAPQWQ
GKKVAVVLCGKNIVLEKYLGAVSGC

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=315, Percent_Identity=36.1904761904762, Blast_Score=179, Evalue=2e-45,
Organism=Homo sapiens, GI295821202, Length=289, Percent_Identity=29.4117647058824, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI295821200, Length=289, Percent_Identity=29.4117647058824, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI4557415, Length=289, Percent_Identity=29.4117647058824, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1789505, Length=311, Percent_Identity=36.3344051446945, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1790207, Length=291, Percent_Identity=35.7388316151203, Blast_Score=142, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17508781, Length=314, Percent_Identity=32.8025477707006, Blast_Score=134, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI71991565, Length=307, Percent_Identity=34.8534201954397, Blast_Score=134, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI17537387, Length=308, Percent_Identity=35.0649350649351, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322631, Length=315, Percent_Identity=34.6031746031746, Blast_Score=168, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6320930, Length=337, Percent_Identity=33.8278931750742, Blast_Score=142, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6319788, Length=283, Percent_Identity=24.3816254416961, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321594, Length=281, Percent_Identity=27.4021352313167, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21355833, Length=321, Percent_Identity=37.6947040498442, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24645328, Length=210, Percent_Identity=37.1428571428571, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 36479; Mature: 36479

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEAASAQTTCCTTDILKIKFKGIEMNTLFDAIREAHQILRPQVRVTPLEHSPLLSQHSG
CCCCCCCCCCEEEEEEEEEEEECCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCC
CEIYLKCEHLQHTGSFKFRGASNKLRLLNEAQRQQGVITASTGNHGQGVALAAKLAGIKS
CEEEEEEEECCCCCCEEEECCCCHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHH
TIYAPEQAAAIKLDVIRALGGQIELVSGDALNAELAAGIAAEQQGKVYISPYNDPQVIAG
HCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHCCCCCCCCEEEECCCCCCEEEEC
QGTCGMEMVEQQPDLDAVFVAVGGGGLISGIATVLKTLSDKTQVIGCWPANATSLYTCLE
CCCCCHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHH
KGQIQEVAEQETLSDGTAGGIEPGAITFALCQQLIDQKVLVSEQEIKEAMGLIARTDRWM
CCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEE
IEGAAGVALAAALKLAPQWQGKKVAVVLCGKNIVLEKYLGAVSGC
EECCHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHCCC
>Mature Secondary Structure
MQEAASAQTTCCTTDILKIKFKGIEMNTLFDAIREAHQILRPQVRVTPLEHSPLLSQHSG
CCCCCCCCCCEEEEEEEEEEEECCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCC
CEIYLKCEHLQHTGSFKFRGASNKLRLLNEAQRQQGVITASTGNHGQGVALAAKLAGIKS
CEEEEEEEECCCCCCEEEECCCCHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHH
TIYAPEQAAAIKLDVIRALGGQIELVSGDALNAELAAGIAAEQQGKVYISPYNDPQVIAG
HCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHCCCCCCCCEEEECCCCCCEEEEC
QGTCGMEMVEQQPDLDAVFVAVGGGGLISGIATVLKTLSDKTQVIGCWPANATSLYTCLE
CCCCCHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHH
KGQIQEVAEQETLSDGTAGGIEPGAITFALCQQLIDQKVLVSEQEIKEAMGLIARTDRWM
CCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEE
IEGAAGVALAAALKLAPQWQGKKVAVVLCGKNIVLEKYLGAVSGC
EECCHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA