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The map label for this gene is hutU [H]

Identifier: 22127908

GI number: 22127908

Start: 4477784

End: 4479490

Strand: Reverse

Name: hutU [H]

Synonym: y4038

Alternate gene names: 22127908

Gene position: 4479490-4477784 (Counterclockwise)

Preceding gene: 22127917

Following gene: 22127907

Centisome position: 97.36

GC content: 51.14

Gene sequence:

>1707_bases
TTGAAGGAAATTGCCGTGACGACTCAAAACAGATTCCGAGATAATGAGATTCGAGCCCCGCAGGGTACGCAACTGACAGC
GAAAAGCTGGCTGACTGAAGCCGCGCTACGCATGCTGATGAATAACCTCGATCCTGACGTGGCTGAGAATCCAAAAGAAT
TAGTGGTCTACGGCGGTATTGGTCGCGCAGCCCGTAACTGGGAATGCTATGACAAGATTGTTGAAAGCCTGATCAATTTA
AACGATGACGAAACTTTGTTAATTCAATCGGGTAAGCCTGTCGGGATATTCAAAACCCACAGTAATGCGCCCAGGGTATT
GATTGCCAACTCGAATTTGGTACCTCATTGGGCTAATTGGGAACATTTTAATGAATTGGACGCCAAAGGGCTGGCTATGT
ATGGCCAGATGACGGCGGGCAGTTGGATCTATATTGGTAGCCAAGGCATTGTACAGGGTACTTATGAAACCTTTGTTGAA
GCGGGTCGCCAGCATTTTGGCGGTAGCCTGAAAGGGCGTTGGGTCTTGACTGCTGGGCTAGGAGGAATGGGCGGCGCGCA
ACCTTTGGCCGCAACGTTAGCTGGTGCATGTTCTCTGAACATCGAATGCCAACAAAGCCGCATCGATTTTCGTCTCAAAA
CCCGTTATGTGGATGAGCAAGCAACCGATCTGGATGATGCTTTAGCGCGCATCGAGAAATATACCGCTACAGGTGTCGCG
GTTTCTATTGCACTGTGCGGCAATGCGGCTGAAATCTTACCTGAGCTGGTGCGCCGTGGTGTTCGGCCTGATATGGTCAC
CGACCAAACCAGTGCTCATGATCCATTGAACGGTTATCTGCCGAAGGGTTGGAATTGGGAAGAGTACCGCCAACGCGCTC
AACATGAGCCAGCGCTGGTGATCAATGCCGCGAAAATCTCCATGGCAGAGCATGTTGAAGCGATGTTAGCCTTCCACAAC
ATGGGTATCCCAACCTTTGATTACGGCAATAATATCCGTCAAATGGCCCACGATATGGGGGTTATTCGTGCCTTTGATTT
CCCCGGTTTTGTTCCGGCGTATATTCGTCCTCTTTTTTGTCGTGGTATTGGCCCATTCCGTTGGGTCGCGTTGTCGGGTA
ACCCAGACGATATTTATAAAACCGATGCTAAGGTCAAAGCACTGATCCCTGATGATGCACATTTGCATCATTGGCTAGAT
ATGGCGCGTGAGCGTATTCGTTTTCAGGGGCTGCCAGCACGTATTTGCTGGGTTGGTCTAGGCCAGCGTGCCAAATTAGG
TTTGGCATTTAACGAAATGGTGCGCAGCGGCGAGCTCTCTGCGCCCGTTGTGATTGGCCGCGATCATCTGGATTCTGGAT
CGGTTGCCAGCCCTAATCGTGAAACGGAAGCGATGCAGGATGGCTCCGATGCGGTGTCTGACTGGCCGCTGCTCAATGCA
TTACTGAATACGGCTAGCGGTGCGACGTGGGTATCTCTGCATCATGGTGGTGGCGTAGGGATGGGCTTCTCGCAACATTC
AGGCATGGTGGTGGTTTGTGATGGCAGTGATGAAGCCGCTGAACGTATTGCCAGAGTACTACATAACGATCCGGCTACGG
GTGTGATGCGCCATGCAGATGCGGGTTATGACATTGCGGTTAACTGCGCGCAAGAGCAAGGACTTAACCTACCAATGGTT
GCCGCAACTCAGGGGAAAAAATCATGA

Upstream 100 bases:

>100_bases
TATTTGGCTTTTTTCTCTGATCTTGATTGTACTTGTCTATACAAGTATATGTTAATAAGCACTCAAGGTGAGTAATGTCG
TTTGACACCTGAAAAATTGG

Downstream 100 bases:

>100_bases
AGACAATAACACTACGTCCTGGTCAGATGACGCTGGCTGACTTACGGCATATTTATCAACATCCCGTACATATCACATTG
GATGAAAGTGCCTATGTACC

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 568; Mature: 568

Protein sequence:

>568_residues
MKEIAVTTQNRFRDNEIRAPQGTQLTAKSWLTEAALRMLMNNLDPDVAENPKELVVYGGIGRAARNWECYDKIVESLINL
NDDETLLIQSGKPVGIFKTHSNAPRVLIANSNLVPHWANWEHFNELDAKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVE
AGRQHFGGSLKGRWVLTAGLGGMGGAQPLAATLAGACSLNIECQQSRIDFRLKTRYVDEQATDLDDALARIEKYTATGVA
VSIALCGNAAEILPELVRRGVRPDMVTDQTSAHDPLNGYLPKGWNWEEYRQRAQHEPALVINAAKISMAEHVEAMLAFHN
MGIPTFDYGNNIRQMAHDMGVIRAFDFPGFVPAYIRPLFCRGIGPFRWVALSGNPDDIYKTDAKVKALIPDDAHLHHWLD
MARERIRFQGLPARICWVGLGQRAKLGLAFNEMVRSGELSAPVVIGRDHLDSGSVASPNRETEAMQDGSDAVSDWPLLNA
LLNTASGATWVSLHHGGGVGMGFSQHSGMVVVCDGSDEAAERIARVLHNDPATGVMRHADAGYDIAVNCAQEQGLNLPMV
AATQGKKS

Sequences:

>Translated_568_residues
MKEIAVTTQNRFRDNEIRAPQGTQLTAKSWLTEAALRMLMNNLDPDVAENPKELVVYGGIGRAARNWECYDKIVESLINL
NDDETLLIQSGKPVGIFKTHSNAPRVLIANSNLVPHWANWEHFNELDAKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVE
AGRQHFGGSLKGRWVLTAGLGGMGGAQPLAATLAGACSLNIECQQSRIDFRLKTRYVDEQATDLDDALARIEKYTATGVA
VSIALCGNAAEILPELVRRGVRPDMVTDQTSAHDPLNGYLPKGWNWEEYRQRAQHEPALVINAAKISMAEHVEAMLAFHN
MGIPTFDYGNNIRQMAHDMGVIRAFDFPGFVPAYIRPLFCRGIGPFRWVALSGNPDDIYKTDAKVKALIPDDAHLHHWLD
MARERIRFQGLPARICWVGLGQRAKLGLAFNEMVRSGELSAPVVIGRDHLDSGSVASPNRETEAMQDGSDAVSDWPLLNA
LLNTASGATWVSLHHGGGVGMGFSQHSGMVVVCDGSDEAAERIARVLHNDPATGVMRHADAGYDIAVNCAQEQGLNLPMV
AATQGKKS
>Mature_568_residues
MKEIAVTTQNRFRDNEIRAPQGTQLTAKSWLTEAALRMLMNNLDPDVAENPKELVVYGGIGRAARNWECYDKIVESLINL
NDDETLLIQSGKPVGIFKTHSNAPRVLIANSNLVPHWANWEHFNELDAKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVE
AGRQHFGGSLKGRWVLTAGLGGMGGAQPLAATLAGACSLNIECQQSRIDFRLKTRYVDEQATDLDDALARIEKYTATGVA
VSIALCGNAAEILPELVRRGVRPDMVTDQTSAHDPLNGYLPKGWNWEEYRQRAQHEPALVINAAKISMAEHVEAMLAFHN
MGIPTFDYGNNIRQMAHDMGVIRAFDFPGFVPAYIRPLFCRGIGPFRWVALSGNPDDIYKTDAKVKALIPDDAHLHHWLD
MARERIRFQGLPARICWVGLGQRAKLGLAFNEMVRSGELSAPVVIGRDHLDSGSVASPNRETEAMQDGSDAVSDWPLLNA
LLNTASGATWVSLHHGGGVGMGFSQHSGMVVVCDGSDEAAERIARVLHNDPATGVMRHADAGYDIAVNCAQEQGLNLPMV
AATQGKKS

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=572, Percent_Identity=33.041958041958, Blast_Score=294, Evalue=1e-79,
Organism=Homo sapiens, GI260306182, Length=219, Percent_Identity=38.3561643835616, Blast_Score=161, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71997891, Length=560, Percent_Identity=34.4642857142857, Blast_Score=316, Evalue=2e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 62076; Mature: 62076

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEIAVTTQNRFRDNEIRAPQGTQLTAKSWLTEAALRMLMNNLDPDVAENPKELVVYGGI
CCCEEEECHHCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCC
GRAARNWECYDKIVESLINLNDDETLLIQSGKPVGIFKTHSNAPRVLIANSNLVPHWANW
CCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCC
EHFNELDAKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRQHFGGSLKGRWVLTAGL
HHHHHCCCCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECC
GGMGGAQPLAATLAGACSLNIECQQSRIDFRLKTRYVDEQATDLDDALARIEKYTATGVA
CCCCCCHHHHHHHHHHEEEEEEEECCCCCEEEEEEECCCHHCCHHHHHHHHHHHHHCCEE
VSIALCGNAAEILPELVRRGVRPDMVTDQTSAHDPLNGYLPKGWNWEEYRQRAQHEPALV
EEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEE
INAAKISMAEHVEAMLAFHNMGIPTFDYGNNIRQMAHDMGVIRAFDFPGFVPAYIRPLFC
EEHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCEEEEECCCCCCHHHHHHHHH
RGIGPFRWVALSGNPDDIYKTDAKVKALIPDDAHLHHWLDMARERIRFQGLPARICWVGL
CCCCCEEEEEECCCCCHHEECCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEC
GQRAKLGLAFNEMVRSGELSAPVVIGRDHLDSGSVASPNRETEAMQDGSDAVSDWPLLNA
CCCCEECHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHH
LLNTASGATWVSLHHGGGVGMGFSQHSGMVVVCDGSDEAAERIARVLHNDPATGVMRHAD
HHHCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHCC
AGYDIAVNCAQEQGLNLPMVAATQGKKS
CCCEEEEEEHHHCCCCCCEEECCCCCCC
>Mature Secondary Structure
MKEIAVTTQNRFRDNEIRAPQGTQLTAKSWLTEAALRMLMNNLDPDVAENPKELVVYGGI
CCCEEEECHHCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCC
GRAARNWECYDKIVESLINLNDDETLLIQSGKPVGIFKTHSNAPRVLIANSNLVPHWANW
CCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCC
EHFNELDAKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRQHFGGSLKGRWVLTAGL
HHHHHCCCCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECC
GGMGGAQPLAATLAGACSLNIECQQSRIDFRLKTRYVDEQATDLDDALARIEKYTATGVA
CCCCCCHHHHHHHHHHEEEEEEEECCCCCEEEEEEECCCHHCCHHHHHHHHHHHHHCCEE
VSIALCGNAAEILPELVRRGVRPDMVTDQTSAHDPLNGYLPKGWNWEEYRQRAQHEPALV
EEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEE
INAAKISMAEHVEAMLAFHNMGIPTFDYGNNIRQMAHDMGVIRAFDFPGFVPAYIRPLFC
EEHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCEEEEECCCCCCHHHHHHHHH
RGIGPFRWVALSGNPDDIYKTDAKVKALIPDDAHLHHWLDMARERIRFQGLPARICWVGL
CCCCCEEEEEECCCCCHHEECCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEC
GQRAKLGLAFNEMVRSGELSAPVVIGRDHLDSGSVASPNRETEAMQDGSDAVSDWPLLNA
CCCCEECHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHH
LLNTASGATWVSLHHGGGVGMGFSQHSGMVVVCDGSDEAAERIARVLHNDPATGVMRHAD
HHHCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHCC
AGYDIAVNCAQEQGLNLPMVAATQGKKS
CCCEEEEEEHHHCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA