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The map label for this gene is proY [H]

Identifier: 22127906

GI number: 22127906

Start: 4474434

End: 4475852

Strand: Reverse

Name: proY [H]

Synonym: y4036

Alternate gene names: 22127906

Gene position: 4475852-4474434 (Counterclockwise)

Preceding gene: 22127907

Following gene: 22127905

Centisome position: 97.29

GC content: 48.98

Gene sequence:

>1419_bases
TTGCGAGAATGTACCATGAAGAATGATTCATCCACGCTCAAGCGCGGCCTTAGTGCACGGCATATCCGGTTTATGGCATT
AGGTTCTGCCATTGGTACTGGCCTATTTTATGGTTCGGCTGAGGCAATCCGTCTGGCGGGGCCTGCAGTGTTATTAGCTT
ATTTGATTGGCGGTGCGGCAGTCTTTATGGTGATGCGAGCCTTGGGCGAAATGGCCGTACATGACCCCGTGGCCGGCTCT
TTTGGTCACTATGCCAGCCGTTATCTGGGGCCATTGGCGGGGTTCCTGACGGGCTGGACCTATACCTTTGAAATGGTTGT
TGTGGCACTGGCTGATGTTACCGCTTTTGGTATTTATATGGGGCTGTGGTTTCCTGATGCGCCCCAATGGGTATGGGTGC
TAAGTATCATTTTCTTTATCGGTGCGCTGAATCTATGTTCAGTGAAAGTCTTTGGTGAAATGGAGTTCTGGCTCTCGTTG
CTAAAAGTGGCTGCCATTATCGCCATGATTGCCGCAGGTTTGGGCATTATGATGTTTGGTTTCGGGGCGGGGCATGACAG
CACAGGCGTCAGTAATTTATGGGCTCATCAAGGGTTTATGCCAAATGGGATCACGGGGGTGATTGCATCATTTGCTGTAG
TGATGTTTGCTTTTGGGGGAATTGAAATTATTGGGGTGACGGCCAGTGAAGCGAAGGATCCGGGAAAGGTATTACCACGA
GCCATCAATACAGTGCCAATACGTATTCTATTGTTCTATGTTTTGACCCTGTTTGTCCTGATGGCTATCTATCCGTGGAA
TAGTATTGGGCAAAATGGCAGCCCCTTTGTGGAGATTTTTAGTAGTTTAGGCATAAACTCTGCCGCTAATATTCTTAATT
TGGTGGTAATAACCGCTGCAATTTCAGCGATTAACAGTGATATTTACGGTGCTGGCCGTATGATGTACGGCCTCGCGCAG
GAAGGATTGGCCCCTAAGAGCTTCAGTCGATTGACACGTAATGGCGTGCCCTATATGACTATCTTGGTGATGGCGATTAC
GCTGCTGTGCGGTGTGGTATTGAATTACCTTATCCCGAAAAACGTGTTCTTGGTTATTGCATCGATCGCCACTTTTGCAA
CCGTCTGGGTGTGGCTAATGATTCTGGTATCACAAGTGGCTATGCGCCGCTCAATGAGCAAAGCACAAGTCGCTCGGCTG
GCATTCCCCGTGCCATTTTGGCCGCTAGCGCCTATCCTTACCATTCTCTTTATGGCCTTTATTATTGCTGTGTTAGGTTA
CTTCCCTGCGACTCGTATTGCGATGTATGTCGGCCTGGCGTGGGTGGCATTAATGACACTGGCGTGGTGGATTTGGTTAC
GTAAAGCCCCTTCATGCGTTATTCAAGAGCGGGCGAAAAGCAGTGAGATGCCATCGTAA

Upstream 100 bases:

>100_bases
TTCACTGTAAAAAAACCAGTTCGCTGTAAAAACCCAGTTCAATGGAGGCTCTGATTACCGGATCCTCCTCTCTGAATCCC
TGCCTGAAAAGGCACAAACT

Downstream 100 bases:

>100_bases
GGGAACAAATGTTAACGGGCGGTTGATGGGGTATCAGCGGCCCGATTTATTTTTTTCAAGCATGTGGCGGTAGTGAGGGT
GGGTTAAGTACCAATTTTTG

Product: aromatic amino acid permease

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MRECTMKNDSSTLKRGLSARHIRFMALGSAIGTGLFYGSAEAIRLAGPAVLLAYLIGGAAVFMVMRALGEMAVHDPVAGS
FGHYASRYLGPLAGFLTGWTYTFEMVVVALADVTAFGIYMGLWFPDAPQWVWVLSIIFFIGALNLCSVKVFGEMEFWLSL
LKVAAIIAMIAAGLGIMMFGFGAGHDSTGVSNLWAHQGFMPNGITGVIASFAVVMFAFGGIEIIGVTASEAKDPGKVLPR
AINTVPIRILLFYVLTLFVLMAIYPWNSIGQNGSPFVEIFSSLGINSAANILNLVVITAAISAINSDIYGAGRMMYGLAQ
EGLAPKSFSRLTRNGVPYMTILVMAITLLCGVVLNYLIPKNVFLVIASIATFATVWVWLMILVSQVAMRRSMSKAQVARL
AFPVPFWPLAPILTILFMAFIIAVLGYFPATRIAMYVGLAWVALMTLAWWIWLRKAPSCVIQERAKSSEMPS

Sequences:

>Translated_472_residues
MRECTMKNDSSTLKRGLSARHIRFMALGSAIGTGLFYGSAEAIRLAGPAVLLAYLIGGAAVFMVMRALGEMAVHDPVAGS
FGHYASRYLGPLAGFLTGWTYTFEMVVVALADVTAFGIYMGLWFPDAPQWVWVLSIIFFIGALNLCSVKVFGEMEFWLSL
LKVAAIIAMIAAGLGIMMFGFGAGHDSTGVSNLWAHQGFMPNGITGVIASFAVVMFAFGGIEIIGVTASEAKDPGKVLPR
AINTVPIRILLFYVLTLFVLMAIYPWNSIGQNGSPFVEIFSSLGINSAANILNLVVITAAISAINSDIYGAGRMMYGLAQ
EGLAPKSFSRLTRNGVPYMTILVMAITLLCGVVLNYLIPKNVFLVIASIATFATVWVWLMILVSQVAMRRSMSKAQVARL
AFPVPFWPLAPILTILFMAFIIAVLGYFPATRIAMYVGLAWVALMTLAWWIWLRKAPSCVIQERAKSSEMPS
>Mature_472_residues
MRECTMKNDSSTLKRGLSARHIRFMALGSAIGTGLFYGSAEAIRLAGPAVLLAYLIGGAAVFMVMRALGEMAVHDPVAGS
FGHYASRYLGPLAGFLTGWTYTFEMVVVALADVTAFGIYMGLWFPDAPQWVWVLSIIFFIGALNLCSVKVFGEMEFWLSL
LKVAAIIAMIAAGLGIMMFGFGAGHDSTGVSNLWAHQGFMPNGITGVIASFAVVMFAFGGIEIIGVTASEAKDPGKVLPR
AINTVPIRILLFYVLTLFVLMAIYPWNSIGQNGSPFVEIFSSLGINSAANILNLVVITAAISAINSDIYGAGRMMYGLAQ
EGLAPKSFSRLTRNGVPYMTILVMAITLLCGVVLNYLIPKNVFLVIASIATFATVWVWLMILVSQVAMRRSMSKAQVARL
AFPVPFWPLAPILTILFMAFIIAVLGYFPATRIAMYVGLAWVALMTLAWWIWLRKAPSCVIQERAKSSEMPS

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of proline [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=362, Percent_Identity=24.8618784530387, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI181337167, Length=321, Percent_Identity=25.5451713395639, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI258645169, Length=437, Percent_Identity=22.1967963386728, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI258614005, Length=371, Percent_Identity=22.3719676549865, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI258614003, Length=371, Percent_Identity=22.3719676549865, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786602, Length=442, Percent_Identity=61.0859728506787, Blast_Score=530, Evalue=1e-152,
Organism=Escherichia coli, GI1786789, Length=454, Percent_Identity=43.3920704845815, Blast_Score=380, Evalue=1e-106,
Organism=Escherichia coli, GI1786302, Length=444, Percent_Identity=44.3693693693694, Blast_Score=373, Evalue=1e-104,
Organism=Escherichia coli, GI48994972, Length=436, Percent_Identity=42.8899082568807, Blast_Score=354, Evalue=5e-99,
Organism=Escherichia coli, GI1790653, Length=446, Percent_Identity=41.4798206278027, Blast_Score=350, Evalue=2e-97,
Organism=Escherichia coli, GI87081708, Length=472, Percent_Identity=38.5593220338983, Blast_Score=304, Evalue=9e-84,
Organism=Escherichia coli, GI87081915, Length=398, Percent_Identity=37.6884422110553, Blast_Score=291, Evalue=6e-80,
Organism=Escherichia coli, GI1789017, Length=428, Percent_Identity=36.214953271028, Blast_Score=260, Evalue=2e-70,
Organism=Escherichia coli, GI1788480, Length=441, Percent_Identity=36.0544217687075, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI87081869, Length=195, Percent_Identity=26.1538461538462, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI87082023, Length=283, Percent_Identity=24.7349823321555, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17532491, Length=422, Percent_Identity=22.7488151658768, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17531343, Length=380, Percent_Identity=23.1578947368421, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17540018, Length=417, Percent_Identity=27.0983213429257, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17533459, Length=337, Percent_Identity=23.7388724035608, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324061, Length=446, Percent_Identity=32.2869955156951, Blast_Score=208, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6324990, Length=423, Percent_Identity=33.5697399527187, Blast_Score=198, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6320772, Length=441, Percent_Identity=32.6530612244898, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6324924, Length=452, Percent_Identity=29.8672566371681, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6324059, Length=488, Percent_Identity=29.3032786885246, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6324553, Length=395, Percent_Identity=32.1518987341772, Blast_Score=174, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6322892, Length=475, Percent_Identity=29.2631578947368, Blast_Score=171, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6320717, Length=404, Percent_Identity=27.970297029703, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6319824, Length=401, Percent_Identity=27.6807980049875, Blast_Score=160, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6321629, Length=419, Percent_Identity=27.9236276849642, Blast_Score=155, Evalue=9e-39,
Organism=Saccharomyces cerevisiae, GI6319543, Length=399, Percent_Identity=28.0701754385965, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6319542, Length=406, Percent_Identity=29.064039408867, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6320251, Length=404, Percent_Identity=27.970297029703, Blast_Score=152, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6321053, Length=431, Percent_Identity=26.9141531322506, Blast_Score=150, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6322967, Length=401, Percent_Identity=29.426433915212, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6319608, Length=467, Percent_Identity=25.9100642398287, Blast_Score=143, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6324981, Length=401, Percent_Identity=28.6783042394015, Blast_Score=134, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6320364, Length=498, Percent_Identity=23.2931726907631, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24667468, Length=411, Percent_Identity=22.8710462287105, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI221512776, Length=413, Percent_Identity=22.0338983050847, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24666159, Length=413, Percent_Identity=22.0338983050847, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI161077963, Length=356, Percent_Identity=24.7191011235955, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51116; Mature: 51116

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]