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The map label for this gene is ppiA [H]

Identifier: 22127821

GI number: 22127821

Start: 4409170

End: 4409769

Strand: Direct

Name: ppiA [H]

Synonym: y3951

Alternate gene names: 22127821

Gene position: 4409170-4409769 (Clockwise)

Preceding gene: 22127818

Following gene: 22127822

Centisome position: 95.84

GC content: 45.33

Gene sequence:

>600_bases
TTGTCCGCATCCCATAGAAAGGAACCGTTAATGTTTAAACGTACTTTAGTGACCTTCATTGCCCTATGTTCCCTCAGCGC
CGTAGCGCCTGCTGCTTTAGCTGCCGGTGAGCCTCATGTGTTGTTAACAACGTCGGCCGGGAATATTGAGCTGGAGCTCA
ATAGCCAGAAGGCACCCATTTCAACCCAGAATTTCGTTGATTATGTTAACAATGGTTACTATAACAACACTATTTTCCAC
CGTGTTATCCCTGGCTTTATGATTCAAGGCGGCGGTTTTACCGCAGATTTCAAAGAAAAAACGCCTAAAACACCAATCAA
AAATGAAGCAGATAATGGCCTGCGTAACCTACGTGGTACCATTTCGATGGCCCGTACTGCAGATAAAGACAGCGCCACCA
GTCAGTTCTTCTTGAACGTGGCAGACAATGCTTTCCTTGACCACGGCCAACGTGACTTTGGTTATGCGGTATTCGGTAAA
GTCGTTAAAGGCATGGATGTCGTCGAAAAAATTTCTCAGGTTCAGACAGAAAACGTCGGCCCTTATCAGAATGTACCCGT
TAAACCGATCACTATCCTGTCAGCAAAAGTTTTACCTTAA

Upstream 100 bases:

>100_bases
TGTGGCGGGTTTTCAGTGAAAATGTGCATTCTGTTACGTAAATATCCGTAAATGGGTGGCATTGCGTGGGTCAGCTCTCT
AGAATCAAAGCGCTTTTCCG

Downstream 100 bases:

>100_bases
TTGGGGTTGTTGAAACAGAGCTCGCAGCGGAGGGAAGAAGCAGATTGTAAAGACGCCGTCTTCCCCGCATAAAAATAATA
TCCATGTAGGCTCAAGCCGC

Product: peptidyl-prolyl cis-trans isomerase A (rotamase A)

Products: NA

Alternate protein names: PPIase A; Cyclophilin A; Rotamase A [H]

Number of amino acids: Translated: 199; Mature: 198

Protein sequence:

>199_residues
MSASHRKEPLMFKRTLVTFIALCSLSAVAPAALAAGEPHVLLTTSAGNIELELNSQKAPISTQNFVDYVNNGYYNNTIFH
RVIPGFMIQGGGFTADFKEKTPKTPIKNEADNGLRNLRGTISMARTADKDSATSQFFLNVADNAFLDHGQRDFGYAVFGK
VVKGMDVVEKISQVQTENVGPYQNVPVKPITILSAKVLP

Sequences:

>Translated_199_residues
MSASHRKEPLMFKRTLVTFIALCSLSAVAPAALAAGEPHVLLTTSAGNIELELNSQKAPISTQNFVDYVNNGYYNNTIFH
RVIPGFMIQGGGFTADFKEKTPKTPIKNEADNGLRNLRGTISMARTADKDSATSQFFLNVADNAFLDHGQRDFGYAVFGK
VVKGMDVVEKISQVQTENVGPYQNVPVKPITILSAKVLP
>Mature_198_residues
SASHRKEPLMFKRTLVTFIALCSLSAVAPAALAAGEPHVLLTTSAGNIELELNSQKAPISTQNFVDYVNNGYYNNTIFHR
VIPGFMIQGGGFTADFKEKTPKTPIKNEADNGLRNLRGTISMARTADKDSATSQFFLNVADNAFLDHGQRDFGYAVFGKV
VKGMDVVEKISQVQTENVGPYQNVPVKPITILSAKVLP

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI64276486, Length=164, Percent_Identity=37.1951219512195, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI24308049, Length=178, Percent_Identity=35.9550561797753, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI7706339, Length=173, Percent_Identity=32.9479768786127, Blast_Score=84, Evalue=6e-17,
Organism=Homo sapiens, GI19557636, Length=158, Percent_Identity=32.2784810126582, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI22547212, Length=163, Percent_Identity=32.5153374233129, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI7657473, Length=163, Percent_Identity=32.5153374233129, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI22547215, Length=163, Percent_Identity=32.5153374233129, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI4758950, Length=158, Percent_Identity=34.8101265822785, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1789763, Length=190, Percent_Identity=79.4736842105263, Blast_Score=316, Evalue=6e-88,
Organism=Escherichia coli, GI1786736, Length=161, Percent_Identity=52.7950310559006, Blast_Score=166, Evalue=9e-43,
Organism=Caenorhabditis elegans, GI17532641, Length=162, Percent_Identity=34.5679012345679, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17539496, Length=169, Percent_Identity=36.6863905325444, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71980590, Length=142, Percent_Identity=38.0281690140845, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71980594, Length=142, Percent_Identity=38.0281690140845, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71997782, Length=147, Percent_Identity=36.734693877551, Blast_Score=81, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17506311, Length=157, Percent_Identity=32.484076433121, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17565860, Length=197, Percent_Identity=30.9644670050761, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320510, Length=128, Percent_Identity=38.28125, Blast_Score=68, Evalue=9e-13,
Organism=Drosophila melanogaster, GI17986117, Length=167, Percent_Identity=38.3233532934132, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI19922376, Length=163, Percent_Identity=32.5153374233129, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21357249, Length=162, Percent_Identity=33.9506172839506, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI19922912, Length=158, Percent_Identity=34.1772151898734, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI20130249, Length=174, Percent_Identity=33.9080459770115, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45549139, Length=153, Percent_Identity=34.640522875817, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 21664; Mature: 21533

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASHRKEPLMFKRTLVTFIALCSLSAVAPAALAAGEPHVLLTTSAGNIELELNSQKAPI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEEECCCCCCC
STQNFVDYVNNGYYNNTIFHRVIPGFMIQGGGFTADFKEKTPKTPIKNEADNGLRNLRGT
CHHHHHHHHHCCCCCCCHHHHHCCCEEEECCCCCCCHHHCCCCCCCCCCHHHHHHHHHHH
ISMARTADKDSATSQFFLNVADNAFLDHGQRDFGYAVFGKVVKGMDVVEKISQVQTENVG
HHHHHHCCCCCCCHHEEEECCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
PYQNVPVKPITILSAKVLP
CCCCCCCCCEEEEEEECCC
>Mature Secondary Structure 
SASHRKEPLMFKRTLVTFIALCSLSAVAPAALAAGEPHVLLTTSAGNIELELNSQKAPI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEEECCCCCCC
STQNFVDYVNNGYYNNTIFHRVIPGFMIQGGGFTADFKEKTPKTPIKNEADNGLRNLRGT
CHHHHHHHHHCCCCCCCHHHHHCCCEEEECCCCCCCHHHCCCCCCCCCCHHHHHHHHHHH
ISMARTADKDSATSQFFLNVADNAFLDHGQRDFGYAVFGKVVKGMDVVEKISQVQTENVG
HHHHHHCCCCCCCHHEEEECCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
PYQNVPVKPITILSAKVLP
CCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]