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The map label for this gene is shlB [H]

Identifier: 22127695

GI number: 22127695

Start: 4253228

End: 4255015

Strand: Direct

Name: shlB [H]

Synonym: y3824

Alternate gene names: 22127695

Gene position: 4253228-4255015 (Clockwise)

Preceding gene: 22127694

Following gene: 22127696

Centisome position: 92.45

GC content: 45.75

Gene sequence:

>1788_bases
TTGATTGAAATGGAGTTCATTAGCATGATATTTAAAATAAATGTGAGGTGGAGGGATAAAATTGGAGATTTTTGGTGGGG
GATATTGTGCCTATTATATCTTCAAATTATGATTGGGATGCTTCCGTTTAAAGTTTTTGCTGAAATGGCGTTGCCAGAAA
TGGACCTGCTTGAAATGGATATAGCCGAGCCGCAGATCCCAAATAGTATTATTCCTCCTCTATCACATGCTCAACTGGCC
AGTGAACCGGTTCTGCCAGAGAATCTTTATAATGATGAAGTACAATGTGTAGCAATTAATAATGTCGAATTGATTAATCT
TGATGCTTTCCCAAATGCAGCTCACTTAAAAGAAAAGGCTGAAGAAGCTCACGGGCGTTGCTTGGGGGAACAGGGGCTGT
CAGTGCTTGTGGCTAACTTACAGCAACAATTAGTGGTTGATGGCTATATCACGTCTCGTGTGGTTTTTGTCGATGACAGT
GAGCGTGACGGTACTTTAATGTTGAAATTAATGCCCGGCAGGATTGAGGATATCAGGCATCATCAAGATAGCGTCGGCAA
TGCTCATCTCAGCTCCCTTTTCCCCGGTAAACGTGGTGATTTGGTTAATTTACGCCATCTTGAGCAAGGATTAGAAAACT
TGCAGCGTTTGCCTTCAGTGAATGCCACCCTGGATGTCGAATTAAACCGGGACGATTTAAGCAGCCAGATTATCGTGAAT
CGCCAGCAATCACGTCTCTGGCGTATTAATGCCTACCTTGATGATGCAGGGCATGATGCCGTTGGCCGCTATCGTACGGG
CCTGATATTGTCTTTTGATAATCCATTATCCCGTTATAACCCCTTGTCTCTCAGTGATTTACTCTACTTCTCTGTTAACC
GTGACCTTGATAGCCAACCCGATAAAGGGCACAACAGCTACGGGGTTCATTATTCTGTCCCGTATGGCAACTGGCTATTT
AGCATGACGGGCAATCAAGGTGAGCGTTATCAATCGTTCTCTTTTGCCGGTAAAAGACTTGCCGGTAAAAAATTTGGCTA
TCGTTCCCATTGGTCTGTATTGGATACACAAATTCAACATTTACTCACCCGTGGAGTAAATTATAAAACAGTGGGTTATG
CCGGGGTGTTAATTCGTCAGTCTGCCAGTTTTTGGACCCATCGGGAGATAGATATTCAGCGGTTCAATACCACGGACTGG
CAGCTAGGGATTGAGCATCTACATTACATGCCATGGGCGACTTTCAGAGGGGGGGTTCGTTATCAACAGGGGGCTTCATG
GTTTGGTGCCCAACCTATTCCCGGTAAAATGAGCACTGCACCGGCGAGGTTGGTCGATATCACCAGCTCACTGGATATCC
CTTTTAAGATCGGAACACAGTCCTTCCAGTATCGGCCCGCTTTCAGCCAGCAACATACCTACTCGGATATTAGTTCACTG
GATAAATTTACGATTGGTGGCAGGAGTTCAGTGCGAGGTTTTAATGAGAATAACGCTCTGACGGGGTCGCGGGGGTGGTC
TCTAAAAAATGATATTTCATGGATCAGCCCGATACCCGGCCAGACATTCGTGGGCCAGCAATTCTATATCGGCATGGATT
ATGGTGAGGTGAGTGAGCAGGGCCAACCATTTCTTTTGGGCGAGCGTTTAGCGGGGGCCGTGGTAGGGACTCGTGGAAAT
TATCATGCGTTTGGTTACGATTTTAATGTCGGCGTGCCGATAACCAAACCCGCAGAATTTGATGCCGATCCGTTGGTTTT
TGGGTTTACGCTAACTTGGCAATATTAG

Upstream 100 bases:

>100_bases
TTCTGATTTTAATTAATTTCTTTGTAAGTGAGAGATGATTTTTTATTTAAAGTTAGTTGCTTTCGTGGCTAACTTTTATT
GATTTTGTATTAATCGTGTT

Downstream 100 bases:

>100_bases
GGTCTATACCTTCTCTGATGTTGAGTGTTTATTGTGCTGCCCTGATTAGGGGCATCACTATGGTGCACCTCTTTGGGAAG
CTATGTGGTTTCTTGGGTGA

Product: hemolysin activator protein precursor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 595; Mature: 595

Protein sequence:

>595_residues
MIEMEFISMIFKINVRWRDKIGDFWWGILCLLYLQIMIGMLPFKVFAEMALPEMDLLEMDIAEPQIPNSIIPPLSHAQLA
SEPVLPENLYNDEVQCVAINNVELINLDAFPNAAHLKEKAEEAHGRCLGEQGLSVLVANLQQQLVVDGYITSRVVFVDDS
ERDGTLMLKLMPGRIEDIRHHQDSVGNAHLSSLFPGKRGDLVNLRHLEQGLENLQRLPSVNATLDVELNRDDLSSQIIVN
RQQSRLWRINAYLDDAGHDAVGRYRTGLILSFDNPLSRYNPLSLSDLLYFSVNRDLDSQPDKGHNSYGVHYSVPYGNWLF
SMTGNQGERYQSFSFAGKRLAGKKFGYRSHWSVLDTQIQHLLTRGVNYKTVGYAGVLIRQSASFWTHREIDIQRFNTTDW
QLGIEHLHYMPWATFRGGVRYQQGASWFGAQPIPGKMSTAPARLVDITSSLDIPFKIGTQSFQYRPAFSQQHTYSDISSL
DKFTIGGRSSVRGFNENNALTGSRGWSLKNDISWISPIPGQTFVGQQFYIGMDYGEVSEQGQPFLLGERLAGAVVGTRGN
YHAFGYDFNVGVPITKPAEFDADPLVFGFTLTWQY

Sequences:

>Translated_595_residues
MIEMEFISMIFKINVRWRDKIGDFWWGILCLLYLQIMIGMLPFKVFAEMALPEMDLLEMDIAEPQIPNSIIPPLSHAQLA
SEPVLPENLYNDEVQCVAINNVELINLDAFPNAAHLKEKAEEAHGRCLGEQGLSVLVANLQQQLVVDGYITSRVVFVDDS
ERDGTLMLKLMPGRIEDIRHHQDSVGNAHLSSLFPGKRGDLVNLRHLEQGLENLQRLPSVNATLDVELNRDDLSSQIIVN
RQQSRLWRINAYLDDAGHDAVGRYRTGLILSFDNPLSRYNPLSLSDLLYFSVNRDLDSQPDKGHNSYGVHYSVPYGNWLF
SMTGNQGERYQSFSFAGKRLAGKKFGYRSHWSVLDTQIQHLLTRGVNYKTVGYAGVLIRQSASFWTHREIDIQRFNTTDW
QLGIEHLHYMPWATFRGGVRYQQGASWFGAQPIPGKMSTAPARLVDITSSLDIPFKIGTQSFQYRPAFSQQHTYSDISSL
DKFTIGGRSSVRGFNENNALTGSRGWSLKNDISWISPIPGQTFVGQQFYIGMDYGEVSEQGQPFLLGERLAGAVVGTRGN
YHAFGYDFNVGVPITKPAEFDADPLVFGFTLTWQY
>Mature_595_residues
MIEMEFISMIFKINVRWRDKIGDFWWGILCLLYLQIMIGMLPFKVFAEMALPEMDLLEMDIAEPQIPNSIIPPLSHAQLA
SEPVLPENLYNDEVQCVAINNVELINLDAFPNAAHLKEKAEEAHGRCLGEQGLSVLVANLQQQLVVDGYITSRVVFVDDS
ERDGTLMLKLMPGRIEDIRHHQDSVGNAHLSSLFPGKRGDLVNLRHLEQGLENLQRLPSVNATLDVELNRDDLSSQIIVN
RQQSRLWRINAYLDDAGHDAVGRYRTGLILSFDNPLSRYNPLSLSDLLYFSVNRDLDSQPDKGHNSYGVHYSVPYGNWLF
SMTGNQGERYQSFSFAGKRLAGKKFGYRSHWSVLDTQIQHLLTRGVNYKTVGYAGVLIRQSASFWTHREIDIQRFNTTDW
QLGIEHLHYMPWATFRGGVRYQQGASWFGAQPIPGKMSTAPARLVDITSSLDIPFKIGTQSFQYRPAFSQQHTYSDISSL
DKFTIGGRSSVRGFNENNALTGSRGWSLKNDISWISPIPGQTFVGQQFYIGMDYGEVSEQGQPFLLGERLAGAVVGTRGN
YHAFGYDFNVGVPITKPAEFDADPLVFGFTLTWQY

Specific function: Member of a two partner secretion pathway (TPS) in which it mediates the secretion of hemolysin [H]

COG id: COG2831

COG function: function code U; Hemolysin activation/secretion protein

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tpsB (TC 1.B.20) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005565
- InterPro:   IPR013686 [H]

Pfam domain/function: PF08479 POTRA_2; PF03865 ShlB [H]

EC number: NA

Molecular weight: Translated: 67249; Mature: 67249

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEMEFISMIFKINVRWRDKIGDFWWGILCLLYLQIMIGMLPFKVFAEMALPEMDLLEMD
CCCHHHEEEEHEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCC
IAEPQIPNSIIPPLSHAQLASEPVLPENLYNDEVQCVAINNVELINLDAFPNAAHLKEKA
CCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCEEEEEECCEEEEEECCCCCHHHHHHHH
EEAHGRCLGEQGLSVLVANLQQQLVVDGYITSRVVFVDDSERDGTLMLKLMPGRIEDIRH
HHHHCCCHHHHHHHHHHHHHHHHHEEEEEEEEEEEEEECCCCCCEEEEEECCCHHHHHHH
HQDSVGNAHLSSLFPGKRGDLVNLRHLEQGLENLQRLPSVNATLDVELNRDDLSSQIIVN
HHHHCCCCHHHHCCCCCCCCEEEHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEE
RQQSRLWRINAYLDDAGHDAVGRYRTGLILSFDNPLSRYNPLSLSDLLYFSVNRDLDSQP
CCCCCEEEEEEEECCCCCCCCCHHHCEEEEEECCCHHHCCCCCHHHEEEEEECCCCCCCC
DKGHNSYGVHYSVPYGNWLFSMTGNQGERYQSFSFAGKRLAGKKFGYRSHWSVLDTQIQH
CCCCCCCCEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
LLTRGVNYKTVGYAGVLIRQSASFWTHREIDIQRFNTTDWQLGIEHLHYMPWATFRGGVR
HHHCCCCEEEECEEEEEEECCCCCCEEEEEEEEECCCCHHHHHHHHHHCCCCHHHCCCEE
YQQGASWFGAQPIPGKMSTAPARLVDITSSLDIPFKIGTQSFQYRPAFSQQHTYSDISSL
ECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEECCCCEEECCCCCCCCCHHHHHHH
DKFTIGGRSSVRGFNENNALTGSRGWSLKNDISWISPIPGQTFVGQQFYIGMDYGEVSEQ
HHEECCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHCCC
GQPFLLGERLAGAVVGTRGNYHAFGYDFNVGVPITKPAEFDADPLVFGFTLTWQY
CCCEEEHHHHCCEEEECCCCEEEEEEEEECCCCCCCCCCCCCCCEEEEEEEEEEC
>Mature Secondary Structure
MIEMEFISMIFKINVRWRDKIGDFWWGILCLLYLQIMIGMLPFKVFAEMALPEMDLLEMD
CCCHHHEEEEHEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCC
IAEPQIPNSIIPPLSHAQLASEPVLPENLYNDEVQCVAINNVELINLDAFPNAAHLKEKA
CCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCEEEEEECCEEEEEECCCCCHHHHHHHH
EEAHGRCLGEQGLSVLVANLQQQLVVDGYITSRVVFVDDSERDGTLMLKLMPGRIEDIRH
HHHHCCCHHHHHHHHHHHHHHHHHEEEEEEEEEEEEEECCCCCCEEEEEECCCHHHHHHH
HQDSVGNAHLSSLFPGKRGDLVNLRHLEQGLENLQRLPSVNATLDVELNRDDLSSQIIVN
HHHHCCCCHHHHCCCCCCCCEEEHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEE
RQQSRLWRINAYLDDAGHDAVGRYRTGLILSFDNPLSRYNPLSLSDLLYFSVNRDLDSQP
CCCCCEEEEEEEECCCCCCCCCHHHCEEEEEECCCHHHCCCCCHHHEEEEEECCCCCCCC
DKGHNSYGVHYSVPYGNWLFSMTGNQGERYQSFSFAGKRLAGKKFGYRSHWSVLDTQIQH
CCCCCCCCEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
LLTRGVNYKTVGYAGVLIRQSASFWTHREIDIQRFNTTDWQLGIEHLHYMPWATFRGGVR
HHHCCCCEEEECEEEEEEECCCCCCEEEEEEEEECCCCHHHHHHHHHHCCCCHHHCCCEE
YQQGASWFGAQPIPGKMSTAPARLVDITSSLDIPFKIGTQSFQYRPAFSQQHTYSDISSL
ECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEECCCCEEECCCCCCCCCHHHHHHH
DKFTIGGRSSVRGFNENNALTGSRGWSLKNDISWISPIPGQTFVGQQFYIGMDYGEVSEQ
HHEECCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHCCC
GQPFLLGERLAGAVVGTRGNYHAFGYDFNVGVPITKPAEFDADPLVFGFTLTWQY
CCCEEEHHHHCCEEEECCCCEEEEEEEEECCCCCCCCCCCCCCCEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3290200 [H]