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The map label for this gene is serA [H]

Identifier: 22127177

GI number: 22127177

Start: 3633170

End: 3634513

Strand: Reverse

Name: serA [H]

Synonym: y3301

Alternate gene names: 22127177

Gene position: 3634513-3633170 (Counterclockwise)

Preceding gene: 22127178

Following gene: 22127174

Centisome position: 79.0

GC content: 48.66

Gene sequence:

>1344_bases
TTGTATTGCTGCTTACGTAATATTTGTTATGTTGACAGGGTGCTGACCGGATTCATTCGATATCGGCAGCCGCATCTGAA
GTCTGAAAATAGGGTCGGGGACATGGCAAAAGTATCACTGGAGAAAGACAGAATTAAGTTTCTGTTAGTGGAAGGGGTGC
ACCAGAGCGCGGTTGATAACCTGCGTGCAGCCGGATATAGCAATATTGAATACCATAAAGGTGCCTTAGACGCCGAATCA
CTGAAGGCATCCATTCGTGATGCTCACTTTATCGGAATTAGATCGCGCACTCATCTTTCCGAAGACGTTTTTGCGGCAGC
AGAAAAATTGGTTGCTGTGGGGTGTTTCTGTATCGGTACTAACCAGGTTGATTTAAAAGCGGCGACCAAACGTGGTGTGC
CAGTATTCAATGCGCCTTTCTCCAATACCCGTTCGGTAGCCGAAATGGTATTGGGTGAGTTGCTGCTGATGTTCCGAGGC
ATTCCGTCTGCTAACGCGAAAGCGCACCGTGGCGAGTGGAACAAGTTGGCGGTAGGTTCCTTCGAGGCCCGAGGTAAGAA
GCTGGGGATTATCGGTTACGGTCATATCGGTACTCAACTGGGGATTCTGGCTGAAAGTATCGGTATGAAAGTCTTCTTTT
ACGACATCGAAAATAAACTGTCGTTAGGGAATGCGCAGCAAGTTCGCCAACTGTCAGATTTACTGAATATGAGTGATGTG
GTCAGCCTGCATGTACCGGAAAACCACACTACCAAGAATATGATTGGCGCTGAGCAATTGGCACAGATGAAGCCGGGTGC
GCTGTTGATTAATGCCTCTCGCGGCACCGTGGTCGATATTCCGGCCCTGTGCGATGCGCTGTCCAGCAATCACTTGTCAG
GTGCGGCAATTGACGTCTTCCCTGAAGAGCCTGCGACCAATAAAGACCCGTTCAATTCACCACTGTGTGAATTTGATAAT
GTGTTACTGACCCCGCATATTGGCGGTTCTACTCAGGAAGCGCAGGAGAATATCGGTGATGAAGTCGCGGGTAAGCTGGC
GAAGTATTCCGATAATGGCTCAACGCTATCTGCGGTGAATTTCCCCGAAGTTTCTCTGCCAGCACATGGTGATAATACCC
GTCGCCTGTTGCATATTCATGAAAACCGGCCAGGCATTTTGACCAGCATTAACACCATTTTTGCTGAGCAGAATGTCAAT
ATCGCGGCACAGTATCTACAAACCAGCGCTGATATTGGTTATGTCGTGATTGATGTTGAAACCGATGATGCAGATAATGC
GGAAAAAGCCTTGCAGGCGATGAAGGCCATTCCAGGGACGATCCGCGCTCGCTTATTGTACTAA

Upstream 100 bases:

>100_bases
ATTTCCTTTGATTAACCTGTCGCCCTCTCTCGGTTCGCTAGTTTTTTCTTCCATAAATTAACATTCACACTGACGGTTAT
GTTGATGGGCAGGCAATCGT

Downstream 100 bases:

>100_bases
TTCCTGAAATGATTAAACGCCTGGGATCCATAGGATCTCAGGTGTGAGGTTATTGACAAAGTGCCCGCGACGGAGAGAAC
AGGCAGATCGTAAAGACGCC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MYCCLRNICYVDRVLTGFIRYRQPHLKSENRVGDMAKVSLEKDRIKFLLVEGVHQSAVDNLRAAGYSNIEYHKGALDAES
LKASIRDAHFIGIRSRTHLSEDVFAAAEKLVAVGCFCIGTNQVDLKAATKRGVPVFNAPFSNTRSVAEMVLGELLLMFRG
IPSANAKAHRGEWNKLAVGSFEARGKKLGIIGYGHIGTQLGILAESIGMKVFFYDIENKLSLGNAQQVRQLSDLLNMSDV
VSLHVPENHTTKNMIGAEQLAQMKPGALLINASRGTVVDIPALCDALSSNHLSGAAIDVFPEEPATNKDPFNSPLCEFDN
VLLTPHIGGSTQEAQENIGDEVAGKLAKYSDNGSTLSAVNFPEVSLPAHGDNTRRLLHIHENRPGILTSINTIFAEQNVN
IAAQYLQTSADIGYVVIDVETDDADNAEKALQAMKAIPGTIRARLLY

Sequences:

>Translated_447_residues
MYCCLRNICYVDRVLTGFIRYRQPHLKSENRVGDMAKVSLEKDRIKFLLVEGVHQSAVDNLRAAGYSNIEYHKGALDAES
LKASIRDAHFIGIRSRTHLSEDVFAAAEKLVAVGCFCIGTNQVDLKAATKRGVPVFNAPFSNTRSVAEMVLGELLLMFRG
IPSANAKAHRGEWNKLAVGSFEARGKKLGIIGYGHIGTQLGILAESIGMKVFFYDIENKLSLGNAQQVRQLSDLLNMSDV
VSLHVPENHTTKNMIGAEQLAQMKPGALLINASRGTVVDIPALCDALSSNHLSGAAIDVFPEEPATNKDPFNSPLCEFDN
VLLTPHIGGSTQEAQENIGDEVAGKLAKYSDNGSTLSAVNFPEVSLPAHGDNTRRLLHIHENRPGILTSINTIFAEQNVN
IAAQYLQTSADIGYVVIDVETDDADNAEKALQAMKAIPGTIRARLLY
>Mature_447_residues
MYCCLRNICYVDRVLTGFIRYRQPHLKSENRVGDMAKVSLEKDRIKFLLVEGVHQSAVDNLRAAGYSNIEYHKGALDAES
LKASIRDAHFIGIRSRTHLSEDVFAAAEKLVAVGCFCIGTNQVDLKAATKRGVPVFNAPFSNTRSVAEMVLGELLLMFRG
IPSANAKAHRGEWNKLAVGSFEARGKKLGIIGYGHIGTQLGILAESIGMKVFFYDIENKLSLGNAQQVRQLSDLLNMSDV
VSLHVPENHTTKNMIGAEQLAQMKPGALLINASRGTVVDIPALCDALSSNHLSGAAIDVFPEEPATNKDPFNSPLCEFDN
VLLTPHIGGSTQEAQENIGDEVAGKLAKYSDNGSTLSAVNFPEVSLPAHGDNTRRLLHIHENRPGILTSINTIFAEQNVN
IAAQYLQTSADIGYVVIDVETDDADNAEKALQAMKAIPGTIRARLLY

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=317, Percent_Identity=35.0157728706625, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI61743967, Length=258, Percent_Identity=31.0077519379845, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI4557497, Length=258, Percent_Identity=31.0077519379845, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI145580578, Length=258, Percent_Identity=31.3953488372093, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI4557499, Length=258, Percent_Identity=31.3953488372093, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI145580575, Length=268, Percent_Identity=30.5970149253731, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI6912396, Length=270, Percent_Identity=25.9259259259259, Blast_Score=89, Evalue=9e-18,
Organism=Escherichia coli, GI1789279, Length=413, Percent_Identity=83.7772397094431, Blast_Score=710, Evalue=0.0,
Organism=Escherichia coli, GI87082289, Length=255, Percent_Identity=32.156862745098, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1787645, Length=232, Percent_Identity=28.8793103448276, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1788660, Length=309, Percent_Identity=26.8608414239482, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=322, Percent_Identity=31.9875776397516, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI25147481, Length=242, Percent_Identity=30.1652892561983, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320925, Length=437, Percent_Identity=45.766590389016, Blast_Score=393, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6322116, Length=437, Percent_Identity=44.8512585812357, Blast_Score=387, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6324055, Length=280, Percent_Identity=29.2857142857143, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6324964, Length=273, Percent_Identity=27.4725274725275, Blast_Score=103, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6324980, Length=220, Percent_Identity=26.3636363636364, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6321253, Length=162, Percent_Identity=27.1604938271605, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6325144, Length=155, Percent_Identity=30.3225806451613, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19921140, Length=301, Percent_Identity=31.5614617940199, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24646446, Length=236, Percent_Identity=32.6271186440678, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24646448, Length=236, Percent_Identity=32.6271186440678, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24646452, Length=236, Percent_Identity=32.6271186440678, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24646450, Length=236, Percent_Identity=32.6271186440678, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI62472511, Length=236, Percent_Identity=32.6271186440678, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28574286, Length=260, Percent_Identity=30, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28571528, Length=260, Percent_Identity=28.0769230769231, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI45552429, Length=250, Percent_Identity=25.6, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24585514, Length=250, Percent_Identity=25.6, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI28574282, Length=250, Percent_Identity=25.6, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI45551003, Length=250, Percent_Identity=25.6, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI28574284, Length=250, Percent_Identity=25.6, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24585516, Length=241, Percent_Identity=25.7261410788382, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 48609; Mature: 48609

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYCCLRNICYVDRVLTGFIRYRQPHLKSENRVGDMAKVSLEKDRIKFLLVEGVHQSAVDN
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHEEECCCCEEEEEECCHHHHHHHH
LRAAGYSNIEYHKGALDAESLKASIRDAHFIGIRSRTHLSEDVFAAAEKLVAVGCFCIGT
HHHCCCCCCCCCCCCCCHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHEEEEECC
NQVDLKAATKRGVPVFNAPFSNTRSVAEMVLGELLLMFRGIPSANAKAHRGEWNKLAVGS
CCEEEEHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECC
FEARGKKLGIIGYGHIGTQLGILAESIGMKVFFYDIENKLSLGNAQQVRQLSDLLNMSDV
CCCCCCEEEEEEECCHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHHCHHHE
VSLHVPENHTTKNMIGAEQLAQMKPGALLINASRGTVVDIPALCDALSSNHLSGAAIDVF
EEEECCCCCCHHHHHCHHHHHHCCCCEEEEECCCCCEEEHHHHHHHHHCCCCCCCEEEEC
PEEPATNKDPFNSPLCEFDNVLLTPHIGGSTQEAQENIGDEVAGKLAKYSDNGSTLSAVN
CCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHCCHHHHHHHHHCCCCCCEEEEEC
FPEVSLPAHGDNTRRLLHIHENRPGILTSINTIFAEQNVNIAAQYLQTSADIGYVVIDVE
CCCEECCCCCCCCEEEEEEECCCCCEEEEHHHHHCCCCCHHHHHHHHHCCCCCEEEEEEE
TDDADNAEKALQAMKAIPGTIRARLLY
CCCCCCHHHHHHHHHHCCCHHEEEECC
>Mature Secondary Structure
MYCCLRNICYVDRVLTGFIRYRQPHLKSENRVGDMAKVSLEKDRIKFLLVEGVHQSAVDN
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHEEECCCCEEEEEECCHHHHHHHH
LRAAGYSNIEYHKGALDAESLKASIRDAHFIGIRSRTHLSEDVFAAAEKLVAVGCFCIGT
HHHCCCCCCCCCCCCCCHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHEEEEECC
NQVDLKAATKRGVPVFNAPFSNTRSVAEMVLGELLLMFRGIPSANAKAHRGEWNKLAVGS
CCEEEEHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECC
FEARGKKLGIIGYGHIGTQLGILAESIGMKVFFYDIENKLSLGNAQQVRQLSDLLNMSDV
CCCCCCEEEEEEECCHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHHCHHHE
VSLHVPENHTTKNMIGAEQLAQMKPGALLINASRGTVVDIPALCDALSSNHLSGAAIDVF
EEEECCCCCCHHHHHCHHHHHHCCCCEEEEECCCCCEEEHHHHHHHHHCCCCCCCEEEEC
PEEPATNKDPFNSPLCEFDNVLLTPHIGGSTQEAQENIGDEVAGKLAKYSDNGSTLSAVN
CCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHCCHHHHHHHHHCCCCCCEEEEEC
FPEVSLPAHGDNTRRLLHIHENRPGILTSINTIFAEQNVNIAAQYLQTSADIGYVVIDVE
CCCEECCCCCCCCEEEEEEECCCCCEEEEHHHHHCCCCCHHHHHHHHHCCCCCEEEEEEE
TDDADNAEKALQAMKAIPGTIRARLLY
CCCCCCHHHHHHHHHHCCCHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]