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The map label for this gene is gloB [H]

Identifier: 22126973

GI number: 22126973

Start: 3406842

End: 3407684

Strand: Direct

Name: gloB [H]

Synonym: y3097

Alternate gene names: 22126973

Gene position: 3406842-3407684 (Clockwise)

Preceding gene: 22126971

Following gene: 229013125

Centisome position: 74.05

GC content: 43.89

Gene sequence:

>843_bases
ATGCAGGTGTCTCAATATTTTGGCGTATTTGCGCTGGTTTCATATTTTATTATCTTCTTTCAAGCTGTTGCCAACGAGAG
GTATCTAATGAATCTTATCAGCATTCCGGCATTTCAAGACAATTACATTTGGCTACTGGCTAATCGACAAAAACACTGTG
TTATCGTTGACCCTGGTGAGTCAGCGCCAGTTCTAGCCACGCTGGCCCAAGGCCAATATGTGCCACAAGCCATATTATTG
ACCCATCATCATAACGATCACGTGGGGGGGGTTGCTGATTTACGCCACCATTTCCCCGATATTCCCGTCTATGGGCCACA
AGAAACTGCGAAAAAAGGGGCCACCGTCATTGTTAATGATGGCGATAGCCTCACCATTGCCGGACAAAATTACACCATTA
TAGCCGTCCCCGGCCATACTCTAGGTCATATCGCATACTACAGTTCTCCTTATCTTTTTTGTGGAGACACCCTGTTTTCT
GCTGGCTGTGGGCGACTCTTAGAAGGCACACCAGAGCAAATGTACGCTTCAATTCAACGACTCGCGCAGTTACCCGACGA
AACCTTAATATGCTGCGCACATGAATATACTCTCTCAAATCTTAAGTTTGCCCACGCAATTTTGCCTGCTGATCAAGATA
TTGCTACATATCAACAACAAATTGAGCAATTACGGTCAAAAAACCTACCTAGCCTGCCCGTAAAATTGCAATTTGAGCGC
AAAATTAATGTTTTTTTACGTTGCAATGACATTGATTTACAAAGAAAAATAGGAACAACTTCGCCTCCAGACTCACTTGT
CTCTGTTTTCTGCGAATTACGCTCCCGAAAAGACAGCTTTTGA

Upstream 100 bases:

>100_bases
ACCTTCAGCAAGTGAAAACCAAAAAATTTTGGCCACCAGGGTTGCAGTTGCTGTTCAAGCGCCGCGCGGTAATATTCCCC
CCAAGGTAATTCAGCCCAAG

Downstream 100 bases:

>100_bases
GCTTTTAGTTGTGTTTTTTATCGAAGCAAAGTATGATTGCTCGTCTTTTAAGCAACCACATTGACACACACATGAAGACC
AAAGCGATACTTCTCGCCTC

Product: hydroxyacylglutathione hydrolase

Products: NA

Alternate protein names: Glyoxalase II; Glx II [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MQVSQYFGVFALVSYFIIFFQAVANERYLMNLISIPAFQDNYIWLLANRQKHCVIVDPGESAPVLATLAQGQYVPQAILL
THHHNDHVGGVADLRHHFPDIPVYGPQETAKKGATVIVNDGDSLTIAGQNYTIIAVPGHTLGHIAYYSSPYLFCGDTLFS
AGCGRLLEGTPEQMYASIQRLAQLPDETLICCAHEYTLSNLKFAHAILPADQDIATYQQQIEQLRSKNLPSLPVKLQFER
KINVFLRCNDIDLQRKIGTTSPPDSLVSVFCELRSRKDSF

Sequences:

>Translated_280_residues
MQVSQYFGVFALVSYFIIFFQAVANERYLMNLISIPAFQDNYIWLLANRQKHCVIVDPGESAPVLATLAQGQYVPQAILL
THHHNDHVGGVADLRHHFPDIPVYGPQETAKKGATVIVNDGDSLTIAGQNYTIIAVPGHTLGHIAYYSSPYLFCGDTLFS
AGCGRLLEGTPEQMYASIQRLAQLPDETLICCAHEYTLSNLKFAHAILPADQDIATYQQQIEQLRSKNLPSLPVKLQFER
KINVFLRCNDIDLQRKIGTTSPPDSLVSVFCELRSRKDSF
>Mature_280_residues
MQVSQYFGVFALVSYFIIFFQAVANERYLMNLISIPAFQDNYIWLLANRQKHCVIVDPGESAPVLATLAQGQYVPQAILL
THHHNDHVGGVADLRHHFPDIPVYGPQETAKKGATVIVNDGDSLTIAGQNYTIIAVPGHTLGHIAYYSSPYLFCGDTLFS
AGCGRLLEGTPEQMYASIQRLAQLPDETLICCAHEYTLSNLKFAHAILPADQDIATYQQQIEQLRSKNLPSLPVKLQFER
KINVFLRCNDIDLQRKIGTTSPPDSLVSVFCELRSRKDSF

Specific function: Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid [H]

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family [H]

Homologues:

Organism=Homo sapiens, GI14150041, Length=255, Percent_Identity=32.9411764705882, Blast_Score=138, Evalue=4e-33,
Organism=Homo sapiens, GI94538320, Length=261, Percent_Identity=34.0996168582375, Blast_Score=137, Evalue=8e-33,
Organism=Homo sapiens, GI94538322, Length=261, Percent_Identity=34.0996168582375, Blast_Score=137, Evalue=9e-33,
Organism=Homo sapiens, GI21703352, Length=262, Percent_Identity=33.587786259542, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI116642887, Length=262, Percent_Identity=33.587786259542, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI46361987, Length=193, Percent_Identity=35.2331606217617, Blast_Score=115, Evalue=3e-26,
Organism=Escherichia coli, GI1786406, Length=251, Percent_Identity=57.3705179282869, Blast_Score=293, Evalue=8e-81,
Organism=Escherichia coli, GI1787158, Length=208, Percent_Identity=27.8846153846154, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17536925, Length=219, Percent_Identity=36.986301369863, Blast_Score=117, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6320478, Length=261, Percent_Identity=30.2681992337165, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6324614, Length=261, Percent_Identity=28.3524904214559, Blast_Score=83, Evalue=6e-17,
Organism=Drosophila melanogaster, GI21356335, Length=262, Percent_Identity=34.7328244274809, Blast_Score=161, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24667703, Length=262, Percent_Identity=34.7328244274809, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI24667711, Length=262, Percent_Identity=34.7328244274809, Blast_Score=160, Evalue=7e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR017782 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.2.6 [H]

Molecular weight: Translated: 31270; Mature: 31270

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVSQYFGVFALVSYFIIFFQAVANERYLMNLISIPAFQDNYIWLLANRQKHCVIVDPGE
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCEEEEEECCCCEEEEECCCC
SAPVLATLAQGQYVPQAILLTHHHNDHVGGVADLRHHFPDIPVYGPQETAKKGATVIVND
CCCCEEEECCCCCCCEEEEEEECCCCCCCCHHHHHHHCCCCCCCCCHHHHHCCCEEEEEC
GDSLTIAGQNYTIIAVPGHTLGHIAYYSSPYLFCGDTLFSAGCGRLLEGTPEQMYASIQR
CCEEEEECCCEEEEEECCCCHHHEEEECCCEEEECHHHHHHCCCHHHCCCHHHHHHHHHH
LAQLPDETLICCAHEYTLSNLKFAHAILPADQDIATYQQQIEQLRSKNLPSLPVKLQFER
HHHCCCCEEEEEEEHHHHHCCEEEHEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEC
KINVFLRCNDIDLQRKIGTTSPPDSLVSVFCELRSRKDSF
EEEEEEEECCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQVSQYFGVFALVSYFIIFFQAVANERYLMNLISIPAFQDNYIWLLANRQKHCVIVDPGE
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCEEEEEECCCCEEEEECCCC
SAPVLATLAQGQYVPQAILLTHHHNDHVGGVADLRHHFPDIPVYGPQETAKKGATVIVND
CCCCEEEECCCCCCCEEEEEEECCCCCCCCHHHHHHHCCCCCCCCCHHHHHCCCEEEEEC
GDSLTIAGQNYTIIAVPGHTLGHIAYYSSPYLFCGDTLFSAGCGRLLEGTPEQMYASIQR
CCEEEEECCCEEEEEECCCCHHHEEEECCCEEEECHHHHHHCCCHHHCCCHHHHHHHHHH
LAQLPDETLICCAHEYTLSNLKFAHAILPADQDIATYQQQIEQLRSKNLPSLPVKLQFER
HHHCCCCEEEEEEEHHHHHCCEEEHEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEC
KINVFLRCNDIDLQRKIGTTSPPDSLVSVFCELRSRKDSF
EEEEEEEECCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA