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The map label for this gene is modE [H]

Identifier: 22126916

GI number: 22126916

Start: 3346618

End: 3347478

Strand: Direct

Name: modE [H]

Synonym: y3040

Alternate gene names: 22126916

Gene position: 3346618-3347478 (Clockwise)

Preceding gene: 22126911

Following gene: 161484770

Centisome position: 72.74

GC content: 49.94

Gene sequence:

>861_bases
ATGTTGTTTAGCTATCTATGCCATTTAGCTATCTATGACAATAACTGTTTCCCGCCGGAGCAAAAAACAATGCAGGCCGA
AATTCTTCTTACACTAAAACTTCAACAGCGCCTGTTTGCCGATCCACGCCGTATTGCACTGTTAAAGCAAATTCAGCATA
CCGGTTCCATCAGCCAGGGAGCCAAGCTCGCGGGTATCAGCTATAAAAGTGCCTGGGATGCCATAAATGACATGAATACA
CTGTCCGAGGAGATACTGGTTGAACGGGCCACTGGCGGCAAAGGTGGAGGGGGTGCACATCTGACCCGCTACGGTGAACG
CTTAATCCAGCTTTATGATTTACTCGCAACCATCCAGCAAAAAGCCTTTGATACCCTGAAAGATGATTCACTGCCGCTGG
ACAGCTTGCTGGCGGCAATTTCCCGTTTTTCACTGCAAACCAGCGCCCGTAATCAATTTTTCGGTACCCTTATTGAACGC
GACCACCAGCAGGTGCAACAGCATGTCAATATTCTGCTATCGGACGGTAAAACTCGCTTAACGGCGGCGATCACCCAACA
AAGCGCGGATCGCCTGCAACTTTCAGCAGGTAAAGAAGTGCTGGCATTGATTAAAGCACCTTGGGTAAAACTGGTTACCG
ATCCGGCACTGGCAGGTGCAGCGGATAACGCATTGCCGGGAACGGTCGCCAGCATTGAGCCGGGCAACGATCATAGCGAA
GTTATTGTCACCTTAACTGGCGGGGCCAACCTGTGTTCAACCCAAAACAACAGCGAACTCCATGCGCTGAATTTACGGGT
TGGCAGTGCCGTCATTGCACAATTCAATGCAGATCGGGTGATTATCGCCACATTGTGTTGA

Upstream 100 bases:

>100_bases
AACCGACGATAAAAAAATGTAACCTGCCAAACGTGCGATTTATCTATCTATGTTGTTTATCTATCTATGTTGTTTATCTA
TCTATGTTGTTTAGCTATCT

Downstream 100 bases:

>100_bases
ATGATTATTCCCAGTAATCACTGTTGGACCATACATTTGTTCGTTGACATTTTTCGTCTTTCCGCTTATCCCTAACATCT
TTACTACGTTGCAAAATATG

Product: DNA-binding transcriptional regulator ModE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MLFSYLCHLAIYDNNCFPPEQKTMQAEILLTLKLQQRLFADPRRIALLKQIQHTGSISQGAKLAGISYKSAWDAINDMNT
LSEEILVERATGGKGGGGAHLTRYGERLIQLYDLLATIQQKAFDTLKDDSLPLDSLLAAISRFSLQTSARNQFFGTLIER
DHQQVQQHVNILLSDGKTRLTAAITQQSADRLQLSAGKEVLALIKAPWVKLVTDPALAGAADNALPGTVASIEPGNDHSE
VIVTLTGGANLCSTQNNSELHALNLRVGSAVIAQFNADRVIIATLC

Sequences:

>Translated_286_residues
MLFSYLCHLAIYDNNCFPPEQKTMQAEILLTLKLQQRLFADPRRIALLKQIQHTGSISQGAKLAGISYKSAWDAINDMNT
LSEEILVERATGGKGGGGAHLTRYGERLIQLYDLLATIQQKAFDTLKDDSLPLDSLLAAISRFSLQTSARNQFFGTLIER
DHQQVQQHVNILLSDGKTRLTAAITQQSADRLQLSAGKEVLALIKAPWVKLVTDPALAGAADNALPGTVASIEPGNDHSE
VIVTLTGGANLCSTQNNSELHALNLRVGSAVIAQFNADRVIIATLC
>Mature_286_residues
MLFSYLCHLAIYDNNCFPPEQKTMQAEILLTLKLQQRLFADPRRIALLKQIQHTGSISQGAKLAGISYKSAWDAINDMNT
LSEEILVERATGGKGGGGAHLTRYGERLIQLYDLLATIQQKAFDTLKDDSLPLDSLLAAISRFSLQTSARNQFFGTLIER
DHQQVQQHVNILLSDGKTRLTAAITQQSADRLQLSAGKEVLALIKAPWVKLVTDPALAGAADNALPGTVASIEPGNDHSE
VIVTLTGGANLCSTQNNSELHALNLRVGSAVIAQFNADRVIIATLC

Specific function: The modE-Mo complex acts as a repressor of the modABC operon, involved in the transport of molybdate. Upon binding molybdate, the conformation of the protein changes, promoting dimerization of ModE-Mo. The protein dimer is then competent to bind a DNA reg

COG id: COG2005

COG function: function code R; N-terminal domain of molybdenum-binding protein

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the modE family [H]

Homologues:

Organism=Escherichia coli, GI1786976, Length=264, Percent_Identity=70.4545454545455, Blast_Score=315, Evalue=3e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR004606
- InterPro:   IPR008995
- InterPro:   IPR003725
- InterPro:   IPR016462
- InterPro:   IPR005116
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03459 TOBE [H]

EC number: NA

Molecular weight: Translated: 31029; Mature: 31029

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFSYLCHLAIYDNNCFPPEQKTMQAEILLTLKLQQRLFADPRRIALLKQIQHTGSISQG
CHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCC
AKLAGISYKSAWDAINDMNTLSEEILVERATGGKGGGGAHLTRYGERLIQLYDLLATIQQ
CEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KAFDTLKDDSLPLDSLLAAISRFSLQTSARNQFFGTLIERDHQQVQQHVNILLSDGKTRL
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHH
TAAITQQSADRLQLSAGKEVLALIKAPWVKLVTDPALAGAADNALPGTVASIEPGNDHSE
HHHHHHHCHHHHHHHCCHHHHHHHHCCHHHEECCCHHCCCCCCCCCCCEEECCCCCCCCE
VIVTLTGGANLCSTQNNSELHALNLRVGSAVIAQFNADRVIIATLC
EEEEEECCCCCCCCCCCCCEEEEEEEHHHHHEEEECCCEEEEEEEC
>Mature Secondary Structure
MLFSYLCHLAIYDNNCFPPEQKTMQAEILLTLKLQQRLFADPRRIALLKQIQHTGSISQG
CHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCC
AKLAGISYKSAWDAINDMNTLSEEILVERATGGKGGGGAHLTRYGERLIQLYDLLATIQQ
CEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KAFDTLKDDSLPLDSLLAAISRFSLQTSARNQFFGTLIERDHQQVQQHVNILLSDGKTRL
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHH
TAAITQQSADRLQLSAGKEVLALIKAPWVKLVTDPALAGAADNALPGTVASIEPGNDHSE
HHHHHHHCHHHHHHHCCHHHHHHHHCCHHHEECCCHHCCCCCCCCCCCEEECCCCCCCCE
VIVTLTGGANLCSTQNNSELHALNLRVGSAVIAQFNADRVIIATLC
EEEEEECCCCCCCCCCCCCEEEEEEEHHHHHEEEECCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]