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The map label for this gene is adiC

Identifier: 22126865

GI number: 22126865

Start: 3296317

End: 3297651

Strand: Reverse

Name: adiC

Synonym: y2988

Alternate gene names: 22126865

Gene position: 3297651-3296317 (Counterclockwise)

Preceding gene: 22126867

Following gene: 22126864

Centisome position: 71.68

GC content: 47.12

Gene sequence:

>1335_bases
ATGTCTACAGATGATCAGAAGGTAGGGTTAATTCCTGTAACCCTTATGGTTGCAGGAAATATAATGGGGTCTGGTGTTTT
TTTATTACCGGCAAATTTGGCTTCTACAGGTGGAATTGCGATATGGGGATGGCTAGTGACTATTATTGGTGCTCTAGCAC
TATCAATGGTTTACGCCAAAATTTCATCTTTGGATGATAGCCCAGGGGGGTCTTATGCTTATGCGCGGCGTGCCTTTGGG
CCATTTTTAGGTTATCAAACGAATGTCTTGTATTGGTTGGCATGTTGGATCGGTAATATTGCGATGGTCGTTATTGGGGT
CGGCTATCTCAGTTATTTTTTCCCTATTTTAAAAGAACCCATGGTATTAACGATTACTTGCGTAGTATTTCTATGGATAT
TTGTCGGGCTGAATATTATTGGGCCAAAAATGATCACCCGTGTACAAGCAGTAGCTACGTCACTGGCGCTTATTCCGATT
GTGGGTATCGCTTTATTTGGGTGGTTCTGGTTTAAGGGCGAAACCTATATGGCAGCCTGGAATGTCAGTGGGTTAGGTAC
CTTTGGTGCAATTCAAAGTACTCTGAATGTGACGCTGTGGTCATTTATCGGCGTCGAGACGGCATCGGTGGCGGCAGGGG
TAGTTAAAAATCCAAAACGTAATGTCCCGATTGCCACCGTGGGCGGGGTGTTAATTGCGGCTGTTTGTTATGTTCTTTCC
AGTAGCGCCATTATGGGAATGATCCCTAATGCAGAATTGCGTTTATCAGCATCGCCATTTGGTGATGCTGCCCGTTTAGC
TCTGGGAGATACGGCAGGGGCGGTCGTTTCACTCTGTGCGGCGGCGGGGTGTTTAGGGTCTTTAGGCGGTTGGACGCTGG
TGGCCGGGCAGACGGCTAAAGCGGCGGCTGATGATGGGCTGTTCCCCCCCATTTTCGGTAAGGTCAATAAAGCCGGTACG
CCAGTGGCCGGGTTACTTATTCTTGGCGTACTGATGACCATTTTCCAAATTAGCAGTATTTCGCCGAATGCGGCCAAAGA
GTTTGGCCTGGTTTCTTCCGTTTCTGTGATTTTTACTCTGGTACCGTACCTGTATACCTGTTCAGCCTTATTACTGGTTG
GTCATGGCCATTTAGGCAATCAAGTGAAAACGTATGTCGGCATAACCCTTATTGCTTTCGTGTATTGCATTTGGGCCGTA
GTCGGTTCGGGTGCCGAGGAAGTGATGTGGTCATTTGTTACCTTGATGGTTATCACCGCGCTTTATACTTTCAATTACAA
CCGTACCCACAAAAACCCATTCCCACTCGATGCACCTGTTAAGAACGGGCAGTAA

Upstream 100 bases:

>100_bases
TTTTTAACTTTATTTATAAAATATATCGTCTACCTTTATAACTGCGTCTGGCTATTCATCATCATTTTCAGCCTATTATA
GGGATTTGTAAGGATTACCT

Downstream 100 bases:

>100_bases
TACCCACTCCCATCTGTAGCTGGGTGGGCATCATTGATGTGATGAATTATAGATAAAGGGATAAATACGATGATTGATTT
AAGCAGTCACAAGAAACGCA

Product: arginine:agmatin antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MSTDDQKVGLIPVTLMVAGNIMGSGVFLLPANLASTGGIAIWGWLVTIIGALALSMVYAKISSLDDSPGGSYAYARRAFG
PFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFPILKEPMVLTITCVVFLWIFVGLNIIGPKMITRVQAVATSLALIPI
VGIALFGWFWFKGETYMAAWNVSGLGTFGAIQSTLNVTLWSFIGVETASVAAGVVKNPKRNVPIATVGGVLIAAVCYVLS
SSAIMGMIPNAELRLSASPFGDAARLALGDTAGAVVSLCAAAGCLGSLGGWTLVAGQTAKAAADDGLFPPIFGKVNKAGT
PVAGLLILGVLMTIFQISSISPNAAKEFGLVSSVSVIFTLVPYLYTCSALLLVGHGHLGNQVKTYVGITLIAFVYCIWAV
VGSGAEEVMWSFVTLMVITALYTFNYNRTHKNPFPLDAPVKNGQ

Sequences:

>Translated_444_residues
MSTDDQKVGLIPVTLMVAGNIMGSGVFLLPANLASTGGIAIWGWLVTIIGALALSMVYAKISSLDDSPGGSYAYARRAFG
PFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFPILKEPMVLTITCVVFLWIFVGLNIIGPKMITRVQAVATSLALIPI
VGIALFGWFWFKGETYMAAWNVSGLGTFGAIQSTLNVTLWSFIGVETASVAAGVVKNPKRNVPIATVGGVLIAAVCYVLS
SSAIMGMIPNAELRLSASPFGDAARLALGDTAGAVVSLCAAAGCLGSLGGWTLVAGQTAKAAADDGLFPPIFGKVNKAGT
PVAGLLILGVLMTIFQISSISPNAAKEFGLVSSVSVIFTLVPYLYTCSALLLVGHGHLGNQVKTYVGITLIAFVYCIWAV
VGSGAEEVMWSFVTLMVITALYTFNYNRTHKNPFPLDAPVKNGQ
>Mature_443_residues
STDDQKVGLIPVTLMVAGNIMGSGVFLLPANLASTGGIAIWGWLVTIIGALALSMVYAKISSLDDSPGGSYAYARRAFGP
FLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFPILKEPMVLTITCVVFLWIFVGLNIIGPKMITRVQAVATSLALIPIV
GIALFGWFWFKGETYMAAWNVSGLGTFGAIQSTLNVTLWSFIGVETASVAAGVVKNPKRNVPIATVGGVLIAAVCYVLSS
SAIMGMIPNAELRLSASPFGDAARLALGDTAGAVVSLCAAAGCLGSLGGWTLVAGQTAKAAADDGLFPPIFGKVNKAGTP
VAGLLILGVLMTIFQISSISPNAAKEFGLVSSVSVIFTLVPYLYTCSALLLVGHGHLGNQVKTYVGITLIAFVYCIWAVV
GSGAEEVMWSFVTLMVITALYTFNYNRTHKNPFPLDAPVKNGQ

Specific function: Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach. Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular p

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily

Homologues:

Organism=Homo sapiens, GI115648063, Length=357, Percent_Identity=24.9299719887955, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI115648022, Length=357, Percent_Identity=24.9299719887955, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI186910308, Length=355, Percent_Identity=24.2253521126761, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI186910306, Length=355, Percent_Identity=24.2253521126761, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI186910304, Length=355, Percent_Identity=24.2253521126761, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI187423910, Length=354, Percent_Identity=24.0112994350282, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI7657591, Length=354, Percent_Identity=24.0112994350282, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI2367353, Length=441, Percent_Identity=86.8480725623583, Blast_Score=778, Evalue=0.0,
Organism=Escherichia coli, GI1790575, Length=437, Percent_Identity=38.4439359267735, Blast_Score=289, Evalue=3e-79,
Organism=Escherichia coli, GI1786908, Length=417, Percent_Identity=33.5731414868106, Blast_Score=245, Evalue=5e-66,
Organism=Escherichia coli, GI1787890, Length=450, Percent_Identity=28, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI87082250, Length=343, Percent_Identity=27.9883381924198, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI87081708, Length=410, Percent_Identity=24.1463414634146, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790653, Length=397, Percent_Identity=23.6775818639798, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17540018, Length=342, Percent_Identity=25.1461988304094, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71995382, Length=399, Percent_Identity=23.8095238095238, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71995388, Length=399, Percent_Identity=23.8095238095238, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71993915, Length=386, Percent_Identity=24.3523316062176, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=358, Percent_Identity=26.8156424581006, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI32566699, Length=314, Percent_Identity=23.2484076433121, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI221331183, Length=424, Percent_Identity=24.0566037735849, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17647653, Length=424, Percent_Identity=24.0566037735849, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24664379, Length=424, Percent_Identity=24.0566037735849, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI45550968, Length=422, Percent_Identity=22.9857819905213, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19921172, Length=422, Percent_Identity=22.9857819905213, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24641993, Length=341, Percent_Identity=24.633431085044, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24641995, Length=341, Percent_Identity=24.633431085044, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ADIC_YERPE (Q8ZGS9)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AE0147
- RefSeq:   NP_670288.1
- RefSeq:   NP_992315.1
- RefSeq:   YP_002346236.1
- ProteinModelPortal:   Q8ZGS9
- GeneID:   1147935
- GeneID:   1174048
- GeneID:   2764182
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO1200
- KEGG:   ypk:y2988
- KEGG:   ypm:YP_0937
- HOGENOM:   HBG586921
- OMA:   MSPSASE
- ProtClustDB:   PRK10644
- BioCyc:   YPES187410:Y2988-MONOMER
- BioCyc:   YPES214092:YPO1200-MONOMER
- InterPro:   IPR004841
- InterPro:   IPR002293
- PANTHER:   PTHR11785
- PIRSF:   PIRSF006060

Pfam domain/function: PF00324 AA_permease

EC number: NA

Molecular weight: Translated: 46640; Mature: 46508

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: NA

Important sites: BINDING 20-20 BINDING 24-24 BINDING 91-91 BINDING 206-206 BINDING 363-363

Signals:

None

Transmembrane regions:

HASH(0xf82334c)-; HASH(0x115652c4)-; HASH(0x10bd5858)-; HASH(0xb8d822c)-; HASH(0x1168fa1c)-; HASH(0xe134034)-; HASH(0x10e0597c)-; HASH(0x103f0b6c)-; HASH(0xe134190)-; HASH(0xe134298)-; HASH(0x1153fac4)-; HASH(0x1094ae68)-;

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTDDQKVGLIPVTLMVAGNIMGSGVFLLPANLASTGGIAIWGWLVTIIGALALSMVYAK
CCCCCCCCCEEEEHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ISSLDDSPGGSYAYARRAFGPFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFPILKEP
HHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
MVLTITCVVFLWIFVGLNIIGPKMITRVQAVATSLALIPIVGIALFGWFWFKGETYMAAW
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
NVSGLGTFGAIQSTLNVTLWSFIGVETASVAAGVVKNPKRNVPIATVGGVLIAAVCYVLS
CCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
SSAIMGMIPNAELRLSASPFGDAARLALGDTAGAVVSLCAAAGCLGSLGGWTLVAGQTAK
CCHHEEECCCCCEEEECCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEECCCHH
AAADDGLFPPIFGKVNKAGTPVAGLLILGVLMTIFQISSISPNAAKEFGLVSSVSVIFTL
HCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
VPYLYTCSALLLVGHGHLGNQVKTYVGITLIAFVYCIWAVVGSGAEEVMWSFVTLMVITA
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LYTFNYNRTHKNPFPLDAPVKNGQ
HHHCCCCCCCCCCCCCCCCCCCCH
>Mature Secondary Structure 
STDDQKVGLIPVTLMVAGNIMGSGVFLLPANLASTGGIAIWGWLVTIIGALALSMVYAK
CCCCCCCCEEEEHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ISSLDDSPGGSYAYARRAFGPFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFPILKEP
HHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
MVLTITCVVFLWIFVGLNIIGPKMITRVQAVATSLALIPIVGIALFGWFWFKGETYMAAW
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
NVSGLGTFGAIQSTLNVTLWSFIGVETASVAAGVVKNPKRNVPIATVGGVLIAAVCYVLS
CCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
SSAIMGMIPNAELRLSASPFGDAARLALGDTAGAVVSLCAAAGCLGSLGGWTLVAGQTAK
CCHHEEECCCCCEEEECCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEECCCHH
AAADDGLFPPIFGKVNKAGTPVAGLLILGVLMTIFQISSISPNAAKEFGLVSSVSVIFTL
HCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
VPYLYTCSALLLVGHGHLGNQVKTYVGITLIAFVYCIWAVVGSGAEEVMWSFVTLMVITA
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LYTFNYNRTHKNPFPLDAPVKNGQ
HHHCCCCCCCCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430