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The map label for this gene is clpA [H]

Identifier: 22126686

GI number: 22126686

Start: 3112053

End: 3114335

Strand: Reverse

Name: clpA [H]

Synonym: y2809

Alternate gene names: 22126686

Gene position: 3114335-3112053 (Counterclockwise)

Preceding gene: 22126687

Following gene: 22126685

Centisome position: 67.69

GC content: 49.5

Gene sequence:

>2283_bases
GTGCCTATGCTCAATCAAGAACTTGAACTCAGTCTTAATATGGCTTTCGCCAGAGCGCGTGAGCACAGACACGAGTTTAT
GACCGTGGAGCACCTGTTGCTGGCATTGCTGAGCAATCCAGCCGCGCGGGAAGCGTTGGAGGCCTGTACGGTTGACCTGG
TGGCGTTACGCCAGGAATTAGAAGCGTTTATCGAACAAACTACACCGACACTACCTGTCAGTGAGGAAGAGCGTGATACC
CAGCCAACGCTCAGTTTTCAGCGCGTACTACAACGTGCGGTCTTTCATGTGCAGTCATCGGGCCGTAATGAGGTTTCCGG
CGCGAACGTGTTGGTCGCCATCTTCAGTGAACAAGAGTCTCAGGCGGCCTACCTGTTGCGTAAGCATGATGTCAGCCGCT
TGGATGTCGTGAACTTTATTTCCCATGGTGCCCGTAAGGACGAGCCTAGCCAGACGCCGAATGTCGATAACTCGCCAAGT
GAAGAGCAGGCCAGCGGGGAAGACCGTATGGAAAACTTCACCACAAACCTAAATCAACTGGCCCGTGTTGGCGGCATTGA
TCCGCTTATTGGGCGCGATAAAGAGCTGGAGCGGACCATTCAGGTACTGTGCCGTCGGCGTAAAAACAACCCGCTGCTGG
TGGGGGAATCCGGTGTTGGTAAAACTGCCATTGCTGAGGGGCTGGCTTGGCGTATTGTGCAAGGTGATGTTCCTGACGTC
ATATCCGAATGCACGCTGTACTCATTGGATATCGGTTCATTGCTGGCGGGTACCAAATACCGTGGTGACTTTGAAAAACG
GTTTAAGGCACTGCTAAAGCAGTTGGAAAACGACAAAGACAGCATCCTGTTTATCGATGAAATCCACACAATCATTGGCG
CTGGTGCGGCTTCTGGTGGTCAGGTGGATGCCGCGAATCTGATTAAACCTCTGCTTTCCAGTGGCAAGATCCGGGTTATT
GGTTCCACGACGTATCAGGAATTCAGTAATATCTTTGAGAAAGATCGCGCGCTGGCACGTCGTTTCCAGAAAATTGATAT
CATTGAACCAACACCAGAAGAGACGGTTCAAATTATTAATGGTCTGAAACCCAAATATGAAGCGCACCACGATGTGCGTT
ACACCGCGAAAGCGATACGTGCTGCGGTTGAATTGTCGGTTAAATATATTAATGACCGCCATTTGCCAGACAAAGCCATT
GATGTCATTGATGAAGCAGGTGCGCGTAGCCGCCTGATGCCAGTGAATAAACGCAAGAAAACGGTCAATGTCTCGGATAT
CGAATCGGTGGTAGCCCGTATTGCCCGTATCCCGGAGAAAACGGTTTCTGCCAGTGACCGCGATGTCCTACGAAATCTGA
GTGATCGCCTAAACATGTTGGTATTCGGTCAAGATAAGGCGATTGAGGCGTTATCTGAAGCGATCAAAATGAGCCGTGCG
GGGTTAGGGCATGAGCGTCAACCTGTCGGGTCCTTCTTGTTTGCTGGCCCTACGGGGGTAGGTAAAACAGAAGTGACGGT
GCAGTTGGCCAAAGCGCTCGATATCGAATTGCTCCGCTTTGATATGTCTGAGTATATGGAGCGCCATACTGTCAGCCGCC
TGATTGGTGCGCCCCCAGGGTATGTTGGTTACGATCAGGGCGGGTTATTGACTGATTCAGTGATCAAACATCCTCATGCT
GTGTTGTTATTGGACGAAATTGAAAAAGCGCATCCTGATGTGTTTAATCTGTTATTGCAGGTGATGGATAACGGAACACT
GACTGATAACAATGGGCGTAAGGCCGATTTCCGTAACGTCATTTTGGTGATGACCACCAACGCCGGTGTACGGGAAACGC
AGCGCACTTCCATTGGTTTTAAACAGCAGGATAGCAGCACTGATGCGCTGGAAGAGATCAAAAAAATATTCACACCGGAG
TTCCGTAACCGGTTAGATAATATTATTTGGTTCAACCATTTGTCTCCTGCGGTTATCCAGCAGGTGGTCGATAAATTTAT
CGTTGAGTTGCAGGCACAATTAGATGCGAAAGGCGTGTCATTGGAGGTCAGTGATGAAGCGCGCGATTGGTTATCTGAGA
AGGGCTATGACAAAGCGATGGGTGCTCGACCAATGACCCGGGTGATTCAGGAGAATCTGAAGAAACCACTGGCGAATGAA
TTGTTATTTGGTTCTCTGGTTGATGGTGGTTCGGTTACGGTTAATCTGGATAAAGAGAAACAACAACTGGCCTATGAATT
CCAGAGCGCGCAAAAACGTAAAACTGAAGGGGCAGTTCATTAA

Upstream 100 bases:

>100_bases
GCAGAGACAAAAGTCGCCCATGTAAATCAATACGCCAGGGAGAACGAGCATCCACTGCTTTGTACGCTGGAAAAAGCCTG
ATTAAGGCAATTATTGGGAG

Downstream 100 bases:

>100_bases
GTCAACGGGCTAGAAAGCGGCAGCCAACGACATTGGCGTGGTAATCAGGCTGAAACCACGCCTGCAACGTCCATGTCTGC
AACATCCATGTCTGCAATAT

Product: ATP-dependent Clp protease ATP-binding subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 760; Mature: 759

Protein sequence:

>760_residues
MPMLNQELELSLNMAFARAREHRHEFMTVEHLLLALLSNPAAREALEACTVDLVALRQELEAFIEQTTPTLPVSEEERDT
QPTLSFQRVLQRAVFHVQSSGRNEVSGANVLVAIFSEQESQAAYLLRKHDVSRLDVVNFISHGARKDEPSQTPNVDNSPS
EEQASGEDRMENFTTNLNQLARVGGIDPLIGRDKELERTIQVLCRRRKNNPLLVGESGVGKTAIAEGLAWRIVQGDVPDV
ISECTLYSLDIGSLLAGTKYRGDFEKRFKALLKQLENDKDSILFIDEIHTIIGAGAASGGQVDAANLIKPLLSSGKIRVI
GSTTYQEFSNIFEKDRALARRFQKIDIIEPTPEETVQIINGLKPKYEAHHDVRYTAKAIRAAVELSVKYINDRHLPDKAI
DVIDEAGARSRLMPVNKRKKTVNVSDIESVVARIARIPEKTVSASDRDVLRNLSDRLNMLVFGQDKAIEALSEAIKMSRA
GLGHERQPVGSFLFAGPTGVGKTEVTVQLAKALDIELLRFDMSEYMERHTVSRLIGAPPGYVGYDQGGLLTDSVIKHPHA
VLLLDEIEKAHPDVFNLLLQVMDNGTLTDNNGRKADFRNVILVMTTNAGVRETQRTSIGFKQQDSSTDALEEIKKIFTPE
FRNRLDNIIWFNHLSPAVIQQVVDKFIVELQAQLDAKGVSLEVSDEARDWLSEKGYDKAMGARPMTRVIQENLKKPLANE
LLFGSLVDGGSVTVNLDKEKQQLAYEFQSAQKRKTEGAVH

Sequences:

>Translated_760_residues
MPMLNQELELSLNMAFARAREHRHEFMTVEHLLLALLSNPAAREALEACTVDLVALRQELEAFIEQTTPTLPVSEEERDT
QPTLSFQRVLQRAVFHVQSSGRNEVSGANVLVAIFSEQESQAAYLLRKHDVSRLDVVNFISHGARKDEPSQTPNVDNSPS
EEQASGEDRMENFTTNLNQLARVGGIDPLIGRDKELERTIQVLCRRRKNNPLLVGESGVGKTAIAEGLAWRIVQGDVPDV
ISECTLYSLDIGSLLAGTKYRGDFEKRFKALLKQLENDKDSILFIDEIHTIIGAGAASGGQVDAANLIKPLLSSGKIRVI
GSTTYQEFSNIFEKDRALARRFQKIDIIEPTPEETVQIINGLKPKYEAHHDVRYTAKAIRAAVELSVKYINDRHLPDKAI
DVIDEAGARSRLMPVNKRKKTVNVSDIESVVARIARIPEKTVSASDRDVLRNLSDRLNMLVFGQDKAIEALSEAIKMSRA
GLGHERQPVGSFLFAGPTGVGKTEVTVQLAKALDIELLRFDMSEYMERHTVSRLIGAPPGYVGYDQGGLLTDSVIKHPHA
VLLLDEIEKAHPDVFNLLLQVMDNGTLTDNNGRKADFRNVILVMTTNAGVRETQRTSIGFKQQDSSTDALEEIKKIFTPE
FRNRLDNIIWFNHLSPAVIQQVVDKFIVELQAQLDAKGVSLEVSDEARDWLSEKGYDKAMGARPMTRVIQENLKKPLANE
LLFGSLVDGGSVTVNLDKEKQQLAYEFQSAQKRKTEGAVH
>Mature_759_residues
PMLNQELELSLNMAFARAREHRHEFMTVEHLLLALLSNPAAREALEACTVDLVALRQELEAFIEQTTPTLPVSEEERDTQ
PTLSFQRVLQRAVFHVQSSGRNEVSGANVLVAIFSEQESQAAYLLRKHDVSRLDVVNFISHGARKDEPSQTPNVDNSPSE
EQASGEDRMENFTTNLNQLARVGGIDPLIGRDKELERTIQVLCRRRKNNPLLVGESGVGKTAIAEGLAWRIVQGDVPDVI
SECTLYSLDIGSLLAGTKYRGDFEKRFKALLKQLENDKDSILFIDEIHTIIGAGAASGGQVDAANLIKPLLSSGKIRVIG
STTYQEFSNIFEKDRALARRFQKIDIIEPTPEETVQIINGLKPKYEAHHDVRYTAKAIRAAVELSVKYINDRHLPDKAID
VIDEAGARSRLMPVNKRKKTVNVSDIESVVARIARIPEKTVSASDRDVLRNLSDRLNMLVFGQDKAIEALSEAIKMSRAG
LGHERQPVGSFLFAGPTGVGKTEVTVQLAKALDIELLRFDMSEYMERHTVSRLIGAPPGYVGYDQGGLLTDSVIKHPHAV
LLLDEIEKAHPDVFNLLLQVMDNGTLTDNNGRKADFRNVILVMTTNAGVRETQRTSIGFKQQDSSTDALEEIKKIFTPEF
RNRLDNIIWFNHLSPAVIQQVVDKFIVELQAQLDAKGVSLEVSDEARDWLSEKGYDKAMGARPMTRVIQENLKKPLANEL
LFGSLVDGGSVTVNLDKEKQQLAYEFQSAQKRKTEGAVH

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=339, Percent_Identity=30.9734513274336, Blast_Score=152, Evalue=9e-37,
Organism=Escherichia coli, GI1787109, Length=757, Percent_Identity=89.4319682959049, Blast_Score=1400, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=325, Percent_Identity=43.6923076923077, Blast_Score=283, Evalue=3e-77,
Organism=Saccharomyces cerevisiae, GI6320464, Length=327, Percent_Identity=46.4831804281346, Blast_Score=296, Evalue=6e-81,
Organism=Saccharomyces cerevisiae, GI6323002, Length=404, Percent_Identity=36.1386138613861, Blast_Score=248, Evalue=3e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 84633; Mature: 84502

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMLNQELELSLNMAFARAREHRHEFMTVEHLLLALLSNPAAREALEACTVDLVALRQEL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
EAFIEQTTPTLPVSEEERDTQPTLSFQRVLQRAVFHVQSSGRNEVSGANVLVAIFSEQES
HHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCH
QAAYLLRKHDVSRLDVVNFISHGARKDEPSQTPNVDNSPSEEQASGEDRMENFTTNLNQL
HHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHH
ARVGGIDPLIGRDKELERTIQVLCRRRKNNPLLVGESGVGKTAIAEGLAWRIVQGDVPDV
HHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHCCEEEEECCCHHHH
ISECTLYSLDIGSLLAGTKYRGDFEKRFKALLKQLENDKDSILFIDEIHTIIGAGAASGG
HHHCEEEEECHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCCCCC
QVDAANLIKPLLSSGKIRVIGSTTYQEFSNIFEKDRALARRFQKIDIIEPTPEETVQIIN
CCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
GLKPKYEAHHDVRYTAKAIRAAVELSVKYINDRHLPDKAIDVIDEAGARSRLMPVNKRKK
CCCCCHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCC
TVNVSDIESVVARIARIPEKTVSASDRDVLRNLSDRLNMLVFGQDKAIEALSEAIKMSRA
CCCHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHH
GLGHERQPVGSFLFAGPTGVGKTEVTVQLAKALDIELLRFDMSEYMERHTVSRLIGAPPG
CCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YVGYDQGGLLTDSVIKHPHAVLLLDEIEKAHPDVFNLLLQVMDNGTLTDNNGRKADFRNV
CCCCCCCCCCCHHHHCCCCCEEEHHHHHHHCCHHHHHHHHHHCCCCEECCCCCCCCCCCE
ILVMTTNAGVRETQRTSIGFKQQDSSTDALEEIKKIFTPEFRNRLDNIIWFNHLSPAVIQ
EEEEECCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHEEEECCCCHHHHH
QVVDKFIVELQAQLDAKGVSLEVSDEARDWLSEKGYDKAMGARPMTRVIQENLKKPLANE
HHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHHHHHHH
LLFGSLVDGGSVTVNLDKEKQQLAYEFQSAQKRKTEGAVH
HHHHHEECCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PMLNQELELSLNMAFARAREHRHEFMTVEHLLLALLSNPAAREALEACTVDLVALRQEL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
EAFIEQTTPTLPVSEEERDTQPTLSFQRVLQRAVFHVQSSGRNEVSGANVLVAIFSEQES
HHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCH
QAAYLLRKHDVSRLDVVNFISHGARKDEPSQTPNVDNSPSEEQASGEDRMENFTTNLNQL
HHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHH
ARVGGIDPLIGRDKELERTIQVLCRRRKNNPLLVGESGVGKTAIAEGLAWRIVQGDVPDV
HHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHCCEEEEECCCHHHH
ISECTLYSLDIGSLLAGTKYRGDFEKRFKALLKQLENDKDSILFIDEIHTIIGAGAASGG
HHHCEEEEECHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCCCCC
QVDAANLIKPLLSSGKIRVIGSTTYQEFSNIFEKDRALARRFQKIDIIEPTPEETVQIIN
CCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
GLKPKYEAHHDVRYTAKAIRAAVELSVKYINDRHLPDKAIDVIDEAGARSRLMPVNKRKK
CCCCCHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCC
TVNVSDIESVVARIARIPEKTVSASDRDVLRNLSDRLNMLVFGQDKAIEALSEAIKMSRA
CCCHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHH
GLGHERQPVGSFLFAGPTGVGKTEVTVQLAKALDIELLRFDMSEYMERHTVSRLIGAPPG
CCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YVGYDQGGLLTDSVIKHPHAVLLLDEIEKAHPDVFNLLLQVMDNGTLTDNNGRKADFRNV
CCCCCCCCCCCHHHHCCCCCEEEHHHHHHHCCHHHHHHHHHHCCCCEECCCCCCCCCCCE
ILVMTTNAGVRETQRTSIGFKQQDSSTDALEEIKKIFTPEFRNRLDNIIWFNHLSPAVIQ
EEEEECCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHEEEECCCCHHHHH
QVVDKFIVELQAQLDAKGVSLEVSDEARDWLSEKGYDKAMGARPMTRVIQENLKKPLANE
HHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHHHHHHH
LLFGSLVDGGSVTVNLDKEKQQLAYEFQSAQKRKTEGAVH
HHHHHEECCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]