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The map label for this gene is fabF [H]

Identifier: 22126622

GI number: 22126622

Start: 3027228

End: 3028256

Strand: Direct

Name: fabF [H]

Synonym: y2744

Alternate gene names: 22126622

Gene position: 3027228-3028256 (Clockwise)

Preceding gene: 22126621

Following gene: 22126627

Centisome position: 65.8

GC content: 52.58

Gene sequence:

>1029_bases
TTGGGCCGTTGGTGGAGATATAAGTGGATCACTTTTCATCCGTCGTTGACACATGCGGATAACACAGAGAAACAAGAGCG
TACCGCGACAATCATAGGCGCGGGTATTGGTGGTTTTCCGGCCATTGCCCATGCAGTGCGGACTTCCGACAGCCGTGGGC
CAAAACGCCTCTCACCGTTTACTGTCCCTTCATTCTTAGTGAATTTGGCCGCTGGCCATGTTTCTATCAAACATCATTTT
AAAGGCCCGATTGGCGCACCAGTCACTGCCTGTGCTGCCGGTGTACAGGCAATCGGTGACGCCGTGCGGATGATCCGCAA
CAATGAAGCAGATGTTGCCCTGTGCGGTGGCGCAGAAGCCGTGATCGATACCGTGAGTCTGGCCGGTTTTGCTGCCGCTC
GTGCGTTATCAACACACTTTAATAGCACACCAGAAAAAGCCTCCCGCCCCTTCGACACTGCCCGTGACGGTTTTGTGATG
GGAGAAGGTGCTGGTTTACTGATTATTGAGGAGTTGGAGCATGCTTTAGCCAGAGGCGCGAAGCCACTAGCAGAAATAGT
CGGCTATGGTACCAGTGCCGATGCTTACCATATGACCTCTGGCGCTGAGGATGGCGACGGGGCCTATCGCGCCATGAAAA
TCGCTTTGCGTCAGGCCGGTATTACGCCCGAGCAAGTTCAGCATCTGAATGCCCACGCGACCTCAACACCGGTAGGTGAT
CTCGGTGAAATTAATGCCATTAAACATTTGTTTGGCGAGAGTAATGCGTTAGCGATTACCTCAACAAAATCCGCCACAGG
GCACCTGTTGGGCGCTGCTGGTGGGCTGGAAACCATTTTCACTGTACTGGCATTGCGTGATCAAATCGTGCCCGCAACGT
TGAATCTGGAAAATCCAGATCCTGCAGCCAAGGGACTCAACATTATTGCAGGTAACGCACAACCTCATGACATGACGTAT
GCCCTTTCCAATGGTTTTGGCTTTGCTGGGGTGAACGCAAGTATCTTACTGAAACGCTGGGTGGACTAA

Upstream 100 bases:

>100_bases
ACATGTCGTTCAAATCAAAGGAGAAAGCTATCGACTCAGACAGAAACGAAAGGCCGGGGTTATAGCAGAAGCTAATCCTG
AGTAAAACGGTGGATCAATA

Downstream 100 bases:

>100_bases
CGCAATAAAATAAATATCCTCCGGCATAGCCGGAGGTTTTTCATATGCGCCTATAAGGCTCTGTTACCAGCCGCGCCCTA
ACAGGCGCATCGCGATCTGA

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MGRWWRYKWITFHPSLTHADNTEKQERTATIIGAGIGGFPAIAHAVRTSDSRGPKRLSPFTVPSFLVNLAAGHVSIKHHF
KGPIGAPVTACAAGVQAIGDAVRMIRNNEADVALCGGAEAVIDTVSLAGFAAARALSTHFNSTPEKASRPFDTARDGFVM
GEGAGLLIIEELEHALARGAKPLAEIVGYGTSADAYHMTSGAEDGDGAYRAMKIALRQAGITPEQVQHLNAHATSTPVGD
LGEINAIKHLFGESNALAITSTKSATGHLLGAAGGLETIFTVLALRDQIVPATLNLENPDPAAKGLNIIAGNAQPHDMTY
ALSNGFGFAGVNASILLKRWVD

Sequences:

>Translated_342_residues
MGRWWRYKWITFHPSLTHADNTEKQERTATIIGAGIGGFPAIAHAVRTSDSRGPKRLSPFTVPSFLVNLAAGHVSIKHHF
KGPIGAPVTACAAGVQAIGDAVRMIRNNEADVALCGGAEAVIDTVSLAGFAAARALSTHFNSTPEKASRPFDTARDGFVM
GEGAGLLIIEELEHALARGAKPLAEIVGYGTSADAYHMTSGAEDGDGAYRAMKIALRQAGITPEQVQHLNAHATSTPVGD
LGEINAIKHLFGESNALAITSTKSATGHLLGAAGGLETIFTVLALRDQIVPATLNLENPDPAAKGLNIIAGNAQPHDMTY
ALSNGFGFAGVNASILLKRWVD
>Mature_341_residues
GRWWRYKWITFHPSLTHADNTEKQERTATIIGAGIGGFPAIAHAVRTSDSRGPKRLSPFTVPSFLVNLAAGHVSIKHHFK
GPIGAPVTACAAGVQAIGDAVRMIRNNEADVALCGGAEAVIDTVSLAGFAAARALSTHFNSTPEKASRPFDTARDGFVMG
EGAGLLIIEELEHALARGAKPLAEIVGYGTSADAYHMTSGAEDGDGAYRAMKIALRQAGITPEQVQHLNAHATSTPVGDL
GEINAIKHLFGESNALAITSTKSATGHLLGAAGGLETIFTVLALRDQIVPATLNLENPDPAAKGLNIIAGNAQPHDMTYA
LSNGFGFAGVNASILLKRWVD

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=324, Percent_Identity=47.5308641975309, Blast_Score=283, Evalue=2e-76,
Organism=Homo sapiens, GI223972627, Length=167, Percent_Identity=44.9101796407186, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI41872631, Length=297, Percent_Identity=27.6094276094276, Blast_Score=95, Evalue=9e-20,
Organism=Escherichia coli, GI1787337, Length=289, Percent_Identity=52.5951557093426, Blast_Score=280, Evalue=1e-76,
Organism=Escherichia coli, GI1788663, Length=344, Percent_Identity=38.0813953488372, Blast_Score=211, Evalue=6e-56,
Organism=Caenorhabditis elegans, GI71983541, Length=327, Percent_Identity=39.7553516819572, Blast_Score=231, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI71983535, Length=266, Percent_Identity=42.1052631578947, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI212642053, Length=296, Percent_Identity=26.3513513513513, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17550940, Length=280, Percent_Identity=25, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320904, Length=343, Percent_Identity=42.2740524781341, Blast_Score=248, Evalue=1e-66,
Organism=Drosophila melanogaster, GI24644341, Length=320, Percent_Identity=47.8125, Blast_Score=288, Evalue=5e-78,
Organism=Drosophila melanogaster, GI221330659, Length=279, Percent_Identity=26.8817204301075, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI19920632, Length=279, Percent_Identity=26.8817204301075, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24581345, Length=281, Percent_Identity=25.2669039145907, Blast_Score=88, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 35782; Mature: 35651

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRWWRYKWITFHPSLTHADNTEKQERTATIIGAGIGGFPAIAHAVRTSDSRGPKRLSPF
CCCEEEEEEEEECCCCCCCCCCCHHHHEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCC
TVPSFLVNLAAGHVSIKHHFKGPIGAPVTACAAGVQAIGDAVRMIRNNEADVALCGGAEA
CHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHH
VIDTVSLAGFAAARALSTHFNSTPEKASRPFDTARDGFVMGEGAGLLIIEELEHALARGA
HHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCEEEECCCCEEEHHHHHHHHHCCC
KPLAEIVGYGTSADAYHMTSGAEDGDGAYRAMKIALRQAGITPEQVQHLNAHATSTPVGD
HHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCC
LGEINAIKHLFGESNALAITSTKSATGHLLGAAGGLETIFTVLALRDQIVPATLNLENPD
CHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCC
PAAKGLNIIAGNAQPHDMTYALSNGFGFAGVNASILLKRWVD
HHHCCCEEEECCCCCCCEEEEECCCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
GRWWRYKWITFHPSLTHADNTEKQERTATIIGAGIGGFPAIAHAVRTSDSRGPKRLSPF
CCEEEEEEEEECCCCCCCCCCCHHHHEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCC
TVPSFLVNLAAGHVSIKHHFKGPIGAPVTACAAGVQAIGDAVRMIRNNEADVALCGGAEA
CHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHH
VIDTVSLAGFAAARALSTHFNSTPEKASRPFDTARDGFVMGEGAGLLIIEELEHALARGA
HHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCEEEECCCCEEEHHHHHHHHHCCC
KPLAEIVGYGTSADAYHMTSGAEDGDGAYRAMKIALRQAGITPEQVQHLNAHATSTPVGD
HHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCC
LGEINAIKHLFGESNALAITSTKSATGHLLGAAGGLETIFTVLALRDQIVPATLNLENPD
CHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCC
PAAKGLNIIAGNAQPHDMTYALSNGFGFAGVNASILLKRWVD
HHHCCCEEEECCCCCCCEEEEECCCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]