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The map label for this gene is yegH [H]

Identifier: 22126522

GI number: 22126522

Start: 2911651

End: 2913264

Strand: Direct

Name: yegH [H]

Synonym: y2643

Alternate gene names: 22126522

Gene position: 2911651-2913264 (Clockwise)

Preceding gene: 22126516

Following gene: 22126527

Centisome position: 63.29

GC content: 46.84

Gene sequence:

>1614_bases
ATGGAATGGATCGCGGATCCAACTATTTGGGCAGGACTGGCTACATTGGTTGTGCTCGAAATTGTATTGGGTATTGATAA
CCTTATATTTATTGCCATCTTGGCAGAGAAACTTCCTCGTCATCAACGAGACAAAGCCAGAGTCACTGGTTTACTCTGCG
CATTGTTAATGCGTCTGGCACTGTTGGCCTGTATTTCGTGGCTGGCTACATTGACCACACCAATAGTCACTCTCTCTGAA
CATTCGTTCAGTGCACGTGACTTGATTATGTTGGTCGGGGGAATATTCCTGCTGTTCAAAGCTACGATGGAGCTAAATGA
ACGGCTGGAAGGGAAAGATCATCAGCAGAATCAGCAACGCAAAGCGGCTCGTTTCTGGCCGGTGGTGGCACAGATAGTGG
TTCTGGATGCTATCTTCTCGCTCGATTCCGTGATCACCGCCGTCGGCATGGTTGATCACCTTGCGGTGATGATGGTCGCC
GTTTGTATCGCAATTGGCTTGATGTTACTCGCCAGTAAACCGTTGACTCGCTTTGTCAATGCACATCCAACGATTGTCAT
TCTGTGCTTGAGCTTCTTACTGATGATCGGTTTCAGCTTAGTCGCTGAAGGTTTTGGTTACCATATTCCTAAGGGCTACC
TGTACGCGGCTATTGGTTTCTCAGTAATTATTGAGTCACTGAACCAGTTTGCACAATTCAATCGTCGGCGCTTCCTGTCA
ACGGTTAGACCATTACGCGAACGTACCGCAGAGGCCGTTTTACGGATGCTCAGTGGCAAACACGAAGAAGCTGAATTGGA
TAACCATACTGCCAATCTGATCGCTGATAATACCAGCGAAGGCCAGGAAGTGTTCAATGCACAAGAACGGCGCATGATTG
AACGGGTCTTAGGGCTGGCACAGCGAACCGTCAGTAGCATCATGACATCACGCCATGATGTTGAATATTTGGACCTCAAT
GACCCACCAGAGAAATTGACTCAGTTGCTGGCGAAAAATCTGCATACCCGGATCGTGGTTACTGAAGATAGCTCTACTGA
TGAACCTTTGGGAGTTATTCACGTAATTGATTTATTGAAACAACAATTAGCGAATGAAAAACTCGACTTGCGGTCATTAA
TTCGCCAACCACTTATCTTTCCTGAGCAAGTTTCATTGCTGATGGCTCTGGAACAATTCCGTCAGGCACAGACACATTTT
GCTTTTGTCGTCGATGAGTTCGGTTCTATTGAGGGGGTTGTGACCCTTACCGACGTGATGGAAACTATCGCAGGTAATTT
ACCCGTAGCAGGGGAAGAGTTAGATGCGCGCCACGATATTCAGCAAACTGAAGATGGCTGTTGGATAGCGAACGGTTATA
TGCCGCTGGAAGATTTGGTGCTCTATTTGCCGCTGGAAGATTTGGTGCTCTATTTGCCGCTGCCAATTGATGAAAAACGT
GAATACCACACACTGGCCGGGTTACTCATGGAGCATACCCAGAGGATACCCAAAGTAGGTGAACAACTGACCATTGGCGA
TTACTTATTCGAACCTCTGGTGGTCAATAGCCACAGGATCTTAAAAGTGAAGATAACACCATTGAAGATTCCTGAGCCAG
ATTACGAAGTGTAG

Upstream 100 bases:

>100_bases
ATTTTTTTGTGATCGACTCTGGTCGATGCACTTCTTTAACAAATGGCTATTTTTCTGATTGACGGCATAAGCCGTAGCAA
TACAAGGTGAAACTGGATAT

Downstream 100 bases:

>100_bases
TTAATTGATAACGCTATAGATTAGGTGAATTAACAAAAGCCTGGAAAAATAAATGATTAGGCCCGGTGGAGAAACCATCG
GGCCTATCTCTTTCCACTAC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 537; Mature: 537

Protein sequence:

>537_residues
MEWIADPTIWAGLATLVVLEIVLGIDNLIFIAILAEKLPRHQRDKARVTGLLCALLMRLALLACISWLATLTTPIVTLSE
HSFSARDLIMLVGGIFLLFKATMELNERLEGKDHQQNQQRKAARFWPVVAQIVVLDAIFSLDSVITAVGMVDHLAVMMVA
VCIAIGLMLLASKPLTRFVNAHPTIVILCLSFLLMIGFSLVAEGFGYHIPKGYLYAAIGFSVIIESLNQFAQFNRRRFLS
TVRPLRERTAEAVLRMLSGKHEEAELDNHTANLIADNTSEGQEVFNAQERRMIERVLGLAQRTVSSIMTSRHDVEYLDLN
DPPEKLTQLLAKNLHTRIVVTEDSSTDEPLGVIHVIDLLKQQLANEKLDLRSLIRQPLIFPEQVSLLMALEQFRQAQTHF
AFVVDEFGSIEGVVTLTDVMETIAGNLPVAGEELDARHDIQQTEDGCWIANGYMPLEDLVLYLPLEDLVLYLPLPIDEKR
EYHTLAGLLMEHTQRIPKVGEQLTIGDYLFEPLVVNSHRILKVKITPLKIPEPDYEV

Sequences:

>Translated_537_residues
MEWIADPTIWAGLATLVVLEIVLGIDNLIFIAILAEKLPRHQRDKARVTGLLCALLMRLALLACISWLATLTTPIVTLSE
HSFSARDLIMLVGGIFLLFKATMELNERLEGKDHQQNQQRKAARFWPVVAQIVVLDAIFSLDSVITAVGMVDHLAVMMVA
VCIAIGLMLLASKPLTRFVNAHPTIVILCLSFLLMIGFSLVAEGFGYHIPKGYLYAAIGFSVIIESLNQFAQFNRRRFLS
TVRPLRERTAEAVLRMLSGKHEEAELDNHTANLIADNTSEGQEVFNAQERRMIERVLGLAQRTVSSIMTSRHDVEYLDLN
DPPEKLTQLLAKNLHTRIVVTEDSSTDEPLGVIHVIDLLKQQLANEKLDLRSLIRQPLIFPEQVSLLMALEQFRQAQTHF
AFVVDEFGSIEGVVTLTDVMETIAGNLPVAGEELDARHDIQQTEDGCWIANGYMPLEDLVLYLPLEDLVLYLPLPIDEKR
EYHTLAGLLMEHTQRIPKVGEQLTIGDYLFEPLVVNSHRILKVKITPLKIPEPDYEV
>Mature_537_residues
MEWIADPTIWAGLATLVVLEIVLGIDNLIFIAILAEKLPRHQRDKARVTGLLCALLMRLALLACISWLATLTTPIVTLSE
HSFSARDLIMLVGGIFLLFKATMELNERLEGKDHQQNQQRKAARFWPVVAQIVVLDAIFSLDSVITAVGMVDHLAVMMVA
VCIAIGLMLLASKPLTRFVNAHPTIVILCLSFLLMIGFSLVAEGFGYHIPKGYLYAAIGFSVIIESLNQFAQFNRRRFLS
TVRPLRERTAEAVLRMLSGKHEEAELDNHTANLIADNTSEGQEVFNAQERRMIERVLGLAQRTVSSIMTSRHDVEYLDLN
DPPEKLTQLLAKNLHTRIVVTEDSSTDEPLGVIHVIDLLKQQLANEKLDLRSLIRQPLIFPEQVSLLMALEQFRQAQTHF
AFVVDEFGSIEGVVTLTDVMETIAGNLPVAGEELDARHDIQQTEDGCWIANGYMPLEDLVLYLPLEDLVLYLPLPIDEKR
EYHTLAGLLMEHTQRIPKVGEQLTIGDYLFEPLVVNSHRILKVKITPLKIPEPDYEV

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=267, Percent_Identity=22.8464419475655, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI87082033, Length=538, Percent_Identity=70.817843866171, Blast_Score=744, Evalue=0.0,
Organism=Escherichia coli, GI1788119, Length=525, Percent_Identity=49.1428571428571, Blast_Score=448, Evalue=1e-127,
Organism=Escherichia coli, GI1789197, Length=226, Percent_Identity=50.8849557522124, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI1790664, Length=245, Percent_Identity=31.0204081632653, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI145693175, Length=258, Percent_Identity=25.968992248062, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786879, Length=257, Percent_Identity=28.0155642023346, Blast_Score=86, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR005496
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF03741 TerC [H]

EC number: NA

Molecular weight: Translated: 60324; Mature: 60324

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCEECCCEEEEEEEEEEECCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCEECCCEEEEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]