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The map label for this gene is aroP [H]

Identifier: 22126445

GI number: 22126445

Start: 2827315

End: 2828826

Strand: Reverse

Name: aroP [H]

Synonym: y2564

Alternate gene names: 22126445

Gene position: 2828826-2827315 (Counterclockwise)

Preceding gene: 22126446

Following gene: 257168081

Centisome position: 61.49

GC content: 46.36

Gene sequence:

>1512_bases
GTGTTTGTACCTCAACCATCAAACAAGCCTTTATCCTTGATGCTGGCGGGTTTAAGTGTTAAAAAAACCGCCGCAGACTC
ATTTATGAAATGCGTTGTTTATTCACACCAGTGCGTAATCAGTGCAACAGAGGGTAGGATGGAACAGCAGTTACAGAACT
CATCGTTAAAACGCGGTTTAAAAAATAGACATATTCAACTAATAGCTTTGGGTGGCGCAATCGGAACCGGGTTATTTCTC
GGGATTGCCCAAACCATCAATATGGCCGGCCCCTCAGTAATATTGGGGTATGCAATAGGCGGGTTTATTGCTTTTCTGAT
TATGCGTCAATTAGGTGAAATGGTCGTCGAAGAGCCTGTTGCTGGCTCATTCAGCCACTTTGCCTATAAGTATTGGGGCG
ATTTTGCTGGTTTTCTATCGGGCTGGAACTACTGGGCCATGTTTATTCTGGTCGGTATGGCTGAATTGACTGCGGTAGGC
ATATATATTCAGTATTGGTGGCCTGAGATACCGACATGGGTTTCAGCAGCAGTATTCTTTATCATAATCAACGCTATCAA
CTTAGTTAACGTACGTCTGTATGGCGAAACGGAGTTTTGGTTTGCCATCATTAAAGTGGCTGCAATTATCGGTATGATTG
TGTTCGGTGCTTATCTACTGGCATCGGGATCTGGTGGGCCAGCCGCCTCGGTGACAAATCTCTGGGCGCAGGGGGGTTTT
ATGCCCCATGGCTTTCGTGGTTTGATCATGGCAATGGCGGTTATTATGTTCTCTTTTGGCGGTCTGGAGATGGTAGGGAT
TACTGCAGCAGAAGCCGAAGATCCACGGAACAGTATTCCTAAAGCGACTAATCAGGTCGTTTATCGCATTCTTATTTTTT
ATATTGGCTCACTGACGGTGCTTCTGTCTCTTTTCCCGTGGAACAATGTCGTCGAAGGGGGAAGTCCTTTCGTGATGATT
TTCGATGCGTTAGATAGCCCTTGGGTGGCAACAGCATTGAATGTGGTTGTCCTGACCGCCGCCCTGTCGGTGTATAACAG
TGGTGTGTATTGTAACAGTCGTATGCTTTTTGGGCTGGCATCACAGGGGAATGCGCCTAAGTTGTTGACCAAGTTAAATA
AGCGTGGTGTCCCCATCCGTTCAATTGCACTTTCAGCATTAGCGACTTCAGCTGGCGTGGTGATTAACTATATTATGCCC
GGCAAAGCCTTTGAATTACTTATGGCGTTGGTGGTTTCAACACTGGTAATCAACTGGGTGATGATTTGCCTGGCGCATCT
GAAGTTTCGCAAGGCTAAAGTTAAAGAGGGCGTTGTGCCTCGCTTCAAAGCACTCTGGTACCCCTACGGCAATTATCTGT
GCCTGGTCTTCCTCGCATTAATTCTCGTCATTATGTATCTCACCGAAGGGATTCGGATCTCTGTGTTGATGATGCCAGTA
TGGATAGCGTTACTTTGGTGTGGTTTTGTACTTACTCGGCGTAAGTGTCCAAAAACGGTGACTAGCCTCTAA

Upstream 100 bases:

>100_bases
AATTATGATTTATCTATTGGGTAGACAATATGATATTTCATCAAGTAGTGGTGCGCGTTAAAGCATATCGTTGTGTGCGT
TAAATCACGGAAGTGTATGA

Downstream 100 bases:

>100_bases
TGCTTCCTGATTAGCAGGGCAGTAAAATGCCGCGCTTGGAAGGGTGCGGCTTGAGCTTATATCAATAGTGATTGTTTGAT
TATTGTACTTTATTGTTATT

Product: aromatic amino acid transporter

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: General aromatic amino acid permease [H]

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MFVPQPSNKPLSLMLAGLSVKKTAADSFMKCVVYSHQCVISATEGRMEQQLQNSSLKRGLKNRHIQLIALGGAIGTGLFL
GIAQTINMAGPSVILGYAIGGFIAFLIMRQLGEMVVEEPVAGSFSHFAYKYWGDFAGFLSGWNYWAMFILVGMAELTAVG
IYIQYWWPEIPTWVSAAVFFIIINAINLVNVRLYGETEFWFAIIKVAAIIGMIVFGAYLLASGSGGPAASVTNLWAQGGF
MPHGFRGLIMAMAVIMFSFGGLEMVGITAAEAEDPRNSIPKATNQVVYRILIFYIGSLTVLLSLFPWNNVVEGGSPFVMI
FDALDSPWVATALNVVVLTAALSVYNSGVYCNSRMLFGLASQGNAPKLLTKLNKRGVPIRSIALSALATSAGVVINYIMP
GKAFELLMALVVSTLVINWVMICLAHLKFRKAKVKEGVVPRFKALWYPYGNYLCLVFLALILVIMYLTEGIRISVLMMPV
WIALLWCGFVLTRRKCPKTVTSL

Sequences:

>Translated_503_residues
MFVPQPSNKPLSLMLAGLSVKKTAADSFMKCVVYSHQCVISATEGRMEQQLQNSSLKRGLKNRHIQLIALGGAIGTGLFL
GIAQTINMAGPSVILGYAIGGFIAFLIMRQLGEMVVEEPVAGSFSHFAYKYWGDFAGFLSGWNYWAMFILVGMAELTAVG
IYIQYWWPEIPTWVSAAVFFIIINAINLVNVRLYGETEFWFAIIKVAAIIGMIVFGAYLLASGSGGPAASVTNLWAQGGF
MPHGFRGLIMAMAVIMFSFGGLEMVGITAAEAEDPRNSIPKATNQVVYRILIFYIGSLTVLLSLFPWNNVVEGGSPFVMI
FDALDSPWVATALNVVVLTAALSVYNSGVYCNSRMLFGLASQGNAPKLLTKLNKRGVPIRSIALSALATSAGVVINYIMP
GKAFELLMALVVSTLVINWVMICLAHLKFRKAKVKEGVVPRFKALWYPYGNYLCLVFLALILVIMYLTEGIRISVLMMPV
WIALLWCGFVLTRRKCPKTVTSL
>Mature_503_residues
MFVPQPSNKPLSLMLAGLSVKKTAADSFMKCVVYSHQCVISATEGRMEQQLQNSSLKRGLKNRHIQLIALGGAIGTGLFL
GIAQTINMAGPSVILGYAIGGFIAFLIMRQLGEMVVEEPVAGSFSHFAYKYWGDFAGFLSGWNYWAMFILVGMAELTAVG
IYIQYWWPEIPTWVSAAVFFIIINAINLVNVRLYGETEFWFAIIKVAAIIGMIVFGAYLLASGSGGPAASVTNLWAQGGF
MPHGFRGLIMAMAVIMFSFGGLEMVGITAAEAEDPRNSIPKATNQVVYRILIFYIGSLTVLLSLFPWNNVVEGGSPFVMI
FDALDSPWVATALNVVVLTAALSVYNSGVYCNSRMLFGLASQGNAPKLLTKLNKRGVPIRSIALSALATSAGVVINYIMP
GKAFELLMALVVSTLVINWVMICLAHLKFRKAKVKEGVVPRFKALWYPYGNYLCLVFLALILVIMYLTEGIRISVLMMPV
WIALLWCGFVLTRRKCPKTVTSL

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan) [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=355, Percent_Identity=23.3802816901408, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI258645169, Length=395, Percent_Identity=19.493670886076, Blast_Score=70, Evalue=7e-12,
Organism=Homo sapiens, GI181337167, Length=283, Percent_Identity=25.0883392226148, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786302, Length=456, Percent_Identity=70.3947368421053, Blast_Score=654, Evalue=0.0,
Organism=Escherichia coli, GI1786789, Length=444, Percent_Identity=69.1441441441441, Blast_Score=629, Evalue=0.0,
Organism=Escherichia coli, GI48994972, Length=430, Percent_Identity=41.6279069767442, Blast_Score=349, Evalue=3e-97,
Organism=Escherichia coli, GI1790653, Length=456, Percent_Identity=39.2543859649123, Blast_Score=346, Evalue=2e-96,
Organism=Escherichia coli, GI1786602, Length=447, Percent_Identity=43.8478747203579, Blast_Score=338, Evalue=7e-94,
Organism=Escherichia coli, GI87081915, Length=390, Percent_Identity=38.4615384615385, Blast_Score=301, Evalue=6e-83,
Organism=Escherichia coli, GI87081708, Length=460, Percent_Identity=34.3478260869565, Blast_Score=286, Evalue=3e-78,
Organism=Escherichia coli, GI1789017, Length=437, Percent_Identity=36.1556064073227, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI1788480, Length=401, Percent_Identity=35.6608478802993, Blast_Score=238, Evalue=1e-63,
Organism=Escherichia coli, GI87081869, Length=173, Percent_Identity=27.1676300578035, Blast_Score=66, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6324061, Length=500, Percent_Identity=33.2, Blast_Score=236, Evalue=7e-63,
Organism=Saccharomyces cerevisiae, GI6320772, Length=442, Percent_Identity=34.1628959276018, Blast_Score=236, Evalue=9e-63,
Organism=Saccharomyces cerevisiae, GI6322892, Length=401, Percent_Identity=33.4164588528678, Blast_Score=205, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6324924, Length=447, Percent_Identity=30.8724832214765, Blast_Score=204, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6321629, Length=443, Percent_Identity=30.2483069977427, Blast_Score=201, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6321053, Length=514, Percent_Identity=28.5992217898833, Blast_Score=199, Evalue=6e-52,
Organism=Saccharomyces cerevisiae, GI6319824, Length=401, Percent_Identity=30.6733167082294, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6320717, Length=469, Percent_Identity=28.3582089552239, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6324553, Length=408, Percent_Identity=31.8627450980392, Blast_Score=193, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6324059, Length=477, Percent_Identity=31.6561844863732, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6320251, Length=483, Percent_Identity=28.1573498964803, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6324990, Length=449, Percent_Identity=30.2895322939866, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6319608, Length=450, Percent_Identity=28.8888888888889, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6322967, Length=448, Percent_Identity=29.0178571428571, Blast_Score=179, Evalue=9e-46,
Organism=Saccharomyces cerevisiae, GI6319543, Length=403, Percent_Identity=30.0248138957816, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6319542, Length=412, Percent_Identity=27.9126213592233, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6324981, Length=482, Percent_Identity=26.5560165975104, Blast_Score=156, Evalue=7e-39,
Organism=Saccharomyces cerevisiae, GI6320364, Length=501, Percent_Identity=27.3453093812375, Blast_Score=124, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24667468, Length=361, Percent_Identity=24.0997229916898, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI221512776, Length=292, Percent_Identity=22.9452054794521, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24666159, Length=292, Percent_Identity=22.9452054794521, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24668806, Length=354, Percent_Identity=23.1638418079096, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21356285, Length=354, Percent_Identity=23.1638418079096, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24668802, Length=354, Percent_Identity=23.1638418079096, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 55008; Mature: 55008

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: PS00024 HEMOPEXIN ; PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVPQPSNKPLSLMLAGLSVKKTAADSFMKCVVYSHQCVISATEGRMEQQLQNSSLKRGL
CCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHCCH
KNRHIQLIALGGAIGTGLFLGIAQTINMAGPSVILGYAIGGFIAFLIMRQLGEMVVEEPV
HHCCEEEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AGSFSHFAYKYWGDFAGFLSGWNYWAMFILVGMAELTAVGIYIQYWWPEIPTWVSAAVFF
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHH
IIINAINLVNVRLYGETEFWFAIIKVAAIIGMIVFGAYLLASGSGGPAASVTNLWAQGGF
HHHHHHHEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCC
MPHGFRGLIMAMAVIMFSFGGLEMVGITAAEAEDPRNSIPKATNQVVYRILIFYIGSLTV
CCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LLSLFPWNNVVEGGSPFVMIFDALDSPWVATALNVVVLTAALSVYNSGVYCNSRMLFGLA
HHHHCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEECCEEEEEEC
SQGNAPKLLTKLNKRGVPIRSIALSALATSAGVVINYIMPGKAFELLMALVVSTLVINWV
CCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHH
MICLAHLKFRKAKVKEGVVPRFKALWYPYGNYLCLVFLALILVIMYLTEGIRISVLMMPV
HHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHH
WIALLWCGFVLTRRKCPKTVTSL
HHHHHHHHHHHHHHCCCHHHHCC
>Mature Secondary Structure
MFVPQPSNKPLSLMLAGLSVKKTAADSFMKCVVYSHQCVISATEGRMEQQLQNSSLKRGL
CCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHCCH
KNRHIQLIALGGAIGTGLFLGIAQTINMAGPSVILGYAIGGFIAFLIMRQLGEMVVEEPV
HHCCEEEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AGSFSHFAYKYWGDFAGFLSGWNYWAMFILVGMAELTAVGIYIQYWWPEIPTWVSAAVFF
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHH
IIINAINLVNVRLYGETEFWFAIIKVAAIIGMIVFGAYLLASGSGGPAASVTNLWAQGGF
HHHHHHHEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCC
MPHGFRGLIMAMAVIMFSFGGLEMVGITAAEAEDPRNSIPKATNQVVYRILIFYIGSLTV
CCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LLSLFPWNNVVEGGSPFVMIFDALDSPWVATALNVVVLTAALSVYNSGVYCNSRMLFGLA
HHHHCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEECCEEEEEEC
SQGNAPKLLTKLNKRGVPIRSIALSALATSAGVVINYIMPGKAFELLMALVVSTLVINWV
CCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHH
MICLAHLKFRKAKVKEGVVPRFKALWYPYGNYLCLVFLALILVIMYLTEGIRISVLMMPV
HHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHH
WIALLWCGFVLTRRKCPKTVTSL
HHHHHHHHHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]