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The map label for this gene is shlB [H]

Identifier: 22126154

GI number: 22126154

Start: 2501386

End: 2503020

Strand: Reverse

Name: shlB [H]

Synonym: y2268

Alternate gene names: 22126154

Gene position: 2503020-2501386 (Counterclockwise)

Preceding gene: 22126155

Following gene: 22126153

Centisome position: 54.4

GC content: 37.25

Gene sequence:

>1635_bases
ATGATTATTTTGTTGCTTAGTAATGCTGTTTTAGCAACAGAGAATAATAAAAATAGATTAAATGATAATGTGGTATCACA
CGCTGACATAGATGTGCGTAATGAATATAACGAGGAAGGCAATAGAGTAGGAAAACGTTTTTTTTCTACAAACCATCATA
GTGTTGCATCACAGAAAAAAATCTCCCCAGAGAAAATATGCCTGCCAATTACTGGGGTATTTTTGCAAGGGAATACATTA
CTGTCGTCGCAAGACTTAAATCAGATTGATCATATTCTTGGTGAATGCATTAGTGAAGATGATATTAATATCTTAGCCAA
GGAAGTGACTCGATTATATTTGTCTAAAGGTTATCTGGCGGCCAGAGTCAATTTCATTCCATTAAATAATGCGGGGGAGT
TGGGACTGAATGTGACTGAGGGTATTGTTGAAAAAATTGAAGGTGGAGGACGAAGAGTCAACCCTTATTTTATATTCCCT
AACTTTATTGATAAACCCCTTCGGTTATCCGAGCTTGATCAGGCCATCGATCAGGCTAACAGACTACGATCAAATAAAGT
AAACGTCGATATCTTACCAGGAAGTCAGGCGGGCAAATCAATTATTAGAATTAATAATGTCAATAATAAACCTTGGAGCT
TATCGACCGTCATTGATAATTATGGATATAAAAATTCTGATGAGTGGCAAGCAAGAGTGTCACTGGCTTTAGATAGCCCA
TTCGGACTATCTGATTCTATTAATTTTAATGCTAATCGCACGCTAGAGAATGCAAAGAATCGCTATAAGAATGATTTTAC
TGTTTCTTATTCGGTACCTTATGGTGCATTAACTTTCAGTGCTCTTGCTAATTATCTGGAATACCGGCGCTATGAGAAAT
TAAAAAATGGGACAGTGAATTTTAATGGTAACTCACAGCAGTATAACTTCCGTACTGATTATATGTTCCATCGTACACAA
AAGCAGATAAACAGTTTAAGTATGCAAGTAGAGCACAAACAGATTAATAACTATGTCGATGAGGCAAAAGTAGGTGTCTA
CAGTTATCGATTTACTAATCTTGAATTAGGTGTCAATCAATTTCGTATTCTTCCTCATGGTTCAGTGAATGTTAATGCGG
CAATAAAAAGAGGTGTGCCATGGTTTGGTACTCATCAGAAAAATAAAATAAATGCAGTACAATTTACCACAGGAAAATTG
ATGGTTAATTTTAATCACAATTTCTCTCTATTAAATTCTCCGTACCAATTTGATCATGCTTTAGTTGGGCAATACAGTAA
GAATTATGCGCCTTCTCCTGAGTGGATAAGTTTGACTGAACGTAATGCCATTAGAGGATTTAGTCGTAGTTCACAATCGG
CAGATCATGGTTGGTATATGAAAAATACGTTATCCAAGCACTTTTTTATGGGGAATATACTTTTTACCCCTCGAATGGGT
GTTGATGGCGGACGTGCTTTAAAGCATGGAAGTCAGCAAGGGTGGCAAAGTAATGCGGGTGTGAGTGCTGGTATATCCAT
GCGCTATCACCAAGCATTATTTGATGTGGAAGCCAGCCGTGGTTGGTGGCTTTCCGATAGTAATAAACAGAACGAACCTG
TACAGGTATTGGGCCGTATAGCTTATACCTTCTAA

Upstream 100 bases:

>100_bases
ATCTAGTGTGTTGTTAATCCTCTGTTTTTTAAATTCTATCGCACATTGGATTCATTCACGGGTGTTATGGCAAATGAATA
TTTTTTTTAGAAAAAAATAT

Downstream 100 bases:

>100_bases
CTCAACGTAATTTAAATAAGGTTATTTTAATGAAAATAAATAAATTTAAACTTTCCCCAGCAGGAAAGTTGACGGTTATC
TTATCTTTAATTCTTACTCC

Product: hemolysin activator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 544; Mature: 544

Protein sequence:

>544_residues
MIILLLSNAVLATENNKNRLNDNVVSHADIDVRNEYNEEGNRVGKRFFSTNHHSVASQKKISPEKICLPITGVFLQGNTL
LSSQDLNQIDHILGECISEDDINILAKEVTRLYLSKGYLAARVNFIPLNNAGELGLNVTEGIVEKIEGGGRRVNPYFIFP
NFIDKPLRLSELDQAIDQANRLRSNKVNVDILPGSQAGKSIIRINNVNNKPWSLSTVIDNYGYKNSDEWQARVSLALDSP
FGLSDSINFNANRTLENAKNRYKNDFTVSYSVPYGALTFSALANYLEYRRYEKLKNGTVNFNGNSQQYNFRTDYMFHRTQ
KQINSLSMQVEHKQINNYVDEAKVGVYSYRFTNLELGVNQFRILPHGSVNVNAAIKRGVPWFGTHQKNKINAVQFTTGKL
MVNFNHNFSLLNSPYQFDHALVGQYSKNYAPSPEWISLTERNAIRGFSRSSQSADHGWYMKNTLSKHFFMGNILFTPRMG
VDGGRALKHGSQQGWQSNAGVSAGISMRYHQALFDVEASRGWWLSDSNKQNEPVQVLGRIAYTF

Sequences:

>Translated_544_residues
MIILLLSNAVLATENNKNRLNDNVVSHADIDVRNEYNEEGNRVGKRFFSTNHHSVASQKKISPEKICLPITGVFLQGNTL
LSSQDLNQIDHILGECISEDDINILAKEVTRLYLSKGYLAARVNFIPLNNAGELGLNVTEGIVEKIEGGGRRVNPYFIFP
NFIDKPLRLSELDQAIDQANRLRSNKVNVDILPGSQAGKSIIRINNVNNKPWSLSTVIDNYGYKNSDEWQARVSLALDSP
FGLSDSINFNANRTLENAKNRYKNDFTVSYSVPYGALTFSALANYLEYRRYEKLKNGTVNFNGNSQQYNFRTDYMFHRTQ
KQINSLSMQVEHKQINNYVDEAKVGVYSYRFTNLELGVNQFRILPHGSVNVNAAIKRGVPWFGTHQKNKINAVQFTTGKL
MVNFNHNFSLLNSPYQFDHALVGQYSKNYAPSPEWISLTERNAIRGFSRSSQSADHGWYMKNTLSKHFFMGNILFTPRMG
VDGGRALKHGSQQGWQSNAGVSAGISMRYHQALFDVEASRGWWLSDSNKQNEPVQVLGRIAYTF
>Mature_544_residues
MIILLLSNAVLATENNKNRLNDNVVSHADIDVRNEYNEEGNRVGKRFFSTNHHSVASQKKISPEKICLPITGVFLQGNTL
LSSQDLNQIDHILGECISEDDINILAKEVTRLYLSKGYLAARVNFIPLNNAGELGLNVTEGIVEKIEGGGRRVNPYFIFP
NFIDKPLRLSELDQAIDQANRLRSNKVNVDILPGSQAGKSIIRINNVNNKPWSLSTVIDNYGYKNSDEWQARVSLALDSP
FGLSDSINFNANRTLENAKNRYKNDFTVSYSVPYGALTFSALANYLEYRRYEKLKNGTVNFNGNSQQYNFRTDYMFHRTQ
KQINSLSMQVEHKQINNYVDEAKVGVYSYRFTNLELGVNQFRILPHGSVNVNAAIKRGVPWFGTHQKNKINAVQFTTGKL
MVNFNHNFSLLNSPYQFDHALVGQYSKNYAPSPEWISLTERNAIRGFSRSSQSADHGWYMKNTLSKHFFMGNILFTPRMG
VDGGRALKHGSQQGWQSNAGVSAGISMRYHQALFDVEASRGWWLSDSNKQNEPVQVLGRIAYTF

Specific function: Member of a two partner secretion pathway (TPS) in which it mediates the secretion of hemolysin [H]

COG id: COG2831

COG function: function code U; Hemolysin activation/secretion protein

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tpsB (TC 1.B.20) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005565
- InterPro:   IPR013686 [H]

Pfam domain/function: PF08479 POTRA_2; PF03865 ShlB [H]

EC number: NA

Molecular weight: Translated: 61581; Mature: 61581

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIILLLSNAVLATENNKNRLNDNVVSHADIDVRNEYNEEGNRVGKRFFSTNHHSVASQKK
CEEEEEECEEEEECCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHCCCCCHHHHHHC
ISPEKICLPITGVFLQGNTLLSSQDLNQIDHILGECISEDDINILAKEVTRLYLSKGYLA
CCCCCEEEEEEEEEEECCEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCEEE
ARVNFIPLNNAGELGLNVTEGIVEKIEGGGRRVNPYFIFPNFIDKPLRLSELDQAIDQAN
EEEEEEECCCCCCCCCCHHHHHHHHHCCCCEEECEEEECHHHCCCCCCHHHHHHHHHHHH
RLRSNKVNVDILPGSQAGKSIIRINNVNNKPWSLSTVIDNYGYKNSDEWQARVSLALDSP
HHHCCCCEEEEECCCCCCCEEEEEECCCCCCEEHHHHHHCCCCCCCCCCEEEEEEEECCC
FGLSDSINFNANRTLENAKNRYKNDFTVSYSVPYGALTFSALANYLEYRRYEKLKNGTVN
CCCCCCCCCCCCCCHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCEEE
FNGNSQQYNFRTDYMFHRTQKQINSLSMQVEHKQINNYVDEAKVGVYSYRFTNLELGVNQ
ECCCCCEEEEECHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHEEEEEEEEEEEEECCCE
FRILPHGSVNVNAAIKRGVPWFGTHQKNKINAVQFTTGKLMVNFNHNFSLLNSPYQFDHA
EEEECCCCCEEEHHHHCCCCCCCCCCCCCEEEEEEEECEEEEEECCCEEECCCCCHHHHH
LVGQYSKNYAPSPEWISLTERNAIRGFSRSSQSADHGWYMKNTLSKHFFMGNILFTPRMG
HHHHHCCCCCCCCCEEEEECCHHHHCCCCCCCCCCCCCCHHHHHHHHEEECEEEECCCCC
VDGGRALKHGSQQGWQSNAGVSAGISMRYHQALFDVEASRGWWLSDSNKQNEPVQVLGRI
CCCCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHEEECCCCEEECCCCCCCCHHHHHHHH
AYTF
HHCC
>Mature Secondary Structure
MIILLLSNAVLATENNKNRLNDNVVSHADIDVRNEYNEEGNRVGKRFFSTNHHSVASQKK
CEEEEEECEEEEECCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHCCCCCHHHHHHC
ISPEKICLPITGVFLQGNTLLSSQDLNQIDHILGECISEDDINILAKEVTRLYLSKGYLA
CCCCCEEEEEEEEEEECCEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCEEE
ARVNFIPLNNAGELGLNVTEGIVEKIEGGGRRVNPYFIFPNFIDKPLRLSELDQAIDQAN
EEEEEEECCCCCCCCCCHHHHHHHHHCCCCEEECEEEECHHHCCCCCCHHHHHHHHHHHH
RLRSNKVNVDILPGSQAGKSIIRINNVNNKPWSLSTVIDNYGYKNSDEWQARVSLALDSP
HHHCCCCEEEEECCCCCCCEEEEEECCCCCCEEHHHHHHCCCCCCCCCCEEEEEEEECCC
FGLSDSINFNANRTLENAKNRYKNDFTVSYSVPYGALTFSALANYLEYRRYEKLKNGTVN
CCCCCCCCCCCCCCHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCEEE
FNGNSQQYNFRTDYMFHRTQKQINSLSMQVEHKQINNYVDEAKVGVYSYRFTNLELGVNQ
ECCCCCEEEEECHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHEEEEEEEEEEEEECCCE
FRILPHGSVNVNAAIKRGVPWFGTHQKNKINAVQFTTGKLMVNFNHNFSLLNSPYQFDHA
EEEECCCCCEEEHHHHCCCCCCCCCCCCCEEEEEEEECEEEEEECCCEEECCCCCHHHHH
LVGQYSKNYAPSPEWISLTERNAIRGFSRSSQSADHGWYMKNTLSKHFFMGNILFTPRMG
HHHHHCCCCCCCCCEEEEECCHHHHCCCCCCCCCCCCCCHHHHHHHHEEECEEEECCCCC
VDGGRALKHGSQQGWQSNAGVSAGISMRYHQALFDVEASRGWWLSDSNKQNEPVQVLGRI
CCCCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHEEECCCCEEECCCCCCCCHHHHHHHH
AYTF
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3290200 [H]