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The map label for this gene is tyrR [H]

Identifier: 22125880

GI number: 22125880

Start: 2187482

End: 2189149

Strand: Direct

Name: tyrR [H]

Synonym: y1988

Alternate gene names: 22125880

Gene position: 2187482-2189149 (Clockwise)

Preceding gene: 22125877

Following gene: 22125883

Centisome position: 47.55

GC content: 48.32

Gene sequence:

>1668_bases
TTGCTGACAGACTGCTTCATCAGTAAGAGGGGACAGGGTATTATCATCGCCAGTGATTCCGCACCTGTCATATATATAAG
GTCAATACTGATGCGCTTGGAAGTTTTTTGCGAAGACCGGCTCGGTCTCACCAGAGAGTTGCTTGATCTCTTGGTATTAC
GCAGCATTGATTTACGGGGGATCGAAATTGATCCTATTGGTCGCATTTACCTGAATTTTTCCAGTCTGGATTTCAGTATA
TTCAGTGCACTAATGATGGAGATTCGGCATATTGATGGGGTAACAGATGTCCGTACCGTTTCCTTTATGCCATCAGAGCG
CGAACACCGTTCGTTGCGAGCGCTGCTGGAATCTATGCCAGAACCGGTATTCTCTATTGATTTAAAAGGGAACCTTGAGC
TGTCTAACCCCGCAGCCCGGGCGCTATTCTCCCTCAGTGAAGAAAAAATTCGCCATAAAACGGCGGGCAGCCTGCTGGGT
GGCTATAATTTTTCACGCTGGTTTGAAGGCGGCGATACGGCCCCTCACACTGAACGGGTATTGATCAATAATCAGGATTA
CCTGATGGAGATTACACCGATTAATCTCGAAGACGAAAACCAGAAAAAACAAACCGTTGGCGCGGTTGTGATGTTGAAAT
CAACCGCACGCATGGGGCAGCAACTGCAAACTTTATCGGTCAATGATGATACCGAGTTTAGACAGATAGTGGCGGCCAGC
ACGAAGATGCGCCAGGTTTTGGCTCAAGCCCGAAAATTAGCCATGCTTGATGCGCCGTTATTGCTGGTGGGGGATACAGG
GACCGGTAAAGATCTGCTGGCTCGTGCCTGTCACTTGCGCAGTCCTCGGGGGAAAATGCCATTTCTTGGTCTGAATTGTG
CTTCACTGCCAGATGAAGTGGTCGAGAGTGAATTATTCGGTTATGCGGCTGGCGCGTACCCAAACGCTATTGAAGGCAAA
AAGGGCTTCTTCGAACAGGCAAATGGGGGTTCGGTCCTGTTGGATGAAATTGGTGAAATGTCACCTCGTATGCAAATCAA
ACTGTTGCGTTTCCTTAATGACGGAACATTCCGCCGTGTAGGCGAAGAACATGAAGTGCATGTTGATGTGCGTGTCATTT
GTGCCACCCAAAAAAATCTGGTGGAGTTGGTGCAACGTGGGGAATTCCGTGAAGACTTATATTATCGGCTGAATGTCCTG
ACCATCACATTACCGCCATTGCGTGAGCGTCAGACCGATATTATGCCATTGACTGAGTTGTTTGTAGCGCGATTCTCTGA
TGAGCAAGGTGTGCCGCGGCCAAAATTGTCACCAGAGTTGGCCAGTTTCCTGACTCACTACGGTTGGCCGGGTAATGTGC
GTCAGCTTAAAAATGCGATTTATCGTGCGCTCACTCAGTTGGAGGGGGCCGAATTAAGGCCACAGGATATCATCCTGCCG
GAGTTTGAAATTGAAGCCACGTTGGGTGATGAAGTCCTTGATGGTTCACTTGATGACATCAGTAAGCGGTTCGAACGTTC
TGTGCTGACTCGCCTTTATCGTAATTATCCCAGCACCCGTAAACTGGCTAAACGGCTAGGTGTTTCGCATACTGCGATCG
CCAATAAATTACGGGAGTATGGTTTAAGCAGTAAACGGCCCGCCAGTGATGAAAATGAAGAAGAATAA

Upstream 100 bases:

>100_bases
TAATAACACACTATTTATAGTTAATTTAATCGTTAAATATATTGCCTGATATGATTCAATCAGGGAAAAAAAATAACAAA
AAGACGATTCCTGTCAACTT

Downstream 100 bases:

>100_bases
AGCGCAAAACGGCCAGTAATCAAACATAAAAAAGAGTAAATAAATATCCTCCGGCATAGCCGGAGGTTTTTCATATGCGC
CTATAAGGCTCTGTTACCAG

Product: DNA-binding transcriptional regulator TyrR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 555; Mature: 555

Protein sequence:

>555_residues
MLTDCFISKRGQGIIIASDSAPVIYIRSILMRLEVFCEDRLGLTRELLDLLVLRSIDLRGIEIDPIGRIYLNFSSLDFSI
FSALMMEIRHIDGVTDVRTVSFMPSEREHRSLRALLESMPEPVFSIDLKGNLELSNPAARALFSLSEEKIRHKTAGSLLG
GYNFSRWFEGGDTAPHTERVLINNQDYLMEITPINLEDENQKKQTVGAVVMLKSTARMGQQLQTLSVNDDTEFRQIVAAS
TKMRQVLAQARKLAMLDAPLLLVGDTGTGKDLLARACHLRSPRGKMPFLGLNCASLPDEVVESELFGYAAGAYPNAIEGK
KGFFEQANGGSVLLDEIGEMSPRMQIKLLRFLNDGTFRRVGEEHEVHVDVRVICATQKNLVELVQRGEFREDLYYRLNVL
TITLPPLRERQTDIMPLTELFVARFSDEQGVPRPKLSPELASFLTHYGWPGNVRQLKNAIYRALTQLEGAELRPQDIILP
EFEIEATLGDEVLDGSLDDISKRFERSVLTRLYRNYPSTRKLAKRLGVSHTAIANKLREYGLSSKRPASDENEEE

Sequences:

>Translated_555_residues
MLTDCFISKRGQGIIIASDSAPVIYIRSILMRLEVFCEDRLGLTRELLDLLVLRSIDLRGIEIDPIGRIYLNFSSLDFSI
FSALMMEIRHIDGVTDVRTVSFMPSEREHRSLRALLESMPEPVFSIDLKGNLELSNPAARALFSLSEEKIRHKTAGSLLG
GYNFSRWFEGGDTAPHTERVLINNQDYLMEITPINLEDENQKKQTVGAVVMLKSTARMGQQLQTLSVNDDTEFRQIVAAS
TKMRQVLAQARKLAMLDAPLLLVGDTGTGKDLLARACHLRSPRGKMPFLGLNCASLPDEVVESELFGYAAGAYPNAIEGK
KGFFEQANGGSVLLDEIGEMSPRMQIKLLRFLNDGTFRRVGEEHEVHVDVRVICATQKNLVELVQRGEFREDLYYRLNVL
TITLPPLRERQTDIMPLTELFVARFSDEQGVPRPKLSPELASFLTHYGWPGNVRQLKNAIYRALTQLEGAELRPQDIILP
EFEIEATLGDEVLDGSLDDISKRFERSVLTRLYRNYPSTRKLAKRLGVSHTAIANKLREYGLSSKRPASDENEEE
>Mature_555_residues
MLTDCFISKRGQGIIIASDSAPVIYIRSILMRLEVFCEDRLGLTRELLDLLVLRSIDLRGIEIDPIGRIYLNFSSLDFSI
FSALMMEIRHIDGVTDVRTVSFMPSEREHRSLRALLESMPEPVFSIDLKGNLELSNPAARALFSLSEEKIRHKTAGSLLG
GYNFSRWFEGGDTAPHTERVLINNQDYLMEITPINLEDENQKKQTVGAVVMLKSTARMGQQLQTLSVNDDTEFRQIVAAS
TKMRQVLAQARKLAMLDAPLLLVGDTGTGKDLLARACHLRSPRGKMPFLGLNCASLPDEVVESELFGYAAGAYPNAIEGK
KGFFEQANGGSVLLDEIGEMSPRMQIKLLRFLNDGTFRRVGEEHEVHVDVRVICATQKNLVELVQRGEFREDLYYRLNVL
TITLPPLRERQTDIMPLTELFVARFSDEQGVPRPKLSPELASFLTHYGWPGNVRQLKNAIYRALTQLEGAELRPQDIILP
EFEIEATLGDEVLDGSLDDISKRFERSVLTRLYRNYPSTRKLAKRLGVSHTAIANKLREYGLSSKRPASDENEEE

Specific function: Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport. Modulates the expression of at least 8 unlinked operons. Seven of these operons are regulated in response to changes in the concentration of the three aromatic amino

COG id: COG3283

COG function: function code KE; Transcriptional regulator of aromatic amino acids metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1787583, Length=517, Percent_Identity=70.5996131528046, Blast_Score=743, Evalue=0.0,
Organism=Escherichia coli, GI1788550, Length=362, Percent_Identity=37.5690607734807, Blast_Score=234, Evalue=9e-63,
Organism=Escherichia coli, GI1790299, Length=345, Percent_Identity=38.8405797101449, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI1790437, Length=302, Percent_Identity=37.7483443708609, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI87082152, Length=337, Percent_Identity=37.6854599406528, Blast_Score=208, Evalue=6e-55,
Organism=Escherichia coli, GI1789233, Length=329, Percent_Identity=35.258358662614, Blast_Score=208, Evalue=7e-55,
Organism=Escherichia coli, GI1789087, Length=317, Percent_Identity=38.801261829653, Blast_Score=201, Evalue=7e-53,
Organism=Escherichia coli, GI1788905, Length=244, Percent_Identity=41.8032786885246, Blast_Score=199, Evalue=6e-52,
Organism=Escherichia coli, GI87082117, Length=338, Percent_Identity=34.9112426035503, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI87081872, Length=249, Percent_Identity=39.3574297188755, Blast_Score=185, Evalue=6e-48,
Organism=Escherichia coli, GI1786524, Length=275, Percent_Identity=40.3636363636364, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI1789828, Length=240, Percent_Identity=36.6666666666667, Blast_Score=138, Evalue=8e-34,
Organism=Escherichia coli, GI87081858, Length=448, Percent_Identity=24.7767857142857, Blast_Score=125, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR003593
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR000014
- InterPro:   IPR002078 [H]

Pfam domain/function: PF01842 ACT; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 62546; Mature: 62546

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS50112 PAS ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTDCFISKRGQGIIIASDSAPVIYIRSILMRLEVFCEDRLGLTRELLDLLVLRSIDLRG
CCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCC
IEIDPIGRIYLNFSSLDFSIFSALMMEIRHIDGVTDVRTVSFMPSEREHRSLRALLESMP
EEECCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHCC
EPVFSIDLKGNLELSNPAARALFSLSEEKIRHKTAGSLLGGYNFSRWFEGGDTAPHTERV
CCEEEEEECCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCEE
LINNQDYLMEITPINLEDENQKKQTVGAVVMLKSTARMGQQLQTLSVNDDTEFRQIVAAS
EECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHH
TKMRQVLAQARKLAMLDAPLLLVGDTGTGKDLLARACHLRSPRGKMPFLGLNCASLPDEV
HHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCEECCCHHCCCHHH
VESELFGYAAGAYPNAIEGKKGFFEQANGGSVLLDEIGEMSPRMQIKLLRFLNDGTFRRV
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEHHHHHCCCCCHHHHHHHHHHCCCHHHHC
GEEHEVHVDVRVICATQKNLVELVQRGEFREDLYYRLNVLTITLPPLRERQTDIMPLTEL
CCCCEEEEEEEEEECCHHHHHHHHHCCCHHHHHHEEEEEEEEECCCCCCCCCCCHHHHHH
FVARFSDEQGVPRPKLSPELASFLTHYGWPGNVRQLKNAIYRALTQLEGAELRPQDIILP
HHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEECC
EFEIEATLGDEVLDGSLDDISKRFERSVLTRLYRNYPSTRKLAKRLGVSHTAIANKLREY
CEEEEECCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHC
GLSSKRPASDENEEE
CCCCCCCCCCCCCCC
>Mature Secondary Structure
MLTDCFISKRGQGIIIASDSAPVIYIRSILMRLEVFCEDRLGLTRELLDLLVLRSIDLRG
CCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCC
IEIDPIGRIYLNFSSLDFSIFSALMMEIRHIDGVTDVRTVSFMPSEREHRSLRALLESMP
EEECCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHCC
EPVFSIDLKGNLELSNPAARALFSLSEEKIRHKTAGSLLGGYNFSRWFEGGDTAPHTERV
CCEEEEEECCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCEE
LINNQDYLMEITPINLEDENQKKQTVGAVVMLKSTARMGQQLQTLSVNDDTEFRQIVAAS
EECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHH
TKMRQVLAQARKLAMLDAPLLLVGDTGTGKDLLARACHLRSPRGKMPFLGLNCASLPDEV
HHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCEECCCHHCCCHHH
VESELFGYAAGAYPNAIEGKKGFFEQANGGSVLLDEIGEMSPRMQIKLLRFLNDGTFRRV
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEHHHHHCCCCCHHHHHHHHHHCCCHHHHC
GEEHEVHVDVRVICATQKNLVELVQRGEFREDLYYRLNVLTITLPPLRERQTDIMPLTEL
CCCCEEEEEEEEEECCHHHHHHHHHCCCHHHHHHEEEEEEEEECCCCCCCCCCCHHHHHH
FVARFSDEQGVPRPKLSPELASFLTHYGWPGNVRQLKNAIYRALTQLEGAELRPQDIILP
HHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEECC
EFEIEATLGDEVLDGSLDDISKRFERSVLTRLYRNYPSTRKLAKRLGVSHTAIANKLREY
CEEEEECCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHC
GLSSKRPASDENEEE
CCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11055921 [H]