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The map label for this gene is cpsG [H]

Identifier: 22125604

GI number: 22125604

Start: 1889604

End: 1891037

Strand: Reverse

Name: cpsG [H]

Synonym: y1710

Alternate gene names: 22125604

Gene position: 1891037-1889604 (Counterclockwise)

Preceding gene: 22125605

Following gene: 22125603

Centisome position: 41.1

GC content: 46.09

Gene sequence:

>1434_bases
TTGAACTTGTCGTCCGTGATTCAGCATAATCAGATTGGAAAGGAAATGGAAAAATTAACCTGTTTTAAAGCTTACGATAT
TCGGGGAAAACTGGGCTCGGAGTTAAACGAAGAGATAGCCTATCGAATCGGACGCGCCTATTGCCAGTGGCTAAAACCAG
CCAAAGTCGTGGTGGGTGGGGATGCACGGGCAACCAGTGTCGAATTAAAAAACGCCCTGGCAAAAGGGTTAATGGATGGC
GGTGCGGATGTCATTGATATCGGCATGGTGGGGACTGAAGAAGTCTATTTCGCCACCCGCTTTTATGGTGTCGATGGCGG
GATTCAGGTGACGGCTAGCCATAATCCGATTGACTATAACGGGATGAAGTTAGTTAAAAAAGATGCCCAACCGATTAGCG
GTGATAACGGGCTGTATGAAATTCAGCGGCTGGCACAGGATAATCATTTTGCGCCACCTGGCGTCAGGGGCCAGCTTGAA
ACCCAGTTGGTCCGCGAACACTATGTCGAGCACTTATTAAGTTATATCGATCTGAATGCGTTACTGCCAATGAAAATTGT
GGTTAATGCTGGCAACGGCGCGGCTGGCCCCACTCTTGATGCACTGGAAGCTGCGCTGGCAAAACGTAAGGTGCCAATCA
GTTTTATTAAAATCAACCATCAGCCAGATAGTAGTTTTCCTAACGGGATCCCAAACCCGATGTTGCCAGAGAATCAGTGG
TCAACTCGGCAGGCAGTTTGTGAGCATCAGGCAGATTTAGGCATTGCCTGGGATGGGGATTTTGACCGTTGTTTCTTCTT
CGACCACCTTGGGAATTTTATTGAGGGCTATTACATTGTGGGGCTGCTGGCAGAAAAATTCCTGCTCACCAATAATATGG
GTAAAGCGACTCACAATACTGACAAAATAATCCACGACCCTAGGTTGACGTGGAATACGATAGATATCGTACAGACACTT
AATGGTACAGCAATCGAATCTAAAACCGGCCATGCCTTTATTAAAGATGCCATGCGCCACCATGATGCCGTCTATGGCGG
GGAGATGAGCGCTCATCACTATTTCCGAGAGTTCGGCTATTGCGACAGCGGTATGATCCCTTGGCTGTTAGTCATCGAAT
TACTGTCGAAAAAAACCACGTCGCTGTTTTCATTAATTGAATCCCGCAAGGCGAAATTCCCGGTATCGGGCGAACTTAAT
TTCACCGTTAGCGATCCAAAAACTAAAATCCAGCAGATAAAACAGTTTTACGCTGATAGTGCCATCCACGTAACTGGAAT
TGATGGCCTTAGTATGGAATTTGAACACTGGCGTTTTAATTTACGCTCATCGAATACTGAACCACTTGTGCGTTTAAATA
TTGAAACTCGTGGTGATGTCACACTTCTGGAGCAGAAAACAGCGCAATTAACTCAACTGCTTTATCCAAAGTAA

Upstream 100 bases:

>100_bases
GTTGGTTTAACGACCATTCGCCAACCTACCGTTTTAAAAGGCCGTGAAGCCGCAAGGGCCCTTATTTCAGGCCAATTAGA
CAATGATATATCTTTAGATT

Downstream 100 bases:

>100_bases
TTAAAGTTGCAAATAACCTTTCGTTAAAAACTAATAAAATCAACCTCGCGTTCATTATTGAACGCGAGGGTAAATAGCAG
CATATTGTTGGAGCTTATAA

Product: phosphomannomutase

Products: NA

Alternate protein names: PMM [H]

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MNLSSVIQHNQIGKEMEKLTCFKAYDIRGKLGSELNEEIAYRIGRAYCQWLKPAKVVVGGDARATSVELKNALAKGLMDG
GADVIDIGMVGTEEVYFATRFYGVDGGIQVTASHNPIDYNGMKLVKKDAQPISGDNGLYEIQRLAQDNHFAPPGVRGQLE
TQLVREHYVEHLLSYIDLNALLPMKIVVNAGNGAAGPTLDALEAALAKRKVPISFIKINHQPDSSFPNGIPNPMLPENQW
STRQAVCEHQADLGIAWDGDFDRCFFFDHLGNFIEGYYIVGLLAEKFLLTNNMGKATHNTDKIIHDPRLTWNTIDIVQTL
NGTAIESKTGHAFIKDAMRHHDAVYGGEMSAHHYFREFGYCDSGMIPWLLVIELLSKKTTSLFSLIESRKAKFPVSGELN
FTVSDPKTKIQQIKQFYADSAIHVTGIDGLSMEFEHWRFNLRSSNTEPLVRLNIETRGDVTLLEQKTAQLTQLLYPK

Sequences:

>Translated_477_residues
MNLSSVIQHNQIGKEMEKLTCFKAYDIRGKLGSELNEEIAYRIGRAYCQWLKPAKVVVGGDARATSVELKNALAKGLMDG
GADVIDIGMVGTEEVYFATRFYGVDGGIQVTASHNPIDYNGMKLVKKDAQPISGDNGLYEIQRLAQDNHFAPPGVRGQLE
TQLVREHYVEHLLSYIDLNALLPMKIVVNAGNGAAGPTLDALEAALAKRKVPISFIKINHQPDSSFPNGIPNPMLPENQW
STRQAVCEHQADLGIAWDGDFDRCFFFDHLGNFIEGYYIVGLLAEKFLLTNNMGKATHNTDKIIHDPRLTWNTIDIVQTL
NGTAIESKTGHAFIKDAMRHHDAVYGGEMSAHHYFREFGYCDSGMIPWLLVIELLSKKTTSLFSLIESRKAKFPVSGELN
FTVSDPKTKIQQIKQFYADSAIHVTGIDGLSMEFEHWRFNLRSSNTEPLVRLNIETRGDVTLLEQKTAQLTQLLYPK
>Mature_477_residues
MNLSSVIQHNQIGKEMEKLTCFKAYDIRGKLGSELNEEIAYRIGRAYCQWLKPAKVVVGGDARATSVELKNALAKGLMDG
GADVIDIGMVGTEEVYFATRFYGVDGGIQVTASHNPIDYNGMKLVKKDAQPISGDNGLYEIQRLAQDNHFAPPGVRGQLE
TQLVREHYVEHLLSYIDLNALLPMKIVVNAGNGAAGPTLDALEAALAKRKVPISFIKINHQPDSSFPNGIPNPMLPENQW
STRQAVCEHQADLGIAWDGDFDRCFFFDHLGNFIEGYYIVGLLAEKFLLTNNMGKATHNTDKIIHDPRLTWNTIDIVQTL
NGTAIESKTGHAFIKDAMRHHDAVYGGEMSAHHYFREFGYCDSGMIPWLLVIELLSKKTTSLFSLIESRKAKFPVSGELN
FTVSDPKTKIQQIKQFYADSAIHVTGIDGLSMEFEHWRFNLRSSNTEPLVRLNIETRGDVTLLEQKTAQLTQLLYPK

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O antigen [H]

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=461, Percent_Identity=60.3036876355748, Blast_Score=583, Evalue=1e-168,
Organism=Escherichia coli, GI1789566, Length=475, Percent_Identity=23.7894736842105, Blast_Score=78, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.8 [H]

Molecular weight: Translated: 53273; Mature: 53273

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLSSVIQHNQIGKEMEKLTCFKAYDIRGKLGSELNEEIAYRIGRAYCQWLKPAKVVVGG
CCHHHHHHHHHHHHHHHHHHHHHEECCCCHHCCHHHHHHHHHHHHHHHHHCCCCEEEECC
DARATSVELKNALAKGLMDGGADVIDIGMVGTEEVYFATRFYGVDGGIQVTASHNPIDYN
CCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEEEEEECCCCEEEEECCCCCCCC
GMKLVKKDAQPISGDNGLYEIQRLAQDNHFAPPGVRGQLETQLVREHYVEHLLSYIDLNA
CHHHEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
LLPMKIVVNAGNGAAGPTLDALEAALAKRKVPISFIKINHQPDSSFPNGIPNPMLPENQW
CCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCC
STRQAVCEHQADLGIAWDGDFDRCFFFDHLGNFIEGYYIVGLLAEKFLLTNNMGKATHNT
HHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
DKIIHDPRLTWNTIDIVQTLNGTAIESKTGHAFIKDAMRHHDAVYGGEMSAHHYFREFGY
CCEEECCCCCCHHHHHHHHCCCCEECCCCCHHHHHHHHHHHCHHCCCCCHHHHHHHHHCC
CDSGMIPWLLVIELLSKKTTSLFSLIESRKAKFPVSGELNFTVSDPKTKIQQIKQFYADS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHCCC
AIHVTGIDGLSMEFEHWRFNLRSSNTEPLVRLNIETRGDVTLLEQKTAQLTQLLYPK
CEEEECCCCCCEEHHHHEEEECCCCCCCEEEEEECCCCCEEEHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNLSSVIQHNQIGKEMEKLTCFKAYDIRGKLGSELNEEIAYRIGRAYCQWLKPAKVVVGG
CCHHHHHHHHHHHHHHHHHHHHHEECCCCHHCCHHHHHHHHHHHHHHHHHCCCCEEEECC
DARATSVELKNALAKGLMDGGADVIDIGMVGTEEVYFATRFYGVDGGIQVTASHNPIDYN
CCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEEEEEECCCCEEEEECCCCCCCC
GMKLVKKDAQPISGDNGLYEIQRLAQDNHFAPPGVRGQLETQLVREHYVEHLLSYIDLNA
CHHHEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
LLPMKIVVNAGNGAAGPTLDALEAALAKRKVPISFIKINHQPDSSFPNGIPNPMLPENQW
CCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCC
STRQAVCEHQADLGIAWDGDFDRCFFFDHLGNFIEGYYIVGLLAEKFLLTNNMGKATHNT
HHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
DKIIHDPRLTWNTIDIVQTLNGTAIESKTGHAFIKDAMRHHDAVYGGEMSAHHYFREFGY
CCEEECCCCCCHHHHHHHHCCCCEECCCCCHHHHHHHHHHHCHHCCCCCHHHHHHHHHCC
CDSGMIPWLLVIELLSKKTTSLFSLIESRKAKFPVSGELNFTVSDPKTKIQQIKQFYADS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHCCC
AIHVTGIDGLSMEFEHWRFNLRSSNTEPLVRLNIETRGDVTLLEQKTAQLTQLLYPK
CEEEECCCCCCEEHHHHEEEECCCCCCCEEEEEECCCCCEEEHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1383393 [H]