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The map label for this gene is hpmB [H]

Identifier: 22125590

GI number: 22125590

Start: 1872539

End: 1874227

Strand: Direct

Name: hpmB [H]

Synonym: y1696

Alternate gene names: 22125590

Gene position: 1872539-1874227 (Clockwise)

Preceding gene: 22125589

Following gene: 161484826

Centisome position: 40.7

GC content: 53.88

Gene sequence:

>1689_bases
TTGCGTTATTGTTATTTTATATTACACACGGCTATATTATTTCCACTGTTGGTTATTTCTCGCGCCGGACAGAGTGCGGA
ATTAACGCCTATTCAACAGCAAACTCTCCATCAGCAAGAGCGGCAGCGGGCGCTGGAAGAACGTCTGGCTCCACCGACGC
CAGATGTGCGCTTATCTGCACCTTCGGCCTCTTCGGATCGCCTTATTTTCCCTGTGGAAAAGCCCTGCTTTGTTATTGAC
CGCGTCACACTCAGCGGCACTGAACCGTTACCCCGTTGGTTGCCGTTACAGCGTATTGCTAATCAGGCACTGGGGCAGTG
TTTGGGCGGGCAGGGGATTAACCAATTGATGAGCCAATTACAAAACCGTTTAGTGGGTCATGGTTATGTCACGACCCGGG
TGCTTGCTCCACAGCAGGATTTGAACAGCGGCACACTGGCGTTACAAGTGGTGCCCGGCAAAATACACCGCGTGGCGCTG
ACACCAGAGAGTGACCGCCATGTCACGCTGTTCAGTGCCTTTCCCGCACGCCCCGGTCACTTATTGGATCTGCGTGATAT
TGAGCAAGGGCTGGAGAATCTTCAACGTATCCCCACAGTGCAAGCCAGCATGGAATTGATCCCCGGCAGCGCGCCCGGAG
AGACCGATATCGCCCTAAGCTGGAAGCAGAGCAAAATGTGGCGTTTGGCCGCCTCACTGGATGACTCAGGGACTCGCAGT
ACTGGCCGTTATCAGGGCGGTGCGACGCTGTTTCTGGATAACCCATTCTCTTTGAGTGACCAGTTTTATGTCTCGGCGGG
TGGCTCAATAAAAAATCGCGGCGATAAAGGCACCAATAACCTGACTGGCCACTACTCGTTGCCGTTCGGTTACTGGACAG
CCGGCATAACCGCCAGCAGTTATGATTATCACCAGACAGTGGCGGGCCTGAATAGCGATTACAACTATCGGGGCGAAAGT
GAAAATGTGTCATTGCAACTCAGCCGCCTGTTGCACCGCAATGCCAGCCAAAAAACCACACTCACCTACGATGTCCTGAC
CCGTTCGTCGAAAAACTACATCAATGATACCGAAGTTGAGGTTCAACGCCGCCGCACATCTGCCTGGCGCATAGGGCTGC
AACATCGCCACTTTATTTCGCAGGCCACGCTGGATGCCGGGGTGAGTTATCAGCGCGGTACCCGTTGGTTTGGGGCGGTT
CCGGCTCAAGAAGAATATTTTGATGAAGGCACGGCGTTAAGCAAGATTCTGCAATTGAATGCACAACTGGATATTCCCTT
CTCGGTGATGGCGCAAAATTTCCATTACAACGTGCAATACCAGCGTCAGAGCAGCAGCACCCCGTTGACCCCACAGGATC
AATTCAGCATTGGTGGCCGTTGGTCAGTGCGCGGCTTTAATGGGGAGCGGACCCTCAGTGCTGATCGTGGCTGGACGGTG
CGTAATGATCTGGGTTGGTACACACCGATACAGGGGCAAGAGATCTATGTCGGCCTTGATTATGGCGAAGTGGGTGGCCG
CGGAAGCGCTTATCTGCTGGGTAACCATCTGGCGGGTGCCGCTGTCGGTATTCGTGGCAACGTACTCAATACCCGCTATG
ACCTGTTTGCCGGCAAACCCCTGTCTGAACCCGATGGCTTCCAATCCGATGCCGTGACCGTGGGCTTTAACCTGAACTGG
CAATACTAA

Upstream 100 bases:

>100_bases
TAAACCTCATGTTTTGATTGAAAAAAACGCTATTGGCAGCATAATGCAGAAAATTATTTCTATATATACATGCCTCTAAT
GCAGAGGCGAGGCATTCTCT

Downstream 100 bases:

>100_bases
TACTCCTTTTATTGCACCCAACGTCATTGGCGTTGCAGGTAGGCAGCCAGCAAACTCATCCCGATGAGCTTACTCAAGTA
AGTGATTCGAGTGAGTGCGT

Product: hemolysin activator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MRYCYFILHTAILFPLLVISRAGQSAELTPIQQQTLHQQERQRALEERLAPPTPDVRLSAPSASSDRLIFPVEKPCFVID
RVTLSGTEPLPRWLPLQRIANQALGQCLGGQGINQLMSQLQNRLVGHGYVTTRVLAPQQDLNSGTLALQVVPGKIHRVAL
TPESDRHVTLFSAFPARPGHLLDLRDIEQGLENLQRIPTVQASMELIPGSAPGETDIALSWKQSKMWRLAASLDDSGTRS
TGRYQGGATLFLDNPFSLSDQFYVSAGGSIKNRGDKGTNNLTGHYSLPFGYWTAGITASSYDYHQTVAGLNSDYNYRGES
ENVSLQLSRLLHRNASQKTTLTYDVLTRSSKNYINDTEVEVQRRRTSAWRIGLQHRHFISQATLDAGVSYQRGTRWFGAV
PAQEEYFDEGTALSKILQLNAQLDIPFSVMAQNFHYNVQYQRQSSSTPLTPQDQFSIGGRWSVRGFNGERTLSADRGWTV
RNDLGWYTPIQGQEIYVGLDYGEVGGRGSAYLLGNHLAGAAVGIRGNVLNTRYDLFAGKPLSEPDGFQSDAVTVGFNLNW
QY

Sequences:

>Translated_562_residues
MRYCYFILHTAILFPLLVISRAGQSAELTPIQQQTLHQQERQRALEERLAPPTPDVRLSAPSASSDRLIFPVEKPCFVID
RVTLSGTEPLPRWLPLQRIANQALGQCLGGQGINQLMSQLQNRLVGHGYVTTRVLAPQQDLNSGTLALQVVPGKIHRVAL
TPESDRHVTLFSAFPARPGHLLDLRDIEQGLENLQRIPTVQASMELIPGSAPGETDIALSWKQSKMWRLAASLDDSGTRS
TGRYQGGATLFLDNPFSLSDQFYVSAGGSIKNRGDKGTNNLTGHYSLPFGYWTAGITASSYDYHQTVAGLNSDYNYRGES
ENVSLQLSRLLHRNASQKTTLTYDVLTRSSKNYINDTEVEVQRRRTSAWRIGLQHRHFISQATLDAGVSYQRGTRWFGAV
PAQEEYFDEGTALSKILQLNAQLDIPFSVMAQNFHYNVQYQRQSSSTPLTPQDQFSIGGRWSVRGFNGERTLSADRGWTV
RNDLGWYTPIQGQEIYVGLDYGEVGGRGSAYLLGNHLAGAAVGIRGNVLNTRYDLFAGKPLSEPDGFQSDAVTVGFNLNW
QY
>Mature_562_residues
MRYCYFILHTAILFPLLVISRAGQSAELTPIQQQTLHQQERQRALEERLAPPTPDVRLSAPSASSDRLIFPVEKPCFVID
RVTLSGTEPLPRWLPLQRIANQALGQCLGGQGINQLMSQLQNRLVGHGYVTTRVLAPQQDLNSGTLALQVVPGKIHRVAL
TPESDRHVTLFSAFPARPGHLLDLRDIEQGLENLQRIPTVQASMELIPGSAPGETDIALSWKQSKMWRLAASLDDSGTRS
TGRYQGGATLFLDNPFSLSDQFYVSAGGSIKNRGDKGTNNLTGHYSLPFGYWTAGITASSYDYHQTVAGLNSDYNYRGES
ENVSLQLSRLLHRNASQKTTLTYDVLTRSSKNYINDTEVEVQRRRTSAWRIGLQHRHFISQATLDAGVSYQRGTRWFGAV
PAQEEYFDEGTALSKILQLNAQLDIPFSVMAQNFHYNVQYQRQSSSTPLTPQDQFSIGGRWSVRGFNGERTLSADRGWTV
RNDLGWYTPIQGQEIYVGLDYGEVGGRGSAYLLGNHLAGAAVGIRGNVLNTRYDLFAGKPLSEPDGFQSDAVTVGFNLNW
QY

Specific function: Probable member of a two partner secretion pathway (TPS) in which it mediates the secretion of hemolysin [H]

COG id: COG2831

COG function: function code U; Hemolysin activation/secretion protein

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tpsB (TC 1.B.20) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005565
- InterPro:   IPR013686 [H]

Pfam domain/function: PF08479 POTRA_2; PF03865 ShlB [H]

EC number: NA

Molecular weight: Translated: 62458; Mature: 62458

Theoretical pI: Translated: 8.39; Mature: 8.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYCYFILHTAILFPLLVISRAGQSAELTPIQQQTLHQQERQRALEERLAPPTPDVRLSA
CEEEHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEC
PSASSDRLIFPVEKPCFVIDRVTLSGTEPLPRWLPLQRIANQALGQCLGGQGINQLMSQL
CCCCCCCEEEECCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QNRLVGHGYVTTRVLAPQQDLNSGTLALQVVPGKIHRVALTPESDRHVTLFSAFPARPGH
HHHHCCCCEEEEEEECCCCCCCCCEEEEEEECCCEEEEEECCCCCCEEEEEEECCCCCCC
LLDLRDIEQGLENLQRIPTVQASMELIPGSAPGETDIALSWKQSKMWRLAASLDDSGTRS
EEEHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEECCCCCCCCC
TGRYQGGATLFLDNPFSLSDQFYVSAGGSIKNRGDKGTNNLTGHYSLPFGYWTAGITASS
CCCCCCCEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEECCCHHHCCCCEECC
YDYHQTVAGLNSDYNYRGESENVSLQLSRLLHRNASQKTTLTYDVLTRSSKNYINDTEVE
CCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEHHHCCCCCCCCCCHHH
VQRRRTSAWRIGLQHRHFISQATLDAGVSYQRGTRWFGAVPAQEEYFDEGTALSKILQLN
HHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCEEECCCCCCHHHHCCHHHHHHHHHHC
AQLDIPFSVMAQNFHYNVQYQRQSSSTPLTPQDQFSIGGRWSVRGFNGERTLSADRGWTV
CCCCCCHHHHHCCEEEEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCEEEECCCCEEE
RNDLGWYTPIQGQEIYVGLDYGEVGGRGSAYLLGNHLAGAAVGIRGNVLNTRYDLFAGKP
ECCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEECCCCCEEEEEECCEECCEEEEEECCC
LSEPDGFQSDAVTVGFNLNWQY
CCCCCCCCCCCEEEEEEEEECC
>Mature Secondary Structure
MRYCYFILHTAILFPLLVISRAGQSAELTPIQQQTLHQQERQRALEERLAPPTPDVRLSA
CEEEHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEC
PSASSDRLIFPVEKPCFVIDRVTLSGTEPLPRWLPLQRIANQALGQCLGGQGINQLMSQL
CCCCCCCEEEECCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QNRLVGHGYVTTRVLAPQQDLNSGTLALQVVPGKIHRVALTPESDRHVTLFSAFPARPGH
HHHHCCCCEEEEEEECCCCCCCCCEEEEEEECCCEEEEEECCCCCCEEEEEEECCCCCCC
LLDLRDIEQGLENLQRIPTVQASMELIPGSAPGETDIALSWKQSKMWRLAASLDDSGTRS
EEEHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEECCCCCCCCC
TGRYQGGATLFLDNPFSLSDQFYVSAGGSIKNRGDKGTNNLTGHYSLPFGYWTAGITASS
CCCCCCCEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEECCCHHHCCCCEECC
YDYHQTVAGLNSDYNYRGESENVSLQLSRLLHRNASQKTTLTYDVLTRSSKNYINDTEVE
CCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEHHHCCCCCCCCCCHHH
VQRRRTSAWRIGLQHRHFISQATLDAGVSYQRGTRWFGAVPAQEEYFDEGTALSKILQLN
HHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCEEECCCCCCHHHHCCHHHHHHHHHHC
AQLDIPFSVMAQNFHYNVQYQRQSSSTPLTPQDQFSIGGRWSVRGFNGERTLSADRGWTV
CCCCCCHHHHHCCEEEEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCEEEECCCCEEE
RNDLGWYTPIQGQEIYVGLDYGEVGGRGSAYLLGNHLAGAAVGIRGNVLNTRYDLFAGKP
ECCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEECCCCCEEEEEECCEECCEEEEEECCC
LSEPDGFQSDAVTVGFNLNWQY
CCCCCCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2407716 [H]