Click here to switch to the map view.

The map label for this gene is patB [H]

Identifier: 22125372

GI number: 22125372

Start: 1636083

End: 1637309

Strand: Direct

Name: patB [H]

Synonym: y1475

Alternate gene names: 22125372

Gene position: 1636083-1637309 (Clockwise)

Preceding gene: 22125368

Following gene: 22125373

Centisome position: 35.56

GC content: 39.45

Gene sequence:

>1227_bases
ATGGTATTAAATTTCCTTACAAGTCGAACCAGTGAGGAAAGGGACATGGACTACAATTTTGATGAAGTCATCGATAGAAG
TAATACAGCATGTGAAAAGTGGGATGCTCATTATTTAAATGCTCGATTTGGTATGACTGATTTAACGCCTATGTGGGTTG
CGGATATGGACTTTAGATCTCCGGACTCAGTGATTAGTGCACTTTCCGAAAGAGTTAACCACGGTATTTATGGCTATACT
TTCAGACCTGATAGTTTTTTAGATGCCATTACACAGTGGGTTAAAAAAAGACATCAATGGTTAATTAAGCCTGAGTGGAT
CTCTCATAGCCCCGGCGTTGTTCCTGGATTAGCCATGGCTATTCGTGGGTTAACAAAACCGGGAGATAAAATACTCATTC
AATCCCCTGTTTATCATCACTTCGCCAATGTTATTGCACGAAATGATCGTGAAGTTGTCGCGAGTGAATTGCTCTATGAT
AACGAAAAATATGATATAGACTTTGCACATTTTGAAGCGTGTATCGCCACTGGCGTGAAATTGTTTATCCTTTGCAATCC
TCATAACCCAGTGGGAAGAGTATGGACACGGGATGAACTGACGACCATGGGTAATATATGCTTACGGCATAACGTGATTG
TCATCGCAGATGAAATACATTGTGATATTGTTTTTAAAGGCAGTAAATTCACTCCTTTTGCCTCTATCTCACCTGATTTC
GAAAATAATTCAATTACCTGCATGGCACCCAGTAAAACCTTCAATCTTTTAGGGACACAAACTTCAGCGATCATTATCCC
TAATCAAGAATTACGTAATAAATATGAAACCGAATTAAATAGCCTGGCATTAGGGAATCCTAATCCCTTTGGCGTGATAG
CATTGGAAACAGCATATAAAGAAGGTGAGGAGTGGTTAGAGAGTTTGCTGGGTTACTTACAACATAATCTAGACTTTGCT
GTGGACTTCTTTAAAAAATATATACCGAAGATCACATTGGTTAAGCCTGAGGGAACGTATCTACTCTGGTTAGATTGCCG
TGGGCTAGGGTTGACTCCGTATGAACTGGAGCAATTCATACTAACAAAAGCAAAATTAGCCTTAAACGAAGGCCACATCT
TTGGCGAAAGTGGTGAAAACTTCATGAGGATGAATATTGGTTGTCCAAAATCAGTCCTCACCACTGCATTAATACAACTA
AAATACGCGGTAGATGATTTAAACTAG

Upstream 100 bases:

>100_bases
TTGTCGAAATCATTAATACTAGTACGATGCACTTTTAAGGGTAAATTTTTCTAAAAAAACCACCAATTAGGAGTATTAAT
AGTAAGAAATTATCAAGATA

Downstream 100 bases:

>100_bases
AATAGCGTATAGGTTATTTTGCAGGGGATAAAAATGAACAGTGAAAAAAAAGAACATCTTAATACAGTATCAAGAAAGTT
AAGAACGATCATGGAGCGTG

Product: aminotransferase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MVLNFLTSRTSEERDMDYNFDEVIDRSNTACEKWDAHYLNARFGMTDLTPMWVADMDFRSPDSVISALSERVNHGIYGYT
FRPDSFLDAITQWVKKRHQWLIKPEWISHSPGVVPGLAMAIRGLTKPGDKILIQSPVYHHFANVIARNDREVVASELLYD
NEKYDIDFAHFEACIATGVKLFILCNPHNPVGRVWTRDELTTMGNICLRHNVIVIADEIHCDIVFKGSKFTPFASISPDF
ENNSITCMAPSKTFNLLGTQTSAIIIPNQELRNKYETELNSLALGNPNPFGVIALETAYKEGEEWLESLLGYLQHNLDFA
VDFFKKYIPKITLVKPEGTYLLWLDCRGLGLTPYELEQFILTKAKLALNEGHIFGESGENFMRMNIGCPKSVLTTALIQL
KYAVDDLN

Sequences:

>Translated_408_residues
MVLNFLTSRTSEERDMDYNFDEVIDRSNTACEKWDAHYLNARFGMTDLTPMWVADMDFRSPDSVISALSERVNHGIYGYT
FRPDSFLDAITQWVKKRHQWLIKPEWISHSPGVVPGLAMAIRGLTKPGDKILIQSPVYHHFANVIARNDREVVASELLYD
NEKYDIDFAHFEACIATGVKLFILCNPHNPVGRVWTRDELTTMGNICLRHNVIVIADEIHCDIVFKGSKFTPFASISPDF
ENNSITCMAPSKTFNLLGTQTSAIIIPNQELRNKYETELNSLALGNPNPFGVIALETAYKEGEEWLESLLGYLQHNLDFA
VDFFKKYIPKITLVKPEGTYLLWLDCRGLGLTPYELEQFILTKAKLALNEGHIFGESGENFMRMNIGCPKSVLTTALIQL
KYAVDDLN
>Mature_408_residues
MVLNFLTSRTSEERDMDYNFDEVIDRSNTACEKWDAHYLNARFGMTDLTPMWVADMDFRSPDSVISALSERVNHGIYGYT
FRPDSFLDAITQWVKKRHQWLIKPEWISHSPGVVPGLAMAIRGLTKPGDKILIQSPVYHHFANVIARNDREVVASELLYD
NEKYDIDFAHFEACIATGVKLFILCNPHNPVGRVWTRDELTTMGNICLRHNVIVIADEIHCDIVFKGSKFTPFASISPDF
ENNSITCMAPSKTFNLLGTQTSAIIIPNQELRNKYETELNSLALGNPNPFGVIALETAYKEGEEWLESLLGYLQHNLDFA
VDFFKKYIPKITLVKPEGTYLLWLDCRGLGLTPYELEQFILTKAKLALNEGHIFGESGENFMRMNIGCPKSVLTTALIQL
KYAVDDLN

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=179, Percent_Identity=24.0223463687151, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI56713254, Length=257, Percent_Identity=22.9571984435798, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI1787909, Length=390, Percent_Identity=33.5897435897436, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI1786816, Length=297, Percent_Identity=21.5488215488215, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788627, Length=262, Percent_Identity=24.8091603053435, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71994476, Length=166, Percent_Identity=30.1204819277108, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71994472, Length=165, Percent_Identity=30.3030303030303, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17567663, Length=295, Percent_Identity=23.3898305084746, Blast_Score=75, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6322401, Length=301, Percent_Identity=27.906976744186, Blast_Score=112, Evalue=8e-26,
Organism=Drosophila melanogaster, GI28573069, Length=247, Percent_Identity=25.9109311740891, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24646114, Length=247, Percent_Identity=25.9109311740891, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI28573067, Length=247, Percent_Identity=25.9109311740891, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI28573065, Length=247, Percent_Identity=25.9109311740891, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 46375; Mature: 46375

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLNFLTSRTSEERDMDYNFDEVIDRSNTACEKWDAHYLNARFGMTDLTPMWVADMDFRS
CEEEEECCCCCCCCCCCCCHHHHHCCCCCCHHHCCCCEEECCCCCCCCCCEEEECCCCCC
PDSVISALSERVNHGIYGYTFRPDSFLDAITQWVKKRHQWLIKPEWISHSPGVVPGLAMA
HHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHCEEECCCCCCCCCCCCHHHHHH
IRGLTKPGDKILIQSPVYHHFANVIARNDREVVASELLYDNEKYDIDFAHFEACIATGVK
HHCCCCCCCEEEEECHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCEE
LFILCNPHNPVGRVWTRDELTTMGNICLRHNVIVIADEIHCDIVFKGSKFTPFASISPDF
EEEEECCCCCCCCCEECHHHHHHHCCHHHCCEEEEEECEEEEEEEECCCCCCCCCCCCCC
ENNSITCMAPSKTFNLLGTQTSAIIIPNQELRNKYETELNSLALGNPNPFGVIALETAYK
CCCEEEEEECCCCEEEECCCCEEEEECCHHHHHHHHHHHHHEECCCCCCEEEEEEEHHHH
EGEEWLESLLGYLQHNLDFAVDFFKKYIPKITLVKPEGTYLLWLDCRGLGLTPYELEQFI
HHHHHHHHHHHHHHHCHHHHHHHHHHHCCEEEEECCCCCEEEEEECCCCCCCHHHHHHHH
LTKAKLALNEGHIFGESGENFMRMNIGCPKSVLTTALIQLKYAVDDLN
HHHHHHEECCCEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVLNFLTSRTSEERDMDYNFDEVIDRSNTACEKWDAHYLNARFGMTDLTPMWVADMDFRS
CEEEEECCCCCCCCCCCCCHHHHHCCCCCCHHHCCCCEEECCCCCCCCCCEEEECCCCCC
PDSVISALSERVNHGIYGYTFRPDSFLDAITQWVKKRHQWLIKPEWISHSPGVVPGLAMA
HHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHCEEECCCCCCCCCCCCHHHHHH
IRGLTKPGDKILIQSPVYHHFANVIARNDREVVASELLYDNEKYDIDFAHFEACIATGVK
HHCCCCCCCEEEEECHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCEE
LFILCNPHNPVGRVWTRDELTTMGNICLRHNVIVIADEIHCDIVFKGSKFTPFASISPDF
EEEEECCCCCCCCCEECHHHHHHHCCHHHCCEEEEEECEEEEEEEECCCCCCCCCCCCCC
ENNSITCMAPSKTFNLLGTQTSAIIIPNQELRNKYETELNSLALGNPNPFGVIALETAYK
CCCEEEEEECCCCEEEECCCCEEEEECCHHHHHHHHHHHHHEECCCCCCEEEEEEEHHHH
EGEEWLESLLGYLQHNLDFAVDFFKKYIPKITLVKPEGTYLLWLDCRGLGLTPYELEQFI
HHHHHHHHHHHHHHHCHHHHHHHHHHHCCEEEEECCCCCEEEEEECCCCCCCHHHHHHHH
LTKAKLALNEGHIFGESGENFMRMNIGCPKSVLTTALIQLKYAVDDLN
HHHHHHEECCCEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]