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The map label for this gene is maeB [H]

Identifier: 22125346

GI number: 22125346

Start: 1605757

End: 1608036

Strand: Direct

Name: maeB [H]

Synonym: y1449

Alternate gene names: 22125346

Gene position: 1605757-1608036 (Clockwise)

Preceding gene: 22125345

Following gene: 22125349

Centisome position: 34.9

GC content: 51.18

Gene sequence:

>2280_bases
ATGGACGAACAATTGAAACAGAGTGCGCTTGATTTTCATCAATTTCCTGTTCCAGGGAAAATCCAGGTTTCGCCAACCAA
ACCGTTGGCGACCCAACGGGATTTGGCACTGGCGTATTCTCCCGGCGTTGCTGCACCCTGTCTGGAAATTGCTGCAGATC
CTTTAGCTGCCTACAAATACACTGCCCGTGGCAATTTAGTGGCCGTTATCTCTAACGGTACCGCCGTGCTGGGGCTGGGT
AATATCGGCGCATTGGCCGGTAAACCCGTGATGGAAGGTAAAGGCGTTCTGTTTAAGAAATTCTCAGGCATTGATGTTTT
CGATATTGAGGTGGATGAACTCGATCCAGATAAACTGATCGATATTATTGCGTCTTTGGAACCCACCTTTGGCGGTATCA
ATCTGGAAGATATCAAAGCGCCAGAGTGTTTTTATATTGAGAAAAAACTCCGTGAACGCATGAAAATCCCAGTATTCCAT
GACGATCAGCATGGTACGGCGATCATCTGCACCGCCGCAGTACTGAACGGTTTACGGGTTGTGAAGAAAGATATCAGCGA
TGTGAAATTGGTGGTCTCCGGCGCAGGTGCGGCCTCTATCGCCTGCTTAAACTTGCTGGTGGCGCTGGGGTTAAAACAGC
ACAATATCATTGCATGTGATTCTAAAGGTGTCATCTATAAAGGCCGTGAAGCGAATATGGCCGAAACCAAAGCGGCCTAT
GCTATCGATGATAACGGCCAGCGCACATTGGGGGATGTCATGCCGGGTAGCGATATTTTCCTCGGCTGCTCTGGCTCCGG
TGTTTTAACGCCAGAGATGGTGAAAACCATGGCACCGAATCCGTTGATTCTGGCCCTGGCAAACCCGGAACCGGAAATCC
TACCGCCGTTAGCCAAAGCGGTGCGTCCCGATGCAATTATTTGTACTGGCCGCTCGGATTACCCTAATCAGGTTAATAAC
GTGCTGTGCTTCCCGTTTATCTTCCGTGGCGCGCTGGATGTCGGTGCCACCACCATTAATGAAGAGATGAAGCTGGCTTG
TGTCCATGCTATTGCTGATCTGGCGCTGGCTGAGCAGAGTGATGTGGTGGCTTCCGCTTACGGGGAGCAAGACCTCTCCT
TCGGCCCGGAATACATTATTCCTAAACCCTTCGATCCGCGCTTAATCGTAAAAATTGCCCCCGCAGTGGCCAAAGCGGCG
ATGGCGTCAGGAGTGGCAACTCGCCCAATCACTGACTTCAATGCTTACGTCGAAAAACTGTCTGAGTTTGTCTACAAAAC
CAACCTGTTTATGAAGCCAATCTTCTCGCAAGCGAAGAAAGAGATGAAACGGGTTGTGCTGGCGGAAGGGGAAGAGGAGC
GGGTGCTTCATGCCACGCAAGAGCTGATTTCACAAGGGCTGGCTTATCCTATCTTGATTGGCCGCCCAAGCGTAATTGAG
ACTCGGTTGAAAAAATTGGGCTTGCAAATCAGTGCCGGGAAAGATTTTGAAGTGGTCAATAATGAGTCCGATCCGCGCTT
TAATGAATACTGGCACGAATATTATCAAATCATGAAACGTCGTGGTGTTTCGCAGGAACAGGCCCGCCGTGCGGTGATTG
GTAATCCGACGCTGATTGGCTCAATCATGGTTCATCGCGGCGAGGCTGATGCGATGATTTGTGGCACCATCGGTACCTAT
CACGAACACTACGATGTGGTCGAGAAAGTGTTTGGCTTCCGTGAAGGGGCGCATGTGGCTGGGGCGATGAATGCCTTGTT
GCTGCCGAGCGGCAATACCTTTATCGCTGATACCTACGTTAATAACGATCCGACAGCGGAACAACTGGCAGAAATTACTC
TGATGGCAGCTGAAACCGTGCGCCGTTTTGGTATTGAGCCCAAAGTGGCGTTGTTGTCCCATTCCAGTTTCGGCACATCA
GATTGCCCGGCGGCCCGTAAAATGCGTCAGACGCTGGCGCTGGTGAATCAGATGGCACCGGAATTGGAAATTGACGGTGA
AATGCACGGTGACGCGGCACTGGTGGAGAGTATTCGCCATAACCTGATGCCAGATAGCCCACTGAAAGGTTCAGCGAATA
TCTTGATTATGCCGAACATGGAGGCTGCACGTATCAGCTACAACCTGTTGCGTGTCACGTCGTCAGAAGGGGTGACCGTA
GGCCCGGTCCTGATGGGAATAACGAAACCGGTCCATATTCTGACACCGATTGCGTCGGTGCGGCGGATTGTGAATATGGT
GGCGTTGGCGGTAGTGGAGGCGATTACTCTTCGTCCTTGA

Upstream 100 bases:

>100_bases
GGTTCATAGATTGTGATAAATCACTCACTATACTGGTTCTGTTATTGGTCATACCTCTTCACTTCAATGCATAAGAACAT
AAAAACAAAGGGAACCTACG

Downstream 100 bases:

>100_bases
TGCCGCAGCTGTGTTAGCGGCGCTTACTTACCCGAATCACTTACCTGAGTAAGCTCATCGGGATGCGCTCGCTTGCTGCC
TTGCTGCAACGCCAATGACG

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 759; Mature: 759

Protein sequence:

>759_residues
MDEQLKQSALDFHQFPVPGKIQVSPTKPLATQRDLALAYSPGVAAPCLEIAADPLAAYKYTARGNLVAVISNGTAVLGLG
NIGALAGKPVMEGKGVLFKKFSGIDVFDIEVDELDPDKLIDIIASLEPTFGGINLEDIKAPECFYIEKKLRERMKIPVFH
DDQHGTAIICTAAVLNGLRVVKKDISDVKLVVSGAGAASIACLNLLVALGLKQHNIIACDSKGVIYKGREANMAETKAAY
AIDDNGQRTLGDVMPGSDIFLGCSGSGVLTPEMVKTMAPNPLILALANPEPEILPPLAKAVRPDAIICTGRSDYPNQVNN
VLCFPFIFRGALDVGATTINEEMKLACVHAIADLALAEQSDVVASAYGEQDLSFGPEYIIPKPFDPRLIVKIAPAVAKAA
MASGVATRPITDFNAYVEKLSEFVYKTNLFMKPIFSQAKKEMKRVVLAEGEEERVLHATQELISQGLAYPILIGRPSVIE
TRLKKLGLQISAGKDFEVVNNESDPRFNEYWHEYYQIMKRRGVSQEQARRAVIGNPTLIGSIMVHRGEADAMICGTIGTY
HEHYDVVEKVFGFREGAHVAGAMNALLLPSGNTFIADTYVNNDPTAEQLAEITLMAAETVRRFGIEPKVALLSHSSFGTS
DCPAARKMRQTLALVNQMAPELEIDGEMHGDAALVESIRHNLMPDSPLKGSANILIMPNMEAARISYNLLRVTSSEGVTV
GPVLMGITKPVHILTPIASVRRIVNMVALAVVEAITLRP

Sequences:

>Translated_759_residues
MDEQLKQSALDFHQFPVPGKIQVSPTKPLATQRDLALAYSPGVAAPCLEIAADPLAAYKYTARGNLVAVISNGTAVLGLG
NIGALAGKPVMEGKGVLFKKFSGIDVFDIEVDELDPDKLIDIIASLEPTFGGINLEDIKAPECFYIEKKLRERMKIPVFH
DDQHGTAIICTAAVLNGLRVVKKDISDVKLVVSGAGAASIACLNLLVALGLKQHNIIACDSKGVIYKGREANMAETKAAY
AIDDNGQRTLGDVMPGSDIFLGCSGSGVLTPEMVKTMAPNPLILALANPEPEILPPLAKAVRPDAIICTGRSDYPNQVNN
VLCFPFIFRGALDVGATTINEEMKLACVHAIADLALAEQSDVVASAYGEQDLSFGPEYIIPKPFDPRLIVKIAPAVAKAA
MASGVATRPITDFNAYVEKLSEFVYKTNLFMKPIFSQAKKEMKRVVLAEGEEERVLHATQELISQGLAYPILIGRPSVIE
TRLKKLGLQISAGKDFEVVNNESDPRFNEYWHEYYQIMKRRGVSQEQARRAVIGNPTLIGSIMVHRGEADAMICGTIGTY
HEHYDVVEKVFGFREGAHVAGAMNALLLPSGNTFIADTYVNNDPTAEQLAEITLMAAETVRRFGIEPKVALLSHSSFGTS
DCPAARKMRQTLALVNQMAPELEIDGEMHGDAALVESIRHNLMPDSPLKGSANILIMPNMEAARISYNLLRVTSSEGVTV
GPVLMGITKPVHILTPIASVRRIVNMVALAVVEAITLRP
>Mature_759_residues
MDEQLKQSALDFHQFPVPGKIQVSPTKPLATQRDLALAYSPGVAAPCLEIAADPLAAYKYTARGNLVAVISNGTAVLGLG
NIGALAGKPVMEGKGVLFKKFSGIDVFDIEVDELDPDKLIDIIASLEPTFGGINLEDIKAPECFYIEKKLRERMKIPVFH
DDQHGTAIICTAAVLNGLRVVKKDISDVKLVVSGAGAASIACLNLLVALGLKQHNIIACDSKGVIYKGREANMAETKAAY
AIDDNGQRTLGDVMPGSDIFLGCSGSGVLTPEMVKTMAPNPLILALANPEPEILPPLAKAVRPDAIICTGRSDYPNQVNN
VLCFPFIFRGALDVGATTINEEMKLACVHAIADLALAEQSDVVASAYGEQDLSFGPEYIIPKPFDPRLIVKIAPAVAKAA
MASGVATRPITDFNAYVEKLSEFVYKTNLFMKPIFSQAKKEMKRVVLAEGEEERVLHATQELISQGLAYPILIGRPSVIE
TRLKKLGLQISAGKDFEVVNNESDPRFNEYWHEYYQIMKRRGVSQEQARRAVIGNPTLIGSIMVHRGEADAMICGTIGTY
HEHYDVVEKVFGFREGAHVAGAMNALLLPSGNTFIADTYVNNDPTAEQLAEITLMAAETVRRFGIEPKVALLSHSSFGTS
DCPAARKMRQTLALVNQMAPELEIDGEMHGDAALVESIRHNLMPDSPLKGSANILIMPNMEAARISYNLLRVTSSEGVTV
GPVLMGITKPVHILTPIASVRRIVNMVALAVVEAITLRP

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=390, Percent_Identity=25.6410256410256, Blast_Score=84, Evalue=7e-16,
Organism=Homo sapiens, GI62420882, Length=369, Percent_Identity=27.3712737127371, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI62420880, Length=369, Percent_Identity=27.3712737127371, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI239049447, Length=369, Percent_Identity=27.3712737127371, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI4505145, Length=378, Percent_Identity=25.9259259259259, Blast_Score=74, Evalue=8e-13,
Organism=Homo sapiens, GI270265879, Length=320, Percent_Identity=27.8125, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1788806, Length=756, Percent_Identity=84.1269841269841, Blast_Score=1329, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=346, Percent_Identity=29.1907514450867, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1788800, Length=319, Percent_Identity=32.9153605015674, Blast_Score=144, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17537199, Length=407, Percent_Identity=27.027027027027, Blast_Score=70, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6322823, Length=274, Percent_Identity=28.1021897810219, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI281362672, Length=404, Percent_Identity=25.990099009901, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI281362674, Length=404, Percent_Identity=25.990099009901, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21356279, Length=404, Percent_Identity=25.990099009901, Blast_Score=87, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24646388, Length=347, Percent_Identity=27.3775216138329, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24646386, Length=347, Percent_Identity=27.3775216138329, Blast_Score=74, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 81984; Mature: 81984

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEQLKQSALDFHQFPVPGKIQVSPTKPLATQRDLALAYSPGVAAPCLEIAADPLAAYKY
CCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHCCCHHHEEE
TARGNLVAVISNGTAVLGLGNIGALAGKPVMEGKGVLFKKFSGIDVFDIEVDELDPDKLI
ECCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCHHHHH
DIIASLEPTFGGINLEDIKAPECFYIEKKLRERMKIPVFHDDQHGTAIICTAAVLNGLRV
HHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCEEEEHHHHHHHHHH
VKKDISDVKLVVSGAGAASIACLNLLVALGLKQHNIIACDSKGVIYKGREANMAETKAAY
HHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCEEEECCCCCEEECCCCCCHHHCEEE
AIDDNGQRTLGDVMPGSDIFLGCSGSGVLTPEMVKTMAPNPLILALANPEPEILPPLAKA
EECCCCCEEHHCCCCCCCEEEEECCCCCCCHHHHHHCCCCCEEEEECCCCCCCCCHHHHH
VRPDAIICTGRSDYPNQVNNVLCFPFIFRGALDVGATTINEEMKLACVHAIADLALAEQS
CCCCEEEEECCCCCCHHHCCEEEHHHHHHHHHHCCCHHHCHHHHHHHHHHHHHHHHHCCC
DVVASAYGEQDLSFGPEYIIPKPFDPRLIVKIAPAVAKAAMASGVATRPITDFNAYVEKL
CHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCCHHHHHHHHHH
SEFVYKTNLFMKPIFSQAKKEMKRVVLAEGEEERVLHATQELISQGLAYPILIGRPSVIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEECCCHHHH
TRLKKLGLQISAGKDFEVVNNESDPRFNEYWHEYYQIMKRRGVSQEQARRAVIGNPTLIG
HHHHHCCEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEE
SIMVHRGEADAMICGTIGTYHEHYDVVEKVFGFREGAHVAGAMNALLLPSGNTFIADTYV
EEEEECCCCCEEEEECHHHHHHHHHHHHHHHCCCCCCHHHHHCCEEEECCCCEEEEEEEE
NNDPTAEQLAEITLMAAETVRRFGIEPKVALLSHSSFGTSDCPAARKMRQTLALVNQMAP
CCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCC
ELEIDGEMHGDAALVESIRHNLMPDSPLKGSANILIMPNMEAARISYNLLRVTSSEGVTV
CEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHEEEEEEEEECCCCCEE
GPVLMGITKPVHILTPIASVRRIVNMVALAVVEAITLRP
CHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDEQLKQSALDFHQFPVPGKIQVSPTKPLATQRDLALAYSPGVAAPCLEIAADPLAAYKY
CCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHCCCHHHEEE
TARGNLVAVISNGTAVLGLGNIGALAGKPVMEGKGVLFKKFSGIDVFDIEVDELDPDKLI
ECCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCHHHHH
DIIASLEPTFGGINLEDIKAPECFYIEKKLRERMKIPVFHDDQHGTAIICTAAVLNGLRV
HHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCEEEEHHHHHHHHHH
VKKDISDVKLVVSGAGAASIACLNLLVALGLKQHNIIACDSKGVIYKGREANMAETKAAY
HHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCEEEECCCCCEEECCCCCCHHHCEEE
AIDDNGQRTLGDVMPGSDIFLGCSGSGVLTPEMVKTMAPNPLILALANPEPEILPPLAKA
EECCCCCEEHHCCCCCCCEEEEECCCCCCCHHHHHHCCCCCEEEEECCCCCCCCCHHHHH
VRPDAIICTGRSDYPNQVNNVLCFPFIFRGALDVGATTINEEMKLACVHAIADLALAEQS
CCCCEEEEECCCCCCHHHCCEEEHHHHHHHHHHCCCHHHCHHHHHHHHHHHHHHHHHCCC
DVVASAYGEQDLSFGPEYIIPKPFDPRLIVKIAPAVAKAAMASGVATRPITDFNAYVEKL
CHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCCHHHHHHHHHH
SEFVYKTNLFMKPIFSQAKKEMKRVVLAEGEEERVLHATQELISQGLAYPILIGRPSVIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEECCCHHHH
TRLKKLGLQISAGKDFEVVNNESDPRFNEYWHEYYQIMKRRGVSQEQARRAVIGNPTLIG
HHHHHCCEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEE
SIMVHRGEADAMICGTIGTYHEHYDVVEKVFGFREGAHVAGAMNALLLPSGNTFIADTYV
EEEEECCCCCEEEEECHHHHHHHHHHHHHHHCCCCCCHHHHHCCEEEECCCCEEEEEEEE
NNDPTAEQLAEITLMAAETVRRFGIEPKVALLSHSSFGTSDCPAARKMRQTLALVNQMAP
CCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCC
ELEIDGEMHGDAALVESIRHNLMPDSPLKGSANILIMPNMEAARISYNLLRVTSSEGVTV
CEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHEEEEEEEEECCCCCEE
GPVLMGITKPVHILTPIASVRRIVNMVALAVVEAITLRP
CHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]