Click here to switch to the map view.

The map label for this gene is ung [H]

Identifier: 22125181

GI number: 22125181

Start: 1426445

End: 1427155

Strand: Reverse

Name: ung [H]

Synonym: y1281

Alternate gene names: 22125181

Gene position: 1427155-1426445 (Counterclockwise)

Preceding gene: 22125183

Following gene: 22125170

Centisome position: 31.02

GC content: 46.55

Gene sequence:

>711_bases
TTGCAGAAACCAAGGAGAGTGTTTATGTCCCCCTCCCTTACTTGGCACGATGTAATCGGCCAAGAAAAAGAACAACCGTA
TTTTAAAGATACGCTGGCCTATGTGGCAGCAGAACGCCGTGCGGGTAAGACCATCTATCCACCACAAAAAGATATATTTA
ACGCTTTTCGCCTGACCGAACTGGATCAAGTAAAAGTCGTCATTCTGGGGCAAGATCCGTATCACGGCCCCAACCAGGCT
CATGGATTATCATTTTCGGTTCTACCTGGTGTTCCTGCCCCCCCTTCATTGGGGAATATATACAAGGAACTGGTCACTGA
TATTCCAGGATTCCAGCGCCCTAACCACGGTTTTTTACAAAGCTGGGCCGAGCAAGGCGTTTTATTACTTAATACGGTCC
TGACGGTAGAAGCGGGCAAAGCCCACTCTCATGCTAACCTTGGTTGGGAAACCTTTACGGATAAAGTGATTGCTGCGTTG
AATGAACACCGAGAAGGTGTGATTTTTATGTTGTGGGGATCACATGCTCAGAAAAAAGGCCGCATTATTAATACTGAGCG
CCATTATATTTTGAAAGCACCTCATCCATCACCCTTGTCAGCACACCGTGGTTTTCTGGGCTGTAAGCACTTTTCGCAAG
CTAATCAATTACTGCAACAACAAAATCAGCAGCCTATTGATTGGCAACCTAAGCTGCCAGCGGTGGAGTAA

Upstream 100 bases:

>100_bases
TTTTTTATATAAAGGTCAAAAAAACAACATCATGTCACAGACATCGGTTTAACAGTTTCACTCATCGGTTTGAACCGGTA
AGCTAGCGCACATCAATACT

Downstream 100 bases:

>100_bases
ATCACCGTTCAGATCACAACCCCACCTCTTAAGCCAGGACGTTGTCTGTAACCTCACGCCACCTTCGGCTGCCGTGAGGT
TATTGGAAGATCAGTGAACT

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MQKPRRVFMSPSLTWHDVIGQEKEQPYFKDTLAYVAAERRAGKTIYPPQKDIFNAFRLTELDQVKVVILGQDPYHGPNQA
HGLSFSVLPGVPAPPSLGNIYKELVTDIPGFQRPNHGFLQSWAEQGVLLLNTVLTVEAGKAHSHANLGWETFTDKVIAAL
NEHREGVIFMLWGSHAQKKGRIINTERHYILKAPHPSPLSAHRGFLGCKHFSQANQLLQQQNQQPIDWQPKLPAVE

Sequences:

>Translated_236_residues
MQKPRRVFMSPSLTWHDVIGQEKEQPYFKDTLAYVAAERRAGKTIYPPQKDIFNAFRLTELDQVKVVILGQDPYHGPNQA
HGLSFSVLPGVPAPPSLGNIYKELVTDIPGFQRPNHGFLQSWAEQGVLLLNTVLTVEAGKAHSHANLGWETFTDKVIAAL
NEHREGVIFMLWGSHAQKKGRIINTERHYILKAPHPSPLSAHRGFLGCKHFSQANQLLQQQNQQPIDWQPKLPAVE
>Mature_236_residues
MQKPRRVFMSPSLTWHDVIGQEKEQPYFKDTLAYVAAERRAGKTIYPPQKDIFNAFRLTELDQVKVVILGQDPYHGPNQA
HGLSFSVLPGVPAPPSLGNIYKELVTDIPGFQRPNHGFLQSWAEQGVLLLNTVLTVEAGKAHSHANLGWETFTDKVIAAL
NEHREGVIFMLWGSHAQKKGRIINTERHYILKAPHPSPLSAHRGFLGCKHFSQANQLLQQQNQQPIDWQPKLPAVE

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=216, Percent_Identity=55.5555555555556, Blast_Score=254, Evalue=4e-68,
Organism=Homo sapiens, GI6224979, Length=216, Percent_Identity=55.5555555555556, Blast_Score=254, Evalue=6e-68,
Organism=Escherichia coli, GI1788934, Length=226, Percent_Identity=73.0088495575221, Blast_Score=358, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17556304, Length=230, Percent_Identity=46.9565217391304, Blast_Score=224, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6323620, Length=232, Percent_Identity=46.551724137931, Blast_Score=193, Evalue=3e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 26603; Mature: 26603

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKPRRVFMSPSLTWHDVIGQEKEQPYFKDTLAYVAAERRAGKTIYPPQKDIFNAFRLTE
CCCCCEEEECCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCC
LDQVKVVILGQDPYHGPNQAHGLSFSVLPGVPAPPSLGNIYKELVTDIPGFQRPNHGFLQ
CCCEEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHH
SWAEQGVLLLNTVLTVEAGKAHSHANLGWETFTDKVIAALNEHREGVIFMLWGSHAQKKG
HHHHCCEEEEEHEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCC
RIINTERHYILKAPHPSPLSAHRGFLGCKHFSQANQLLQQQNQQPIDWQPKLPAVE
CEEECCCEEEEECCCCCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQKPRRVFMSPSLTWHDVIGQEKEQPYFKDTLAYVAAERRAGKTIYPPQKDIFNAFRLTE
CCCCCEEEECCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCC
LDQVKVVILGQDPYHGPNQAHGLSFSVLPGVPAPPSLGNIYKELVTDIPGFQRPNHGFLQ
CCCEEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHH
SWAEQGVLLLNTVLTVEAGKAHSHANLGWETFTDKVIAALNEHREGVIFMLWGSHAQKKG
HHHHCCEEEEEHEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCC
RIINTERHYILKAPHPSPLSAHRGFLGCKHFSQANQLLQQQNQQPIDWQPKLPAVE
CEEECCCEEEEECCCCCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA