| Definition | Yersinia pestis KIM 10 chromosome, complete genome. |
|---|---|
| Accession | NC_004088 |
| Length | 4,600,755 |
Click here to switch to the map view.
The map label for this gene is lon [H]
Identifier: 22124936
GI number: 22124936
Start: 1158788
End: 1161196
Strand: Direct
Name: lon [H]
Synonym: y1029
Alternate gene names: 22124936
Gene position: 1158788-1161196 (Clockwise)
Preceding gene: 22124935
Following gene: 22124937
Centisome position: 25.19
GC content: 47.99
Gene sequence:
>2409_bases GTGTTTCACGAGATTTCCAGTAATCTGGCGGAAGCTAAACTAAGAGAGAGCTCTATGAACCCTGAGCGTTCCGAACGCAT AGAAATCCCCGTATTGCCTCTGCGCGATGTGGTGGTTTATCCGCATATGGTGATCCCACTATTTGTTGGCCGGGAAAAGT CGATTCGGTGCCTGGAAGCTGCGATGGACCATGATAAAAGAATCATGCTGGTTGCGCAGAAAGAAGCTTCGACCGACGAA CCTGGTATCAACGATCTGTTTTCGGTGGGTACCGTAGCCTCGATTTTGCAAATGCTGAAGTTGCCTGACGGCACAGTAAA AGTGTTGGTTGAAGGTTTACAGCGTGCGCGTATCACCACGCTTTCTGACAGTGGCGAGCATTTTGCTGCCCAAGCGGAAT ACCTTGAATCACCCGTGATGGATGATCGCGAGCAAGAAGTCTTGGTGCGTACCGCGATTAATCAGTTTGAAGGTTATATC AAACTGAACAAAAAAATTCCGCCGGAAGTGCTGGCTTCGCTGCACAGTATTGATGATGCGGCACGTCTTGCTGATACCAT CGCTGCACATATGCCATTGAAGTTAAATGATAAACAAGCTGTTCTGGAAATGTTCGATATCACCGAACGTCTGGAATACT TGATGGCGATGATGGAGTCGGAAATCGATCTGTTACAGGTCGAAAAGCGGATCCGTAATCGTGTTAAAAAACAGATGGAA AAGAGCCAGCGCGAGTACTATCTGAATGAGCAAATGAAAGCTATTCAGAAAGAACTGGGCGAGATGGACGATACGCCAGA CGAGCATGAAGCGCTGAAGCGTAAAATTGAAGCGGCTAAAATGCCGAAAGATGCACGTGAAAAAACCGAAGCGGAACTGC AAAAACTGAAAATGATGTCGCCAATGTCTGCGGAAGCAACCGTGGTACGTGGTTACATCGACTGGATGTTGCAGGTTCCT TGGAATAGCCGCAGCAAAGTTAAAAAAGATCTGGTTAAAGCACAAGAAGTTCTGGATACCGACCACTACGGTTTAGAGCG TGTTAAAGATCGTATCTTGGAATATCTCGCAGTCCAGAGCCGGGTCAGCAAAATTAAAGGGCCAATCCTCTGCTTGGTTG GGCCTCCTGGGGTCGGTAAAACCTCTCTAGGGCAGTCAATTGCTAAGGCAACGGGCCGCCAGTATGTGCGTATGGCATTG GGTGGGGTGCGTGATGAAGCTGAAATCCGTGGTCACCGTCGGACGTATATTGGTTCTATGCCGGGTAAATTGATCCAGAA GATGGCAAAAGTGGGTGTGAAAAATCCACTCTTCCTATTGGATGAGATCGATAAAATGGCATCGGATATGCGCGGAGATC CTGCTTCTGCGTTACTGGAGGTGCTGGATCCAGAACAAAACGTTGCATTTAACGATCACTACCTGGAAGTGGATTACGAT CTCTCGGATGTGATGTTTGTGGCGACCTCTAACTCCATGAATATTCCAGCCCCGTTGCTGGATCGTATGGAAGTTATTCG TCTGTCCGGCTATACCGAAGATGAGAAACTCAATATTGCTAAACAGCATTTGCTGCCAAAACAATTTGAGCGTAATGCCA TCAAGAAAGGTGAGTTGACCATTGATGACAGCGCCATTATGAGCATCATCCGTTACTACACCCGTGAAGCTGGGGTGCGT AGTTTGGAACGTGAAATTTCTAAACTGTGTCGTAAGGCGGTAAAAAATCTGCTGATGGACAAAACGGTTAAGCACATTGA AATCAACGGGGATAACCTAAAAGATTTCCTTGGCGTTCAGAAGGTTGACTATGGTCGTGCCGATACTGAAAACCGCGTAG GTCAGGTAACGGGTCTAGCGTGGACTGAAGTGGGTGGTGACTTACTTACTATCGAGACCGCTTGTGTTCCAGGTAAAGGC AAGTTGACTTATACCGGCTCACTGGGTGAAGTGATGCAAGAGTCGATTCAGGCGGCTCTAACCGTAGTGCGTGCGCGTGC GGATAAATTGGGTATCAATCCTGATTTCTATGAAAAACGCGACATCCACGTGCATGTGCCGGAAGGGGCGACACCTAAAG ATGGCCCAAGCGCAGGTATTGCAATGTGCACAGCACTGGTTTCTTGTCTGACGGGTAACCCCGTTCGTGCTGATGTTGCA ATGACGGGTGAGATAACCTTACGCGGCTTAGTATTGCCGATTGGCGGTTTGAAAGAGAAATTACTGGCCGCTCACCGTGG TGGGATCAAAGTGGTGTTGATTCCAGATGATAACAAACGTGATCTGGAAGAGATTCCTGACAATGTTATCGCTGATCTGG AGATCCACCCGGTTAAACGAATTGATGATGTTTTAGCCATTGCGTTGGAACACCCGGCCTTTGGTGCCCAGCCAGTAGCG CCAAAATAG
Upstream 100 bases:
>100_bases TTTTATCCCCCATTTCTTTTTCCTCGCATTGTTATCGTTGAATGTAAGACATTCGTCCCCATATACTCAAATACCTATTT AGTGAAACTCGTGATGACTC
Downstream 100 bases:
>100_bases TGACGGATCGCAAGAAGTATTGATAAAACTAATGCTGGTAAGTGAAATCCTGCTTGCCAGCTATTTTTTGTGCCGCTAAG TTAGTTCGGCTGTCCGGCAA
Product: DNA-binding ATP-dependent protease La
Products: NA
Alternate protein names: ATP-dependent protease La [H]
Number of amino acids: Translated: 802; Mature: 802
Protein sequence:
>802_residues MFHEISSNLAEAKLRESSMNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMDHDKRIMLVAQKEASTDE PGINDLFSVGTVASILQMLKLPDGTVKVLVEGLQRARITTLSDSGEHFAAQAEYLESPVMDDREQEVLVRTAINQFEGYI KLNKKIPPEVLASLHSIDDAARLADTIAAHMPLKLNDKQAVLEMFDITERLEYLMAMMESEIDLLQVEKRIRNRVKKQME KSQREYYLNEQMKAIQKELGEMDDTPDEHEALKRKIEAAKMPKDAREKTEAELQKLKMMSPMSAEATVVRGYIDWMLQVP WNSRSKVKKDLVKAQEVLDTDHYGLERVKDRILEYLAVQSRVSKIKGPILCLVGPPGVGKTSLGQSIAKATGRQYVRMAL GGVRDEAEIRGHRRTYIGSMPGKLIQKMAKVGVKNPLFLLDEIDKMASDMRGDPASALLEVLDPEQNVAFNDHYLEVDYD LSDVMFVATSNSMNIPAPLLDRMEVIRLSGYTEDEKLNIAKQHLLPKQFERNAIKKGELTIDDSAIMSIIRYYTREAGVR SLEREISKLCRKAVKNLLMDKTVKHIEINGDNLKDFLGVQKVDYGRADTENRVGQVTGLAWTEVGGDLLTIETACVPGKG KLTYTGSLGEVMQESIQAALTVVRARADKLGINPDFYEKRDIHVHVPEGATPKDGPSAGIAMCTALVSCLTGNPVRADVA MTGEITLRGLVLPIGGLKEKLLAAHRGGIKVVLIPDDNKRDLEEIPDNVIADLEIHPVKRIDDVLAIALEHPAFGAQPVA PK
Sequences:
>Translated_802_residues MFHEISSNLAEAKLRESSMNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMDHDKRIMLVAQKEASTDE PGINDLFSVGTVASILQMLKLPDGTVKVLVEGLQRARITTLSDSGEHFAAQAEYLESPVMDDREQEVLVRTAINQFEGYI KLNKKIPPEVLASLHSIDDAARLADTIAAHMPLKLNDKQAVLEMFDITERLEYLMAMMESEIDLLQVEKRIRNRVKKQME KSQREYYLNEQMKAIQKELGEMDDTPDEHEALKRKIEAAKMPKDAREKTEAELQKLKMMSPMSAEATVVRGYIDWMLQVP WNSRSKVKKDLVKAQEVLDTDHYGLERVKDRILEYLAVQSRVSKIKGPILCLVGPPGVGKTSLGQSIAKATGRQYVRMAL GGVRDEAEIRGHRRTYIGSMPGKLIQKMAKVGVKNPLFLLDEIDKMASDMRGDPASALLEVLDPEQNVAFNDHYLEVDYD LSDVMFVATSNSMNIPAPLLDRMEVIRLSGYTEDEKLNIAKQHLLPKQFERNAIKKGELTIDDSAIMSIIRYYTREAGVR SLEREISKLCRKAVKNLLMDKTVKHIEINGDNLKDFLGVQKVDYGRADTENRVGQVTGLAWTEVGGDLLTIETACVPGKG KLTYTGSLGEVMQESIQAALTVVRARADKLGINPDFYEKRDIHVHVPEGATPKDGPSAGIAMCTALVSCLTGNPVRADVA MTGEITLRGLVLPIGGLKEKLLAAHRGGIKVVLIPDDNKRDLEEIPDNVIADLEIHPVKRIDDVLAIALEHPAFGAQPVA PK >Mature_802_residues MFHEISSNLAEAKLRESSMNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMDHDKRIMLVAQKEASTDE PGINDLFSVGTVASILQMLKLPDGTVKVLVEGLQRARITTLSDSGEHFAAQAEYLESPVMDDREQEVLVRTAINQFEGYI KLNKKIPPEVLASLHSIDDAARLADTIAAHMPLKLNDKQAVLEMFDITERLEYLMAMMESEIDLLQVEKRIRNRVKKQME KSQREYYLNEQMKAIQKELGEMDDTPDEHEALKRKIEAAKMPKDAREKTEAELQKLKMMSPMSAEATVVRGYIDWMLQVP WNSRSKVKKDLVKAQEVLDTDHYGLERVKDRILEYLAVQSRVSKIKGPILCLVGPPGVGKTSLGQSIAKATGRQYVRMAL GGVRDEAEIRGHRRTYIGSMPGKLIQKMAKVGVKNPLFLLDEIDKMASDMRGDPASALLEVLDPEQNVAFNDHYLEVDYD LSDVMFVATSNSMNIPAPLLDRMEVIRLSGYTEDEKLNIAKQHLLPKQFERNAIKKGELTIDDSAIMSIIRYYTREAGVR SLEREISKLCRKAVKNLLMDKTVKHIEINGDNLKDFLGVQKVDYGRADTENRVGQVTGLAWTEVGGDLLTIETACVPGKG KLTYTGSLGEVMQESIQAALTVVRARADKLGINPDFYEKRDIHVHVPEGATPKDGPSAGIAMCTALVSCLTGNPVRADVA MTGEITLRGLVLPIGGLKEKLLAAHRGGIKVVLIPDDNKRDLEEIPDNVIADLEIHPVKRIDDVLAIALEHPAFGAQPVA PK
Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced
COG id: COG0466
COG function: function code O; ATP-dependent Lon protease, bacterial type
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 Lon domain [H]
Homologues:
Organism=Homo sapiens, GI31377667, Length=564, Percent_Identity=45.7446808510638, Blast_Score=504, Evalue=1e-143, Organism=Homo sapiens, GI21396489, Length=624, Percent_Identity=41.5064102564103, Blast_Score=503, Evalue=1e-142, Organism=Escherichia coli, GI1786643, Length=784, Percent_Identity=91.0714285714286, Blast_Score=1456, Evalue=0.0, Organism=Caenorhabditis elegans, GI17505831, Length=696, Percent_Identity=38.5057471264368, Blast_Score=488, Evalue=1e-138, Organism=Caenorhabditis elegans, GI17556486, Length=785, Percent_Identity=32.8662420382166, Blast_Score=413, Evalue=1e-115, Organism=Saccharomyces cerevisiae, GI6319449, Length=678, Percent_Identity=40.117994100295, Blast_Score=483, Evalue=1e-137, Organism=Drosophila melanogaster, GI221513036, Length=680, Percent_Identity=43.5294117647059, Blast_Score=535, Evalue=1e-152, Organism=Drosophila melanogaster, GI24666867, Length=680, Percent_Identity=43.5294117647059, Blast_Score=534, Evalue=1e-152,
Paralogues:
None
Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003593 - InterPro: IPR003959 - InterPro: IPR008269 - InterPro: IPR004815 - InterPro: IPR003111 - InterPro: IPR008268 - InterPro: IPR001984 - InterPro: IPR015947 - InterPro: IPR020568 [H]
Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]
EC number: =3.4.21.53 [H]
Molecular weight: Translated: 89465; Mature: 89465
Theoretical pI: Translated: 6.11; Mature: 6.11
Prosite motif: PS01046 LON_SER
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 4.1 %Met (Translated Protein) 4.9 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 4.1 %Met (Mature Protein) 4.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MFHEISSNLAEAKLRESSMNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEA CCCHHHHHHHHHHHHHHCCCCCHHCEEECCCCCHHHHHHCCHHHHHHHCCCCHHHHHHHH AMDHDKRIMLVAQKEASTDEPGINDLFSVGTVASILQMLKLPDGTVKVLVEGLQRARITT HHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEE LSDSGEHFAAQAEYLESPVMDDREQEVLVRTAINQFEGYIKLNKKIPPEVLASLHSIDDA ECCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCEEEECCCCCHHHHHHHHHHHHH ARLADTIAAHMPLKLNDKQAVLEMFDITERLEYLMAMMESEIDLLQVEKRIRNRVKKQME HHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH KSQREYYLNEQMKAIQKELGEMDDTPDEHEALKRKIEAAKMPKDAREKTEAELQKLKMMS HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC PMSAEATVVRGYIDWMLQVPWNSRSKVKKDLVKAQEVLDTDHYGLERVKDRILEYLAVQS CCCCHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH RVSKIKGPILCLVGPPGVGKTSLGQSIAKATGRQYVRMALGGVRDEAEIRGHRRTYIGSM HHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCC PGKLIQKMAKVGVKNPLFLLDEIDKMASDMRGDPASALLEVLDPEQNVAFNDHYLEVDYD CHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEECCCEEEEECC LSDVMFVATSNSMNIPAPLLDRMEVIRLSGYTEDEKLNIAKQHLLPKQFERNAIKKGELT CCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHCCCCCCEE IDDSAIMSIIRYYTREAGVRSLEREISKLCRKAVKNLLMDKTVKHIEINGDNLKDFLGVQ ECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEECCCCHHHHHCCH KVDYGRADTENRVGQVTGLAWTEVGGDLLTIETACVPGKGKLTYTGSLGEVMQESIQAAL HCCCCCCCCCCCCHHHCCEEHHHCCCCEEEEEEEECCCCCCEEECCCHHHHHHHHHHHHH TVVRARADKLGINPDFYEKRDIHVHVPEGATPKDGPSAGIAMCTALVSCLTGNPVRADVA HHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEE MTGEITLRGLVLPIGGLKEKLLAAHRGGIKVVLIPDDNKRDLEEIPDNVIADLEIHPVKR EECCEEEEEEEECCCCHHHHHHHHHCCCEEEEEECCCCCCHHHHCCHHHEECCEECCHHH IDDVLAIALEHPAFGAQPVAPK HHHHHHHHHCCCCCCCCCCCCC >Mature Secondary Structure MFHEISSNLAEAKLRESSMNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEA CCCHHHHHHHHHHHHHHCCCCCHHCEEECCCCCHHHHHHCCHHHHHHHCCCCHHHHHHHH AMDHDKRIMLVAQKEASTDEPGINDLFSVGTVASILQMLKLPDGTVKVLVEGLQRARITT HHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEE LSDSGEHFAAQAEYLESPVMDDREQEVLVRTAINQFEGYIKLNKKIPPEVLASLHSIDDA ECCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCEEEECCCCCHHHHHHHHHHHHH ARLADTIAAHMPLKLNDKQAVLEMFDITERLEYLMAMMESEIDLLQVEKRIRNRVKKQME HHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH KSQREYYLNEQMKAIQKELGEMDDTPDEHEALKRKIEAAKMPKDAREKTEAELQKLKMMS HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC PMSAEATVVRGYIDWMLQVPWNSRSKVKKDLVKAQEVLDTDHYGLERVKDRILEYLAVQS CCCCHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH RVSKIKGPILCLVGPPGVGKTSLGQSIAKATGRQYVRMALGGVRDEAEIRGHRRTYIGSM HHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCC PGKLIQKMAKVGVKNPLFLLDEIDKMASDMRGDPASALLEVLDPEQNVAFNDHYLEVDYD CHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEECCCEEEEECC LSDVMFVATSNSMNIPAPLLDRMEVIRLSGYTEDEKLNIAKQHLLPKQFERNAIKKGELT CCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHCCCCCCEE IDDSAIMSIIRYYTREAGVRSLEREISKLCRKAVKNLLMDKTVKHIEINGDNLKDFLGVQ ECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEECCCCHHHHHCCH KVDYGRADTENRVGQVTGLAWTEVGGDLLTIETACVPGKGKLTYTGSLGEVMQESIQAAL HCCCCCCCCCCCCHHHCCEEHHHCCCCEEEEEEEECCCCCCEEECCCHHHHHHHHHHHHH TVVRARADKLGINPDFYEKRDIHVHVPEGATPKDGPSAGIAMCTALVSCLTGNPVRADVA HHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEE MTGEITLRGLVLPIGGLKEKLLAAHRGGIKVVLIPDDNKRDLEEIPDNVIADLEIHPVKR EECCEEEEEEEECCCCHHHHHHHHHCCCEEEEEECCCCCCHHHHCCHHHEECCEECCHHH IDDVLAIALEHPAFGAQPVAPK HHHHHHHHHCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA