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The map label for this gene is cyoE [H]

Identifier: 22124925

GI number: 22124925

Start: 1145303

End: 1146211

Strand: Reverse

Name: cyoE [H]

Synonym: y1018

Alternate gene names: 22124925

Gene position: 1146211-1145303 (Counterclockwise)

Preceding gene: 22124926

Following gene: 22124924

Centisome position: 24.91

GC content: 46.53

Gene sequence:

>909_bases
TTGACTGAAGAGCTGCATGTGATGATTAAGCAATACCTGCAAGTCACTAAGCCAGGAATTATTTTCGGTAATTTAATTTC
TGTCATTGGGGGTTTTCTCCTCGCTTCCAAGGGCGATATTGATTACCCCCTGTTTCTCTCCACCTTATTAGGTGTCTCGT
TAGTTGTTGCCTCCGGGTGCGTATTTAACAACTATATCGATCGAGATATCGATAAAATCATGGAGAGAACGAAGAATCGT
GTCCTGGTCAAAGGGCTTATCGATCCGAAGGTATCCCTGATTTATGCATCGGTACTGGGTATTGCTGGCATGCTGTTGCT
CTACGTGGCAGCTAATGCATTAGCAATGATGCTGGCTGTTATTGGTTTCGTTATCTATGTTGGGGTGTATAGCCTCTACA
TGAAACGTAAATCAGTCTACGGCACCTTGATTGGCAGCTTGTCAGGCGCCGCTCCCCCCGTTATTGGTTACTGTGCCGTA
ACGGGGCAATTCGACACTGGCGCACTGATCTTGTTGCTGATCTTCAGTCTGTGGCAAATGCCTCATTCCTATGCCATCGC
CATCTTCCGCTTTAAGGATTATCAGGCCGCCAACATTCCGGTACTCCCGGTGATAAAAGGGATATCGGTCACCAAAAACC
ATATTACCCTTTATATTTTGGCGTTTATGGTCGCAACCTTGATGCTGACATTAAGTGGCTATGCCGGTTATAAATATCTG
GTTGTGGCTGCCGCGGTTAGCGTCTGGTGGCTGGGTATGGCACTGCGCGGTTATAAGGCAACGAATGACAGCGTATGGGC
GAGAAAACTCTTTGTCTTCTCTATCATTGCCATTACGTCATTGAGCGTCATGATGTCAGTTGATTTCAATGTACACTCTT
CGGCAGTACTCCTGACTTACGCTGGATAG

Upstream 100 bases:

>100_bases
CGCTGGAATCTGGTGGCGCTCCTGTTCACCGCTATGATTATTGCAATCGTTGTAGTGGGCTCACTCTGGATTATGTACAA
CCTCAACATCAATATGATGG

Downstream 100 bases:

>100_bases
TCTTAGCGAAAATGATGAGAGTGAAATAAATCAAGTGGCTGGCAGGAATCGCTCTTGCCAGCCACTTTGTATTTGTTCCC
TGTTTTGTATTTGTACCCAG

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MTEELHVMIKQYLQVTKPGIIFGNLISVIGGFLLASKGDIDYPLFLSTLLGVSLVVASGCVFNNYIDRDIDKIMERTKNR
VLVKGLIDPKVSLIYASVLGIAGMLLLYVAANALAMMLAVIGFVIYVGVYSLYMKRKSVYGTLIGSLSGAAPPVIGYCAV
TGQFDTGALILLLIFSLWQMPHSYAIAIFRFKDYQAANIPVLPVIKGISVTKNHITLYILAFMVATLMLTLSGYAGYKYL
VVAAAVSVWWLGMALRGYKATNDSVWARKLFVFSIIAITSLSVMMSVDFNVHSSAVLLTYAG

Sequences:

>Translated_302_residues
MTEELHVMIKQYLQVTKPGIIFGNLISVIGGFLLASKGDIDYPLFLSTLLGVSLVVASGCVFNNYIDRDIDKIMERTKNR
VLVKGLIDPKVSLIYASVLGIAGMLLLYVAANALAMMLAVIGFVIYVGVYSLYMKRKSVYGTLIGSLSGAAPPVIGYCAV
TGQFDTGALILLLIFSLWQMPHSYAIAIFRFKDYQAANIPVLPVIKGISVTKNHITLYILAFMVATLMLTLSGYAGYKYL
VVAAAVSVWWLGMALRGYKATNDSVWARKLFVFSIIAITSLSVMMSVDFNVHSSAVLLTYAG
>Mature_301_residues
TEELHVMIKQYLQVTKPGIIFGNLISVIGGFLLASKGDIDYPLFLSTLLGVSLVVASGCVFNNYIDRDIDKIMERTKNRV
LVKGLIDPKVSLIYASVLGIAGMLLLYVAANALAMMLAVIGFVIYVGVYSLYMKRKSVYGTLIGSLSGAAPPVIGYCAVT
GQFDTGALILLLIFSLWQMPHSYAIAIFRFKDYQAANIPVLPVIKGISVTKNHITLYILAFMVATLMLTLSGYAGYKYLV
VAAAVSVWWLGMALRGYKATNDSVWARKLFVFSIIAITSLSVMMSVDFNVHSSAVLLTYAG

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=168, Percent_Identity=35.1190476190476, Blast_Score=106, Evalue=2e-23,
Organism=Escherichia coli, GI1786631, Length=293, Percent_Identity=83.617747440273, Blast_Score=492, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI71998235, Length=229, Percent_Identity=28.82096069869, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6325085, Length=194, Percent_Identity=28.3505154639175, Blast_Score=83, Evalue=4e-17,
Organism=Drosophila melanogaster, GI19921064, Length=273, Percent_Identity=28.9377289377289, Blast_Score=112, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 32888; Mature: 32757

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEELHVMIKQYLQVTKPGIIFGNLISVIGGFLLASKGDIDYPLFLSTLLGVSLVVASGC
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCH
VFNNYIDRDIDKIMERTKNRVLVKGLIDPKVSLIYASVLGIAGMLLLYVAANALAMMLAV
HHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGFVIYVGVYSLYMKRKSVYGTLIGSLSGAAPPVIGYCAVTGQFDTGALILLLIFSLWQM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHC
PHSYAIAIFRFKDYQAANIPVLPVIKGISVTKNHITLYILAFMVATLMLTLSGYAGYKYL
CCHHEEEEEEEECCCCCCCCHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
VVAAAVSVWWLGMALRGYKATNDSVWARKLFVFSIIAITSLSVMMSVDFNVHSSAVLLTY
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCEEEEEE
AG
CC
>Mature Secondary Structure 
TEELHVMIKQYLQVTKPGIIFGNLISVIGGFLLASKGDIDYPLFLSTLLGVSLVVASGC
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCH
VFNNYIDRDIDKIMERTKNRVLVKGLIDPKVSLIYASVLGIAGMLLLYVAANALAMMLAV
HHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGFVIYVGVYSLYMKRKSVYGTLIGSLSGAAPPVIGYCAVTGQFDTGALILLLIFSLWQM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHC
PHSYAIAIFRFKDYQAANIPVLPVIKGISVTKNHITLYILAFMVATLMLTLSGYAGYKYL
CCHHEEEEEEEECCCCCCCCHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
VVAAAVSVWWLGMALRGYKATNDSVWARKLFVFSIIAITSLSVMMSVDFNVHSSAVLLTY
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCEEEEEE
AG
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA