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The map label for this gene is proY [H]

Identifier: 22124889

GI number: 22124889

Start: 1112206

End: 1113597

Strand: Direct

Name: proY [H]

Synonym: y0982

Alternate gene names: 22124889

Gene position: 1112206-1113597 (Clockwise)

Preceding gene: 22124888

Following gene: 22124890

Centisome position: 24.17

GC content: 45.76

Gene sequence:

>1392_bases
ATGGAATTACCAGTTAAAAATAAGCTTAAACGTGGCCTGACGACACGTCATATTCGTTTTATTGCATTGGGTTCAGCGAT
AGGGACTGGCCTATTCTATGGTTCGGCTGATGCGATAAGAATGGCCGGACCAAGCGTGTTGTTGGCATACCTGATTGGTG
GTGTGGTGGCATTTGTCATCATGCGTGCTTTGGGTGAGATGTCGGTCAATAACCCACAAGCCAGCTCTTTCTCTCGTTAT
GCGCAAGATTATCTTGGGCCGATGGCAGGTTATATCACCGGCTGGACGTATTGTTTTGAGATCTTGATTGTGGCTATTGC
TGATGTGACAGCTTTCGGTATCTATATGGGGCTCTGGTTCCCAGATGTTGCTCATTGGGTATGGGTGCTGAGTGTTGTCT
TGATCATCGGCGCGGTCAATATGATGAGTGTGAAAGTCTTCGGTGAGCTTGAGTTCTGGTTCTCGTTTTTCAAAGTTGCC
ACCATTATCATCATGATTTTAGCCGGTATCGGTATCATTGTTTGGGGTATTGGTAACGGTGGTCAGCCAACGGGTATCCA
TAATTTATGGACTAACGGTGGCTTCTTCAGTAATGGCTTTGTTGGCATGCTCCTGTCATTACAATTGGTGATGTTTGCCT
ATGGCGGTATTGAGATTATTGGTATTACTGCCGGTGAAGCCGAGGATCCGAAAAAATCGATTCCGAAAGCAATCAACTCA
GTACCATGGCGTATTTTAGTCTTTTACGTCGGGACCCTGTTTGTGATTATGTCCATTTACCCATGGAATCAAGTGGGCAC
GAACGGTAGTCCGTTCGTTCTGACCTTCCAGCATATGGGGATCACTATTGCTGCCGGTATTTTGAACTTTGTGGTTATCA
CCGCTTCTGTATCTGCAATTAACAGCGATGTGTTTGGTGTCGGGCGTATGCTGAATGGGATGGCAGAACAAGGCCATGCA
CCAAAAGCTTTTACTGCTATTTCTAAACGCGGTGTGCCGTGGGTCACGGTGCTGGTGATGATGTGTGCCATGCTAATTGC
GGTTTATCTGAACTACATCATGCCGGAAAATGTTTTCTTGGTTATTGCGTCATTAGCGACGTTTGCTACTGTCTGGGTCT
GGATCATGATCCTATTCTCTCAGATTGCTTTCCGCCGTTCACTGAGTAAAGATCAGGTTAAAGCACTGGATTTCCCACTG
CGTGGTGGAACCTTTACTTCGGTGCTAGCCATCATTTTCCTGGTATTTATTATCGGTCTTATTGGTTGGTTCCCTACGAC
TCGAATCTCACTGTATGTCGGATTAGTGTGGATCGTGCTGTTGCTGGTGGGGTATTACTTTAAGGTCAAGTATCAGAAAA
AACAGGCTACGCTGATCAAGAATGCTGATTAA

Upstream 100 bases:

>100_bases
CCAGAAAATTGTGGTTAAACAATAGCTGCGCGGCAATAGAGTATTTTTAGCCACGGTTAATATCCGTGGCTTTTTGCTGA
AAAAAGACGGGGCTTTGTGA

Downstream 100 bases:

>100_bases
AAACACAGTTCAATAAACACTGAGTCGATAATCGATACAAAGCCGGGGTACAGTTCATCTGTCCCGGCTTTTTTCTTTTA
ATTCCGGCAAGTTGAGAATA

Product: putative proline-specific permease

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MELPVKNKLKRGLTTRHIRFIALGSAIGTGLFYGSADAIRMAGPSVLLAYLIGGVVAFVIMRALGEMSVNNPQASSFSRY
AQDYLGPMAGYITGWTYCFEILIVAIADVTAFGIYMGLWFPDVAHWVWVLSVVLIIGAVNMMSVKVFGELEFWFSFFKVA
TIIIMILAGIGIIVWGIGNGGQPTGIHNLWTNGGFFSNGFVGMLLSLQLVMFAYGGIEIIGITAGEAEDPKKSIPKAINS
VPWRILVFYVGTLFVIMSIYPWNQVGTNGSPFVLTFQHMGITIAAGILNFVVITASVSAINSDVFGVGRMLNGMAEQGHA
PKAFTAISKRGVPWVTVLVMMCAMLIAVYLNYIMPENVFLVIASLATFATVWVWIMILFSQIAFRRSLSKDQVKALDFPL
RGGTFTSVLAIIFLVFIIGLIGWFPTTRISLYVGLVWIVLLLVGYYFKVKYQKKQATLIKNAD

Sequences:

>Translated_463_residues
MELPVKNKLKRGLTTRHIRFIALGSAIGTGLFYGSADAIRMAGPSVLLAYLIGGVVAFVIMRALGEMSVNNPQASSFSRY
AQDYLGPMAGYITGWTYCFEILIVAIADVTAFGIYMGLWFPDVAHWVWVLSVVLIIGAVNMMSVKVFGELEFWFSFFKVA
TIIIMILAGIGIIVWGIGNGGQPTGIHNLWTNGGFFSNGFVGMLLSLQLVMFAYGGIEIIGITAGEAEDPKKSIPKAINS
VPWRILVFYVGTLFVIMSIYPWNQVGTNGSPFVLTFQHMGITIAAGILNFVVITASVSAINSDVFGVGRMLNGMAEQGHA
PKAFTAISKRGVPWVTVLVMMCAMLIAVYLNYIMPENVFLVIASLATFATVWVWIMILFSQIAFRRSLSKDQVKALDFPL
RGGTFTSVLAIIFLVFIIGLIGWFPTTRISLYVGLVWIVLLLVGYYFKVKYQKKQATLIKNAD
>Mature_463_residues
MELPVKNKLKRGLTTRHIRFIALGSAIGTGLFYGSADAIRMAGPSVLLAYLIGGVVAFVIMRALGEMSVNNPQASSFSRY
AQDYLGPMAGYITGWTYCFEILIVAIADVTAFGIYMGLWFPDVAHWVWVLSVVLIIGAVNMMSVKVFGELEFWFSFFKVA
TIIIMILAGIGIIVWGIGNGGQPTGIHNLWTNGGFFSNGFVGMLLSLQLVMFAYGGIEIIGITAGEAEDPKKSIPKAINS
VPWRILVFYVGTLFVIMSIYPWNQVGTNGSPFVLTFQHMGITIAAGILNFVVITASVSAINSDVFGVGRMLNGMAEQGHA
PKAFTAISKRGVPWVTVLVMMCAMLIAVYLNYIMPENVFLVIASLATFATVWVWIMILFSQIAFRRSLSKDQVKALDFPL
RGGTFTSVLAIIFLVFIIGLIGWFPTTRISLYVGLVWIVLLLVGYYFKVKYQKKQATLIKNAD

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of proline [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=352, Percent_Identity=23.5795454545455, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI181337167, Length=339, Percent_Identity=24.7787610619469, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI258645169, Length=427, Percent_Identity=21.7798594847775, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1786602, Length=451, Percent_Identity=81.5964523281596, Blast_Score=699, Evalue=0.0,
Organism=Escherichia coli, GI1786789, Length=444, Percent_Identity=45.045045045045, Blast_Score=385, Evalue=1e-108,
Organism=Escherichia coli, GI1786302, Length=447, Percent_Identity=44.0715883668904, Blast_Score=380, Evalue=1e-107,
Organism=Escherichia coli, GI48994972, Length=438, Percent_Identity=45.2054794520548, Blast_Score=372, Evalue=1e-104,
Organism=Escherichia coli, GI1790653, Length=466, Percent_Identity=40.5579399141631, Blast_Score=345, Evalue=4e-96,
Organism=Escherichia coli, GI87081915, Length=404, Percent_Identity=37.8712871287129, Blast_Score=306, Evalue=1e-84,
Organism=Escherichia coli, GI87081708, Length=463, Percent_Identity=37.7969762419007, Blast_Score=295, Evalue=5e-81,
Organism=Escherichia coli, GI1788480, Length=427, Percent_Identity=37.7049180327869, Blast_Score=251, Evalue=6e-68,
Organism=Escherichia coli, GI1789017, Length=386, Percent_Identity=34.1968911917098, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI87081869, Length=237, Percent_Identity=23.6286919831224, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87082023, Length=391, Percent_Identity=21.9948849104859, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=405, Percent_Identity=22.4691358024691, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17533459, Length=400, Percent_Identity=23, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17531343, Length=345, Percent_Identity=21.1594202898551, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17540018, Length=356, Percent_Identity=24.7191011235955, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6324061, Length=486, Percent_Identity=30.6584362139918, Blast_Score=213, Evalue=7e-56,
Organism=Saccharomyces cerevisiae, GI6320772, Length=420, Percent_Identity=32.8571428571429, Blast_Score=198, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6324990, Length=493, Percent_Identity=31.6430020283976, Blast_Score=190, Evalue=5e-49,
Organism=Saccharomyces cerevisiae, GI6324924, Length=410, Percent_Identity=32.1951219512195, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6319824, Length=429, Percent_Identity=28.2051282051282, Blast_Score=176, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6324059, Length=444, Percent_Identity=30.8558558558559, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6322892, Length=407, Percent_Identity=30.958230958231, Blast_Score=173, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6324553, Length=398, Percent_Identity=32.1608040201005, Blast_Score=169, Evalue=7e-43,
Organism=Saccharomyces cerevisiae, GI6319542, Length=407, Percent_Identity=28.009828009828, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6321629, Length=407, Percent_Identity=28.5012285012285, Blast_Score=165, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6320251, Length=410, Percent_Identity=27.0731707317073, Blast_Score=163, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6320717, Length=437, Percent_Identity=26.5446224256293, Blast_Score=158, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6319543, Length=436, Percent_Identity=26.3761467889908, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6321053, Length=432, Percent_Identity=25.9259259259259, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6322967, Length=426, Percent_Identity=25.1173708920188, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6319608, Length=459, Percent_Identity=25.4901960784314, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6324981, Length=403, Percent_Identity=26.5508684863524, Blast_Score=121, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6320364, Length=499, Percent_Identity=26.0521042084168, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI221512776, Length=418, Percent_Identity=20.8133971291866, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24666159, Length=418, Percent_Identity=20.8133971291866, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50772; Mature: 50772

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELPVKNKLKRGLTTRHIRFIALGSAIGTGLFYGSADAIRMAGPSVLLAYLIGGVVAFVI
CCCCCHHHHHCCCHHHHHHHEEEHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHH
MRALGEMSVNNPQASSFSRYAQDYLGPMAGYITGWTYCFEILIVAIADVTAFGIYMGLWF
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PDVAHWVWVLSVVLIIGAVNMMSVKVFGELEFWFSFFKVATIIIMILAGIGIIVWGIGNG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCC
GQPTGIHNLWTNGGFFSNGFVGMLLSLQLVMFAYGGIEIIGITAGEAEDPKKSIPKAINS
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHC
VPWRILVFYVGTLFVIMSIYPWNQVGTNGSPFVLTFQHMGITIAAGILNFVVITASVSAI
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHCCHHHHHHHHHHHHHHHHHHHH
NSDVFGVGRMLNGMAEQGHAPKAFTAISKRGVPWVTVLVMMCAMLIAVYLNYIMPENVFL
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHH
VIASLATFATVWVWIMILFSQIAFRRSLSKDQVKALDFPLRGGTFTSVLAIIFLVFIIGL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
IGWFPTTRISLYVGLVWIVLLLVGYYFKVKYQKKQATLIKNAD
HHHCCHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHHHCCCCC
>Mature Secondary Structure
MELPVKNKLKRGLTTRHIRFIALGSAIGTGLFYGSADAIRMAGPSVLLAYLIGGVVAFVI
CCCCCHHHHHCCCHHHHHHHEEEHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHH
MRALGEMSVNNPQASSFSRYAQDYLGPMAGYITGWTYCFEILIVAIADVTAFGIYMGLWF
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PDVAHWVWVLSVVLIIGAVNMMSVKVFGELEFWFSFFKVATIIIMILAGIGIIVWGIGNG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCC
GQPTGIHNLWTNGGFFSNGFVGMLLSLQLVMFAYGGIEIIGITAGEAEDPKKSIPKAINS
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHC
VPWRILVFYVGTLFVIMSIYPWNQVGTNGSPFVLTFQHMGITIAAGILNFVVITASVSAI
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHCCHHHHHHHHHHHHHHHHHHHH
NSDVFGVGRMLNGMAEQGHAPKAFTAISKRGVPWVTVLVMMCAMLIAVYLNYIMPENVFL
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHH
VIASLATFATVWVWIMILFSQIAFRRSLSKDQVKALDFPLRGGTFTSVLAIIFLVFIIGL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
IGWFPTTRISLYVGLVWIVLLLVGYYFKVKYQKKQATLIKNAD
HHHCCHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]