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The map label for this gene is emrA [H]

Identifier: 22124830

GI number: 22124830

Start: 1039064

End: 1040248

Strand: Reverse

Name: emrA [H]

Synonym: y0922

Alternate gene names: 22124830

Gene position: 1040248-1039064 (Counterclockwise)

Preceding gene: 22124831

Following gene: 22124829

Centisome position: 22.61

GC content: 49.79

Gene sequence:

>1185_bases
GTGGAGAACACCATGAGTGAAAGTGCGGGAGCCCAAGCCCCACAACGACCGCAGAATAAAAAACAGCAACGTAAACGTGT
ACTGCTGTTGCTGACGGCCATTTTTATTATGATCGGGGTGGCTTACCTTATTTATTGGTTCCTGGTGCTACGCCATCACC
AAGAGACTGATAATGCCTATATTTCAGGCAACCAAGTCCAGATTATGTCTCAAGTTCCCGGCAGTGTGGTCAGTGTTCAT
TTCGAAAATACGGACTTCGTCAAAAGTGGCGATGTGCTGGTGACACTCGACCCCACCGATGCAGAACAGGCATTTGAGCA
AGCGAAAACTGCCTTGGCAAATAGCGTGCGCCAAACCCACCAGCTCATTATTAACAGTAAACAGTATCAAGCGAATATTG
CGCTGAAAAAAACGGAATTGAGCCAGGCACAAAATGACCTGAAGCGTCGGGTGGTCCTGGGGGCTGCCGCAGTCATCGGC
CGTGAAGAATTGCAACACGCACGTGATGCTGTTGAGGCGGCACAAGCGTCGTTGGATATGGCAGTGCAGCAATATAACGC
CAATCAGGCGTTGGTCCTCAATACGCCATTGGAGAAACAACCGGCGATTGAGCAGGCGGCCGCTAAAATGCGTGATGCCT
GGCTCACCCTGCAGCGCACCAAAGTAGTTAGCCCAATTAGCGGCTATGTCTCGCGTCGCAGTGTACAAGTGGGTGCTGAA
ATCAGTAGTGGTACGCCGTTAATGGCGGTGGTTCCGGCAGATCAACTGTGGATCGACGCTAACTTCAAAGAAACTCAGTT
GGCGAACATGCGAATTGGCCAACCGGCGACTATCGTGACCGATTTTTACGGTGATGATGTGGTTTATCAAGGGAAAGTGG
TCGGTTTAGATATGGGAACCGGCAGTGCCTTCTCGCTACTACCCGCGCAAAATGCCACCGGTAACTGGATCAAAGTGGTC
CAACGCCTGCCAGTACGAATTGCATTGGATGAGAAACAACTGAAGGAGCATCCGTTACGTATTGGTCTGTCATCGCTGGT
TAAAGTCGACACCGCCAATACCGATGGACACGTTTTGGCACAAAACGTGCGTAAAGAACCCGCGTTCATGACCAATGCAT
TGTCATTAGATTTCGCGCCAGTTAATCAAATAATTAGCGATATTATTCATGCAAACGCCGATTAA

Upstream 100 bases:

>100_bases
GACACCTGAGTGGTTCCCCAAGCCCTGACGAAAATCAAGTGACTGGGGTGAACGAAGGCGGTCAACCCTCATACAACGTG
CAAAATGACGGGTATAGAGC

Downstream 100 bases:

>100_bases
TATCATGCCAATGCGGGTTACGTGCACCGGAGGCTATTGTGGCACAAAAACCGCTTGAAGGAGCACCACTCGCCTGGATG
ACGGTGGCGCTTTCATTAGC

Product: multidrug resistance protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MENTMSESAGAQAPQRPQNKKQQRKRVLLLLTAIFIMIGVAYLIYWFLVLRHHQETDNAYISGNQVQIMSQVPGSVVSVH
FENTDFVKSGDVLVTLDPTDAEQAFEQAKTALANSVRQTHQLIINSKQYQANIALKKTELSQAQNDLKRRVVLGAAAVIG
REELQHARDAVEAAQASLDMAVQQYNANQALVLNTPLEKQPAIEQAAAKMRDAWLTLQRTKVVSPISGYVSRRSVQVGAE
ISSGTPLMAVVPADQLWIDANFKETQLANMRIGQPATIVTDFYGDDVVYQGKVVGLDMGTGSAFSLLPAQNATGNWIKVV
QRLPVRIALDEKQLKEHPLRIGLSSLVKVDTANTDGHVLAQNVRKEPAFMTNALSLDFAPVNQIISDIIHANAD

Sequences:

>Translated_394_residues
MENTMSESAGAQAPQRPQNKKQQRKRVLLLLTAIFIMIGVAYLIYWFLVLRHHQETDNAYISGNQVQIMSQVPGSVVSVH
FENTDFVKSGDVLVTLDPTDAEQAFEQAKTALANSVRQTHQLIINSKQYQANIALKKTELSQAQNDLKRRVVLGAAAVIG
REELQHARDAVEAAQASLDMAVQQYNANQALVLNTPLEKQPAIEQAAAKMRDAWLTLQRTKVVSPISGYVSRRSVQVGAE
ISSGTPLMAVVPADQLWIDANFKETQLANMRIGQPATIVTDFYGDDVVYQGKVVGLDMGTGSAFSLLPAQNATGNWIKVV
QRLPVRIALDEKQLKEHPLRIGLSSLVKVDTANTDGHVLAQNVRKEPAFMTNALSLDFAPVNQIISDIIHANAD
>Mature_394_residues
MENTMSESAGAQAPQRPQNKKQQRKRVLLLLTAIFIMIGVAYLIYWFLVLRHHQETDNAYISGNQVQIMSQVPGSVVSVH
FENTDFVKSGDVLVTLDPTDAEQAFEQAKTALANSVRQTHQLIINSKQYQANIALKKTELSQAQNDLKRRVVLGAAAVIG
REELQHARDAVEAAQASLDMAVQQYNANQALVLNTPLEKQPAIEQAAAKMRDAWLTLQRTKVVSPISGYVSRRSVQVGAE
ISSGTPLMAVVPADQLWIDANFKETQLANMRIGQPATIVTDFYGDDVVYQGKVVGLDMGTGSAFSLLPAQNATGNWIKVV
QRLPVRIALDEKQLKEHPLRIGLSSLVKVDTANTDGHVLAQNVRKEPAFMTNALSLDFAPVNQIISDIIHANAD

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=389, Percent_Identity=69.6658097686375, Blast_Score=555, Evalue=1e-159,
Organism=Escherichia coli, GI1788711, Length=380, Percent_Identity=49.4736842105263, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI87081951, Length=306, Percent_Identity=29.0849673202614, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1790519, Length=322, Percent_Identity=27.639751552795, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1789637, Length=310, Percent_Identity=25.8064516129032, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87082036, Length=243, Percent_Identity=27.1604938271605, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 43253; Mature: 43253

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENTMSESAGAQAPQRPQNKKQQRKRVLLLLTAIFIMIGVAYLIYWFLVLRHHQETDNAY
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
ISGNQVQIMSQVPGSVVSVHFENTDFVKSGDVLVTLDPTDAEQAFEQAKTALANSVRQTH
ECCCEEEEEECCCCCEEEEEECCCCEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHH
QLIINSKQYQANIALKKTELSQAQNDLKRRVVLGAAAVIGREELQHARDAVEAAQASLDM
HHHHCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVQQYNANQALVLNTPLEKQPAIEQAAAKMRDAWLTLQRTKVVSPISGYVSRRSVQVGAE
HHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCEEEECCE
ISSGTPLMAVVPADQLWIDANFKETQLANMRIGQPATIVTDFYGDDVVYQGKVVGLDMGT
ECCCCCEEEEECCCCEEEECCCCHHHHCCEECCCCCEEEEECCCCCEEEECEEEEEECCC
GSAFSLLPAQNATGNWIKVVQRLPVRIALDEKQLKEHPLRIGLSSLVKVDTANTDGHVLA
CCCEEEECCCCCCCHHHHHHHHCCCEEEECHHHHHHCCHHHCHHHHEEEECCCCCCHHHH
QNVRKEPAFMTNALSLDFAPVNQIISDIIHANAD
HHHCCCCCHHHHHHCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MENTMSESAGAQAPQRPQNKKQQRKRVLLLLTAIFIMIGVAYLIYWFLVLRHHQETDNAY
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
ISGNQVQIMSQVPGSVVSVHFENTDFVKSGDVLVTLDPTDAEQAFEQAKTALANSVRQTH
ECCCEEEEEECCCCCEEEEEECCCCEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHH
QLIINSKQYQANIALKKTELSQAQNDLKRRVVLGAAAVIGREELQHARDAVEAAQASLDM
HHHHCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVQQYNANQALVLNTPLEKQPAIEQAAAKMRDAWLTLQRTKVVSPISGYVSRRSVQVGAE
HHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCEEEECCE
ISSGTPLMAVVPADQLWIDANFKETQLANMRIGQPATIVTDFYGDDVVYQGKVVGLDMGT
ECCCCCEEEEECCCCEEEECCCCHHHHCCEECCCCCEEEEECCCCCEEEECEEEEEECCC
GSAFSLLPAQNATGNWIKVVQRLPVRIALDEKQLKEHPLRIGLSSLVKVDTANTDGHVLA
CCCEEEECCCCCCCHHHHHHHHCCCEEEECHHHHHHCCHHHCHHHHEEEECCCCCCHHHH
QNVRKEPAFMTNALSLDFAPVNQIISDIIHANAD
HHHCCCCCHHHHHHCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1409590; 9205837; 9278503; 8203018 [H]