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The map label for this gene is dmsA [H]

Identifier: 22124775

GI number: 22124775

Start: 968422

End: 970893

Strand: Direct

Name: dmsA [H]

Synonym: y0864

Alternate gene names: 22124775

Gene position: 968422-970893 (Clockwise)

Preceding gene: 161484861

Following gene: 22124776

Centisome position: 21.05

GC content: 52.47

Gene sequence:

>2472_bases
ATGCAACTAAGTGGGAATCTTATGAAAGAGACCAACGAATCCCGGCTGTTAACGACAGGTGTCACCCGCCGAAAACTGGT
CCAAACCACGCTTGTCGGCGGACTGGCTATGGCAACCGGGGCGTTTTCGTTACCGTTCTCCCGTACCGCACGAGCCGTTC
AATCCGCACTCAACCCCACCTCAGCCAACGACGGTAAAGTGATCTGGAGCGCCTGCACCGTTAACTGCGGCAGCCGCTGC
CCGCTGCGTATGCATGTGGCTGATGGCGAAATAAAATATGTCGAAACGGATAACACCGGCGATGATGATTTTGAGGGGCT
ACACCAGGTACGCGCCTGTCTGCGAGGGCGGTCTATGCGCCGCCGGGTCTATAACCCAGACCGCTTAAAATACCCGATGA
AACGAATCGGTGCCCGTGGTGAAGGGAAATTCAAACGTATCTCGTGGGAAGAGGCATTCGAGACTATCGCTGGCAGCATG
CAGAATATTATCAAGGAATATGGCAATGAAGCCATTTACCTGAATTACGGTACCGGCACGATAGGCGGCACCATGACCCG
CTCTTGGCCGCCGGGCGCGACGCTCTTGGCTCGCTTGATGAATTGCTGCGGTGGCTACCTCAACCAGTATGGTGATTACA
GTACCGCACAGATTGCCGCGGGACTCAATTATACCTACGGTGGCTGGGCTGACGGTAACAGCCCGTCCGATATCGAAAAC
AGTAAGCTGGTGGTGTTGTTCGGTAATAACCCGGCTGAAACCCGGATGAGTGGCGGTGGGGTCACCTATTATCTGGAGCA
GGCACGAGAGAAATCCAATGCCAAAATGATCGTGATTGACCCCCGTTATACCGACACCGCAGCAGGCCGTGAAGATGAAT
GGATCCCACTACGACCAGGCACTGATGCCGCATTGGCCTCTGCGTTAGCTTATGTGATGATCACTGAAAATCTGGTGGAT
CAACCCTTCCTTGACCAATATTGCGTTGGTTATGACGAGAAGACGCTACCAGAAGGCGCACCCGAAAATAGTCACTACAA
AGCCTATATTTTAGGGCAGGGCGCAGATAAAACCGCCAAAACCCCACAATGGGCAGCGGCTATCACCGGTATTCCCGCCG
CAAAAATCATTACGCTAGGCCGTGAAATAGGGTCAGTGAAGCCGGCTTATATTTCCCAAGGTTGGGGGCCACAACGTCAT
TCCAACGGCGAAAACACCAGCCGAGCCATTGCCATGTTGGCAATCTTGACCGGTAATGTCGGTATTAATGGCGGTAACTC
CGGTGCTCGTGAAGGCTCCTACAGCCTGCCGTTTGTCCGTATGCCTACCTTTGAAAACCCAGTCAAAACCAGTATCTCTA
TGTTCTTGTGGACCGATGCCATTGAGCGTGGACCTGAAATGACCGCCACCCGTGATGGGGTTCAGGGGAAAGATAAGCTG
GATGTCCCGATCAAATTTATTTGGAACTACGCCAGTAACTGTTTGGTGAATCAACATTCTGAAATCAATCGCACCCATGA
CATTCTGCAAGACGATAAGAAATGCGAAATGATTGTGGTCATTGATAACCACATGACCTCGTCGGCTGAATATGCCGATA
TTATCCTGCCAGACTGTACCGCTTCCGAGCAGATGGACTTCTGTCTGGATGCCTCCAGCGGCAATATGGCCTATGTCATT
TTTGCTGATCAGGTGATTAAACCGCGTTTTGAGTGCAAAAATATTTATGACATCACCAGTGGATTGGCAAGACACATGGG
GGTCGAGCAGAAGTTTACCGAAGGGCGAACGCAAGAAGAGTGGATGCGCCACCTCTATCAGCAATCGCAAGCTGCAATCC
CTGAACTGCCTTCTTTCGAGGATTTCCGCGCTCAGGGCATGTTTAAAAAACGAGACCCGGCAGGCCATCACGTTGCCTAT
CACGATTTCCGCACCGATCCGGTTGCTAACCCACTGAGTACCCCATCAGGCAAAATTGAGATCTATTCTGCGGCGCTGGC
CGAGATTGCCGCGACTTGGGAACTGCAAAAAGATGATGTTATCGATCCGTTGCCCGTGTATGCCGCCGGTTTTGAAAGCC
ATGTTGATCCACTGATTGAACAGTATCCGTTGCAATTAACCGGCTTCCACTACAAGGCCAGAACCCACTCCACCTACGGT
AACGTAGATGTGTTGAAAGCCTCCTGTCTTCAGGAGATGTGGATTAACCCGATGGATGCTGAACGGCGAGGGATCAGCAA
TGGCGATATGGTGCGGATCTTCAATGGCCGTGGTGAAGTACAGATTAATGCCAAAGTCACTCCGCGCATGATGCCGGGGG
TTGTCGCTTTGGGTGAGGGGGCGTGGTACAGCCCCGATGCGAAGCGTATTGATCGGGCGGGCAGTATCAACGTATTGACC
ACCCAGCGCCCCTCCCCGTTGGCGAAAGGGAACCCATCCCACACCAACCTCGTTCAAGTCGCCAAGGCATAA

Upstream 100 bases:

>100_bases
CCATTGCGCTCTCACTGAAGCCCCCAATCTCCTGCTGATCTGCTCATTTTTTTTGAATTATTCGGGCGCCATCCACACTG
GGTGACTCTCATTTTCTGGA

Downstream 100 bases:

>100_bases
GGAGCTGACTGATGACAACGCAATATGGTTTTTACATCGACTCCAGCCGTTGTACAGGGTGTAAAACGTGCGAGTTGGCC
TGCAAAGACTTTAAAAATCT

Product: anaerobic dimethyl sulfoxide reductase chain A

Products: Reduced form of N-Oxide compounds [C]

Alternate protein names: DMSO reductase [H]

Number of amino acids: Translated: 823; Mature: 823

Protein sequence:

>823_residues
MQLSGNLMKETNESRLLTTGVTRRKLVQTTLVGGLAMATGAFSLPFSRTARAVQSALNPTSANDGKVIWSACTVNCGSRC
PLRMHVADGEIKYVETDNTGDDDFEGLHQVRACLRGRSMRRRVYNPDRLKYPMKRIGARGEGKFKRISWEEAFETIAGSM
QNIIKEYGNEAIYLNYGTGTIGGTMTRSWPPGATLLARLMNCCGGYLNQYGDYSTAQIAAGLNYTYGGWADGNSPSDIEN
SKLVVLFGNNPAETRMSGGGVTYYLEQAREKSNAKMIVIDPRYTDTAAGREDEWIPLRPGTDAALASALAYVMITENLVD
QPFLDQYCVGYDEKTLPEGAPENSHYKAYILGQGADKTAKTPQWAAAITGIPAAKIITLGREIGSVKPAYISQGWGPQRH
SNGENTSRAIAMLAILTGNVGINGGNSGAREGSYSLPFVRMPTFENPVKTSISMFLWTDAIERGPEMTATRDGVQGKDKL
DVPIKFIWNYASNCLVNQHSEINRTHDILQDDKKCEMIVVIDNHMTSSAEYADIILPDCTASEQMDFCLDASSGNMAYVI
FADQVIKPRFECKNIYDITSGLARHMGVEQKFTEGRTQEEWMRHLYQQSQAAIPELPSFEDFRAQGMFKKRDPAGHHVAY
HDFRTDPVANPLSTPSGKIEIYSAALAEIAATWELQKDDVIDPLPVYAAGFESHVDPLIEQYPLQLTGFHYKARTHSTYG
NVDVLKASCLQEMWINPMDAERRGISNGDMVRIFNGRGEVQINAKVTPRMMPGVVALGEGAWYSPDAKRIDRAGSINVLT
TQRPSPLAKGNPSHTNLVQVAKA

Sequences:

>Translated_823_residues
MQLSGNLMKETNESRLLTTGVTRRKLVQTTLVGGLAMATGAFSLPFSRTARAVQSALNPTSANDGKVIWSACTVNCGSRC
PLRMHVADGEIKYVETDNTGDDDFEGLHQVRACLRGRSMRRRVYNPDRLKYPMKRIGARGEGKFKRISWEEAFETIAGSM
QNIIKEYGNEAIYLNYGTGTIGGTMTRSWPPGATLLARLMNCCGGYLNQYGDYSTAQIAAGLNYTYGGWADGNSPSDIEN
SKLVVLFGNNPAETRMSGGGVTYYLEQAREKSNAKMIVIDPRYTDTAAGREDEWIPLRPGTDAALASALAYVMITENLVD
QPFLDQYCVGYDEKTLPEGAPENSHYKAYILGQGADKTAKTPQWAAAITGIPAAKIITLGREIGSVKPAYISQGWGPQRH
SNGENTSRAIAMLAILTGNVGINGGNSGAREGSYSLPFVRMPTFENPVKTSISMFLWTDAIERGPEMTATRDGVQGKDKL
DVPIKFIWNYASNCLVNQHSEINRTHDILQDDKKCEMIVVIDNHMTSSAEYADIILPDCTASEQMDFCLDASSGNMAYVI
FADQVIKPRFECKNIYDITSGLARHMGVEQKFTEGRTQEEWMRHLYQQSQAAIPELPSFEDFRAQGMFKKRDPAGHHVAY
HDFRTDPVANPLSTPSGKIEIYSAALAEIAATWELQKDDVIDPLPVYAAGFESHVDPLIEQYPLQLTGFHYKARTHSTYG
NVDVLKASCLQEMWINPMDAERRGISNGDMVRIFNGRGEVQINAKVTPRMMPGVVALGEGAWYSPDAKRIDRAGSINVLT
TQRPSPLAKGNPSHTNLVQVAKA
>Mature_823_residues
MQLSGNLMKETNESRLLTTGVTRRKLVQTTLVGGLAMATGAFSLPFSRTARAVQSALNPTSANDGKVIWSACTVNCGSRC
PLRMHVADGEIKYVETDNTGDDDFEGLHQVRACLRGRSMRRRVYNPDRLKYPMKRIGARGEGKFKRISWEEAFETIAGSM
QNIIKEYGNEAIYLNYGTGTIGGTMTRSWPPGATLLARLMNCCGGYLNQYGDYSTAQIAAGLNYTYGGWADGNSPSDIEN
SKLVVLFGNNPAETRMSGGGVTYYLEQAREKSNAKMIVIDPRYTDTAAGREDEWIPLRPGTDAALASALAYVMITENLVD
QPFLDQYCVGYDEKTLPEGAPENSHYKAYILGQGADKTAKTPQWAAAITGIPAAKIITLGREIGSVKPAYISQGWGPQRH
SNGENTSRAIAMLAILTGNVGINGGNSGAREGSYSLPFVRMPTFENPVKTSISMFLWTDAIERGPEMTATRDGVQGKDKL
DVPIKFIWNYASNCLVNQHSEINRTHDILQDDKKCEMIVVIDNHMTSSAEYADIILPDCTASEQMDFCLDASSGNMAYVI
FADQVIKPRFECKNIYDITSGLARHMGVEQKFTEGRTQEEWMRHLYQQSQAAIPELPSFEDFRAQGMFKKRDPAGHHVAY
HDFRTDPVANPLSTPSGKIEIYSAALAEIAATWELQKDDVIDPLPVYAAGFESHVDPLIEQYPLQLTGFHYKARTHSTYG
NVDVLKASCLQEMWINPMDAERRGISNGDMVRIFNGRGEVQINAKVTPRMMPGVVALGEGAWYSPDAKRIDRAGSINVLT
TQRPSPLAKGNPSHTNLVQVAKA

Specific function: Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. Allows E.coli to grow anaerobically on Me(2)SO as respiratory oxidant [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081797, Length=815, Percent_Identity=81.5950920245399, Blast_Score=1401, Evalue=0.0,
Organism=Escherichia coli, GI1787870, Length=810, Percent_Identity=66.2962962962963, Blast_Score=1135, Evalue=0.0,
Organism=Escherichia coli, GI171474008, Length=819, Percent_Identity=63.2478632478632, Blast_Score=1095, Evalue=0.0,
Organism=Escherichia coli, GI1787231, Length=761, Percent_Identity=31.9316688567674, Blast_Score=298, Evalue=7e-82,
Organism=Escherichia coli, GI145693196, Length=755, Percent_Identity=30.4635761589404, Blast_Score=279, Evalue=5e-76,
Organism=Escherichia coli, GI87081994, Length=745, Percent_Identity=31.2751677852349, Blast_Score=276, Evalue=5e-75,
Organism=Escherichia coli, GI3868721, Length=761, Percent_Identity=25.2299605781866, Blast_Score=147, Evalue=3e-36,
Organism=Escherichia coli, GI3868720, Length=471, Percent_Identity=27.8131634819533, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1787477, Length=306, Percent_Identity=28.1045751633987, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI3868719, Length=478, Percent_Identity=25.7322175732218, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1787741, Length=308, Percent_Identity=26.9480519480519, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788534, Length=811, Percent_Identity=22.6880394574599, Blast_Score=73, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011888
- InterPro:   IPR009010
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.8.99.- [C]

Molecular weight: Translated: 90649; Mature: 90649

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1 ; PS00490 MOLYBDOPTERIN_PROK_2 ; PS00932 MOLYBDOPTERIN_PROK_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLSGNLMKETNESRLLTTGVTRRKLVQTTLVGGLAMATGAFSLPFSRTARAVQSALNPT
CCCCCCHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCC
SANDGKVIWSACTVNCGSRCPLRMHVADGEIKYVETDNTGDDDFEGLHQVRACLRGRSMR
CCCCCEEEEEEEEECCCCCCCEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHCHHHH
RRVYNPDRLKYPMKRIGARGEGKFKRISWEEAFETIAGSMQNIIKEYGNEAIYLNYGTGT
HHCCCCHHHHCCHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
IGGTMTRSWPPGATLLARLMNCCGGYLNQYGDYSTAQIAAGLNYTYGGWADGNSPSDIEN
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCC
SKLVVLFGNNPAETRMSGGGVTYYLEQAREKSNAKMIVIDPRYTDTAAGREDEWIPLRPG
CEEEEEECCCCHHCEECCCCEEEHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEECCCC
TDAALASALAYVMITENLVDQPFLDQYCVGYDEKTLPEGAPENSHYKAYILGQGADKTAK
CHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCC
TPQWAAAITGIPAAKIITLGREIGSVKPAYISQGWGPQRHSNGENTSRAIAMLAILTGNV
CCCHHHHHCCCCHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCC
GINGGNSGAREGSYSLPFVRMPTFENPVKTSISMFLWTDAIERGPEMTATRDGVQGKDKL
CCCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHEEHHHHHCCCCCCCCCCCCCCCCCC
DVPIKFIWNYASNCLVNQHSEINRTHDILQDDKKCEMIVVIDNHMTSSAEYADIILPDCT
CCCHHHHHHHHHHHEECCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEEEECCCC
ASEQMDFCLDASSGNMAYVIFADQVIKPRFECKNIYDITSGLARHMGVEQKFTEGRTQEE
CCCCCCEEEECCCCCEEEEEEECCHHCCCHHCCHHHHHHHHHHHHCCCHHHHHCCCCHHH
WMRHLYQQSQAAIPELPSFEDFRAQGMFKKRDPAGHHVAYHDFRTDPVANPLSTPSGKIE
HHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCEE
IYSAALAEIAATWELQKDDVIDPLPVYAAGFESHVDPLIEQYPLQLTGFHYKARTHSTYG
EHHHHHHHHHHHHCCCCCCCCCCCCHHHCCHHHHHHHHHHHCCCEEEEEEEEEECCCCCC
NVDVLKASCLQEMWINPMDAERRGISNGDMVRIFNGRGEVQINAKVTPRMMPGVVALGEG
CHHHHHHHHHHHHCCCCCCHHHCCCCCCCEEEEECCCCEEEEEEEECCCCCCCEEEECCC
AWYSPDAKRIDRAGSINVLTTQRPSPLAKGNPSHTNLVQVAKA
CCCCCCHHHHCCCCCEEEEECCCCCCCCCCCCCCCCEEEEECC
>Mature Secondary Structure
MQLSGNLMKETNESRLLTTGVTRRKLVQTTLVGGLAMATGAFSLPFSRTARAVQSALNPT
CCCCCCHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCC
SANDGKVIWSACTVNCGSRCPLRMHVADGEIKYVETDNTGDDDFEGLHQVRACLRGRSMR
CCCCCEEEEEEEEECCCCCCCEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHCHHHH
RRVYNPDRLKYPMKRIGARGEGKFKRISWEEAFETIAGSMQNIIKEYGNEAIYLNYGTGT
HHCCCCHHHHCCHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
IGGTMTRSWPPGATLLARLMNCCGGYLNQYGDYSTAQIAAGLNYTYGGWADGNSPSDIEN
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCC
SKLVVLFGNNPAETRMSGGGVTYYLEQAREKSNAKMIVIDPRYTDTAAGREDEWIPLRPG
CEEEEEECCCCHHCEECCCCEEEHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEECCCC
TDAALASALAYVMITENLVDQPFLDQYCVGYDEKTLPEGAPENSHYKAYILGQGADKTAK
CHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCC
TPQWAAAITGIPAAKIITLGREIGSVKPAYISQGWGPQRHSNGENTSRAIAMLAILTGNV
CCCHHHHHCCCCHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCC
GINGGNSGAREGSYSLPFVRMPTFENPVKTSISMFLWTDAIERGPEMTATRDGVQGKDKL
CCCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHEEHHHHHCCCCCCCCCCCCCCCCCC
DVPIKFIWNYASNCLVNQHSEINRTHDILQDDKKCEMIVVIDNHMTSSAEYADIILPDCT
CCCHHHHHHHHHHHEECCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEEEECCCC
ASEQMDFCLDASSGNMAYVIFADQVIKPRFECKNIYDITSGLARHMGVEQKFTEGRTQEE
CCCCCCEEEECCCCCEEEEEEECCHHCCCHHCCHHHHHHHHHHHHCCCHHHHHCCCCHHH
WMRHLYQQSQAAIPELPSFEDFRAQGMFKKRDPAGHHVAYHDFRTDPVANPLSTPSGKIE
HHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCEE
IYSAALAEIAATWELQKDDVIDPLPVYAAGFESHVDPLIEQYPLQLTGFHYKARTHSTYG
EHHHHHHHHHHHHCCCCCCCCCCCCHHHCCHHHHHHHHHHHCCCEEEEEEEEEECCCCCC
NVDVLKASCLQEMWINPMDAERRGISNGDMVRIFNGRGEVQINAKVTPRMMPGVVALGEG
CHHHHHHHHHHHHCCCCCCHHHCCCCCCCEEEEECCCCEEEEEEEECCCCCCCEEEECCC
AWYSPDAKRIDRAGSINVLTTQRPSPLAKGNPSHTNLVQVAKA
CCCCCCHHHHCCCCCEEEEECCCCCCCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: May Bind 4Fe-4S Cluster. [C]

Metal ions: Fe; Mo [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-Oxide; Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

Specific reaction: Reduces Various N-Oxide And Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062312; 8905232; 9278503; 2170332; 8125918; 10801884 [H]