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The map label for this gene is fbp [H]

Identifier: 22124578

GI number: 22124578

Start: 748577

End: 749695

Strand: Reverse

Name: fbp [H]

Synonym: y0664

Alternate gene names: 22124578

Gene position: 749695-748577 (Counterclockwise)

Preceding gene: 22124580

Following gene: 22124577

Centisome position: 16.3

GC content: 45.58

Gene sequence:

>1119_bases
ATGGAATTGCCTATGAATCAATCTTACCTTTGGGCTACACTGCTGACATTAGCTGTGTTGTGTATTAATAAATCGATATT
TAACCGTAGATTCAGGGATTGTGTCATGAAAACGTTAGGCGAATTCATCGTCGAGAAACAGCTCGATTTCTCTCACGCCA
CTGGCGAACTAACTGCGTTACTTTCAGCAATCAAACTCGGCGCAAAGATCATTCACCGCGATATCAACAAAGCAGGTCTG
GTTGATATCTTAGGTGCCAGCGGCGTTTCCAATATTCAGGGCGAGGACCAGATGAAACTGGATCTGTTTGCCAATGAAAA
GTTGAAAGCTGCCCTTAAAGCCCGTGGTGAAGTTGCCGGTATAGCCTCCGAAGAAGAAGATGACATTGTCATTTTTGATG
GCGGAAGAGCAGAAAATGCCAAGTATGTGGTTTTGATGGATCCACTGGATGGTTCTTCAAATATTGATGTGAATGTTTCT
GTTGGCACAATTTTCTCAATTTATCGTCGTATTACGCCATTTGGGACACCAATCACTGAAGAAGACTTCCTGCAACCGGG
TACCAAACAAGTCACGGCAGGCTATGTCGTTTACGGTTCCTCAACCATGTTGGTCTATACCACAGGTTACGGTGTCCATG
CCTTTACCTACGATCCTTCTCTGGGTGTTTTCTGTTTATCCCACGAAAAAGTTCGCTATCCCGCAACCGGTTGCATGTAT
TCCATCAACGAAGGGAATTACATTAAATTCCCTCTGGGTGTGAAAAAATACATCAAGTATTGCCAGGAGCAAGACGAAGC
CACTAAGCGCCCATATACCTCCCGTTATATTGGTTCATTAGTTGCTGATTTTCATCGTAACCTGTTGAAGGGCGGTATTT
ATATTTACCCAAGTACCGCCAGCCACCCTCAAGGGAAACTGCGTTTGTTGTATGAGTGCAACCCAATGGCCTTCCTCGCG
GAGCAAGCCGGTGGTAAAGCCACCGATGGGGTGAACCGTATTCTGGACATCGTGCCAGAGAAACTGCATCAACGCGCACC
GTTCTTCGTGGGAACAAAATCCATGGTGGAAGATGCGGAAGGGTTTATCGCTAAATTCCCAGATGAAGAAGCCAAGTAA

Upstream 100 bases:

>100_bases
AATGTGCCGCAGATACCTAAGATGTGAATGCGCATAAATCTTCCGTATTAATAAGCTTAAAATTTGTAGCCATTCTACCG
CTCAGAATCAAAGAGAAGAA

Downstream 100 bases:

>100_bases
CTTGCAGTAATGCCGTCGCTCCCTTCAAAAATAAGCTAACAGCGGCCTTTTAAGCCGCTGTTTTTTATTTCTAACGGAAT
AAAATAGCCCTACCTCTGGC

Product: fructose-1,6-bisphosphatase

Products: NA

Alternate protein names: FBPase class 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MELPMNQSYLWATLLTLAVLCINKSIFNRRFRDCVMKTLGEFIVEKQLDFSHATGELTALLSAIKLGAKIIHRDINKAGL
VDILGASGVSNIQGEDQMKLDLFANEKLKAALKARGEVAGIASEEEDDIVIFDGGRAENAKYVVLMDPLDGSSNIDVNVS
VGTIFSIYRRITPFGTPITEEDFLQPGTKQVTAGYVVYGSSTMLVYTTGYGVHAFTYDPSLGVFCLSHEKVRYPATGCMY
SINEGNYIKFPLGVKKYIKYCQEQDEATKRPYTSRYIGSLVADFHRNLLKGGIYIYPSTASHPQGKLRLLYECNPMAFLA
EQAGGKATDGVNRILDIVPEKLHQRAPFFVGTKSMVEDAEGFIAKFPDEEAK

Sequences:

>Translated_372_residues
MELPMNQSYLWATLLTLAVLCINKSIFNRRFRDCVMKTLGEFIVEKQLDFSHATGELTALLSAIKLGAKIIHRDINKAGL
VDILGASGVSNIQGEDQMKLDLFANEKLKAALKARGEVAGIASEEEDDIVIFDGGRAENAKYVVLMDPLDGSSNIDVNVS
VGTIFSIYRRITPFGTPITEEDFLQPGTKQVTAGYVVYGSSTMLVYTTGYGVHAFTYDPSLGVFCLSHEKVRYPATGCMY
SINEGNYIKFPLGVKKYIKYCQEQDEATKRPYTSRYIGSLVADFHRNLLKGGIYIYPSTASHPQGKLRLLYECNPMAFLA
EQAGGKATDGVNRILDIVPEKLHQRAPFFVGTKSMVEDAEGFIAKFPDEEAK
>Mature_372_residues
MELPMNQSYLWATLLTLAVLCINKSIFNRRFRDCVMKTLGEFIVEKQLDFSHATGELTALLSAIKLGAKIIHRDINKAGL
VDILGASGVSNIQGEDQMKLDLFANEKLKAALKARGEVAGIASEEEDDIVIFDGGRAENAKYVVLMDPLDGSSNIDVNVS
VGTIFSIYRRITPFGTPITEEDFLQPGTKQVTAGYVVYGSSTMLVYTTGYGVHAFTYDPSLGVFCLSHEKVRYPATGCMY
SINEGNYIKFPLGVKKYIKYCQEQDEATKRPYTSRYIGSLVADFHRNLLKGGIYIYPSTASHPQGKLRLLYECNPMAFLA
EQAGGKATDGVNRILDIVPEKLHQRAPFFVGTKSMVEDAEGFIAKFPDEEAK

Specific function: INVOLVED IN SEVERAL METABOLIC PATHWAYS. IN E.COLI AND YEAST IT IS NECESSARY FOR GROWTH ON SUBSTANCES SUCH AS GLYCEROL, SUCCINATE AND ACETATE. [C]

COG id: COG0158

COG function: function code G; Fructose-1,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FBPase class 1 family [H]

Homologues:

Organism=Homo sapiens, GI189083692, Length=320, Percent_Identity=43.125, Blast_Score=249, Evalue=2e-66,
Organism=Homo sapiens, GI16579888, Length=320, Percent_Identity=43.125, Blast_Score=249, Evalue=2e-66,
Organism=Homo sapiens, GI22907028, Length=323, Percent_Identity=42.1052631578947, Blast_Score=248, Evalue=9e-66,
Organism=Escherichia coli, GI1790679, Length=333, Percent_Identity=84.0840840840841, Blast_Score=575, Evalue=1e-165,
Organism=Caenorhabditis elegans, GI17508131, Length=331, Percent_Identity=46.5256797583082, Blast_Score=299, Evalue=1e-81,
Organism=Saccharomyces cerevisiae, GI6323409, Length=342, Percent_Identity=42.6900584795322, Blast_Score=265, Evalue=6e-72,
Organism=Drosophila melanogaster, GI45550998, Length=331, Percent_Identity=46.5256797583082, Blast_Score=284, Evalue=5e-77,
Organism=Drosophila melanogaster, GI19921562, Length=331, Percent_Identity=46.5256797583082, Blast_Score=283, Evalue=1e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000146
- InterPro:   IPR020548 [H]

Pfam domain/function: PF00316 FBPase [H]

EC number: =3.1.3.11 [H]

Molecular weight: Translated: 41140; Mature: 41140

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00124 FBPASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELPMNQSYLWATLLTLAVLCINKSIFNRRFRDCVMKTLGEFIVEKQLDFSHATGELTAL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LSAIKLGAKIIHRDINKAGLVDILGASGVSNIQGEDQMKLDLFANEKLKAALKARGEVAG
HHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCEEEEEECCHHHHHHHHHCCCEEE
IASEEEDDIVIFDGGRAENAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRITPFGTPITE
CCCCCCCCEEEEECCCCCCCEEEEEECCCCCCCCEEEEEEHHHHHHHHHHHCCCCCCCCH
EDFLQPGTKQVTAGYVVYGSSTMLVYTTGYGVHAFTYDPSLGVFCLSHEKVRYPATGCMY
HHHCCCCCCEEEEEEEEECCCEEEEEEECCCEEEEEECCCCCEEEECCCCEECCCCCEEE
SINEGNYIKFPLGVKKYIKYCQEQDEATKRPYTSRYIGSLVADFHRNLLKGGIYIYPSTA
EECCCCEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCC
SHPQGKLRLLYECNPMAFLAEQAGGKATDGVNRILDIVPEKLHQRAPFFVGTKSMVEDAE
CCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHC
GFIAKFPDEEAK
CCEEECCCCCCC
>Mature Secondary Structure
MELPMNQSYLWATLLTLAVLCINKSIFNRRFRDCVMKTLGEFIVEKQLDFSHATGELTAL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LSAIKLGAKIIHRDINKAGLVDILGASGVSNIQGEDQMKLDLFANEKLKAALKARGEVAG
HHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCEEEEEECCHHHHHHHHHCCCEEE
IASEEEDDIVIFDGGRAENAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRITPFGTPITE
CCCCCCCCEEEEECCCCCCCEEEEEECCCCCCCCEEEEEEHHHHHHHHHHHCCCCCCCCH
EDFLQPGTKQVTAGYVVYGSSTMLVYTTGYGVHAFTYDPSLGVFCLSHEKVRYPATGCMY
HHHCCCCCCEEEEEEEEECCCEEEEEEECCCEEEEEECCCCCEEEECCCCEECCCCCEEE
SINEGNYIKFPLGVKKYIKYCQEQDEATKRPYTSRYIGSLVADFHRNLLKGGIYIYPSTA
EECCCCEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCC
SHPQGKLRLLYECNPMAFLAEQAGGKATDGVNRILDIVPEKLHQRAPFFVGTKSMVEDAE
CCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHC
GFIAKFPDEEAK
CCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA