| Definition | Yersinia pestis KIM 10 chromosome, complete genome. |
|---|---|
| Accession | NC_004088 |
| Length | 4,600,755 |
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The map label for this gene is purH [H]
Identifier: 22124417
GI number: 22124417
Start: 563008
End: 564642
Strand: Reverse
Name: purH [H]
Synonym: y0502
Alternate gene names: 22124417
Gene position: 564642-563008 (Counterclockwise)
Preceding gene: 22124420
Following gene: 22124416
Centisome position: 12.27
GC content: 51.01
Gene sequence:
>1635_bases TTGATAATGAAGAAAACTGCGACTCCAAATCCAAGGGATAAAACCATGCAACAACGCCGTCCAATCCGCCGTGCTCTACT CAGTGTGTCTGACAAAGCAGGTATCATCGAATTCGCCCAAGCACTTTCTCAACGCGGTATCGAGTTACTTTCCACCGGTG GGACTGCCCGCCTGCTGGCTGATGCTGGTTTACCCGTTACCGAAGTGTCTGACTACACCGGTTTCCCGGAAATGATGGAT GGACGTGTGAAGACTTTGCATCCAAAGGTGCATGGTGGGATTTTAGGTCGTCGTGGTCAGGATGATGGCATCATGGCTCA ACATGGCATTCAGCCCATTGATATTGTCGTCGTTAATTTATATCCCTTCGCCCAGACGGTTGCCCGCCCGGATTGCTCGT TGGAAGATGCGGTTGAGAATATTGATATTGGTGGCCCAACCATGGTTCGCTCTGCGGCCAAGAACCATAAAGATGTCGCC ATCGTGGTGAAGAGTAGCGACTACCCCGCCATTATTACTGAGCTTGATAATAATGATGGTTCGTTGACTTACCCCACCCG CTTCAATCTGGCCATTAAAGCTTTCGAACACACCGCCGCCTACGACAGCATGATCGCCAACTACTTCGGCACACTGGTGC CACCTTATCATGGTGATACGGAACAGCCTTCCGGCCACTTCCCTCGCACCCTAAATCTTAACTATATAAAGAAGCAGGAT ATGCGTTACGGTGAAAACAGCCACCAGCAAGCTGCCTTCTATATAGAAGAAGATGTCAAAGAGGCATCCGTTGCCACTGC CCAGCAATTACAAGGGAAAGCCCTCTCTTATAACAATATTGCGGATACCGATGCCGCGCTGGAATGCGTGAAAGAGTTCA GTGAACCAGCCTGTGTGATCGTTAAACATGCCAACCCATGCGGTGTGGCTATCGGTGATTCTATTCTTGCCGCTTATGAA CGTGCCTATCAAACCGATCCAACCTCAGCTTTCGGTGGCATCATCGCCTTTAACCGTGAATTGGATGCAGCAACGGCCAG CGCGATCATCAGCCGCCAGTTTGTCGAAGTGATCATTGCGCCAACAGTCAGCTCTGATGCATTGGCATTGCTTGCAGCTA AACAAAATGTCCGAGTCCTGACTTGTGGCCAGTGGCAAGCACGTTCAGCAGGTTTAGATTTCAAACGTGTTAATGGGGGT TTGCTGGTACAAGAACGCGATTTAGGTATGGTGACGGCGGCCGACCTTCGCGTGGTTTCCAAGCGTCAGCCTACCGAACA GGAACTGCGTGATGCGCTGTTCTGCTGGAAAGTGGCTAAGTTTGTTAAATCCAATGCGATTGTCTATGCCCGCGATAACA TGACAATCGGTATAGGTGCCGGCCAAATGAGCCGCGTGTACTCTGCGAAAATAGCCGGTATCAAGGCCGCAGATGAAGGG CTGGAAGTGGCTGGCTCAGCCATGGCCTCTGATGCCTTCTTCCCGTTCCGTGATGGTATTGATGCCGCCGCGGCTGTGGG CATTACTTGTGTCATCCAACCGGGCGGCTCAATTCGTGATGATGAAGTCATCGCGGCTGCTGATGAACACAGTATTGCCA TGATCTTCACCGACATGCGCCATTTCCGTCATTAA
Upstream 100 bases:
>100_bases TTCGCTACAATTCCCCGCGTCGAAAAGGGTGACCTCATCGACAAAATATCAACGAAATAGTCTGTAGCGCCCTATTAATT GATAGTGAAGAACTCTGTAA
Downstream 100 bases:
>100_bases TTAACCCTCTTATATAGGAAGGGGCGCTTGATGATGTGCCCCTTCACGGAGTCATCCAGATGAATATTTTGATAATTGGT AACGGCGGTCGTGAACACGC
Product: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
Products: NA
Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase [H]
Number of amino acids: Translated: 544; Mature: 544
Protein sequence:
>544_residues MIMKKTATPNPRDKTMQQRRPIRRALLSVSDKAGIIEFAQALSQRGIELLSTGGTARLLADAGLPVTEVSDYTGFPEMMD GRVKTLHPKVHGGILGRRGQDDGIMAQHGIQPIDIVVVNLYPFAQTVARPDCSLEDAVENIDIGGPTMVRSAAKNHKDVA IVVKSSDYPAIITELDNNDGSLTYPTRFNLAIKAFEHTAAYDSMIANYFGTLVPPYHGDTEQPSGHFPRTLNLNYIKKQD MRYGENSHQQAAFYIEEDVKEASVATAQQLQGKALSYNNIADTDAALECVKEFSEPACVIVKHANPCGVAIGDSILAAYE RAYQTDPTSAFGGIIAFNRELDAATASAIISRQFVEVIIAPTVSSDALALLAAKQNVRVLTCGQWQARSAGLDFKRVNGG LLVQERDLGMVTAADLRVVSKRQPTEQELRDALFCWKVAKFVKSNAIVYARDNMTIGIGAGQMSRVYSAKIAGIKAADEG LEVAGSAMASDAFFPFRDGIDAAAAVGITCVIQPGGSIRDDEVIAAADEHSIAMIFTDMRHFRH
Sequences:
>Translated_544_residues MIMKKTATPNPRDKTMQQRRPIRRALLSVSDKAGIIEFAQALSQRGIELLSTGGTARLLADAGLPVTEVSDYTGFPEMMD GRVKTLHPKVHGGILGRRGQDDGIMAQHGIQPIDIVVVNLYPFAQTVARPDCSLEDAVENIDIGGPTMVRSAAKNHKDVA IVVKSSDYPAIITELDNNDGSLTYPTRFNLAIKAFEHTAAYDSMIANYFGTLVPPYHGDTEQPSGHFPRTLNLNYIKKQD MRYGENSHQQAAFYIEEDVKEASVATAQQLQGKALSYNNIADTDAALECVKEFSEPACVIVKHANPCGVAIGDSILAAYE RAYQTDPTSAFGGIIAFNRELDAATASAIISRQFVEVIIAPTVSSDALALLAAKQNVRVLTCGQWQARSAGLDFKRVNGG LLVQERDLGMVTAADLRVVSKRQPTEQELRDALFCWKVAKFVKSNAIVYARDNMTIGIGAGQMSRVYSAKIAGIKAADEG LEVAGSAMASDAFFPFRDGIDAAAAVGITCVIQPGGSIRDDEVIAAADEHSIAMIFTDMRHFRH >Mature_544_residues MIMKKTATPNPRDKTMQQRRPIRRALLSVSDKAGIIEFAQALSQRGIELLSTGGTARLLADAGLPVTEVSDYTGFPEMMD GRVKTLHPKVHGGILGRRGQDDGIMAQHGIQPIDIVVVNLYPFAQTVARPDCSLEDAVENIDIGGPTMVRSAAKNHKDVA IVVKSSDYPAIITELDNNDGSLTYPTRFNLAIKAFEHTAAYDSMIANYFGTLVPPYHGDTEQPSGHFPRTLNLNYIKKQD MRYGENSHQQAAFYIEEDVKEASVATAQQLQGKALSYNNIADTDAALECVKEFSEPACVIVKHANPCGVAIGDSILAAYE RAYQTDPTSAFGGIIAFNRELDAATASAIISRQFVEVIIAPTVSSDALALLAAKQNVRVLTCGQWQARSAGLDFKRVNGG LLVQERDLGMVTAADLRVVSKRQPTEQELRDALFCWKVAKFVKSNAIVYARDNMTIGIGAGQMSRVYSAKIAGIKAADEG LEVAGSAMASDAFFPFRDGIDAAAAVGITCVIQPGGSIRDDEVIAAADEHSIAMIFTDMRHFRH
Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]
COG id: COG0138
COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the purH family [H]
Homologues:
Organism=Homo sapiens, GI20127454, Length=486, Percent_Identity=38.6831275720165, Blast_Score=278, Evalue=8e-75, Organism=Escherichia coli, GI1790439, Length=529, Percent_Identity=87.1455576559546, Blast_Score=962, Evalue=0.0, Organism=Caenorhabditis elegans, GI71985564, Length=620, Percent_Identity=34.6774193548387, Blast_Score=294, Evalue=7e-80, Organism=Caenorhabditis elegans, GI71985574, Length=358, Percent_Identity=28.4916201117318, Blast_Score=97, Evalue=3e-20, Organism=Caenorhabditis elegans, GI71985556, Length=115, Percent_Identity=36.5217391304348, Blast_Score=75, Evalue=7e-14, Organism=Saccharomyces cerevisiae, GI6323768, Length=486, Percent_Identity=36.0082304526749, Blast_Score=264, Evalue=2e-71, Organism=Saccharomyces cerevisiae, GI6323056, Length=623, Percent_Identity=31.3001605136437, Blast_Score=263, Evalue=5e-71, Organism=Drosophila melanogaster, GI24649832, Length=612, Percent_Identity=35.7843137254902, Blast_Score=308, Evalue=7e-84,
Paralogues:
None
Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002695 - InterPro: IPR013982 - InterPro: IPR016193 - InterPro: IPR011607 [H]
Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS [H]
EC number: =2.1.2.3; =3.5.4.10 [H]
Molecular weight: Translated: 58869; Mature: 58869
Theoretical pI: Translated: 6.11; Mature: 6.11
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.3 %Cys (Translated Protein) 2.8 %Met (Translated Protein) 4.0 %Cys+Met (Translated Protein) 1.3 %Cys (Mature Protein) 2.8 %Met (Mature Protein) 4.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MIMKKTATPNPRDKTMQQRRPIRRALLSVSDKAGIIEFAQALSQRGIELLSTGGTARLLA CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEEECCCCEEEEE DAGLPVTEVSDYTGFPEMMDGRVKTLHPKVHGGILGRRGQDDGIMAQHGIQPIDIVVVNL CCCCCCEECCCCCCCHHHHCCCEEEECCHHHCCCCCCCCCCCCCHHHCCCCEEEEEEEEE YPFAQTVARPDCSLEDAVENIDIGGPTMVRSAAKNHKDVAIVVKSSDYPAIITELDNNDG EHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHCCCCCEEEEEECCCCCEEEEEEECCCC SLTYPTRFNLAIKAFEHTAAYDSMIANYFGTLVPPYHGDTEQPSGHFPRTLNLNYIKKQD CEECCEEECEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCHHHHHH MRYGENSHQQAAFYIEEDVKEASVATAQQLQGKALSYNNIADTDAALECVKEFSEPACVI HCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCEEEE VKHANPCGVAIGDSILAAYERAYQTDPTSAFGGIIAFNRELDAATASAIISRQFVEVIIA EECCCCCCCHHHHHHHHHHHHHHCCCCCHHHCCEEEECCCCCHHHHHHHHHHHHHHEEEE PTVSSDALALLAAKQNVRVLTCGQWQARSAGLDFKRVNGGLLVQERDLGMVTAADLRVVS CCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCEEECCCCEEEEECCCCEEEHHHHHHHH KRQPTEQELRDALFCWKVAKFVKSNAIVYARDNMTIGIGAGQMSRVYSAKIAGIKAADEG CCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCEEEEECCCHHHHHHHHHHCCCEECCCC LEVAGSAMASDAFFPFRDGIDAAAAVGITCVIQPGGSIRDDEVIAAADEHSIAMIFTDMR HHHHHHHHHCCCCCCCCCCCCHHHHCCEEEEECCCCCCCCCCEEEECCCCCEEEEEEHHH HFRH HHCC >Mature Secondary Structure MIMKKTATPNPRDKTMQQRRPIRRALLSVSDKAGIIEFAQALSQRGIELLSTGGTARLLA CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEEECCCCEEEEE DAGLPVTEVSDYTGFPEMMDGRVKTLHPKVHGGILGRRGQDDGIMAQHGIQPIDIVVVNL CCCCCCEECCCCCCCHHHHCCCEEEECCHHHCCCCCCCCCCCCCHHHCCCCEEEEEEEEE YPFAQTVARPDCSLEDAVENIDIGGPTMVRSAAKNHKDVAIVVKSSDYPAIITELDNNDG EHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHCCCCCEEEEEECCCCCEEEEEEECCCC SLTYPTRFNLAIKAFEHTAAYDSMIANYFGTLVPPYHGDTEQPSGHFPRTLNLNYIKKQD CEECCEEECEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCHHHHHH MRYGENSHQQAAFYIEEDVKEASVATAQQLQGKALSYNNIADTDAALECVKEFSEPACVI HCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCEEEE VKHANPCGVAIGDSILAAYERAYQTDPTSAFGGIIAFNRELDAATASAIISRQFVEVIIA EECCCCCCCHHHHHHHHHHHHHHCCCCCHHHCCEEEECCCCCHHHHHHHHHHHHHHEEEE PTVSSDALALLAAKQNVRVLTCGQWQARSAGLDFKRVNGGLLVQERDLGMVTAADLRVVS CCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCEEECCCCEEEEECCCCEEEHHHHHHHH KRQPTEQELRDALFCWKVAKFVKSNAIVYARDNMTIGIGAGQMSRVYSAKIAGIKAADEG CCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCEEEEECCCHHHHHHHHHHCCCEECCCC LEVAGSAMASDAFFPFRDGIDAAAAVGITCVIQPGGSIRDDEVIAAADEHSIAMIFTDMR HHHHHHHHHCCCCCCCCCCCCHHHHCCEEEEECCCCCCCCCCEEEECCCCCEEEEEEHHH HFRH HHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA